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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for VDR
Z-value: 2.29
Motif logo
Transcription factors associated with VDR
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
VDR
|
ENSG00000111424.6 | vitamin D receptor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VDR | hg19_v2_chr12_-_48276710_48276725 | -0.23 | 3.2e-01 | Click! |
Activity profile of VDR motif
Sorted Z-values of VDR motif
Network of associatons between targets according to the STRING database.
First level regulatory network of VDR
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0015920 | leukocyte chemotaxis involved in inflammatory response(GO:0002232) lipopolysaccharide transport(GO:0015920) |
| 0.6 | 1.7 | GO:0014876 | response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.4 | 1.7 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) phenylpropanoid catabolic process(GO:0046271) |
| 0.3 | 1.0 | GO:0038162 | erythropoietin-mediated signaling pathway(GO:0038162) |
| 0.3 | 1.0 | GO:0090381 | regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.3 | 6.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 0.9 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.3 | 0.8 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 0.2 | 1.2 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.2 | 1.2 | GO:0038169 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.2 | 2.0 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.2 | 0.6 | GO:0043311 | regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.2 | 0.8 | GO:1902530 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.2 | 1.2 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) |
| 0.2 | 1.5 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.2 | 0.8 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.2 | 0.7 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.2 | 0.9 | GO:0035701 | hematopoietic stem cell migration(GO:0035701) |
| 0.2 | 1.4 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.2 | 1.1 | GO:1903899 | lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.1 | 0.4 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.1 | 3.3 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 0.5 | GO:0060032 | notochord regression(GO:0060032) |
| 0.1 | 1.6 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.1 | 1.0 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.1 | 0.4 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.1 | 0.3 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.1 | 1.2 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.3 | GO:0034963 | box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258) |
| 0.1 | 1.3 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.1 | 3.5 | GO:0051923 | sulfation(GO:0051923) |
| 0.1 | 2.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.9 | GO:0051852 | disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.1 | 2.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.5 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.3 | GO:0006788 | heme oxidation(GO:0006788) negative regulation of mast cell cytokine production(GO:0032764) |
| 0.1 | 0.5 | GO:0043606 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 0.3 | GO:0060168 | positive regulation of adenosine receptor signaling pathway(GO:0060168) |
| 0.1 | 0.3 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.1 | 0.9 | GO:0034378 | chylomicron assembly(GO:0034378) positive regulation of viral entry into host cell(GO:0046598) |
| 0.1 | 0.2 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 0.1 | 0.4 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.1 | 0.8 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 0.9 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.1 | 0.2 | GO:1904815 | negative regulation of protein localization to chromosome, telomeric region(GO:1904815) |
| 0.1 | 0.4 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.1 | 0.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.5 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.1 | 0.6 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 1.0 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.6 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.1 | 0.4 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.1 | 1.4 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 9.5 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 0.5 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.1 | 1.1 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 0.2 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 1.1 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 0.2 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.0 | 0.5 | GO:0046015 | regulation of transcription by glucose(GO:0046015) |
| 0.0 | 0.3 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 0.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.3 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.0 | 0.2 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.0 | 0.2 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 0.0 | 1.2 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway(GO:0035791) |
| 0.0 | 0.3 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.0 | 0.2 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.0 | 0.3 | GO:0045229 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.0 | 0.4 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.0 | 0.5 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.3 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.0 | 0.5 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.1 | GO:0030185 | nitric oxide transport(GO:0030185) carbon dioxide transmembrane transport(GO:0035378) |
| 0.0 | 0.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.6 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.7 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.4 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.7 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 0.0 | 1.0 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.0 | 0.6 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 0.0 | 0.2 | GO:0021997 | neural plate axis specification(GO:0021997) |
| 0.0 | 0.6 | GO:0039692 | single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) |
| 0.0 | 0.2 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
| 0.0 | 0.9 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.2 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.0 | 0.1 | GO:0046603 | negative regulation of mitotic centrosome separation(GO:0046603) |
| 0.0 | 0.1 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.0 | 0.6 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 1.3 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 0.0 | 0.2 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.0 | 0.5 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.7 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.6 | GO:1901798 | positive regulation of signal transduction by p53 class mediator(GO:1901798) |
| 0.0 | 0.1 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA(GO:0090625) |
| 0.0 | 0.3 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.0 | 1.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.3 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.1 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.0 | 0.1 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.2 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.0 | 0.3 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.2 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.0 | 0.0 | GO:0019516 | lactate oxidation(GO:0019516) |
| 0.0 | 0.4 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.0 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.0 | 0.0 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.0 | 0.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.4 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.5 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.0 | 0.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.0 | GO:0040019 | positive regulation of embryonic development(GO:0040019) |
| 0.0 | 0.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 2.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.3 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.5 | GO:0001893 | maternal placenta development(GO:0001893) |
| 0.0 | 0.3 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 0.7 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.0 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.0 | 0.4 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
| 0.0 | 0.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.3 | 2.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 2.9 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.3 | 0.9 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.2 | 0.9 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.2 | 0.8 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.2 | 1.6 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.1 | 1.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 1.3 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 0.4 | GO:0036024 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.1 | 1.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 1.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 0.6 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 0.6 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.9 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.3 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.6 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 3.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.7 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.6 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.1 | GO:0070703 | inner mucus layer(GO:0070702) outer mucus layer(GO:0070703) |
| 0.0 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.5 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 0.5 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.2 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.0 | 0.7 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.1 | GO:0020003 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.2 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.0 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.1 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.2 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 0.4 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 4.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.4 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.4 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 2.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.3 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 3.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 1.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 1.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 2.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.5 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 1.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.6 | 1.7 | GO:0102007 | lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007) |
| 0.4 | 1.9 | GO:0016900 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.3 | 1.6 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.3 | 1.2 | GO:0005019 | platelet-derived growth factor beta-receptor activity(GO:0005019) |
| 0.3 | 1.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.2 | 1.2 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.2 | 1.2 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.2 | 2.0 | GO:0071723 | lipoteichoic acid binding(GO:0070891) lipopeptide binding(GO:0071723) |
| 0.2 | 1.7 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.2 | 6.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.2 | 0.5 | GO:0004397 | histidine ammonia-lyase activity(GO:0004397) |
| 0.2 | 0.5 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.2 | 0.6 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.2 | 1.7 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.1 | 0.4 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.1 | 0.4 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.1 | 1.0 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 3.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 1.0 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.1 | 0.3 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.1 | 0.9 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.1 | 0.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.3 | GO:0036009 | protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259) |
| 0.1 | 0.7 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.5 | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060) |
| 0.1 | 0.7 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.5 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 0.5 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 0.4 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 0.3 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 2.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.2 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
| 0.1 | 0.3 | GO:0052642 | lysophosphatidic acid phosphatase activity(GO:0052642) |
| 0.1 | 0.3 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.1 | 0.2 | GO:0070361 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 0.1 | 0.3 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.1 | 0.6 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 1.0 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.1 | 0.3 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.1 | 1.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.2 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.1 | 0.5 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 0.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 1.2 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.2 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.0 | 0.7 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
| 0.0 | 0.3 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.5 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.4 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.0 | 0.1 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.0 | 0.3 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.0 | 0.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 0.9 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.2 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.0 | 1.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 8.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.0 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 1.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.5 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.1 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 0.0 | 0.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.2 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.0 | 0.1 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 5.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.9 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.1 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 0.2 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 0.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.0 | GO:0008480 | sarcosine dehydrogenase activity(GO:0008480) |
| 0.0 | 0.2 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 0.2 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.5 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 1.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 1.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 3.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 2.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.0 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.9 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 1.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.2 | REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| 0.1 | 1.0 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 4.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.4 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 1.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.7 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 1.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.8 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 2.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.5 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.6 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.0 | 0.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.1 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |