avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
TP73 Links Ensembl NCBI GeneCards UniProt	ENSG00000078900.10	tumor protein p73

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TP73	hg19_v2_chr1_+_3598871_3598930	0.23	3.3e-01	Click!

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	7.7	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)
1.2	4.9	GO:2001287	negative regulation of caveolin-mediated endocytosis(GO:2001287)
1.2	10.7	GO:0001661	conditioned taste aversion(GO:0001661)
0.5	1.5	GO:0008057	eye pigment granule organization(GO:0008057)
0.4	2.1	GO:1900106	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3	1.4	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.3	8.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3	0.8	GO:0021577	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2	0.9	GO:0044208	'de novo' AMP biosynthetic process(GO:0044208)
0.2	2.0	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2	1.5	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.1	0.9	GO:0046469	plasma lipoprotein particle oxidation(GO:0034441) platelet activating factor metabolic process(GO:0046469)
0.1	1.4	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1	0.4	GO:0015881	creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.1	2.1	GO:0035878	nail development(GO:0035878)
0.1	1.2	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.1	2.7	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	1.4	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
0.1	1.3	GO:0043248	proteasome assembly(GO:0043248)
0.1	0.4	GO:0002296	T-helper 1 cell lineage commitment(GO:0002296)
0.1	0.9	GO:0099612	protein localization to axon(GO:0099612)
0.1	0.9	GO:0019896	axonal transport of mitochondrion(GO:0019896)
0.1	0.4	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.6	GO:0034378	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) chylomicron assembly(GO:0034378) positive regulation of viral entry into host cell(GO:0046598)
0.0	0.6	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0	0.3	GO:1904222	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	1.8	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0032223	negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0	0.8	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.3	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	1.2	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0	0.7	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0014735	regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0	0.1	GO:0099538	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0	1.2	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0071400	cellular response to oleic acid(GO:0071400)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.4	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	2.1	GO:0048477	oogenesis(GO:0048477)
0.0	0.4	GO:0001946	lymphangiogenesis(GO:0001946)
0.0	0.4	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.2	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.1	GO:0003322	pancreatic A cell development(GO:0003322)
0.0	0.0	GO:1901383	negative regulation of chorionic trophoblast cell proliferation(GO:1901383)
0.0	0.4	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	10.7	GO:0035976	AP1 complex(GO:0035976)
1.0	4.9	GO:0044393	microspike(GO:0044393)
0.7	2.1	GO:0036117	hyaluranon cable(GO:0036117)
0.2	0.6	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.9	GO:1990769	proximal neuron projection(GO:1990769)
0.1	1.3	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1	1.9	GO:0030056	hemidesmosome(GO:0030056)
0.0	2.0	GO:0030057	desmosome(GO:0030057)
0.0	0.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	1.4	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.9	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.8	GO:0042599	lamellar body(GO:0042599)
0.0	1.4	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.0	1.2	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.8	GO:1904115	axon cytoplasm(GO:1904115)
0.0	1.6	GO:0030864	cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	7.7	GO:0042015	interleukin-20 binding(GO:0042015)
0.4	2.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.4	1.2	GO:0052857	NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.3	0.9	GO:0004019	adenylosuccinate synthase activity(GO:0004019)
0.2	1.2	GO:0016936	galactoside binding(GO:0016936)
0.2	1.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.2	2.0	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2	1.4	GO:0042610	CD8 receptor binding(GO:0042610)
0.1	2.1	GO:0038132	neuregulin binding(GO:0038132)
0.1	10.8	GO:0070412	R-SMAD binding(GO:0070412)
0.1	0.4	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.1	0.4	GO:0005308	creatine transmembrane transporter activity(GO:0005308)
0.1	0.9	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1	1.5	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.1	1.4	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.1	1.5	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	1.4	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.6	GO:0019798	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1	0.6	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.1	4.9	GO:0015485	cholesterol binding(GO:0015485)
0.1	8.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.4	GO:0004359	glutaminase activity(GO:0004359)
0.0	2.5	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	2.7	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.9	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.5	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.1	GO:0003990	acetylcholinesterase activity(GO:0003990)
0.0	0.8	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0003938	IMP dehydrogenase activity(GO:0003938)
0.0	0.8	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0060175	brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0	2.1	GO:0005496	steroid binding(GO:0005496)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	1.8	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.3	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.5	GO:0005112	Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	10.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	2.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	2.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.9	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	4.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.4	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	2.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	1.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	1.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	0.8	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	1.9	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.0	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.9	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	1.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.3	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	1.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	1.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.4	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)