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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZBTB18
Z-value: 1.62
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Transcription factors associated with ZBTB18
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ZBTB18
|
ENSG00000179456.9 | zinc finger and BTB domain containing 18 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB18 | hg19_v2_chr1_+_244214577_244214593 | -0.93 | 4.4e-09 | Click! |
Activity profile of ZBTB18 motif
Sorted Z-values of ZBTB18 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB18
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.2 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 1.9 | 5.6 | GO:1902362 | melanocyte apoptotic process(GO:1902362) |
| 0.9 | 6.6 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.9 | 2.6 | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
| 0.7 | 2.0 | GO:0008057 | eye pigment granule organization(GO:0008057) |
| 0.6 | 5.6 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.5 | 1.6 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 0.5 | 3.5 | GO:1902162 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.4 | 9.0 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.3 | 2.1 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.3 | 0.8 | GO:2000625 | regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
| 0.3 | 0.8 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.2 | 0.7 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.2 | 2.4 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.2 | 1.3 | GO:0060437 | lung growth(GO:0060437) |
| 0.2 | 3.4 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.2 | 2.5 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.2 | 3.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.2 | 0.5 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
| 0.1 | 0.7 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.1 | 1.9 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 1.0 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.1 | 1.1 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 1.0 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.1 | 0.3 | GO:0061485 | memory T cell proliferation(GO:0061485) |
| 0.1 | 0.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 1.8 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 1.3 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 0.5 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.1 | 0.6 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.1 | 0.2 | GO:0003408 | optic cup formation involved in camera-type eye development(GO:0003408) |
| 0.1 | 0.3 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 0.4 | GO:0099538 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
| 0.1 | 0.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 0.9 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 0.9 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.1 | 1.1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 1.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 1.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.2 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 1.3 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 2.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.2 | GO:2001170 | positive regulation of fat cell proliferation(GO:0070346) negative regulation of ATP biosynthetic process(GO:2001170) |
| 0.0 | 0.1 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.0 | 2.5 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.0 | 0.7 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 1.9 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.0 | 0.7 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.5 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 3.0 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 1.3 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 1.0 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 1.8 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 1.5 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway(GO:0002755) |
| 0.0 | 0.2 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 1.7 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.0 | 0.3 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.5 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.0 | 2.1 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 1.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 1.4 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.3 | 5.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.3 | 1.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.1 | 1.9 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.1 | 0.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 3.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.2 | GO:0035841 | new growing cell tip(GO:0035841) |
| 0.1 | 1.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.7 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 2.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 2.7 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 1.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 8.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 15.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 2.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.6 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 8.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 0.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.5 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 2.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.4 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 4.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 0.1 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.6 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.4 | 1.6 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.4 | 3.4 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 2.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 5.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.2 | 0.5 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 0.1 | 2.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 2.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 0.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 2.0 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 0.9 | GO:0010853 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
| 0.1 | 0.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 0.4 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 1.0 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.7 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 0.6 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 8.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.7 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.1 | 0.4 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 1.7 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.0 | 2.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 9.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 1.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 2.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 0.8 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 1.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 2.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 4.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.3 | GO:0015926 | glucosidase activity(GO:0015926) |
| 0.0 | 0.6 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 1.1 | GO:0030291 | protein serine/threonine kinase inhibitor activity(GO:0030291) |
| 0.0 | 0.5 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 1.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.0 | 2.6 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 0.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 1.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.1 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 1.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 5.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 3.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.0 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 4.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.8 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 3.4 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 1.5 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 5.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.3 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.5 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 1.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.3 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 1.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |