ISMARA results: TFAP4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFAP4_MSC

Z-value: 2.75

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Transcription factors associated with TFAP4_MSC

Gene Symbol	Gene ID	Gene Info
TFAP4 Ensembl NCBI GeneCards UniProt	ENSG00000090447.7	transcription factor AP-4
MSC Ensembl NCBI GeneCards UniProt	ENSG00000178860.8	musculin

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MSC	hg19_v2_chr8_-_72756667_72756736	-0.89	2.1e-07	Click!
TFAP4	hg19_v2_chr16_-_4323015_4323076	-0.86	1.1e-06	Click!

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

No targets for TFAP4_MSC

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.9	20.8	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.2	13.0	GO:0018032	protein amidation(GO:0018032)
0.6	12.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.5	11.9	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.4	11.0	GO:0008340	determination of adult lifespan(GO:0008340)
0.8	9.9	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.8	9.8	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0	5.8	GO:0000045	autophagosome assembly(GO:0000045)
0.2	5.7	GO:0045332	phospholipid translocation(GO:0045332)
0.5	5.5	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)

Showing 1 to 10 of 257 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.7	GO:0000790	nuclear chromatin(GO:0000790)
0.0	21.8	GO:0005912	adherens junction(GO:0005912)
0.1	21.5	GO:0005802	trans-Golgi network(GO:0005802)
0.0	15.0	GO:0005730	nucleolus(GO:0005730)
0.1	14.5	GO:0016605	PML body(GO:0016605)
0.1	11.6	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	8.6	GO:0001726	ruffle(GO:0001726)
0.1	8.3	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5	7.7	GO:0097449	astrocyte projection(GO:0097449)
0.0	7.5	GO:0044798	nuclear transcription factor complex(GO:0044798)

Showing 1 to 10 of 108 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	15.6	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.1	14.6	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
2.2	13.0	GO:0004504	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.8	12.1	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
1.2	9.9	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2	9.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.3	9.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.2	7.7	GO:0017166	vinculin binding(GO:0017166)
0.0	7.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Showing 1 to 10 of 167 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.6	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	12.2	PID NOTCH PATHWAY	Notch signaling pathway
0.1	11.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	11.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	9.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	9.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	6.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	6.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	5.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	5.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Showing 1 to 10 of 51 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.5	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	11.8	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1	9.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	6.8	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	5.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	5.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	5.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	4.9	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	4.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	3.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 66 entries

Results for TFAP4_MSC

Z-value: 2.75

Motif logo

Transcription factors associated with TFAP4_MSC

Activity-expression correlation:

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

No targets for TFAP4_MSC

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: