ISMARA results: ZBTB12

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZBTB12

Z-value: 2.09

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Transcription factors associated with ZBTB12

Gene Symbol	Gene ID	Gene Info
ZBTB12 Ensembl NCBI GeneCards UniProt	ENSG00000204366.3	zinc finger and BTB domain containing 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB12	hg19_v2_chr6_-_31869769_31869880	-0.88	3.2e-07	Click!

Activity profile of ZBTB12 motif

Sorted Z-values of ZBTB12 motif

No targets for ZBTB12

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	18.5	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
0.0	6.7	GO:0070268	cornification(GO:0070268)
1.5	6.0	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.6	5.2	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.3	4.7	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.9	4.6	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	4.4	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
1.3	3.8	GO:1904784	NLRP1 inflammasome complex assembly(GO:1904784)
0.0	3.5	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.4	3.4	GO:0061198	fungiform papilla formation(GO:0061198)

Showing 1 to 10 of 70 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.6	GO:0016607	nuclear speck(GO:0016607)
1.4	9.8	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.0	7.2	GO:0005882	intermediate filament(GO:0005882)
0.2	4.6	GO:0005922	connexon complex(GO:0005922)
0.1	3.4	GO:0016580	Sin3 complex(GO:0016580)
0.1	1.9	GO:0000124	SAGA complex(GO:0000124)
0.1	1.9	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	1.9	GO:0005581	collagen trimer(GO:0005581)
0.1	1.8	GO:0033391	chromatoid body(GO:0033391)
0.1	1.7	GO:0030478	actin cap(GO:0030478)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	11.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.4	10.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2	7.4	GO:0004707	MAP kinase activity(GO:0004707)
0.1	6.7	GO:0097110	scaffold protein binding(GO:0097110)
0.3	5.2	GO:0008199	ferric iron binding(GO:0008199)
0.1	4.7	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.1	3.5	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	3.4	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1	3.2	GO:0017049	GTP-Rho binding(GO:0017049)

Showing 1 to 10 of 53 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	5.2	PID P53 REGULATION PATHWAY	p53 pathway
0.2	4.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	3.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	3.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	3.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	2.4	ST ADRENERGIC	Adrenergic Pathway
0.0	1.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.8	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	1.8	PID ARF6 PATHWAY	Arf6 signaling events

Showing 1 to 10 of 17 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.3	6.0	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	5.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	4.6	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	4.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.2	3.8	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	3.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	3.1	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	2.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.8	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 10 of 25 entries

Results for ZBTB12

Z-value: 2.09

Motif logo

Transcription factors associated with ZBTB12

Activity-expression correlation:

Activity profile of ZBTB12 motif

Sorted Z-values of ZBTB12 motif

No targets for ZBTB12

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: