avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
TP63 Links Ensembl NCBI GeneCards UniProt	ENSG00000073282.8	tumor protein p63

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TP63	hg19_v2_chr3_+_189507460_189507471	0.99	3.0e-19	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
12.1	84.4	GO:0071461	cellular response to redox state(GO:0071461)
8.5	33.9	GO:0051710	cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
8.3	33.0	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)
8.1	32.4	GO:0060166	olfactory pit development(GO:0060166)
5.4	16.3	GO:0071301	cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
4.9	14.7	GO:0008057	eye pigment granule organization(GO:0008057)
4.6	13.8	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
4.5	18.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
3.3	26.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
2.7	8.1	GO:0002276	basophil activation involved in immune response(GO:0002276)
2.7	13.5	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
2.2	9.0	GO:0035627	ceramide transport(GO:0035627)
1.6	6.5	GO:0021849	neuroblast division in subventricular zone(GO:0021849)
1.6	4.8	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.6	9.5	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.6	37.9	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)
1.4	10.0	GO:0010133	proline catabolic process to glutamate(GO:0010133)
1.4	7.0	GO:0044855	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
1.3	6.6	GO:0036414	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
1.3	32.7	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.2	7.4	GO:0048817	negative regulation of hair follicle maturation(GO:0048817)
1.2	6.1	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
1.2	4.8	GO:0045401	response to molecule of fungal origin(GO:0002238) serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
1.2	7.0	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
1.1	10.2	GO:0003383	apical constriction(GO:0003383)
1.1	4.4	GO:0035397	helper T cell enhancement of adaptive immune response(GO:0035397)
1.1	27.6	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
1.1	72.7	GO:0032732	positive regulation of interleukin-1 production(GO:0032732)
1.0	5.2	GO:2000843	testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
1.0	4.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
1.0	5.0	GO:1900106	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.0	6.9	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
1.0	46.3	GO:0060512	prostate gland morphogenesis(GO:0060512)
1.0	4.8	GO:1904448	negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.8	8.7	GO:0090032	negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.8	3.9	GO:0071874	cellular response to norepinephrine stimulus(GO:0071874)
0.8	7.5	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.7	2.2	GO:0071262	regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.7	8.0	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.7	2.2	GO:1902958	neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.7	5.0	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.7	14.7	GO:0046415	urate metabolic process(GO:0046415)
0.6	1.9	GO:0060406	positive regulation of penile erection(GO:0060406)
0.6	8.0	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.6	2.4	GO:0006408	snRNA export from nucleus(GO:0006408)
0.6	16.3	GO:0051639	actin filament network formation(GO:0051639)
0.5	2.5	GO:1904158	axonemal central apparatus assembly(GO:1904158)
0.5	1.5	GO:0019516	lactate oxidation(GO:0019516)
0.5	8.1	GO:0016540	protein autoprocessing(GO:0016540)
0.5	2.4	GO:0009608	response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.4	13.4	GO:0036010	protein localization to endosome(GO:0036010)
0.4	4.6	GO:0010593	negative regulation of lamellipodium assembly(GO:0010593)
0.4	1.2	GO:0021648	vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve formation(GO:0021650)
0.4	3.2	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.4	1.6	GO:0071284	cellular response to lead ion(GO:0071284)
0.4	7.4	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.4	2.6	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.4	13.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.4	2.5	GO:0070383	DNA cytosine deamination(GO:0070383)
0.3	8.7	GO:0007021	tubulin complex assembly(GO:0007021)
0.3	11.8	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.3	1.4	GO:0046116	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.3	5.3	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.3	7.0	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.3	9.7	GO:0007398	ectoderm development(GO:0007398)
0.3	24.8	GO:0018149	peptide cross-linking(GO:0018149)
0.3	10.7	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.3	1.2	GO:0034476	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.3	4.3	GO:0097264	self proteolysis(GO:0097264)
0.3	3.8	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383)
0.3	1.9	GO:0031642	negative regulation of myelination(GO:0031642)
0.3	1.5	GO:0090131	mesenchyme migration(GO:0090131)
0.2	3.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.2	4.0	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.2	1.6	GO:1903786	mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.2	1.8	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.2	1.3	GO:0031860	telomeric loop formation(GO:0031627) telomeric 3' overhang formation(GO:0031860)
0.2	2.3	GO:2000332	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2	5.7	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2	3.3	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836)
0.2	4.4	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.2	2.3	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2	0.4	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.2	2.5	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.2	10.6	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2	2.9	GO:0001553	luteinization(GO:0001553)
0.2	3.9	GO:0071236	cellular response to antibiotic(GO:0071236)
0.2	1.3	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.2	0.5	GO:0046168	glycerol-3-phosphate catabolic process(GO:0046168)
0.2	1.1	GO:0035878	nail development(GO:0035878)
0.2	3.2	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1	6.0	GO:0018345	protein palmitoylation(GO:0018345)
0.1	0.7	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	23.7	GO:1902476	chloride transmembrane transport(GO:1902476)
0.1	3.2	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.1	0.4	GO:1903367	positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1	7.4	GO:0001913	T cell mediated cytotoxicity(GO:0001913)
0.1	3.1	GO:0051865	protein autoubiquitination(GO:0051865)
0.1	0.4	GO:0048104	establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.1	3.6	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1	9.6	GO:0070206	protein trimerization(GO:0070206)
0.1	14.2	GO:0048477	oogenesis(GO:0048477)
0.1	4.2	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.1	1.8	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.1	1.5	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	1.3	GO:1903943	negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	1.4	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.1	4.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.1	3.9	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	2.3	GO:0010226	response to lithium ion(GO:0010226)
0.1	2.0	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	0.3	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.1	0.2	GO:1901053	sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.1	1.3	GO:0043401	steroid hormone mediated signaling pathway(GO:0043401)
0.1	0.5	GO:0051594	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1	0.9	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.4	GO:0060681	branch elongation involved in ureteric bud branching(GO:0060681)
0.1	1.8	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.1	2.3	GO:0036065	fucosylation(GO:0036065)
0.1	3.6	GO:0006376	mRNA splice site selection(GO:0006376)
0.1	2.7	GO:0030488	tRNA methylation(GO:0030488)
0.1	1.5	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.1	0.7	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1	6.4	GO:0016579	protein deubiquitination(GO:0016579)
0.1	4.5	GO:0032496	response to lipopolysaccharide(GO:0032496)
0.1	4.2	GO:0060976	coronary vasculature development(GO:0060976)
0.1	2.4	GO:0050427	purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	1.5	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	1.7	GO:0016578	histone deubiquitination(GO:0016578)
0.0	1.2	GO:0007614	short-term memory(GO:0007614)
0.0	1.6	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.2	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.6	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.2	GO:2000234	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0	5.0	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0	2.2	GO:0016569	covalent chromatin modification(GO:0016569)
0.0	1.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	1.0	GO:0031297	replication fork processing(GO:0031297)
0.0	2.7	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.0	0.5	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0	1.8	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	9.2	GO:0007266	Rho protein signal transduction(GO:0007266)
0.0	3.5	GO:1900034	regulation of cellular response to heat(GO:1900034)
0.0	0.2	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.0	0.1	GO:0006781	succinyl-CoA pathway(GO:0006781)
0.0	1.4	GO:0046473	phosphatidic acid metabolic process(GO:0046473)
0.0	0.6	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.2	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.0	0.5	GO:0016180	snRNA processing(GO:0016180)
0.0	0.7	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.8	GO:0070271	protein complex assembly(GO:0006461) protein complex biogenesis(GO:0070271)
0.0	1.9	GO:0006396	RNA processing(GO:0006396)
0.0	2.7	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0	1.7	GO:0001895	retina homeostasis(GO:0001895)
0.0	3.8	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.0	0.3	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	2.3	GO:0006334	nucleosome assembly(GO:0006334)
0.0	1.3	GO:0007517	muscle organ development(GO:0007517)
0.0	0.8	GO:0006968	cellular defense response(GO:0006968)
0.0	2.1	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0	0.2	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.3	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0006308	DNA catabolic process(GO:0006308)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	18.1	GO:0072558	NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)
1.9	7.5	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
1.7	5.0	GO:0036117	hyaluranon cable(GO:0036117)
1.6	8.0	GO:0035838	growing cell tip(GO:0035838)
1.3	9.0	GO:0097209	epidermal lamellar body(GO:0097209)
1.3	13.8	GO:0005610	laminin-5 complex(GO:0005610)
1.1	3.3	GO:0000229	cytoplasmic chromosome(GO:0000229)
1.0	34.5	GO:0071682	endocytic vesicle lumen(GO:0071682)
1.0	4.8	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
0.9	3.8	GO:0016939	kinesin II complex(GO:0016939)
0.8	2.5	GO:1990716	axonemal central apparatus(GO:1990716)
0.7	4.8	GO:0019815	B cell receptor complex(GO:0019815)
0.6	54.3	GO:0045095	keratin filament(GO:0045095)
0.5	13.9	GO:0005922	connexon complex(GO:0005922)
0.5	6.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.5	8.7	GO:0097512	cardiac myofibril(GO:0097512)
0.5	7.0	GO:0030478	actin cap(GO:0030478)
0.5	5.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5	4.5	GO:0097413	Lewy body(GO:0097413)
0.4	10.6	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.4	23.9	GO:0009925	basal plasma membrane(GO:0009925)
0.4	3.9	GO:1990812	growth cone filopodium(GO:1990812)
0.3	8.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3	1.6	GO:0071942	XPC complex(GO:0071942)
0.3	11.8	GO:0031105	septin complex(GO:0031105)
0.3	3.2	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.3	21.3	GO:0001533	cornified envelope(GO:0001533)
0.3	6.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.3	1.5	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.2	4.0	GO:0061700	GATOR2 complex(GO:0061700)
0.2	16.9	GO:0015030	Cajal body(GO:0015030)
0.2	1.0	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2	0.9	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	1.3	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.1	2.3	GO:0032433	filopodium tip(GO:0032433)
0.1	11.8	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	0.8	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.1	17.2	GO:0030175	filopodium(GO:0030175)
0.1	14.7	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	4.6	GO:0045178	basal part of cell(GO:0045178)
0.1	1.5	GO:0016235	aggresome(GO:0016235)
0.1	4.6	GO:0031941	filamentous actin(GO:0031941)
0.1	0.4	GO:0060187	cell pole(GO:0060187)
0.1	4.8	GO:0005865	striated muscle thin filament(GO:0005865)
0.1	1.7	GO:0000124	SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.1	3.0	GO:0031306	intrinsic component of mitochondrial outer membrane(GO:0031306)
0.1	6.8	GO:0030315	T-tubule(GO:0030315)
0.1	1.2	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	0.5	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	1.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	0.5	GO:1990393	3M complex(GO:1990393)
0.1	7.6	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	61.6	GO:0016604	nuclear body(GO:0016604)
0.1	1.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	8.3	GO:0043296	apical junction complex(GO:0043296)
0.0	4.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	4.2	GO:0032587	ruffle membrane(GO:0032587)
0.0	4.7	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	3.2	GO:0030286	dynein complex(GO:0030286)
0.0	26.9	GO:0045177	apical part of cell(GO:0045177)
0.0	4.1	GO:0001726	ruffle(GO:0001726)
0.0	2.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.6	GO:0035861	site of double-strand break(GO:0035861)
0.0	3.8	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.5	GO:0032039	integrator complex(GO:0032039)
0.0	2.2	GO:0005844	polysome(GO:0005844)
0.0	1.9	GO:0005694	chromosome(GO:0005694)
0.0	1.8	GO:0019898	extrinsic component of membrane(GO:0019898)
0.0	8.4	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	6.2	GO:0031225	anchored component of membrane(GO:0031225)
0.0	4.4	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.0	3.9	GO:0005681	spliceosomal complex(GO:0005681)
0.0	0.5	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.2	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	109.3	GO:0070062	extracellular exosome(GO:0070062)
0.0	1.6	GO:0005801	cis-Golgi network(GO:0005801)
0.0	1.8	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	5.4	GO:0015629	actin cytoskeleton(GO:0015629)
0.0	1.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	6.8	GO:0009986	cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.0	84.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
5.5	33.0	GO:0042015	interleukin-20 binding(GO:0042015)
5.4	16.3	GO:0061663	NEDD8 ligase activity(GO:0061663)
4.3	12.9	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
3.3	10.0	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
2.2	9.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
2.0	8.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
2.0	32.4	GO:0001758	retinal dehydrogenase activity(GO:0001758)
1.9	11.2	GO:0045569	TRAIL binding(GO:0045569)
1.5	26.1	GO:0008199	ferric iron binding(GO:0008199)
1.3	14.7	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.3	6.6	GO:0004668	protein-arginine deiminase activity(GO:0004668)
1.2	4.8	GO:0005173	stem cell factor receptor binding(GO:0005173)
1.2	7.0	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.1	15.3	GO:0089720	caspase binding(GO:0089720)
1.0	4.1	GO:0098808	mRNA cap binding(GO:0098808)
1.0	5.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
1.0	4.8	GO:0003867	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.9	2.8	GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.8	7.5	GO:0019798	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.8	5.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.8	14.7	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.7	23.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.7	4.6	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.6	34.5	GO:0042056	chemoattractant activity(GO:0042056)
0.6	2.5	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.6	7.4	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.6	4.0	GO:0070728	leucine binding(GO:0070728)
0.6	82.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	1.6	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.5	1.6	GO:0000405	bubble DNA binding(GO:0000405)
0.5	1.6	GO:1904854	proteasome core complex binding(GO:1904854)
0.5	27.6	GO:0042379	chemokine receptor binding(GO:0042379)
0.5	5.3	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.5	1.9	GO:0031685	adenosine receptor binding(GO:0031685)
0.5	7.0	GO:0045159	myosin II binding(GO:0045159)
0.4	8.9	GO:0050700	CARD domain binding(GO:0050700)
0.4	8.7	GO:1990239	steroid hormone binding(GO:1990239)
0.4	10.8	GO:0017049	GTP-Rho binding(GO:0017049)
0.4	2.2	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3	8.7	GO:0005212	structural constituent of eye lens(GO:0005212)
0.3	2.7	GO:0016427	tRNA (cytosine) methyltransferase activity(GO:0016427)
0.3	11.8	GO:0070300	phosphatidic acid binding(GO:0070300)
0.3	2.5	GO:0004126	cytidine deaminase activity(GO:0004126)
0.3	1.5	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3	6.9	GO:0031432	titin binding(GO:0031432)
0.3	3.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.3	7.2	GO:0035325	Toll-like receptor binding(GO:0035325)
0.3	1.4	GO:0008479	queuine tRNA-ribosyltransferase activity(GO:0008479)
0.3	5.8	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.3	61.6	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	8.0	GO:0001972	retinoic acid binding(GO:0001972)
0.2	5.2	GO:0045504	dynein heavy chain binding(GO:0045504)
0.2	2.3	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2	11.8	GO:0003785	actin monomer binding(GO:0003785)
0.2	48.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2	2.2	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.2	24.5	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.2	5.0	GO:0045294	alpha-catenin binding(GO:0045294)
0.2	1.2	GO:1901612	cardiolipin binding(GO:1901612)
0.2	3.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2	9.0	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.2	0.5	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2	21.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.2	3.8	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	1.5	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	48.1	GO:0030674	protein binding, bridging(GO:0030674)
0.1	2.9	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	5.3	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	2.3	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1	4.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	2.4	GO:0015643	toxic substance binding(GO:0015643)
0.1	3.9	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	1.3	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	3.2	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.1	1.9	GO:0008301	four-way junction DNA binding(GO:0000400) DNA binding, bending(GO:0008301)
0.1	1.8	GO:0008432	JUN kinase binding(GO:0008432)
0.1	3.2	GO:0005123	death receptor binding(GO:0005123)
0.1	3.3	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	1.4	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	1.6	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	4.2	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.1	0.7	GO:0043237	laminin-1 binding(GO:0043237)
0.1	2.4	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	0.2	GO:0008480	sarcosine dehydrogenase activity(GO:0008480)
0.1	1.3	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.1	2.9	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.1	1.1	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.1	0.5	GO:0008865	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1	3.6	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	22.6	GO:0003924	GTPase activity(GO:0003924)
0.1	2.7	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.6	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	1.5	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.4	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	8.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.4	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.4	GO:0071253	connexin binding(GO:0071253) gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0	0.6	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	1.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	11.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	2.6	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	1.8	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.0	0.8	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	1.6	GO:0001221	transcription cofactor binding(GO:0001221)
0.0	19.6	GO:0003779	actin binding(GO:0003779)
0.0	1.0	GO:0008266	poly-pyrimidine tract binding(GO:0008187) poly(U) RNA binding(GO:0008266)
0.0	4.0	GO:0031072	heat shock protein binding(GO:0031072)
0.0	1.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.3	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.7	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	1.5	GO:0008236	serine-type peptidase activity(GO:0008236)
0.0	1.7	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	1.1	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	2.5	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.3	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.9	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	0.5	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	1.0	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.3	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	103.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.8	34.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.8	16.3	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.6	13.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	55.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.5	18.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	8.9	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	11.7	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	8.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	17.6	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	7.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	8.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	14.0	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	3.9	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	2.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	1.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	6.5	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	4.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	20.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	4.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	11.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.7	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	1.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.1	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	3.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.5	ST JNK MAPK PATHWAY	JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	39.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
1.1	18.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.6	16.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.6	13.9	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.5	14.7	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.3	9.0	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.3	86.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	7.5	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	6.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.3	26.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	8.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	8.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	5.0	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	3.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.2	7.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	4.8	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	10.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	4.8	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.1	4.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	4.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	9.1	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	2.4	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	4.8	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	2.7	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	2.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	1.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	14.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	1.9	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	2.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	1.8	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	6.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	1.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	1.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	1.7	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.6	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	2.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.8	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	2.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.7	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.4	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	1.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	1.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.5	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	4.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation