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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZKSCAN1

Z-value: 1.40

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Transcription factors associated with ZKSCAN1

Gene Symbol Gene ID Gene Info
ENSG00000106261.12 zinc finger with KRAB and SCAN domains 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN1hg19_v2_chr7_+_99613195_996132060.174.8e-01Click!

Activity profile of ZKSCAN1 motif

Sorted Z-values of ZKSCAN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.4 1.5 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 1.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 2.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 0.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 1.3 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.2 1.7 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 0.5 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.2 1.7 GO:0018377 protein myristoylation(GO:0018377)
0.1 1.5 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.8 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 1.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.4 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1 0.7 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 2.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.2 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.1 0.3 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.1 0.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.5 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.3 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.2 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.2 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.1 GO:0042704 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.0 1.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.2 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 1.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.6 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.8 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 1.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 5.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.8 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 1.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.7 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.3 2.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 1.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 1.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.7 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 1.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 0.3 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.7 GO:0001055 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.1 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.0 0.2 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 1.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.0 GO:0016499 orexin receptor activity(GO:0016499)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 4.0 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 4.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 4.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis