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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFAP4_MSC

Z-value: 2.75

Motif logo

Transcription factors associated with TFAP4_MSC

Gene Symbol Gene ID Gene Info
ENSG00000090447.7 transcription factor AP-4
ENSG00000178860.8 musculin

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSChg19_v2_chr8_-_72756667_72756736-0.892.1e-07Click!
TFAP4hg19_v2_chr16_-_4323015_4323076-0.861.1e-06Click!

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.2 13.0 GO:0018032 protein amidation(GO:0018032)
1.7 5.0 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
1.3 4.0 GO:0048627 myoblast development(GO:0048627)
1.3 5.2 GO:0006218 uridine catabolic process(GO:0006218)
1.2 3.6 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
1.1 4.5 GO:0090095 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
1.0 5.2 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
1.0 3.0 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.9 3.8 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.8 9.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.8 9.8 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.8 2.4 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.7 2.2 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.7 3.5 GO:0015917 aminophospholipid transport(GO:0015917)
0.7 2.1 GO:0048003 synaptic vesicle recycling via endosome(GO:0036466) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.7 2.7 GO:0048936 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.6 12.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 1.8 GO:0008057 eye pigment granule organization(GO:0008057)
0.6 1.7 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.5 5.5 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.5 2.7 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.5 1.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.5 1.6 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.5 11.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.5 2.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 2.0 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.5 4.9 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.5 2.9 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.5 1.9 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.4 2.2 GO:0051621 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.4 2.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 2.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.4 4.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 2.4 GO:0035063 nuclear speck organization(GO:0035063)
0.4 5.0 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.4 11.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 1.1 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.4 1.9 GO:0071874 response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
0.4 1.5 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.4 2.2 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.4 1.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.3 1.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.3 1.6 GO:2000845 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.3 4.4 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.3 4.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 1.1 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.3 1.1 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.3 2.1 GO:0030578 PML body organization(GO:0030578)
0.2 1.2 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 1.2 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 1.2 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.2 0.7 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.2 0.7 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.2 2.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 0.9 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.2 2.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 1.3 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 2.4 GO:0010815 bradykinin catabolic process(GO:0010815)
0.2 1.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 0.8 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.2 5.7 GO:0045332 phospholipid translocation(GO:0045332)
0.2 3.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 3.9 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.2 1.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 1.7 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 0.8 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 0.7 GO:0072254 response to mycophenolic acid(GO:0071505) cellular response to mycophenolic acid(GO:0071506) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.2 0.9 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 3.0 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.2 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.2 1.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.2 1.0 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2 0.5 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.2 0.7 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.2 0.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 1.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 1.8 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 1.8 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 1.0 GO:0006740 NADPH regeneration(GO:0006740)
0.1 2.0 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.9 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 1.5 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 0.4 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.1 2.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 1.8 GO:0030091 protein repair(GO:0030091)
0.1 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1 0.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 3.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.9 GO:0097319 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 1.7 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.4 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.1 3.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.4 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.1 0.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 1.4 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.4 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 5.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 1.1 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.1 0.6 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.7 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 2.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 2.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 0.4 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.1 0.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.7 GO:0071971 extracellular exosome assembly(GO:0071971) regulation of extracellular exosome assembly(GO:1903551)
0.1 0.5 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 0.4 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 1.2 GO:1905247 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 3.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 2.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 5.0 GO:1901998 toxin transport(GO:1901998)
0.1 1.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 3.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 0.3 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.1 1.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.7 GO:0021564 vagus nerve development(GO:0021564)
0.1 2.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 1.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 2.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 1.7 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.8 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 1.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 0.6 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.5 GO:0061086 regulation of mRNA export from nucleus(GO:0010793) negative regulation of histone H3-K27 methylation(GO:0061086) chromatin maintenance(GO:0070827)
0.1 0.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 1.9 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 1.2 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.1 0.6 GO:0021603 cranial nerve formation(GO:0021603)
0.1 2.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 0.2 GO:0033037 polysaccharide localization(GO:0033037)
0.1 3.2 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 0.6 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 0.3 GO:0018879 insecticide metabolic process(GO:0017143) biphenyl metabolic process(GO:0018879) phthalate metabolic process(GO:0018963) response to luteinizing hormone(GO:0034699) cellular response to luteinizing hormone stimulus(GO:0071373)
0.1 0.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.4 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 2.6 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 2.0 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 1.9 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 0.6 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 2.2 GO:0061157 mRNA destabilization(GO:0061157)
0.1 0.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.4 GO:0003334 keratinocyte development(GO:0003334)
0.1 4.0 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 1.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.5 GO:0032418 lysosome localization(GO:0032418)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.0 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 1.4 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.4 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 1.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.8 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 4.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 4.5 GO:0000075 cell cycle checkpoint(GO:0000075)
0.0 0.2 GO:0014870 response to muscle inactivity(GO:0014870)
0.0 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 1.4 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 1.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 5.8 GO:0000045 autophagosome assembly(GO:0000045)
0.0 0.5 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 1.4 GO:0006825 copper ion transport(GO:0006825)
0.0 0.5 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 2.2 GO:0060976 coronary vasculature development(GO:0060976)
0.0 3.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 1.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0010446 response to alkaline pH(GO:0010446)
0.0 1.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 4.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.6 GO:0016540 protein autoprocessing(GO:0016540)
0.0 1.1 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 2.6 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.5 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 1.3 GO:0031648 protein destabilization(GO:0031648)
0.0 1.4 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 0.6 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.0 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 1.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.6 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.7 GO:0006397 mRNA processing(GO:0006397)
0.0 0.3 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 1.9 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 3.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.3 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.3 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.1 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 1.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 4.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 2.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 1.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 4.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.7 GO:0016032 viral process(GO:0016032) multi-organism cellular process(GO:0044764)
0.0 0.2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.3 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.5 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.8 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.0 0.3 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 2.9 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 1.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.2 GO:0060033 anatomical structure regression(GO:0060033)
0.0 1.4 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.3 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 0.1 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 0.8 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.0 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.2 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.0 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0 2.0 GO:0031424 keratinization(GO:0031424)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.0 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.7 2.0 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.5 2.5 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.5 2.5 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.5 7.7 GO:0097449 astrocyte projection(GO:0097449)
0.4 3.8 GO:0097386 glial cell projection(GO:0097386)
0.4 3.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 1.0 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.3 5.5 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 2.7 GO:0070545 PeBoW complex(GO:0070545)
0.3 2.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.3 2.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 2.2 GO:1990635 proximal dendrite(GO:1990635)
0.3 4.6 GO:0097512 cardiac myofibril(GO:0097512)
0.2 2.9 GO:0016011 dystroglycan complex(GO:0016011)
0.2 0.9 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.2 5.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 3.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 1.3 GO:0035061 interchromatin granule(GO:0035061)
0.2 1.9 GO:0005610 laminin-5 complex(GO:0005610)
0.2 2.9 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.8 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.2 3.0 GO:0070938 contractile ring(GO:0070938)
0.2 1.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.9 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.1 GO:0071203 WASH complex(GO:0071203)
0.1 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 2.2 GO:0016600 flotillin complex(GO:0016600)
0.1 2.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 6.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.7 GO:0033565 ESCRT-0 complex(GO:0033565)
0.1 1.9 GO:0008091 spectrin(GO:0008091)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 14.5 GO:0016605 PML body(GO:0016605)
0.1 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.3 GO:0010369 chromocenter(GO:0010369)
0.1 3.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.2 GO:0032433 filopodium tip(GO:0032433)
0.1 1.3 GO:0030914 STAGA complex(GO:0030914)
0.1 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 2.5 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.1 2.6 GO:1990752 microtubule end(GO:1990752)
0.1 21.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 5.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 8.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 6.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 11.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.7 GO:0032009 early phagosome(GO:0032009)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 1.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.0 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 24.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 4.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 7.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.8 GO:0045178 basal part of cell(GO:0045178)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 4.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.2 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 1.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 2.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.0 3.2 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 8.6 GO:0001726 ruffle(GO:0001726)
0.0 21.8 GO:0005912 adherens junction(GO:0005912)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.8 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.6 GO:0031201 SNARE complex(GO:0031201)
0.0 2.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 3.0 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 4.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 4.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.2 GO:0043235 receptor complex(GO:0043235)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.3 GO:0099738 cell cortex region(GO:0099738)
0.0 15.0 GO:0005730 nucleolus(GO:0005730)
0.0 2.8 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.2 GO:0042599 lamellar body(GO:0042599)
0.0 1.8 GO:0000785 chromatin(GO:0000785)
0.0 0.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.7 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.0 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
1.2 9.9 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.2 4.7 GO:0008431 vitamin E binding(GO:0008431)
1.0 5.2 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.0 3.0 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.9 3.8 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.9 3.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.9 2.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.8 12.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 3.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.6 2.5 GO:0070012 oligopeptidase activity(GO:0070012)
0.6 1.7 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.5 2.7 GO:0015254 glycerol channel activity(GO:0015254)
0.4 2.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 5.5 GO:0097016 L27 domain binding(GO:0097016)
0.4 2.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.4 2.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.4 1.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.4 1.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 1.0 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.3 9.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 0.9 GO:0035643 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.3 1.4 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.3 2.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.3 5.2 GO:0005243 gap junction channel activity(GO:0005243)
0.2 1.7 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 1.7 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 0.8 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.2 3.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 15.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 7.7 GO:0017166 vinculin binding(GO:0017166)
0.2 5.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 1.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 0.5 GO:0070984 SET domain binding(GO:0070984)
0.2 9.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 6.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 1.4 GO:0030172 troponin C binding(GO:0030172)
0.2 2.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 4.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 5.1 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 2.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.9 GO:0042731 PH domain binding(GO:0042731)
0.1 1.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 1.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 16.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 3.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 0.4 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 0.9 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.5 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 4.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 5.2 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 2.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.2 GO:0016015 morphogen activity(GO:0016015)
0.1 5.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0005537 mannose binding(GO:0005537)
0.1 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 1.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.4 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.5 GO:0050815 phosphoserine binding(GO:0050815)
0.1 3.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.3 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 1.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.2 GO:0030395 lactose binding(GO:0030395)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.0 GO:0016805 dipeptidase activity(GO:0016805)
0.1 3.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 2.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 14.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.1 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.2 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 1.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 2.2 GO:0005123 death receptor binding(GO:0005123)
0.1 0.8 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.4 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 2.2 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 2.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 5.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.2 GO:0071633 dihydroceramidase activity(GO:0071633)
0.1 1.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.5 GO:0031014 troponin T binding(GO:0031014)
0.1 2.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 7.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.5 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 3.7 GO:0002039 p53 binding(GO:0002039)
0.0 2.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 1.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 6.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 4.1 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 1.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 3.6 GO:0016209 antioxidant activity(GO:0016209)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.0 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 7.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 6.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 2.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.0 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.0 GO:0052642 lysophosphatidic acid phosphatase activity(GO:0052642)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.3 GO:0046332 SMAD binding(GO:0046332)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 21.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 6.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.6 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 1.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 12.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 11.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 5.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 9.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 5.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 1.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.6 PID ALK1 PATHWAY ALK1 signaling events
0.1 6.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.3 PID RHOA PATHWAY RhoA signaling pathway
0.1 4.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 2.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 0.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 0.6 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 1.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 4.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.2 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 4.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 5.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID IGF1 PATHWAY IGF1 pathway
0.0 1.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 11.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.4 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 5.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 5.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 6.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 2.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 4.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 9.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.9 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 13.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 2.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.8 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 4.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 11.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.5 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 2.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 2.1 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 1.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.9 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.8 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 3.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.7 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation