ISMARA results: TLX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX2

Z-value: 2.75

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Transcription factors associated with TLX2

Gene Symbol	Gene ID	Gene Info
TLX2 Ensembl NCBI GeneCards UniProt	ENSG00000115297.9	T cell leukemia homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TLX2	hg19_v2_chr2_+_74741569_74741620	-0.72	3.8e-04	Click!

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

No targets for TLX2

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	12.2	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.3	8.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2	7.7	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
2.5	7.5	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.4	7.0	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)
1.4	6.8	GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.4	6.7	GO:0032119	sequestering of zinc ion(GO:0032119)
0.1	6.3	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.7	6.1	GO:0048050	post-embryonic eye morphogenesis(GO:0048050)
0.2	6.0	GO:0033622	integrin activation(GO:0033622)

Showing 1 to 10 of 232 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.3	GO:0001533	cornified envelope(GO:0001533)
0.1	12.8	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	12.6	GO:0045177	apical part of cell(GO:0045177)
0.0	12.1	GO:0031965	nuclear membrane(GO:0031965)
0.1	8.2	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	7.6	GO:0009925	basal plasma membrane(GO:0009925)
0.2	6.8	GO:0097228	sperm principal piece(GO:0097228)
0.2	6.6	GO:0032839	dendrite cytoplasm(GO:0032839)
0.2	6.1	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.7	5.6	GO:0070876	SOSS complex(GO:0070876)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	15.6	GO:0045499	chemorepellent activity(GO:0045499)
0.4	14.3	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
2.0	14.2	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.8	9.4	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2	9.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	8.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	8.6	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	7.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1	6.9	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	6.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 163 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	14.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	13.4	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	8.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	6.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	6.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	5.8	PID NOTCH PATHWAY	Notch signaling pathway
0.1	5.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	4.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	4.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	6.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.2	5.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	5.4	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.1	5.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	4.7	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	4.6	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	4.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	4.4	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	4.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes

Showing 1 to 10 of 66 entries

Results for TLX2

Z-value: 2.75

Motif logo

Transcription factors associated with TLX2

Activity-expression correlation:

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

No targets for TLX2

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: