ISMARA results: TLX1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX1_NFIC

Z-value: 2.22

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Transcription factors associated with TLX1_NFIC

Gene Symbol	Gene ID	Gene Info
TLX1 Ensembl NCBI GeneCards UniProt	ENSG00000107807.8	T cell leukemia homeobox 1
NFIC Ensembl NCBI GeneCards UniProt	ENSG00000141905.13	nuclear factor I C

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TLX1	hg19_v2_chr10_+_102891048_102891078	0.65	1.9e-03	Click!
NFIC	hg19_v2_chr19_+_3359561_3359681	0.37	1.1e-01	Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

No targets for TLX1_NFIC

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	10.8	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
0.0	9.6	GO:0043542	endothelial cell migration(GO:0043542)
0.9	6.6	GO:0071461	cellular response to redox state(GO:0071461)
0.4	6.6	GO:0032119	sequestering of zinc ion(GO:0032119)
0.5	6.2	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.4	5.8	GO:0015074	DNA integration(GO:0015074)
0.0	5.7	GO:0030038	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.6	5.5	GO:0001661	conditioned taste aversion(GO:0001661)
0.9	5.4	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.1	5.4	GO:0031581	hemidesmosome assembly(GO:0031581)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.3	GO:0016605	PML body(GO:0016605)
0.0	6.7	GO:0005913	cell-cell adherens junction(GO:0005913)
0.6	5.5	GO:0035976	AP1 complex(GO:0035976)
0.4	4.5	GO:0005610	laminin-5 complex(GO:0005610)
0.2	3.8	GO:0097512	cardiac myofibril(GO:0097512)
1.1	3.4	GO:0072563	endothelial microparticle(GO:0072563)
0.7	3.4	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.2	2.9	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	2.7	GO:0005604	basement membrane(GO:0005604)
0.2	2.4	GO:0005593	FACIT collagen trimer(GO:0005593)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.8	GO:0042379	chemokine receptor binding(GO:0042379)
0.0	9.0	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	7.0	GO:0070412	R-SMAD binding(GO:0070412)
1.0	6.8	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	6.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.6	6.6	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2	5.4	GO:0045499	chemorepellent activity(GO:0045499)
0.0	4.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	3.5	GO:0005044	scavenger receptor activity(GO:0005044)
0.4	3.4	GO:0005534	galactose binding(GO:0005534)

Showing 1 to 10 of 102 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	20.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	10.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	7.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	6.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	5.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	5.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	4.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	4.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.2	4.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	4.2	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	5.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	5.5	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.2	5.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	4.7	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0	4.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	3.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	3.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	3.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	2.7	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription

Showing 1 to 10 of 38 entries

Results for TLX1_NFIC

Z-value: 2.22

Motif logo

Transcription factors associated with TLX1_NFIC

Activity-expression correlation:

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

No targets for TLX1_NFIC

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: