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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX2

Z-value: 2.75

Motif logo

Transcription factors associated with TLX2

Gene Symbol Gene ID Gene Info
ENSG00000115297.9 T cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TLX2hg19_v2_chr2_+_74741569_74741620-0.723.8e-04Click!

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.4 6.8 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
1.3 3.9 GO:0042938 dipeptide transport(GO:0042938)
1.2 5.9 GO:0003165 Purkinje myocyte development(GO:0003165)
1.1 5.4 GO:1903282 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
1.0 3.1 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
1.0 2.9 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.9 2.6 GO:0019858 cytosine metabolic process(GO:0019858)
0.9 3.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.9 4.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.9 12.2 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.9 3.4 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.7 2.8 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.7 3.5 GO:0048496 adherens junction maintenance(GO:0034334) maintenance of organ identity(GO:0048496)
0.7 6.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.6 1.9 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.6 2.3 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.5 3.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.5 4.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.5 5.3 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.5 5.7 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.4 6.7 GO:0032119 sequestering of zinc ion(GO:0032119)
0.4 3.5 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.4 1.6 GO:0018277 protein deamination(GO:0018277)
0.4 1.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.4 2.4 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518)
0.4 1.2 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.4 2.4 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.4 4.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.4 7.0 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.4 2.5 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.4 2.5 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.4 1.4 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.4 2.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 8.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3 3.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 2.4 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.3 0.9 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 3.4 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.3 0.8 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.3 1.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.3 0.5 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.3 3.5 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.3 1.6 GO:0010193 response to ozone(GO:0010193)
0.3 0.8 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.3 1.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 4.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 3.4 GO:0015705 iodide transport(GO:0015705)
0.2 1.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 2.1 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.6 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.2 2.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 2.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 2.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 0.9 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.2 0.6 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.2 0.6 GO:0001543 ovarian follicle rupture(GO:0001543)
0.2 3.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 1.5 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.2 0.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 1.4 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 0.6 GO:0061386 closure of optic fissure(GO:0061386)
0.2 1.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.2 1.0 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 0.8 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 0.9 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.2 1.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 1.6 GO:0060174 limb bud formation(GO:0060174)
0.2 0.9 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2 0.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.7 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.2 0.9 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 0.5 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.2 6.0 GO:0033622 integrin activation(GO:0033622)
0.2 0.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747) positive regulation of protein lipidation(GO:1903061)
0.2 1.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.2 7.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 0.5 GO:0031247 actin rod assembly(GO:0031247)
0.1 1.8 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.7 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1 3.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 1.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.0 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1 2.2 GO:0002934 desmosome organization(GO:0002934)
0.1 1.8 GO:0006477 protein sulfation(GO:0006477)
0.1 0.4 GO:0015880 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 1.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.6 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.2 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 1.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.4 GO:1903060 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.1 0.2 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.1 0.2 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.6 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.7 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 4.1 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 2.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 5.4 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.1 0.8 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.2 GO:0032202 telomere assembly(GO:0032202)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 2.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 0.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.4 GO:0015871 choline transport(GO:0015871)
0.1 2.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 3.6 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.1 1.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 2.7 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 0.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.3 GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.1 6.3 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 0.7 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 2.2 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.9 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.1 2.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.5 GO:0060161 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.1 2.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.2 GO:0019254 amino-acid betaine catabolic process(GO:0006579) carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.3 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 0.7 GO:0032887 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 1.3 GO:0002643 regulation of tolerance induction(GO:0002643)
0.1 1.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.0 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 0.2 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 0.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 1.0 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.6 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 0.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 1.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.1 1.7 GO:0042481 regulation of odontogenesis(GO:0042481)
0.1 4.1 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 0.6 GO:0003344 pericardium morphogenesis(GO:0003344)
0.1 1.2 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.1 5.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 0.7 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 0.6 GO:0034398 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 5.5 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 0.7 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 1.8 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.2 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 4.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 1.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 1.0 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.8 GO:0060056 mammary gland involution(GO:0060056)
0.0 1.1 GO:0046519 sphingoid metabolic process(GO:0046519)
0.0 1.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.7 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 1.0 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.6 GO:0042554 superoxide anion generation(GO:0042554)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 3.9 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.5 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 2.9 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.0 GO:0001701 in utero embryonic development(GO:0001701)
0.0 0.3 GO:0051451 myoblast migration(GO:0051451)
0.0 0.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.8 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.7 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.7 GO:0032376 positive regulation of sterol transport(GO:0032373) positive regulation of cholesterol transport(GO:0032376)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 1.3 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0006528 asparagine metabolic process(GO:0006528)
0.0 1.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 3.7 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 4.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 1.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.1 GO:0032431 positive regulation of phospholipase A2 activity(GO:0032430) activation of phospholipase A2 activity(GO:0032431)
0.0 0.4 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.7 GO:0046174 polyol catabolic process(GO:0046174)
0.0 0.2 GO:0046464 neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.9 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.7 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446) detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 3.2 GO:0060071 Wnt signaling pathway, planar cell polarity pathway(GO:0060071)
0.0 0.1 GO:1903525 regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527)
0.0 1.8 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:2000510 positive regulation of sperm motility involved in capacitation(GO:0060474) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 2.4 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 1.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0001955 blood vessel maturation(GO:0001955)
0.0 1.3 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 0.7 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.5 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 3.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.7 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.5 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 0.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.3 GO:0007032 endosome organization(GO:0007032)
0.0 1.9 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.2 GO:0015824 proline transport(GO:0015824)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.2 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.3 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.0 GO:0061056 sclerotome development(GO:0061056)
0.0 0.5 GO:0017144 drug metabolic process(GO:0017144)
0.0 1.3 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0045617 negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of keratinocyte differentiation(GO:0045617)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.6 GO:0070876 SOSS complex(GO:0070876)
0.6 3.2 GO:1990425 ryanodine receptor complex(GO:1990425)
0.6 1.9 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.4 5.4 GO:0061689 tricellular tight junction(GO:0061689)
0.4 2.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.4 1.1 GO:0034515 proteasome storage granule(GO:0034515)
0.3 3.5 GO:0005593 FACIT collagen trimer(GO:0005593)
0.3 2.5 GO:0016013 syntrophin complex(GO:0016013)
0.3 1.1 GO:1990745 EARP complex(GO:1990745)
0.3 2.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 2.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 0.8 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.2 2.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 18.3 GO:0001533 cornified envelope(GO:0001533)
0.2 0.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 6.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.3 GO:0031673 H zone(GO:0031673)
0.2 0.9 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.2 1.8 GO:0032010 phagolysosome(GO:0032010)
0.2 1.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.2 2.0 GO:0000439 core TFIIH complex(GO:0000439)
0.2 4.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 6.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 2.2 GO:0030057 desmosome(GO:0030057)
0.2 0.5 GO:1990015 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.2 6.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 7.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.8 GO:0042587 glycogen granule(GO:0042587)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 1.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 3.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.5 GO:0032449 CBM complex(GO:0032449)
0.1 1.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.1 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 8.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 1.0 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 3.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.4 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 2.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 12.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.7 GO:0055028 cortical microtubule(GO:0055028)
0.1 1.0 GO:0031105 septin complex(GO:0031105)
0.1 0.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 2.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.1 GO:0005605 basal lamina(GO:0005605)
0.1 1.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 1.1 GO:0032433 filopodium tip(GO:0032433)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.8 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 1.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 2.0 GO:0034451 centriolar satellite(GO:0034451)
0.0 3.5 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.6 GO:0005771 multivesicular body(GO:0005771)
0.0 2.3 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0034709 methylosome(GO:0034709)
0.0 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.0 3.7 GO:0005643 nuclear pore(GO:0005643)
0.0 1.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.0 GO:0005871 kinesin complex(GO:0005871)
0.0 12.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0097542 ciliary tip(GO:0097542)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 12.6 GO:0045177 apical part of cell(GO:0045177)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 4.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.1 GO:0001726 ruffle(GO:0001726)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.5 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.0 1.1 GO:0005903 brush border(GO:0005903)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0061695 transferase complex, transferring phosphorus-containing groups(GO:0061695)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.5 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.4 4.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
1.3 3.8 GO:0002113 interleukin-33 binding(GO:0002113)
1.1 5.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.8 9.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.7 6.4 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.6 15.6 GO:0045499 chemorepellent activity(GO:0045499)
0.5 2.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.5 3.9 GO:0004064 arylesterase activity(GO:0004064)
0.5 6.8 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.4 2.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 14.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.4 5.5 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.4 2.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.4 1.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 3.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.3 2.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 1.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.3 5.3 GO:0008199 ferric iron binding(GO:0008199)
0.3 4.4 GO:0008097 5S rRNA binding(GO:0008097)
0.3 0.8 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.3 1.4 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.3 2.4 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3 3.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 1.8 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.2 9.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.7 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 0.7 GO:0070538 oleic acid binding(GO:0070538)
0.2 0.9 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.2 3.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 0.7 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.2 0.9 GO:0052642 lysophosphatidic acid phosphatase activity(GO:0052642)
0.2 0.6 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.2 0.6 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.2 3.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.0 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 4.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 3.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 3.2 GO:0019855 calcium channel inhibitor activity(GO:0019855) type I transforming growth factor beta receptor binding(GO:0034713)
0.2 4.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 1.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 2.4 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 2.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 1.0 GO:0004096 catalase activity(GO:0004096)
0.2 3.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.4 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 1.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 2.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.2 0.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 1.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.4 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.9 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 5.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 7.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 4.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 3.2 GO:0031005 filamin binding(GO:0031005)
0.1 1.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.3 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.1 2.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 3.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 5.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 6.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.8 GO:0052723 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) inositol hexakisphosphate kinase activity(GO:0000828) inositol heptakisphosphate kinase activity(GO:0000829) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 6.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.8 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 1.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.6 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 1.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.7 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 1.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.0 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.5 GO:0032052 bile acid binding(GO:0032052)
0.1 1.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.2 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 0.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.7 GO:0048495 Roundabout binding(GO:0048495)
0.1 3.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 1.6 GO:0031432 titin binding(GO:0031432)
0.1 2.6 GO:0001848 complement binding(GO:0001848)
0.1 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.7 GO:0019864 IgG binding(GO:0019864)
0.1 3.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 5.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 1.6 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 2.4 GO:0005123 death receptor binding(GO:0005123)
0.1 1.6 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.0 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 2.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 6.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 1.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.0 GO:0008432 JUN kinase binding(GO:0008432)
0.0 2.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 8.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.9 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.9 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 3.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 4.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 1.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.5 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 8.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.6 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 13.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 1.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 4.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 6.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 23.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 4.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 8.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 2.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 1.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 4.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 1.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 3.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 2.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 5.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 4.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 3.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 2.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 3.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 2.6 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 2.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 4.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.9 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 5.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.3 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 6.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 6.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.9 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.8 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.1 3.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.8 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.1 5.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.3 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 3.1 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 2.5 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 4.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 1.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 3.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 3.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 4.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.1 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.0 0.4 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins