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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZKSCAN3
Z-value: 0.89
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Transcription factors associated with ZKSCAN3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ZKSCAN3
|
ENSG00000189298.9 | zinc finger with KRAB and SCAN domains 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZKSCAN3 | hg19_v2_chr6_+_28317685_28317761 | -0.48 | 3.2e-02 | Click! |
Activity profile of ZKSCAN3 motif
Sorted Z-values of ZKSCAN3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ZKSCAN3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.6 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.4 | 3.6 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.3 | 1.0 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.2 | 1.3 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 1.0 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 0.6 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.2 | 0.5 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619) |
| 0.1 | 0.6 | GO:2001248 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.1 | 0.5 | GO:1902809 | regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 0.1 | 1.4 | GO:1901078 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 0.2 | GO:0071586 | CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120) |
| 0.1 | 1.4 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 0.2 | GO:0060623 | pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623) |
| 0.1 | 0.5 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 1.7 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 0.3 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.0 | 1.1 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 0.9 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 0.6 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.3 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.0 | 0.4 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.3 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.0 | 1.1 | GO:0043276 | anoikis(GO:0043276) |
| 0.0 | 1.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 0.2 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.0 | 0.7 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.3 | 1.0 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 0.5 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 1.0 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 1.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 1.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 1.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.6 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 0.2 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 0.7 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.3 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 1.4 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.6 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.2 | 1.1 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.2 | 0.5 | GO:0032129 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.2 | 1.3 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 0.6 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.1 | 0.6 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.1 | 1.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.5 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 0.4 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 0.3 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 0.3 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.0 | 0.9 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 1.4 | GO:0043015 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.2 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.0 | 6.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.3 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 1.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.3 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.7 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |