ISMARA results: TP53

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TP53

Z-value: 0.76

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Transcription factors associated with TP53

Gene Symbol	Gene ID	Gene Info
TP53 Ensembl NCBI GeneCards UniProt	ENSG00000141510.11	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TP53	hg19_v2_chr17_-_7590745_7590856	-0.36	1.1e-01	Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

No targets for TP53

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	GO:0070268	cornification(GO:0070268)
1.4	4.1	GO:1904328	regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0	4.0	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.1	3.3	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
0.3	2.5	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.5	2.0	GO:0042247	morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0	2.0	GO:0001706	endoderm formation(GO:0001706)
0.0	1.6	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	1.5	GO:0048477	oogenesis(GO:0048477)
0.4	1.4	GO:1900138	negative regulation of phospholipase A2 activity(GO:1900138)

Showing 1 to 10 of 95 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	GO:0030057	desmosome(GO:0030057)
0.3	4.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	3.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.4	2.0	GO:0042643	actomyosin, actin portion(GO:0042643)
0.1	1.6	GO:0005610	laminin-5 complex(GO:0005610)
0.0	1.4	GO:0070822	Sin3-type complex(GO:0070822)
0.0	1.1	GO:0008023	transcription elongation factor complex(GO:0008023)
0.1	1.0	GO:0005642	annulate lamellae(GO:0005642)
0.0	1.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	0.9	GO:0005797	Golgi medial cisterna(GO:0005797)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.1	4.0	GO:0004707	MAP kinase activity(GO:0004707)
0.0	3.5	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.1	3.1	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	2.9	GO:0042379	chemokine receptor binding(GO:0042379)
0.4	2.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	1.5	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.1	1.4	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0	1.3	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	1.0	GO:0034452	dynactin binding(GO:0034452)

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	2.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	1.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.5	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	1.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.9	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.9	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.5	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.2	2.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	1.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.3	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	1.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	1.0	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.9	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.8	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.7	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.7	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Showing 1 to 10 of 23 entries

Results for TP53

Z-value: 0.76

Motif logo

Transcription factors associated with TP53

Activity-expression correlation:

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

No targets for TP53

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: