avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
TFAP2B Links Ensembl NCBI GeneCards UniProt	ENSG00000008196.8	transcription factor AP-2 beta

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFAP2B	hg19_v2_chr6_+_50786414_50786439	-0.27	2.4e-01	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.9	19.6	GO:1902910	regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
2.4	7.1	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
2.1	6.3	GO:0060489	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.8	9.2	GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
1.8	9.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
1.8	5.3	GO:1904784	NLRP1 inflammasome complex assembly(GO:1904784)
1.7	12.2	GO:0071461	cellular response to redox state(GO:0071461)
1.6	6.5	GO:1990927	vesicle-mediated cholesterol transport(GO:0090119) short-term synaptic potentiation(GO:1990926) calcium ion regulated lysosome exocytosis(GO:1990927)
1.5	4.6	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
1.4	5.6	GO:0060166	olfactory pit development(GO:0060166)
1.3	5.1	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
1.2	6.1	GO:0030807	positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
1.2	3.6	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.1	13.1	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
1.1	3.2	GO:1903526	negative regulation of membrane tubulation(GO:1903526)
1.0	4.9	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.9	5.2	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.8	3.3	GO:0099640	axo-dendritic protein transport(GO:0099640)
0.8	2.4	GO:0003294	atrial ventricular junction remodeling(GO:0003294) atrial cardiac muscle cell to AV node cell communication by electrical coupling(GO:0086044) bundle of His cell to Purkinje myocyte communication by electrical coupling(GO:0086054) Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling(GO:0086055) regulation of Purkinje myocyte action potential(GO:0098906) vasomotion(GO:1990029)
0.8	6.3	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.7	3.0	GO:0009956	radial pattern formation(GO:0009956)
0.7	2.9	GO:0061324	glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.7	5.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.6	1.7	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.6	2.2	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.6	9.9	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.5	20.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.5	1.6	GO:0060532	bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.5	2.2	GO:1990785	response to water-immersion restraint stress(GO:1990785)
0.5	5.9	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.5	1.6	GO:1904204	regulation of skeletal muscle hypertrophy(GO:1904204)
0.5	2.6	GO:0044858	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.5	10.2	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.5	5.6	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.5	1.5	GO:2000744	anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.5	1.4	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5	2.8	GO:0010193	response to ozone(GO:0010193)
0.4	1.3	GO:0070318	response to anoxia(GO:0034059) positive regulation of G0 to G1 transition(GO:0070318)
0.4	1.3	GO:0016256	N-glycan processing to lysosome(GO:0016256)
0.4	2.2	GO:0018101	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4	6.8	GO:0035634	response to stilbenoid(GO:0035634)
0.4	9.9	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
0.4	1.2	GO:0051255	spindle midzone assembly(GO:0051255)
0.4	4.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.4	3.6	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.3	10.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3	3.1	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.3	1.0	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.3	5.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3	0.7	GO:0071895	odontoblast differentiation(GO:0071895)
0.3	5.8	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.3	7.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.3	1.5	GO:1904693	midbrain morphogenesis(GO:1904693)
0.3	2.9	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.3	4.6	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.3	1.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.3	1.4	GO:0070086	ubiquitin-dependent endocytosis(GO:0070086)
0.3	1.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.3	4.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.3	1.1	GO:0001971	negative regulation of activation of membrane attack complex(GO:0001971)
0.3	2.0	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.2	1.7	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.2	0.7	GO:1902908	regulation of melanosome transport(GO:1902908)
0.2	2.4	GO:0070779	gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2	1.3	GO:0002317	plasma cell differentiation(GO:0002317)
0.2	0.7	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.2	1.5	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.2	2.5	GO:2001181	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-10 secretion(GO:2001181)
0.2	1.0	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.2	0.8	GO:0014050	negative regulation of glutamate secretion(GO:0014050)
0.2	3.5	GO:0060019	radial glial cell differentiation(GO:0060019)
0.2	2.8	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.2	0.8	GO:0060152	peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2	1.2	GO:0006311	meiotic gene conversion(GO:0006311)
0.2	2.4	GO:0048102	autophagic cell death(GO:0048102)
0.2	1.9	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.2	0.9	GO:0035900	response to isolation stress(GO:0035900)
0.2	4.9	GO:0051639	actin filament network formation(GO:0051639)
0.2	1.2	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.2	1.6	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.2	0.5	GO:2000657	regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.2	6.1	GO:0060441	epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.2	1.7	GO:0009414	response to water deprivation(GO:0009414)
0.2	0.8	GO:0039019	pronephric nephron development(GO:0039019)
0.2	0.8	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2	0.6	GO:0002384	hepatic immune response(GO:0002384)
0.1	0.6	GO:0046946	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1	0.3	GO:0042662	negative regulation of mesodermal cell fate specification(GO:0042662) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1	2.4	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.1	0.4	GO:2000819	regulation of nucleotide-excision repair(GO:2000819)
0.1	1.7	GO:0044539	long-chain fatty acid import(GO:0044539)
0.1	1.0	GO:0090625	mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.1	2.3	GO:0002934	desmosome organization(GO:0002934)
0.1	0.7	GO:0031291	Ran protein signal transduction(GO:0031291)
0.1	0.5	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1	1.8	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.1	0.8	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.4	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
0.1	3.4	GO:0051412	response to corticosterone(GO:0051412)
0.1	0.1	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.1	1.8	GO:0006228	UTP biosynthetic process(GO:0006228)
0.1	0.7	GO:0060523	prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1	9.8	GO:0015701	bicarbonate transport(GO:0015701)
0.1	0.4	GO:0035521	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1	5.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	0.5	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1	0.3	GO:0071879	UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1	13.9	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1	1.9	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1	0.8	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.1	0.6	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.3	GO:0070666	tolerance induction to self antigen(GO:0002513) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1	1.2	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1	0.5	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.1	1.3	GO:0090385	phagosome-lysosome fusion(GO:0090385)
0.1	0.6	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1	3.4	GO:0006491	N-glycan processing(GO:0006491)
0.1	10.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	8.1	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.1	1.0	GO:1904590	negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
0.1	0.5	GO:0071543	diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1	0.5	GO:0048388	endosomal lumen acidification(GO:0048388) necroptotic signaling pathway(GO:0097527)
0.1	1.1	GO:0046689	response to mercury ion(GO:0046689)
0.1	1.8	GO:0097119	postsynaptic density protein 95 clustering(GO:0097119)
0.1	1.2	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	2.0	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.1	3.9	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.1	0.7	GO:1905247	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1	3.3	GO:0048147	negative regulation of fibroblast proliferation(GO:0048147)
0.1	0.5	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.7	GO:0097105	postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1	0.2	GO:0050894	determination of affect(GO:0050894)
0.1	1.9	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.1	0.5	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.1	1.3	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.1	0.5	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	9.6	GO:0070268	cornification(GO:0070268)
0.1	0.8	GO:0097267	omega-hydroxylase P450 pathway(GO:0097267)
0.1	3.6	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.1	0.5	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1	1.1	GO:0098903	regulation of membrane repolarization during action potential(GO:0098903)
0.1	2.6	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.1	2.8	GO:0033006	regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.1	2.6	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.1	0.9	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.1	2.6	GO:0006376	mRNA splice site selection(GO:0006376)
0.1	0.2	GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1	0.9	GO:0019388	galactose catabolic process(GO:0019388)
0.1	0.3	GO:0046092	deoxycytidine metabolic process(GO:0046092)
0.1	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.1	0.4	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1	1.0	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.1	0.1	GO:0042746	regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.0	1.2	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0	2.3	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
0.0	1.7	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	0.3	GO:0019557	histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0	0.4	GO:0033590	response to cobalamin(GO:0033590) cellular response to erythropoietin(GO:0036018)
0.0	0.5	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.5	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	1.0	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	1.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.7	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.1	GO:0003192	mitral valve formation(GO:0003192)
0.0	0.8	GO:0061298	retina vasculature development in camera-type eye(GO:0061298)
0.0	0.6	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	6.1	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.0	0.3	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.4	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	1.3	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.3	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	6.7	GO:0001764	neuron migration(GO:0001764)
0.0	1.8	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.3	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.7	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0	1.1	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.0	2.5	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	0.5	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0	0.7	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0	2.9	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.4	GO:0030497	fatty acid elongation(GO:0030497)
0.0	0.6	GO:0070987	error-free translesion synthesis(GO:0070987)
0.0	3.2	GO:0043647	inositol phosphate metabolic process(GO:0043647)
0.0	0.4	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	2.4	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.6	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.0	0.8	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	4.0	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0032815	negative regulation of natural killer cell activation(GO:0032815)
0.0	0.2	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	10.5	GO:0016197	endosomal transport(GO:0016197)
0.0	1.5	GO:0032259	methylation(GO:0032259)
0.0	0.5	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.3	GO:0070233	negative regulation of T cell apoptotic process(GO:0070233)
0.0	1.0	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.0	0.1	GO:0021984	adenohypophysis development(GO:0021984)
0.0	0.5	GO:2000505	regulation of energy homeostasis(GO:2000505)
0.0	0.6	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.0	0.2	GO:0035524	proline transmembrane transport(GO:0035524)
0.0	3.0	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0	0.5	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.2	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	1.4	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0071315	cellular response to morphine(GO:0071315) cellular response to isoquinoline alkaloid(GO:0071317)
0.0	0.2	GO:0072402	response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0	1.7	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.9	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.0	2.0	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.9	GO:0060348	bone development(GO:0060348)
0.0	0.1	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	1.9	GO:1902017	regulation of cilium assembly(GO:1902017)
0.0	1.6	GO:0048813	dendrite morphogenesis(GO:0048813)
0.0	1.9	GO:0002181	cytoplasmic translation(GO:0002181)
0.0	0.8	GO:0006469	negative regulation of protein kinase activity(GO:0006469)
0.0	0.2	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.0	0.0	GO:1901857	positive regulation of cellular respiration(GO:1901857)
0.0	0.5	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.2	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)
0.0	0.8	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.4	GO:1903504	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	2.2	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.0	0.2	GO:0002115	store-operated calcium entry(GO:0002115)
0.0	0.1	GO:0001707	mesoderm formation(GO:0001707) mesoderm morphogenesis(GO:0048332)
0.0	2.0	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	0.1	GO:0045872	positive regulation of rhodopsin gene expression(GO:0045872)
0.0	0.3	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.7	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	1.0	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.2	GO:1904886	beta-catenin destruction complex disassembly(GO:1904886)
0.0	0.2	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.0	0.5	GO:0007249	I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0	0.9	GO:0000045	autophagosome assembly(GO:0000045)
0.0	0.3	GO:0002209	behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0	2.0	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)
0.0	0.0	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.3	GO:0040020	regulation of meiotic nuclear division(GO:0040020)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	5.8	GO:0060187	cell pole(GO:0060187)
1.1	13.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.8	5.3	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.5	6.5	GO:0032009	early phagosome(GO:0032009)
0.4	5.9	GO:0030061	mitochondrial crista(GO:0030061)
0.4	5.2	GO:0002116	semaphorin receptor complex(GO:0002116)
0.4	2.9	GO:0070369	Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.4	2.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.3	3.1	GO:0044194	cytolytic granule(GO:0044194)
0.3	2.4	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.3	2.3	GO:0016272	prefoldin complex(GO:0016272)
0.3	4.8	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.3	1.4	GO:0005606	laminin-1 complex(GO:0005606)
0.3	1.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.3	4.6	GO:0000813	ESCRT I complex(GO:0000813)
0.3	0.8	GO:0097444	spine apparatus(GO:0097444)
0.2	0.5	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.2	1.4	GO:0097513	myosin II filament(GO:0097513)
0.2	16.5	GO:0045095	keratin filament(GO:0045095)
0.2	2.6	GO:0030478	actin cap(GO:0030478)
0.2	2.5	GO:0045179	apical cortex(GO:0045179)
0.2	0.2	GO:0030893	meiotic cohesin complex(GO:0030893)
0.2	2.0	GO:0030057	desmosome(GO:0030057)
0.1	1.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.1	13.7	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1	9.6	GO:0001533	cornified envelope(GO:0001533)
0.1	5.6	GO:0097228	sperm principal piece(GO:0097228)
0.1	0.6	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	5.6	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1	1.9	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1	3.0	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	3.2	GO:0001891	phagocytic cup(GO:0001891)
0.1	14.8	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	2.9	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	15.7	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	1.5	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	4.2	GO:0044295	axonal growth cone(GO:0044295)
0.1	0.8	GO:0070847	core mediator complex(GO:0070847)
0.1	1.0	GO:0031931	TORC1 complex(GO:0031931)
0.1	4.8	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.1	1.6	GO:0097539	ciliary transition fiber(GO:0097539)
0.1	12.1	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	17.8	GO:0031225	anchored component of membrane(GO:0031225)
0.1	0.5	GO:0097427	microtubule bundle(GO:0097427)
0.1	6.4	GO:0005882	intermediate filament(GO:0005882)
0.1	2.3	GO:0035145	exon-exon junction complex(GO:0035145)
0.1	1.0	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	0.6	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	1.0	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.1	4.6	GO:0005844	polysome(GO:0005844)
0.1	0.5	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.1	1.4	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	8.8	GO:0005604	basement membrane(GO:0005604)
0.1	0.9	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	0.7	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.1	3.3	GO:1904115	axon cytoplasm(GO:1904115)
0.0	1.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.4	GO:0043196	varicosity(GO:0043196)
0.0	1.7	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	1.7	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	1.0	GO:0035102	PRC1 complex(GO:0035102)
0.0	1.6	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.2	GO:0031251	PAN complex(GO:0031251)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	1.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.7	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.3	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	1.0	GO:0043194	axon initial segment(GO:0043194)
0.0	5.7	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.8	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	1.9	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	6.4	GO:0030426	growth cone(GO:0030426)
0.0	1.7	GO:0035861	site of double-strand break(GO:0035861)
0.0	1.1	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	3.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.2	GO:0099738	cell cortex region(GO:0099738)
0.0	0.4	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	2.1	GO:0005871	kinesin complex(GO:0005871)
0.0	1.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.9	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0030118	clathrin coat(GO:0030118)
0.0	1.8	GO:0031594	neuromuscular junction(GO:0031594)
0.0	1.2	GO:0000795	synaptonemal complex(GO:0000795)
0.0	15.6	GO:0031012	extracellular matrix(GO:0031012)
0.0	1.0	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	1.5	GO:0060170	ciliary membrane(GO:0060170)
0.0	0.6	GO:0005922	connexon complex(GO:0005922)
0.0	1.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0070931	Golgi-associated vesicle lumen(GO:0070931)
0.0	0.4	GO:0031143	pseudopodium(GO:0031143)
0.0	2.9	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.4	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	0.1	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.0	0.7	GO:0034399	nuclear periphery(GO:0034399)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	8.9	GO:0005925	focal adhesion(GO:0005925)
0.0	0.6	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.7	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	7.6	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.7	5.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
1.2	4.9	GO:0004047	aminomethyltransferase activity(GO:0004047)
1.0	12.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.9	11.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.8	3.3	GO:0008426	protein kinase C inhibitor activity(GO:0008426)
0.8	2.4	GO:0086078	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling(GO:0086076) gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling(GO:0086078) gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling(GO:0086079)
0.8	8.5	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.7	14.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7	2.1	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.7	15.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7	2.0	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.7	9.8	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.6	5.6	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.6	3.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.6	16.7	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.6	5.1	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.5	3.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.5	1.6	GO:0001156	TFIIIC-class transcription factor binding(GO:0001156)
0.5	1.4	GO:0008301	DNA binding, bending(GO:0008301)
0.4	2.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.4	1.3	GO:0061663	NEDD8 ligase activity(GO:0061663)
0.4	7.8	GO:0008179	adenylate cyclase binding(GO:0008179)
0.4	5.6	GO:0070324	thyroid hormone binding(GO:0070324)
0.4	2.8	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.4	6.3	GO:0008199	ferric iron binding(GO:0008199)
0.3	1.4	GO:0001515	opioid peptide activity(GO:0001515)
0.3	6.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3	1.3	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.3	1.6	GO:0010736	serum response element binding(GO:0010736)
0.3	5.8	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.3	3.2	GO:0030348	syntaxin-3 binding(GO:0030348)
0.3	1.9	GO:0046899	nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3	2.8	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3	1.1	GO:0000822	inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3	1.8	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.3	2.0	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2	27.2	GO:0097110	scaffold protein binding(GO:0097110)
0.2	13.6	GO:0046875	ephrin receptor binding(GO:0046875)
0.2	0.7	GO:0072544	L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.2	2.4	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.2	5.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.2	4.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.2	0.6	GO:0070119	ciliary neurotrophic factor binding(GO:0070119)
0.2	3.9	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2	2.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2	0.8	GO:0004967	glucagon receptor activity(GO:0004967)
0.2	2.6	GO:0045159	myosin II binding(GO:0045159)
0.2	1.0	GO:0071253	connexin binding(GO:0071253)
0.2	1.5	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.2	2.2	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2	7.4	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2	9.9	GO:0042379	chemokine receptor binding(GO:0042379)
0.1	0.6	GO:0033823	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1	0.6	GO:0017095	heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1	1.9	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.1	4.8	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	0.6	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	0.9	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.1	3.0	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1	0.8	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	3.6	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1	4.5	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	1.2	GO:0004849	uridine kinase activity(GO:0004849)
0.1	1.5	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1	2.5	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1	0.5	GO:0010861	thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1	1.4	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.1	0.4	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.1	4.2	GO:0001968	fibronectin binding(GO:0001968)
0.1	2.5	GO:0043274	phospholipase binding(GO:0043274)
0.1	0.7	GO:0050815	phosphoserine binding(GO:0050815)
0.1	2.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	0.7	GO:0038052	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1	0.3	GO:0005199	structural constituent of cell wall(GO:0005199)
0.1	0.4	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1	1.8	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	13.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	0.5	GO:0052842	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1	4.6	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	0.3	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	1.9	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.1	0.8	GO:0004969	histamine receptor activity(GO:0004969)
0.1	1.9	GO:0000339	RNA cap binding(GO:0000339)
0.1	0.9	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.1	0.5	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1	4.6	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	1.3	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	1.8	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.1	0.6	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1	9.4	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	0.4	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1	9.6	GO:0051087	chaperone binding(GO:0051087)
0.1	1.7	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.1	1.7	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1	4.7	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	1.4	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.1	1.2	GO:0008494	translation activator activity(GO:0008494)
0.1	0.2	GO:0036033	mediator complex binding(GO:0036033)
0.1	5.6	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	0.4	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.1	2.9	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	1.7	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.1	0.2	GO:0005298	proline:sodium symporter activity(GO:0005298)
0.1	1.1	GO:0005537	mannose binding(GO:0005537)
0.0	1.0	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.5	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.3	GO:0004137	deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0	1.4	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	2.6	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.5	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	1.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	1.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.7	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.3	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	1.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	1.1	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	1.0	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.5	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.2	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	7.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	1.4	GO:0016881	acid-amino acid ligase activity(GO:0016881)
0.0	0.9	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.3	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.8	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.6	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.6	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	1.1	GO:0001848	complement binding(GO:0001848)
0.0	0.7	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0045545	syndecan binding(GO:0045545)
0.0	0.6	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	9.2	GO:0030674	protein binding, bridging(GO:0030674)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	2.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.5	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.7	GO:0019956	chemokine binding(GO:0019956)
0.0	5.5	GO:0005125	cytokine activity(GO:0005125)
0.0	0.9	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.5	GO:0005109	frizzled binding(GO:0005109)
0.0	1.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	1.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.9	GO:0015248	sterol transporter activity(GO:0015248)
0.0	2.6	GO:0003777	microtubule motor activity(GO:0003777)
0.0	13.6	GO:0003779	actin binding(GO:0003779)
0.0	0.5	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.7	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	2.7	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.4	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	2.8	GO:0044325	ion channel binding(GO:0044325)
0.0	0.5	GO:0004707	MAP kinase activity(GO:0004707)
0.0	3.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.6	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.8	GO:0043022	ribosome binding(GO:0043022)
0.0	0.4	GO:0015026	coreceptor activity(GO:0015026)
0.0	1.1	GO:0019213	deacetylase activity(GO:0019213)
0.0	2.3	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3	1.5	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	11.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	23.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	10.7	PID EPHA FWDPATHWAY	EPHA forward signaling
0.2	6.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	5.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	5.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	8.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	10.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	9.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	1.9	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	0.9	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	3.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	4.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	10.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	3.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	4.8	PID LKB1 PATHWAY	LKB1 signaling events
0.1	0.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	7.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	3.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	1.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	1.7	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	0.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	3.6	NABA COLLAGENS	Genes encoding collagen proteins
0.0	3.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	2.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.6	ST STAT3 PATHWAY	STAT3 Pathway
0.0	1.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	2.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	2.2	PID ATR PATHWAY	ATR signaling pathway
0.0	13.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	2.4	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	9.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.4	PID FOXO PATHWAY	FoxO family signaling
0.0	2.3	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.6	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.7	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.4	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	2.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	7.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.4	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.7	PID BMP PATHWAY	BMP receptor signaling
0.0	0.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	2.9	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	14.7	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.4	15.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	19.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	3.6	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.2	14.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.2	3.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.2	0.7	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2	2.8	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.2	3.4	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	5.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	6.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	3.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.1	3.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	7.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	1.3	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.1	1.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	6.6	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.1	5.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	2.4	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation
0.1	1.8	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	5.6	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	3.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.9	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	1.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	3.8	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	3.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	2.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	2.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	2.6	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1	5.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.4	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	5.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	4.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	10.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	1.6	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.8	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	1.4	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	1.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	1.1	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.5	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	2.9	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.8	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	7.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.9	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.2	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	2.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	2.0	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.6	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.0	0.5	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.5	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.7	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.5	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.8	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.6	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.0	0.9	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	1.3	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.4	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	2.3	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.3	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription