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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZIC3_ZIC4
Z-value: 1.56
Motif logo
Transcription factors associated with ZIC3_ZIC4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ZIC3
|
ENSG00000156925.7 | Zic family member 3 |
|
ZIC4
|
ENSG00000174963.13 | Zic family member 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC3 | hg19_v2_chrX_+_136648643_136648711 | 0.44 | 5.2e-02 | Click! |
| ZIC4 | hg19_v2_chr3_-_147124547_147124647 | 0.02 | 9.5e-01 | Click! |
Activity profile of ZIC3_ZIC4 motif
Sorted Z-values of ZIC3_ZIC4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC3_ZIC4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 1.4 | 4.3 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.8 | 4.1 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.8 | 3.1 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.6 | 1.8 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.6 | 2.9 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.6 | 1.7 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.6 | 1.7 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.5 | 1.6 | GO:0100012 | regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) |
| 0.5 | 2.5 | GO:1901662 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.5 | 1.5 | GO:0060829 | regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829) |
| 0.5 | 1.4 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.4 | 1.3 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.4 | 3.0 | GO:0097473 | cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.4 | 1.1 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.4 | 1.8 | GO:0033091 | positive regulation of immature T cell proliferation(GO:0033091) |
| 0.4 | 1.1 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.3 | 1.0 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.3 | 1.3 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.3 | 0.9 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.3 | 2.2 | GO:0000066 | mitochondrial ornithine transport(GO:0000066) |
| 0.3 | 1.7 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.3 | 0.8 | GO:0070904 | L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.3 | 0.8 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.3 | 2.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.3 | 1.1 | GO:0006550 | isoleucine catabolic process(GO:0006550) |
| 0.3 | 1.1 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.3 | 0.5 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) |
| 0.3 | 1.0 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 0.3 | 0.8 | GO:1901207 | regulation of heart looping(GO:1901207) |
| 0.2 | 3.2 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.2 | 1.7 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 0.2 | 1.9 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.2 | 0.9 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.2 | 1.6 | GO:0060994 | regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) |
| 0.2 | 1.1 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.2 | 2.6 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.2 | 1.9 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.2 | 0.6 | GO:0051596 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.2 | 0.8 | GO:0044537 | regulation of circulating fibrinogen levels(GO:0044537) |
| 0.2 | 2.4 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.2 | 0.6 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
| 0.2 | 1.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.2 | 2.3 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.2 | 0.6 | GO:0042450 | arginine biosynthetic process via ornithine(GO:0042450) |
| 0.2 | 0.6 | GO:0016260 | selenocysteine biosynthetic process(GO:0016260) |
| 0.2 | 2.3 | GO:0042756 | drinking behavior(GO:0042756) |
| 0.2 | 0.9 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.2 | 2.5 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.2 | 4.6 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.2 | 1.7 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.2 | 0.7 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.2 | 1.1 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
| 0.2 | 1.3 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.2 | 0.8 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
| 0.2 | 0.6 | GO:1904106 | protein localization to microvillus(GO:1904106) |
| 0.2 | 0.9 | GO:1902499 | positive regulation of protein autoubiquitination(GO:1902499) |
| 0.1 | 0.4 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.1 | 0.1 | GO:0060823 | canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) |
| 0.1 | 0.7 | GO:0006549 | isoleucine metabolic process(GO:0006549) |
| 0.1 | 2.4 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 0.7 | GO:1901536 | negative regulation of DNA demethylation(GO:1901536) |
| 0.1 | 0.6 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
| 0.1 | 0.8 | GO:0033490 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 0.1 | 3.1 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 2.4 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.1 | 1.1 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.1 | 0.8 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.1 | 0.6 | GO:0044571 | [2Fe-2S] cluster assembly(GO:0044571) |
| 0.1 | 2.2 | GO:0030238 | male sex determination(GO:0030238) |
| 0.1 | 0.6 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.1 | 1.3 | GO:0006528 | asparagine metabolic process(GO:0006528) |
| 0.1 | 0.2 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.1 | 0.6 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.1 | 2.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 0.9 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.1 | 1.0 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.4 | GO:0072302 | negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) |
| 0.1 | 0.9 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 0.8 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.1 | 0.9 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.1 | 0.6 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 0.8 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.1 | 0.4 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.1 | 0.7 | GO:0048865 | stem cell fate commitment(GO:0048865) |
| 0.1 | 2.5 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.4 | GO:0006272 | leading strand elongation(GO:0006272) |
| 0.1 | 0.7 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.3 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.1 | 0.9 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 0.4 | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.1 | 3.1 | GO:0072662 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 0.5 | GO:0021539 | subthalamus development(GO:0021539) |
| 0.1 | 0.1 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 0.1 | 1.3 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.1 | 0.1 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.1 | 0.3 | GO:0035927 | RNA import into mitochondrion(GO:0035927) |
| 0.1 | 0.8 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.1 | 0.2 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.1 | 0.3 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.1 | 0.2 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.1 | 1.8 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.1 | 0.2 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 0.1 | 0.4 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 0.5 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.2 | GO:0002572 | pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.1 | 1.7 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 0.7 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.1 | 0.3 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.1 | 0.2 | GO:0060723 | spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723) |
| 0.1 | 2.0 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.4 | GO:0098532 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 3.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 0.5 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.1 | 1.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.4 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.1 | 0.3 | GO:0038169 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 0.3 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.1 | 0.2 | GO:1990697 | protein depalmitoleylation(GO:1990697) |
| 0.1 | 1.0 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 1.1 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.4 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 3.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.1 | GO:0000960 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.0 | 0.6 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.4 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.0 | 0.4 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.0 | 0.0 | GO:0030908 | intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) |
| 0.0 | 0.7 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 0.6 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 0.0 | 0.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 1.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.0 | 0.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.5 | GO:1904322 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.0 | 2.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 1.5 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.2 | GO:1902075 | cellular response to salt(GO:1902075) |
| 0.0 | 0.2 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 0.0 | 0.6 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.0 | 0.2 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
| 0.0 | 0.7 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.0 | 0.5 | GO:0060312 | regulation of blood vessel remodeling(GO:0060312) |
| 0.0 | 0.3 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 0.1 | GO:0021912 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) |
| 0.0 | 0.8 | GO:0060746 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 1.1 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.0 | 0.2 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.0 | 0.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.0 | 0.8 | GO:0035413 | positive regulation of catenin import into nucleus(GO:0035413) |
| 0.0 | 0.1 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.0 | 0.2 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
| 0.0 | 0.4 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.0 | 0.1 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.0 | 0.9 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 0.3 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.0 | 0.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 1.1 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.2 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.0 | 0.7 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.2 | GO:2000672 | regulation of motor neuron apoptotic process(GO:2000671) negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.0 | 0.4 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.0 | 0.1 | GO:0051586 | positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.0 | 0.2 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.6 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.1 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.0 | 0.4 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.6 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.6 | GO:0003299 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.0 | 1.3 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 0.4 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.0 | 0.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.0 | 0.6 | GO:1901642 | nucleoside transmembrane transport(GO:1901642) |
| 0.0 | 2.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.5 | GO:0070129 | regulation of mitochondrial translation(GO:0070129) |
| 0.0 | 0.7 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 0.1 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 0.0 | 0.3 | GO:0060174 | limb bud formation(GO:0060174) |
| 0.0 | 0.1 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.0 | 0.4 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.0 | 0.6 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.1 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 0.5 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.0 | 0.3 | GO:0034465 | response to carbon monoxide(GO:0034465) smooth muscle contraction involved in micturition(GO:0060083) |
| 0.0 | 0.3 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.0 | 0.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.2 | GO:2000582 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.4 | GO:0010919 | regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 0.1 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.0 | 0.4 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.0 | 0.4 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 1.9 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.2 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.0 | 0.5 | GO:0097237 | cellular response to toxic substance(GO:0097237) |
| 0.0 | 0.1 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 0.2 | GO:1904251 | regulation of bile acid metabolic process(GO:1904251) |
| 0.0 | 0.5 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.0 | GO:1900020 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.0 | 0.9 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.0 | 0.1 | GO:0001773 | myeloid dendritic cell activation(GO:0001773) |
| 0.0 | 0.1 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058) |
| 0.0 | 0.5 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.7 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.0 | 0.2 | GO:0010990 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.7 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.2 | GO:1903874 | ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874) |
| 0.0 | 1.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 1.0 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.3 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 0.2 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.2 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.0 | 0.7 | GO:0035272 | exocrine system development(GO:0035272) |
| 0.0 | 0.1 | GO:0031087 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.2 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.8 | 2.3 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.6 | 1.8 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.4 | 1.6 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.3 | 1.4 | GO:0097196 | Shu complex(GO:0097196) |
| 0.3 | 1.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.3 | 1.0 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.2 | 1.0 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.2 | 2.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.2 | 3.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 2.0 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.6 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 2.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.8 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 1.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.4 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.1 | 0.4 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 1.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 1.0 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 1.8 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 0.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 0.3 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
| 0.1 | 1.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 0.4 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.1 | 1.3 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.1 | 1.1 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 0.3 | GO:0031523 | Myb complex(GO:0031523) |
| 0.1 | 1.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.8 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 5.7 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 0.6 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 0.9 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 0.3 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.1 | 3.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 1.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.2 | GO:0019031 | viral envelope(GO:0019031) viral membrane(GO:0036338) |
| 0.0 | 0.4 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 0.8 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 0.5 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 4.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.6 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.0 | 4.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.0 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.2 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 1.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.1 | GO:0070703 | inner mucus layer(GO:0070702) outer mucus layer(GO:0070703) |
| 0.0 | 0.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 2.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.2 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 0.1 | GO:0031417 | NatC complex(GO:0031417) |
| 0.0 | 0.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.6 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.1 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 0.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 2.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.4 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.1 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.8 | 2.5 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.7 | 2.0 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 0.6 | 2.8 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.5 | 2.3 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.5 | 1.4 | GO:0016250 | N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826) |
| 0.3 | 4.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.3 | 2.6 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.3 | 1.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.3 | 2.2 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.3 | 2.4 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.3 | 0.9 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.3 | 0.9 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.3 | 0.8 | GO:0015229 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.2 | 3.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 1.3 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 0.2 | 0.6 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.2 | 0.6 | GO:0016781 | selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781) |
| 0.2 | 1.1 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.2 | 0.7 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.2 | 1.1 | GO:0052656 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.2 | 0.5 | GO:0036328 | VEGF-C-activated receptor activity(GO:0036328) |
| 0.2 | 1.1 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.2 | 1.0 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 0.2 | 1.5 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.2 | 1.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 1.1 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 1.9 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.4 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.1 | 0.6 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 3.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 2.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 2.5 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.1 | 2.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.4 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.1 | 1.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.8 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.1 | 2.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.5 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 1.3 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 0.3 | GO:0030943 | mitochondrion targeting sequence binding(GO:0030943) |
| 0.1 | 0.9 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 0.4 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.1 | 0.6 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.1 | 2.8 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.7 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.4 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.1 | 0.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.1 | 2.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.7 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 0.5 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.1 | 0.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 0.9 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 1.1 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.1 | 0.2 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.1 | 0.3 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 1.0 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.9 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.1 | 1.6 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 0.5 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 0.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 1.7 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.6 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.1 | 1.1 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 2.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 0.2 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.1 | 1.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.2 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.1 | 0.3 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 0.4 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.1 | 0.2 | GO:1990699 | palmitoleyl hydrolase activity(GO:1990699) |
| 0.1 | 0.4 | GO:1904047 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) S-adenosyl-L-methionine binding(GO:1904047) |
| 0.0 | 1.4 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.4 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.0 | 0.7 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.0 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.4 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 0.6 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.8 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.0 | 0.5 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.6 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.3 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 0.0 | 0.3 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.0 | 1.9 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 0.7 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.2 | GO:0038181 | bile acid receptor activity(GO:0038181) |
| 0.0 | 1.1 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.1 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.0 | 0.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.0 | 0.2 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.0 | 0.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.2 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.0 | 1.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.7 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 1.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.2 | GO:0015087 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.2 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 0.3 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 4.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 2.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.2 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.2 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.0 | 0.1 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 1.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.8 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.0 | 1.1 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.5 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.3 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.1 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.0 | 0.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 3.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.1 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 1.4 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.0 | 0.6 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.2 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.0 | 0.1 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 2.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.1 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.0 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.9 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 1.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 2.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 1.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.6 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 1.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 4.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.6 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.1 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.7 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 2.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 1.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 3.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.8 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 1.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 0.8 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 3.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.8 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 1.5 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.0 | 2.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.8 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 1.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.9 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 3.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 1.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 3.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 2.5 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 1.0 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.5 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.0 | 0.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.2 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 1.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |