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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TP63

Z-value: 6.51

Motif logo

Transcription factors associated with TP63

Gene Symbol Gene ID Gene Info
ENSG00000073282.8 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP63hg19_v2_chr3_+_189507460_1895074710.993.0e-19Click!

Activity profile of TP63 motif

Sorted Z-values of TP63 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TP63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 84.4 GO:0071461 cellular response to redox state(GO:0071461)
8.5 33.9 GO:0051710 cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
8.3 33.0 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
8.1 32.4 GO:0060166 olfactory pit development(GO:0060166)
5.4 16.3 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
4.9 14.7 GO:0008057 eye pigment granule organization(GO:0008057)
4.6 13.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
4.5 18.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
3.3 26.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
2.7 8.1 GO:0002276 basophil activation involved in immune response(GO:0002276)
2.7 13.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
2.2 9.0 GO:0035627 ceramide transport(GO:0035627)
1.6 6.5 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
1.6 4.8 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.6 9.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.6 37.9 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
1.4 10.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.4 7.0 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
1.3 6.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
1.3 32.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.2 7.4 GO:0048817 negative regulation of hair follicle maturation(GO:0048817)
1.2 6.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
1.2 4.8 GO:0045401 response to molecule of fungal origin(GO:0002238) serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
1.2 7.0 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.1 10.2 GO:0003383 apical constriction(GO:0003383)
1.1 4.4 GO:0035397 helper T cell enhancement of adaptive immune response(GO:0035397)
1.1 27.6 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
1.1 72.7 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
1.0 5.2 GO:2000843 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
1.0 4.1 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
1.0 5.0 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.0 6.9 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
1.0 46.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
1.0 4.8 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.8 8.7 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.8 3.9 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.8 7.5 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.7 2.2 GO:0071262 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.7 8.0 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.7 2.2 GO:1902958 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.7 5.0 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.7 14.7 GO:0046415 urate metabolic process(GO:0046415)
0.6 1.9 GO:0060406 positive regulation of penile erection(GO:0060406)
0.6 8.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.6 2.4 GO:0006408 snRNA export from nucleus(GO:0006408)
0.6 16.3 GO:0051639 actin filament network formation(GO:0051639)
0.5 2.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.5 1.5 GO:0019516 lactate oxidation(GO:0019516)
0.5 8.1 GO:0016540 protein autoprocessing(GO:0016540)
0.5 2.4 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.4 13.4 GO:0036010 protein localization to endosome(GO:0036010)
0.4 4.6 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.4 1.2 GO:0021648 vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve formation(GO:0021650)
0.4 3.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.4 1.6 GO:0071284 cellular response to lead ion(GO:0071284)
0.4 7.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.4 2.6 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.4 13.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 2.5 GO:0070383 DNA cytosine deamination(GO:0070383)
0.3 8.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 11.8 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.3 1.4 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.3 5.3 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.3 7.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.3 9.7 GO:0007398 ectoderm development(GO:0007398)
0.3 24.8 GO:0018149 peptide cross-linking(GO:0018149)
0.3 10.7 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.3 1.2 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.3 4.3 GO:0097264 self proteolysis(GO:0097264)
0.3 3.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.3 1.9 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 1.5 GO:0090131 mesenchyme migration(GO:0090131)
0.2 3.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.2 4.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 1.6 GO:1903786 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.2 1.8 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.2 1.3 GO:0031860 telomeric loop formation(GO:0031627) telomeric 3' overhang formation(GO:0031860)
0.2 2.3 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 5.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 3.3 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.2 4.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 2.3 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 0.4 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.2 2.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 10.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 2.9 GO:0001553 luteinization(GO:0001553)
0.2 3.9 GO:0071236 cellular response to antibiotic(GO:0071236)
0.2 1.3 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 0.5 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.2 1.1 GO:0035878 nail development(GO:0035878)
0.2 3.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 6.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 23.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 3.2 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 0.4 GO:1903367 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 7.4 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 3.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.4 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.1 3.6 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 9.6 GO:0070206 protein trimerization(GO:0070206)
0.1 14.2 GO:0048477 oogenesis(GO:0048477)
0.1 4.2 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 1.8 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.5 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 1.3 GO:1903943 negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 1.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 4.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 3.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.3 GO:0010226 response to lithium ion(GO:0010226)
0.1 2.0 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.3 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.1 0.2 GO:1901053 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.1 1.3 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.1 0.5 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.1 1.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 2.3 GO:0036065 fucosylation(GO:0036065)
0.1 3.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.7 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.5 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 0.7 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 6.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 4.5 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.1 4.2 GO:0060976 coronary vasculature development(GO:0060976)
0.1 2.4 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 1.7 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.2 GO:0007614 short-term memory(GO:0007614)
0.0 1.6 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 5.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 2.2 GO:0016569 covalent chromatin modification(GO:0016569)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.0 GO:0031297 replication fork processing(GO:0031297)
0.0 2.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 1.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 9.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 3.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.2 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.1 GO:0006781 succinyl-CoA pathway(GO:0006781)
0.0 1.4 GO:0046473 phosphatidic acid metabolic process(GO:0046473)
0.0 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.2 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.8 GO:0070271 protein complex assembly(GO:0006461) protein complex biogenesis(GO:0070271)
0.0 1.9 GO:0006396 RNA processing(GO:0006396)
0.0 2.7 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 1.7 GO:0001895 retina homeostasis(GO:0001895)
0.0 3.8 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 2.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.3 GO:0007517 muscle organ development(GO:0007517)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)
0.0 2.1 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006308 DNA catabolic process(GO:0006308)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 18.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)
1.9 7.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.7 5.0 GO:0036117 hyaluranon cable(GO:0036117)
1.6 8.0 GO:0035838 growing cell tip(GO:0035838)
1.3 9.0 GO:0097209 epidermal lamellar body(GO:0097209)
1.3 13.8 GO:0005610 laminin-5 complex(GO:0005610)
1.1 3.3 GO:0000229 cytoplasmic chromosome(GO:0000229)
1.0 34.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
1.0 4.8 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.9 3.8 GO:0016939 kinesin II complex(GO:0016939)
0.8 2.5 GO:1990716 axonemal central apparatus(GO:1990716)
0.7 4.8 GO:0019815 B cell receptor complex(GO:0019815)
0.6 54.3 GO:0045095 keratin filament(GO:0045095)
0.5 13.9 GO:0005922 connexon complex(GO:0005922)
0.5 6.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.5 8.7 GO:0097512 cardiac myofibril(GO:0097512)
0.5 7.0 GO:0030478 actin cap(GO:0030478)
0.5 5.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 4.5 GO:0097413 Lewy body(GO:0097413)
0.4 10.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 23.9 GO:0009925 basal plasma membrane(GO:0009925)
0.4 3.9 GO:1990812 growth cone filopodium(GO:1990812)
0.3 8.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 1.6 GO:0071942 XPC complex(GO:0071942)
0.3 11.8 GO:0031105 septin complex(GO:0031105)
0.3 3.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.3 21.3 GO:0001533 cornified envelope(GO:0001533)
0.3 6.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 4.0 GO:0061700 GATOR2 complex(GO:0061700)
0.2 16.9 GO:0015030 Cajal body(GO:0015030)
0.2 1.0 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 0.9 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 1.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.3 GO:0032433 filopodium tip(GO:0032433)
0.1 11.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 17.2 GO:0030175 filopodium(GO:0030175)
0.1 14.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.6 GO:0045178 basal part of cell(GO:0045178)
0.1 1.5 GO:0016235 aggresome(GO:0016235)
0.1 4.6 GO:0031941 filamentous actin(GO:0031941)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 4.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.7 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.1 3.0 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.1 6.8 GO:0030315 T-tubule(GO:0030315)
0.1 1.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.5 GO:1990393 3M complex(GO:1990393)
0.1 7.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 61.6 GO:0016604 nuclear body(GO:0016604)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 8.3 GO:0043296 apical junction complex(GO:0043296)
0.0 4.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.2 GO:0030286 dynein complex(GO:0030286)
0.0 26.9 GO:0045177 apical part of cell(GO:0045177)
0.0 4.1 GO:0001726 ruffle(GO:0001726)
0.0 2.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 2.2 GO:0005844 polysome(GO:0005844)
0.0 1.9 GO:0005694 chromosome(GO:0005694)
0.0 1.8 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 8.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 6.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 3.9 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 109.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 1.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 6.8 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 84.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
5.5 33.0 GO:0042015 interleukin-20 binding(GO:0042015)
5.4 16.3 GO:0061663 NEDD8 ligase activity(GO:0061663)
4.3 12.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
3.3 10.0 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
2.2 9.0 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
2.0 8.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
2.0 32.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
1.9 11.2 GO:0045569 TRAIL binding(GO:0045569)
1.5 26.1 GO:0008199 ferric iron binding(GO:0008199)
1.3 14.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.3 6.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.2 4.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
1.2 7.0 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.1 15.3 GO:0089720 caspase binding(GO:0089720)
1.0 4.1 GO:0098808 mRNA cap binding(GO:0098808)
1.0 5.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.0 4.8 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.9 2.8 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.8 7.5 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.8 5.0 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.8 14.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.7 23.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.7 4.6 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.6 34.5 GO:0042056 chemoattractant activity(GO:0042056)
0.6 2.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.6 7.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.6 4.0 GO:0070728 leucine binding(GO:0070728)
0.6 82.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 1.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 1.6 GO:0000405 bubble DNA binding(GO:0000405)
0.5 1.6 GO:1904854 proteasome core complex binding(GO:1904854)
0.5 27.6 GO:0042379 chemokine receptor binding(GO:0042379)
0.5 5.3 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.5 1.9 GO:0031685 adenosine receptor binding(GO:0031685)
0.5 7.0 GO:0045159 myosin II binding(GO:0045159)
0.4 8.9 GO:0050700 CARD domain binding(GO:0050700)
0.4 8.7 GO:1990239 steroid hormone binding(GO:1990239)
0.4 10.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.4 2.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 8.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 2.7 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.3 11.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 2.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 1.5 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 6.9 GO:0031432 titin binding(GO:0031432)
0.3 3.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 7.2 GO:0035325 Toll-like receptor binding(GO:0035325)
0.3 1.4 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.3 5.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.3 61.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 8.0 GO:0001972 retinoic acid binding(GO:0001972)
0.2 5.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 2.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 11.8 GO:0003785 actin monomer binding(GO:0003785)
0.2 48.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 24.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 5.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 1.2 GO:1901612 cardiolipin binding(GO:1901612)
0.2 3.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 9.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 0.5 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 21.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 3.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 48.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 5.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 4.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 3.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 3.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.9 GO:0008301 four-way junction DNA binding(GO:0000400) DNA binding, bending(GO:0008301)
0.1 1.8 GO:0008432 JUN kinase binding(GO:0008432)
0.1 3.2 GO:0005123 death receptor binding(GO:0005123)
0.1 3.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 4.2 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 2.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.2 GO:0008480 sarcosine dehydrogenase activity(GO:0008480)
0.1 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 2.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.5 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 3.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 22.6 GO:0003924 GTPase activity(GO:0003924)
0.1 2.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 1.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 8.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.4 GO:0071253 connexin binding(GO:0071253) gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 1.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 11.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 19.6 GO:0003779 actin binding(GO:0003779)
0.0 1.0 GO:0008266 poly-pyrimidine tract binding(GO:0008187) poly(U) RNA binding(GO:0008266)
0.0 4.0 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.5 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 103.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.8 34.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.8 16.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.6 13.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 55.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 18.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 8.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 11.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 8.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.2 17.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 7.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 8.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 14.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 3.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 6.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 4.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 20.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 11.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 3.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 39.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.1 18.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 16.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.6 13.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.5 14.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 9.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 86.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 7.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 6.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.3 26.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 8.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 8.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 5.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 3.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 7.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 10.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 4.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 4.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 9.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 2.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 4.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 14.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 1.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 6.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.6 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 2.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 2.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 4.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation