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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TEAD4
Z-value: 2.11
Motif logo
Transcription factors associated with TEAD4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TEAD4
|
ENSG00000197905.4 | TEA domain transcription factor 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD4 | hg19_v2_chr12_+_3068466_3068496 | 0.94 | 6.8e-10 | Click! |
Activity profile of TEAD4 motif
Sorted Z-values of TEAD4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.1 | GO:2000502 | negative regulation of natural killer cell chemotaxis(GO:2000502) |
| 1.9 | 7.4 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.8 | 5.4 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.6 | 1.8 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.6 | 1.8 | GO:0051795 | positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427) |
| 0.6 | 1.7 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.5 | 1.5 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.5 | 3.8 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.5 | 2.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.4 | 3.6 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.4 | 1.7 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.4 | 2.2 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
| 0.4 | 1.8 | GO:1903615 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.4 | 1.5 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.4 | 6.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.3 | 3.5 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.3 | 1.0 | GO:0061010 | endodermal cell fate determination(GO:0007493) regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796) gall bladder development(GO:0061010) |
| 0.3 | 2.6 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.3 | 2.3 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.3 | 1.2 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.3 | 1.2 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.3 | 1.1 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 0.3 | 4.2 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.3 | 3.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.3 | 1.6 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.3 | 1.6 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.3 | 1.0 | GO:0061743 | motor learning(GO:0061743) |
| 0.2 | 1.2 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.2 | 2.3 | GO:2000809 | regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.2 | 2.8 | GO:0019530 | taurine metabolic process(GO:0019530) |
| 0.2 | 3.4 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 1.6 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.2 | 2.9 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.2 | 0.7 | GO:0072287 | metanephric distal tubule morphogenesis(GO:0072287) |
| 0.2 | 1.3 | GO:1903899 | lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.2 | 1.7 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.2 | 1.2 | GO:0060994 | regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) |
| 0.1 | 0.7 | GO:1904882 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.1 | 3.4 | GO:0044331 | cell-cell adhesion mediated by cadherin(GO:0044331) |
| 0.1 | 2.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.6 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.1 | 6.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 5.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.5 | GO:0019853 | L-ascorbic acid biosynthetic process(GO:0019853) |
| 0.1 | 1.2 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.1 | 2.1 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.4 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 2.7 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) |
| 0.1 | 2.0 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 1.5 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.1 | 0.9 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.1 | 2.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.9 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 1.6 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 0.6 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 0.6 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) |
| 0.1 | 0.2 | GO:0018874 | benzoate metabolic process(GO:0018874) |
| 0.1 | 0.4 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.1 | 0.7 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.1 | 2.0 | GO:0098926 | acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.1 | 0.4 | GO:0032252 | secretory granule localization(GO:0032252) |
| 0.1 | 1.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.4 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.1 | 1.7 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
| 0.1 | 1.6 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.8 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.1 | 1.2 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 0.5 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.0 | 2.8 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 0.3 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.0 | 0.2 | GO:1903278 | regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278) |
| 0.0 | 0.2 | GO:0002304 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 0.0 | 0.5 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.2 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.0 | 0.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 2.8 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.5 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.0 | 1.1 | GO:0030728 | ovulation(GO:0030728) |
| 0.0 | 0.4 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.0 | 0.5 | GO:0048858 | cell part morphogenesis(GO:0032990) cell projection morphogenesis(GO:0048858) |
| 0.0 | 1.7 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 2.5 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.0 | 1.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 5.3 | GO:0050880 | regulation of blood vessel size(GO:0050880) |
| 0.0 | 0.2 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.5 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.0 | 0.2 | GO:0030047 | actin modification(GO:0030047) |
| 0.0 | 0.2 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.0 | 1.3 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.0 | 0.1 | GO:0003363 | lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816) |
| 0.0 | 0.8 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.1 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.0 | 0.5 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.7 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.1 | GO:0072752 | cellular response to rapamycin(GO:0072752) |
| 0.0 | 1.7 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
| 0.0 | 0.3 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 0.7 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.0 | 0.1 | GO:0035995 | skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995) |
| 0.0 | 0.0 | GO:1900737 | regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737) |
| 0.0 | 0.3 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.0 | 0.1 | GO:0036111 | very long-chain fatty-acyl-CoA metabolic process(GO:0036111) |
| 0.0 | 0.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.1 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.0 | 0.3 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 1.1 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.2 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 0.0 | 0.4 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.0 | 0.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.7 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 1.1 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.2 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.5 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.0 | 3.7 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 0.7 | GO:0043486 | histone exchange(GO:0043486) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330) |
| 0.6 | 1.7 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.5 | 6.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 1.7 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.3 | 3.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 2.3 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.3 | 2.8 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.2 | 1.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.2 | 3.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 0.7 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.1 | 0.7 | GO:0002133 | polycystin complex(GO:0002133) |
| 0.1 | 2.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 0.8 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.1 | 1.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 1.2 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.1 | 0.7 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.1 | 2.3 | GO:0005916 | fascia adherens(GO:0005916) catenin complex(GO:0016342) |
| 0.1 | 3.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 2.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 2.1 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 1.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.5 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.1 | 0.6 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 1.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.3 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.2 | GO:0032279 | asymmetric synapse(GO:0032279) symmetric synapse(GO:0032280) |
| 0.0 | 0.6 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 2.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 3.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 6.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 1.3 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 2.5 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 5.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 3.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.3 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 2.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.7 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 1.1 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 0.7 | GO:0016020 | membrane(GO:0016020) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 1.2 | 3.5 | GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.5 | 2.6 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718) |
| 0.5 | 2.0 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.4 | 1.2 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.4 | 1.2 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.4 | 2.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.4 | 6.7 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.3 | 3.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 7.4 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.3 | 2.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 1.6 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.3 | 6.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 0.9 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.2 | 0.7 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.2 | 7.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 2.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.2 | 5.1 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 0.9 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.2 | 3.1 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.2 | 2.3 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.6 | GO:0005018 | platelet-derived growth factor alpha-receptor activity(GO:0005018) |
| 0.1 | 1.5 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 1.7 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.1 | 1.8 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.2 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 0.7 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 1.2 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 1.1 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.1 | 0.5 | GO:0016263 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) |
| 0.1 | 1.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 2.6 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 1.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.7 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.1 | 3.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.2 | GO:0050664 | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664) |
| 0.1 | 1.2 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.5 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.7 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 1.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 3.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.4 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.4 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 0.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.5 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.1 | 0.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 2.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.1 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.6 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 0.3 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 0.1 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.0 | 1.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 0.5 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 1.2 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 0.2 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.1 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.0 | 0.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 1.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.5 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.0 | 0.8 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 1.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 1.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.5 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 1.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.8 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 1.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.7 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.1 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 0.5 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.1 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
| 0.0 | 0.5 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.2 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 1.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.2 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.1 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.0 | 0.4 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 2.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.2 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 10.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.1 | GO:0044594 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594) |
| 0.0 | 2.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.3 | GO:0043295 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.0 | 0.1 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 1.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.2 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.2 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 1.9 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 1.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 7.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 7.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 4.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 3.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 6.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.0 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.2 | 5.4 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 1.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 7.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 2.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 2.8 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 0.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 1.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 4.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 2.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.7 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 3.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 3.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 2.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.6 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 1.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.3 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.0 | 2.5 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 1.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 4.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.6 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.5 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |