ISMARA results: VAX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for VAX2_RHOXF2

Z-value: 0.36

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol	Gene ID	Gene Info
VAX2 Ensembl NCBI GeneCards UniProt	ENSG00000116035.2	ventral anterior homeobox 2
RHOXF2 Ensembl NCBI GeneCards UniProt	ENSG00000131721.4	Rhox homeobox family member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
VAX2	hg19_v2_chr2_+_71127699_71127744	0.73	2.9e-04	Click!
RHOXF2	hg19_v2_chrX_+_119292467_119292467	0.15	5.4e-01	Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

No targets for VAX2_RHOXF2

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:2000863	positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2	0.6	GO:0051795	positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0	0.5	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.4	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.4	GO:0006625	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1	0.3	GO:0090119	vesicle-mediated cholesterol transport(GO:0090119)
0.0	0.3	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0	0.2	GO:0036511	trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0	0.2	GO:0070173	regulation of enamel mineralization(GO:0070173)

Showing 1 to 10 of 27 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.1	0.4	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0	0.3	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.3	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0002947	tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0	0.1	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.0	0.1	GO:0043614	multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)

Showing 1 to 9 of 9 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.6	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.4	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.4	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.1	0.3	GO:0005174	CD40 receptor binding(GO:0005174)
0.1	0.3	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1	0.2	GO:0033858	N-acetylgalactosamine kinase activity(GO:0033858)
0.1	0.2	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.2	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.2	GO:0046790	complement component C1q binding(GO:0001849) virion binding(GO:0046790)

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Showing 1 to 2 of 2 entries

Results for VAX2_RHOXF2

Z-value: 0.36

Motif logo

Transcription factors associated with VAX2_RHOXF2

Activity-expression correlation:

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

No targets for VAX2_RHOXF2

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: