ISMARA results: WT1_MTF1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for WT1_MTF1_ZBTB7B

Z-value: 2.79

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Transcription factors associated with WT1_MTF1_ZBTB7B

Gene Symbol	Gene ID	Gene Info
WT1 Ensembl NCBI GeneCards UniProt	ENSG00000184937.8	WT1 transcription factor
MTF1 Ensembl NCBI GeneCards UniProt	ENSG00000188786.9	metal regulatory transcription factor 1
ZBTB7B Ensembl NCBI GeneCards UniProt	ENSG00000160685.9	zinc finger and BTB domain containing 7B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WT1	hg19_v2_chr11_-_32456891_32456906	-0.88	3.0e-07	Click!
MTF1	hg19_v2_chr1_-_38325256_38325292	0.30	2.0e-01	Click!
ZBTB7B	hg19_v2_chr1_+_154975110_154975149	0.30	2.0e-01	Click!

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

No targets for WT1_MTF1_ZBTB7B

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	31.3	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
1.9	22.6	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.2	17.0	GO:0009301	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
1.9	16.7	GO:0032348	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.7	16.3	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.3	14.0	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.7	13.7	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
1.1	13.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
2.1	12.5	GO:0030421	defecation(GO:0030421)
0.8	11.8	GO:0060613	fat pad development(GO:0060613)

Showing 1 to 10 of 1,456 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	42.1	GO:0016605	PML body(GO:0016605)
0.1	33.6	GO:0030139	endocytic vesicle(GO:0030139)
0.1	25.6	GO:0070160	occluding junction(GO:0070160)
0.1	25.6	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
1.9	22.6	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.7	19.9	GO:0097386	glial cell projection(GO:0097386)
0.5	19.8	GO:0030057	desmosome(GO:0030057)
0.1	19.0	GO:0030018	Z disc(GO:0030018)
0.1	18.2	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	16.2	GO:0055038	recycling endosome membrane(GO:0055038)

Showing 1 to 10 of 433 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	57.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	47.2	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071)
0.2	32.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	30.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
1.3	28.8	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	22.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	21.9	GO:0008013	beta-catenin binding(GO:0008013)
0.2	19.8	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4	18.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.3	15.5	GO:0031492	nucleosomal DNA binding(GO:0031492)

Showing 1 to 10 of 728 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	45.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	27.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	24.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	24.4	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.3	23.6	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.3	19.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.7	18.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6	17.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	15.7	PID FGF PATHWAY	FGF signaling pathway
0.0	14.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 120 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	19.1	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	17.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	17.1	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	16.7	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.7	16.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4	15.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.6	13.9	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.2	13.1	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.3	12.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 166 entries

Results for WT1_MTF1_ZBTB7B

Z-value: 2.79

Motif logo

Transcription factors associated with WT1_MTF1_ZBTB7B

Activity-expression correlation:

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

No targets for WT1_MTF1_ZBTB7B

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: