avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Name	miRBASE accession
hsa-miR-145-5p Links miRBase	MIMAT0000437
hsa-miR-5195-3p Links miRBase	MIMAT0021127

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Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:1904761	negative regulation of myofibroblast differentiation(GO:1904761)
0.3	0.9	GO:0035750	protein localization to myelin sheath abaxonal region(GO:0035750)
0.3	1.4	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)
0.3	1.0	GO:0003274	endocardial cushion fusion(GO:0003274)
0.3	1.0	GO:1903045	neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2	1.3	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.2	1.4	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2	0.5	GO:0006679	glucosylceramide biosynthetic process(GO:0006679)
0.2	0.5	GO:0001300	chronological cell aging(GO:0001300)
0.2	1.0	GO:0001927	exocyst assembly(GO:0001927)
0.2	1.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.1	0.4	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1	1.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.1	0.4	GO:1903450	regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452)
0.1	0.4	GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1	0.6	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.1	0.4	GO:0086044	atrial ventricular junction remodeling(GO:0003294) atrial cardiac muscle cell to AV node cell communication by electrical coupling(GO:0086044) bundle of His cell to Purkinje myocyte communication by electrical coupling(GO:0086054) Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling(GO:0086055) regulation of Purkinje myocyte action potential(GO:0098906) vasomotion(GO:1990029)
0.1	0.8	GO:0001880	Mullerian duct regression(GO:0001880)
0.1	0.8	GO:0051643	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) endoplasmic reticulum localization(GO:0051643)
0.1	0.5	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.1	0.5	GO:0019072	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1	0.4	GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1	0.6	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.1	0.5	GO:1903691	positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1	0.8	GO:0014846	esophagus smooth muscle contraction(GO:0014846)
0.1	0.3	GO:0006864	pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1	0.5	GO:0007509	mesoderm migration involved in gastrulation(GO:0007509)
0.1	0.3	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.1	0.6	GO:0021764	amygdala development(GO:0021764)
0.1	0.3	GO:0050904	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.1	0.5	GO:2001045	negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1	0.3	GO:1902559	3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.1	2.7	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.9	GO:0016584	nucleosome positioning(GO:0016584)
0.1	0.4	GO:0003363	lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1	0.5	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.1	0.5	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1	1.2	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	0.4	GO:0032489	aminophospholipid transport(GO:0015917) regulation of Cdc42 protein signal transduction(GO:0032489) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1	0.5	GO:0015961	diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1	0.3	GO:0046619	optic placode formation involved in camera-type eye formation(GO:0046619)
0.1	2.3	GO:0009950	dorsal/ventral axis specification(GO:0009950)
0.1	0.2	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1	0.2	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1	0.6	GO:1903826	arginine transmembrane transport(GO:1903826)
0.1	0.6	GO:0044861	protein transport into plasma membrane raft(GO:0044861)
0.1	0.8	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.1	0.9	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	0.7	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.1	0.7	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.1	1.3	GO:0051451	myoblast migration(GO:0051451)
0.1	0.3	GO:0098582	innate vocalization behavior(GO:0098582)
0.1	0.9	GO:0043697	dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1	0.5	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.1	0.2	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) response to high density lipoprotein particle(GO:0055099)
0.1	0.5	GO:0060017	parathyroid gland development(GO:0060017)
0.1	0.4	GO:1904688	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.1	0.2	GO:0072034	bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145) renal vesicle induction(GO:0072034)
0.1	0.5	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.1	0.5	GO:1904996	PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1	0.5	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.1	0.6	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.1	0.5	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.1	0.3	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.1	0.7	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.1	0.3	GO:1904219	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1	0.5	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1	0.3	GO:0060005	vestibular reflex(GO:0060005)
0.1	1.1	GO:0097264	self proteolysis(GO:0097264)
0.1	0.3	GO:0035801	adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802)
0.0	0.4	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0031291	Ran protein signal transduction(GO:0031291)
0.0	0.5	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:1904235	regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0	0.4	GO:0008343	adult feeding behavior(GO:0008343)
0.0	0.1	GO:0010360	negative regulation of anion channel activity(GO:0010360) Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.0	0.2	GO:0097069	cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.0	0.3	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.3	GO:0071484	cellular response to light intensity(GO:0071484)
0.0	0.2	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0	0.1	GO:2000616	negative regulation of histone H3-K9 acetylation(GO:2000616)
0.0	0.1	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.4	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.5	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:0034059	response to anoxia(GO:0034059)
0.0	0.7	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	0.2	GO:0002528	regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0	0.2	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.2	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0	1.5	GO:0039694	viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0	0.5	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.2	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.7	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0	0.2	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.4	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0	0.3	GO:0010265	SCF complex assembly(GO:0010265)
0.0	0.4	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.0	0.5	GO:0001682	tRNA 5'-leader removal(GO:0001682)
0.0	0.3	GO:0048875	chemical homeostasis within a tissue(GO:0048875)
0.0	0.8	GO:0099514	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0	0.3	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.6	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0	0.3	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0	0.1	GO:0007387	anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0	0.3	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0032208	regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0	0.2	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.5	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.5	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.0	0.6	GO:0006895	Golgi to endosome transport(GO:0006895)
0.0	0.2	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.5	GO:0010666	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0	0.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0036292	DNA rewinding(GO:0036292)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0032185	septin cytoskeleton organization(GO:0032185)
0.0	0.5	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	0.2	GO:0034378	chylomicron assembly(GO:0034378)
0.0	0.5	GO:2000696	regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.2	GO:0043634	polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.0	0.2	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.4	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.0	0.3	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.5	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.7	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:0097010	eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0	0.2	GO:0032328	alanine transport(GO:0032328)
0.0	0.5	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	0.4	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.2	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.8	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.5	GO:0035067	negative regulation of histone acetylation(GO:0035067)
0.0	0.6	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0	0.3	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	1.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	1.6	GO:0043297	apical junction assembly(GO:0043297)
0.0	0.0	GO:1901420	negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
0.0	0.8	GO:1901998	toxin transport(GO:1901998)
0.0	0.3	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0071955	recycling endosome to Golgi transport(GO:0071955)
0.0	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	2.1	GO:0070268	cornification(GO:0070268)
0.0	0.3	GO:0006825	copper ion transport(GO:0006825)
0.0	0.8	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.1	GO:0072600	establishment of protein localization to Golgi(GO:0072600)
0.0	0.0	GO:1904425	negative regulation of GTP binding(GO:1904425)
0.0	0.5	GO:0070932	histone H3 deacetylation(GO:0070932)
0.0	0.9	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	0.1	GO:2000676	positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0	0.2	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.3	GO:1990126	retrograde transport, endosome to plasma membrane(GO:1990126)
0.0	0.0	GO:0001878	response to yeast(GO:0001878)
0.0	0.4	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.0	0.7	GO:0010501	RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.3	1.8	GO:0044308	axonal spine(GO:0044308)
0.2	0.9	GO:0031213	RSF complex(GO:0031213)
0.2	0.8	GO:0016939	kinesin II complex(GO:0016939)
0.1	0.4	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1	0.5	GO:0031933	telomeric heterochromatin(GO:0031933)
0.1	0.3	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.1	0.3	GO:0031379	RNA-directed RNA polymerase complex(GO:0031379)
0.1	0.7	GO:0033565	ESCRT-0 complex(GO:0033565)
0.1	0.5	GO:0030906	retromer, cargo-selective complex(GO:0030906)
0.1	0.8	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	0.4	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1	1.2	GO:0061700	GATOR2 complex(GO:0061700)
0.1	1.4	GO:0032059	bleb(GO:0032059)
0.1	0.8	GO:0030314	junctional membrane complex(GO:0030314)
0.1	0.2	GO:0000939	condensed chromosome inner kinetochore(GO:0000939)
0.1	0.8	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.5	GO:0001740	Barr body(GO:0001740)
0.1	0.9	GO:0043219	lateral loop(GO:0043219)
0.1	1.6	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.4	GO:0031415	NatA complex(GO:0031415)
0.1	0.6	GO:0005955	calcineurin complex(GO:0005955)
0.1	0.3	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.1	0.5	GO:0070552	BRISC complex(GO:0070552)
0.0	1.5	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.9	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.6	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	2.1	GO:0030057	desmosome(GO:0030057)
0.0	0.6	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.5	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.6	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.5	GO:0030681	multimeric ribonuclease P complex(GO:0030681)
0.0	0.3	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0	0.2	GO:0017109	glutamate-cysteine ligase complex(GO:0017109)
0.0	1.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.4	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.5	GO:0001520	outer dense fiber(GO:0001520)
0.0	0.3	GO:0005638	lamin filament(GO:0005638)
0.0	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.4	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.5	GO:0045180	basal cortex(GO:0045180)
0.0	1.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.3	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.7	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.3	GO:0042382	paraspeckles(GO:0042382)
0.0	0.4	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.8	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.8	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	1.3	GO:1990752	microtubule end(GO:1990752)
0.0	0.3	GO:0000779	condensed chromosome kinetochore(GO:0000777) condensed chromosome, centromeric region(GO:0000779)
0.0	0.3	GO:0032426	stereocilium tip(GO:0032426)
0.0	0.4	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.2	GO:0036020	endolysosome membrane(GO:0036020)
0.0	0.2	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)
0.0	0.3	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	1.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.5	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.6	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.3	GO:0005915	zonula adherens(GO:0005915)
0.0	0.7	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.3	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.0	0.6	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	0.5	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.7	GO:0032420	stereocilium(GO:0032420)
0.0	1.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.5	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	1.0	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.2	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	2.3	GO:0005903	brush border(GO:0005903)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	1.2	GO:0005856	cytoskeleton(GO:0005856)
0.0	2.0	GO:0016605	PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0098770	FBXO family protein binding(GO:0098770)
0.3	0.9	GO:0060001	minus-end directed microfilament motor activity(GO:0060001)
0.2	0.7	GO:0071633	dihydroceramidase activity(GO:0071633)
0.1	0.6	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.4	GO:0086079	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling(GO:0086076) gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling(GO:0086078) gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling(GO:0086079)
0.1	0.7	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1	0.5	GO:0015616	DNA translocase activity(GO:0015616)
0.1	0.4	GO:0047676	arachidonate-CoA ligase activity(GO:0047676)
0.1	0.5	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.1	0.3	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.1	0.3	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.1	0.3	GO:0015218	pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1	0.4	GO:0090556	apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1	0.4	GO:0008426	protein kinase C inhibitor activity(GO:0008426)
0.1	0.3	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.1	0.3	GO:0015091	ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1	2.8	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	0.3	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.1	0.5	GO:0052845	endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1	1.3	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	0.8	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1	1.5	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1	0.6	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.1	0.6	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	0.9	GO:0019211	phosphatase activator activity(GO:0019211)
0.1	0.3	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1	1.3	GO:0051011	microtubule minus-end binding(GO:0051011)
0.1	0.3	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
0.1	0.4	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.7	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	1.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.6	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	1.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.3	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.5	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.0	0.2	GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0	0.6	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.2	GO:0004357	glutamate-cysteine ligase activity(GO:0004357)
0.0	0.5	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	1.8	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.5	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.3	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.3	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.2	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.0	0.5	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.3	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.3	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	1.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0	0.5	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0017095	heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0	1.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.8	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.5	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	0.3	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.0	GO:0000146	microfilament motor activity(GO:0000146)
0.0	0.1	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.6	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.3	GO:0019534	toxin transporter activity(GO:0019534)
0.0	1.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.5	GO:0017166	vinculin binding(GO:0017166)
0.0	0.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.5	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.4	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.2	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	1.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.3	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.2	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.2	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	2.0	GO:0003724	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.4	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.7	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0045174	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0	0.3	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.2	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	1.5	GO:0019003	GDP binding(GO:0019003)
0.0	0.3	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0	1.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.6	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.3	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.5	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.2	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.8	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.3	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	2.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.2	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	1.4	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.5	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.6	GO:0005154	epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	1.7	PID ALK2 PATHWAY	ALK2 signaling events
0.0	3.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.5	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	1.8	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	1.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	3.2	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.5	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	1.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.5	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	2.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	1.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	3.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.6	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	2.1	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.8	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	1.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	1.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.4	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.5	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.2	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.7	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.6	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.7	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	1.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.4	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.0	1.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.5	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.8	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.3	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling