ISMARA results: THRA

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for THRA_RXRB

Z-value: 1.04

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Transcription factors associated with THRA_RXRB

Gene Symbol	Gene ID	Gene Info
THRA Ensembl NCBI GeneCards UniProt	ENSG00000126351.8	thyroid hormone receptor alpha
RXRB Ensembl NCBI GeneCards UniProt	ENSG00000204231.6	retinoid X receptor beta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RXRB	hg19_v2_chr6_-_33168391_33168465	-0.64	2.3e-03	Click!
THRA	hg19_v2_chr17_+_38219063_38219154	0.17	4.8e-01	Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

No targets for THRA_RXRB

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.0	GO:0060629	regulation of homologous chromosome segregation(GO:0060629)
0.0	2.0	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.1	1.9	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	1.5	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.1	1.0	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.1	0.9	GO:0030238	male sex determination(GO:0030238)
0.2	0.8	GO:0060032	notochord regression(GO:0060032)
0.2	0.8	GO:1904049	negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1	0.8	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.8	GO:0045793	positive regulation of cell size(GO:0045793)

Showing 1 to 10 of 97 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0000795	synaptonemal complex(GO:0000795)
0.0	1.6	GO:0035371	microtubule plus-end(GO:0035371)
0.1	1.0	GO:0070578	RISC-loading complex(GO:0070578)
0.1	0.9	GO:0042788	polysomal ribosome(GO:0042788)
0.2	0.8	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1	0.8	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.8	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.8	GO:0097546	ciliary base(GO:0097546)
0.1	0.6	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.6	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	1.0	GO:0070883	pre-miRNA binding(GO:0070883)
0.0	0.9	GO:0000217	DNA secondary structure binding(GO:0000217)
0.0	0.8	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.2	0.7	GO:0004651	polynucleotide 5'-phosphatase activity(GO:0004651)
0.1	0.7	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.7	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.7	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.2	0.6	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.1	0.6	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)

Showing 1 to 10 of 58 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.1	PID NOTCH PATHWAY	Notch signaling pathway
1.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
1.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.5	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	1.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.7	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.7	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.7	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.6	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK

Showing 1 to 10 of 19 entries

Results for THRA_RXRB

Z-value: 1.04

Motif logo

Transcription factors associated with THRA_RXRB

Activity-expression correlation:

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

No targets for THRA_RXRB

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: