ISMARA results: ZIC3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZIC3_ZIC4

Z-value: 1.56

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol	Gene ID	Gene Info
ZIC3 Ensembl NCBI GeneCards UniProt	ENSG00000156925.7	Zic family member 3
ZIC4 Ensembl NCBI GeneCards UniProt	ENSG00000174963.13	Zic family member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZIC3	hg19_v2_chrX_+_136648643_136648711	0.44	5.2e-02	Click!
ZIC4	hg19_v2_chr3_-_147124547_147124647	0.02	9.5e-01	Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

No targets for ZIC3_ZIC4

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	5.2	GO:0099558	maintenance of synapse structure(GO:0099558)
0.2	4.6	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
1.4	4.3	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.8	4.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	3.5	GO:0015701	bicarbonate transport(GO:0015701)
0.2	3.2	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.8	3.1	GO:0002432	granuloma formation(GO:0002432)
0.1	3.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1	3.1	GO:0072662	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.4	3.0	GO:0097473	cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)

Showing 1 to 10 of 216 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	GO:0035580	specific granule lumen(GO:0035580)
1.3	5.2	GO:0044301	climbing fiber(GO:0044301)
0.0	4.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	4.3	GO:0005581	collagen trimer(GO:0005581)
0.1	3.9	GO:0031941	filamentous actin(GO:0031941)
0.0	3.4	GO:0043202	lysosomal lumen(GO:0043202)
0.2	3.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	2.9	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	2.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.8	2.3	GO:0098855	HCN channel complex(GO:0098855)

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.6	GO:0071933	Arp2/3 complex binding(GO:0071933)
1.4	4.3	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0	4.0	GO:0005518	collagen binding(GO:0005518)
0.0	3.8	GO:0044325	ion channel binding(GO:0044325)
0.1	3.5	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.2	3.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	2.9	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	2.9	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.6	2.8	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.1	2.8	GO:0003746	translation elongation factor activity(GO:0003746)

Showing 1 to 10 of 148 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	2.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	2.8	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	2.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	2.5	NABA COLLAGENS	Genes encoding collagen proteins
0.1	2.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	2.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	1.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.7	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	1.7	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Showing 1 to 10 of 35 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	3.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	3.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	3.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	3.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	2.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	2.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	2.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	2.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	2.5	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events

Showing 1 to 10 of 46 entries

Results for ZIC3_ZIC4

Z-value: 1.56

Motif logo

Transcription factors associated with ZIC3_ZIC4

Activity-expression correlation:

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

No targets for ZIC3_ZIC4

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: