ISMARA results: TFEC_MITF_ARNTL

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFEC_MITF_ARNTL_BHLHE41

Z-value: 0.89

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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41

Gene Symbol	Gene ID	Gene Info
TFEC Ensembl NCBI GeneCards UniProt	ENSG00000105967.11	transcription factor EC
MITF Ensembl NCBI GeneCards UniProt	ENSG00000187098.10	melanocyte inducing transcription factor
ARNTL Ensembl NCBI GeneCards UniProt	ENSG00000133794.13	aryl hydrocarbon receptor nuclear translocator like
BHLHE41 Ensembl NCBI GeneCards UniProt	ENSG00000123095.5	basic helix-loop-helix family member e41

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BHLHE41	hg19_v2_chr12_-_26278030_26278060	-0.76	1.1e-04	Click!
TFEC	hg19_v2_chr7_-_115799942_115799955	-0.69	7.2e-04	Click!
ARNTL	hg19_v2_chr11_+_13299186_13299432	-0.56	9.7e-03	Click!
MITF	hg19_v2_chr3_+_69985792_69985874	-0.21	3.6e-01	Click!

Activity profile of TFEC_MITF_ARNTL_BHLHE41 motif

Sorted Z-values of TFEC_MITF_ARNTL_BHLHE41 motif

No targets for TFEC_MITF_ARNTL_BHLHE41

Network of associatons between targets according to the STRING database.

First level regulatory network of TFEC_MITF_ARNTL_BHLHE41

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	7.6	GO:0060155	platelet dense granule organization(GO:0060155)
1.5	6.0	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.5	5.6	GO:0046477	glycosylceramide catabolic process(GO:0046477)
1.4	5.4	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.6	5.1	GO:1904637	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.2	5.0	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.5	3.6	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	3.3	GO:0015701	bicarbonate transport(GO:0015701)
1.1	3.2	GO:0050787	antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
1.0	3.1	GO:0043181	vacuolar sequestering(GO:0043181)

Showing 1 to 10 of 295 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.4	GO:0043202	lysosomal lumen(GO:0043202)
0.0	6.2	GO:0005901	caveola(GO:0005901)
0.2	5.9	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	5.3	GO:0016235	aggresome(GO:0016235)
0.6	4.8	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.3	3.1	GO:0030896	checkpoint clamp complex(GO:0030896)
0.2	3.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.2	2.6	GO:0046581	intercellular canaliculus(GO:0046581)
0.2	2.5	GO:0071986	Ragulator complex(GO:0071986)
0.1	2.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.8	GO:0005507	copper ion binding(GO:0005507)
0.1	5.4	GO:0005109	frizzled binding(GO:0005109)
0.0	4.7	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.5	4.3	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	4.0	GO:0051082	unfolded protein binding(GO:0051082)
0.1	3.9	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6	3.6	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.5	3.6	GO:0016936	galactoside binding(GO:0016936)
0.2	3.4	GO:0004630	phospholipase D activity(GO:0004630)
0.2	3.2	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)

Showing 1 to 10 of 193 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.6	PID ATM PATHWAY	ATM pathway
0.1	5.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	4.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	3.7	PID PLK1 PATHWAY	PLK1 signaling events
0.1	3.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	3.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	3.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	2.6	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	2.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	1.5	PID ATR PATHWAY	ATR signaling pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.6	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	7.6	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	6.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	5.1	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.1	5.0	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	4.9	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.2	4.5	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	4.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	4.3	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.0	3.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Showing 1 to 10 of 47 entries

Results for TFEC_MITF_ARNTL_BHLHE41

Z-value: 0.89

Motif logo

Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41

Activity-expression correlation:

Activity profile of TFEC_MITF_ARNTL_BHLHE41 motif

Sorted Z-values of TFEC_MITF_ARNTL_BHLHE41 motif

No targets for TFEC_MITF_ARNTL_BHLHE41

Network of associatons between targets according to the STRING database.

First level regulatory network of TFEC_MITF_ARNTL_BHLHE41

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: