ISMARA results: ZNF740

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF740_ZNF219

Z-value: 2.28

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Transcription factors associated with ZNF740_ZNF219

Gene Symbol	Gene ID	Gene Info
ZNF740 Ensembl NCBI GeneCards UniProt	ENSG00000139651.9	zinc finger protein 740
ZNF219 Ensembl NCBI GeneCards UniProt	ENSG00000165804.11	zinc finger protein 219

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF219	hg19_v2_chr14_-_21566731_21566836	-0.87	6.1e-07	Click!
ZNF740	hg19_v2_chr12_+_53574464_53574539	0.24	3.0e-01	Click!

Activity profile of ZNF740_ZNF219 motif

Sorted Z-values of ZNF740_ZNF219 motif

No targets for ZNF740_ZNF219

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	22.6	GO:0008543	fibroblast growth factor receptor signaling pathway(GO:0008543)
1.0	15.3	GO:0002191	cap-dependent translational initiation(GO:0002191)
0.1	12.9	GO:0010507	negative regulation of autophagy(GO:0010507)
0.3	11.1	GO:0006783	heme biosynthetic process(GO:0006783)
1.9	9.7	GO:1905167	positive regulation of lysosomal protein catabolic process(GO:1905167)
2.3	9.4	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.8	7.7	GO:1901314	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.8	7.5	GO:0072553	terminal button organization(GO:0072553)
0.8	7.4	GO:0048050	post-embryonic eye morphogenesis(GO:0048050)
0.0	7.4	GO:0006333	chromatin assembly or disassembly(GO:0006333)

Showing 1 to 10 of 279 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	19.7	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	13.7	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	13.6	GO:0000785	chromatin(GO:0000785)
0.0	12.9	GO:0016604	nuclear body(GO:0016604)
0.3	11.3	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	9.1	GO:0016605	PML body(GO:0016605)
0.1	7.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	7.2	GO:0010008	endosome membrane(GO:0010008)
0.2	5.7	GO:0071564	npBAF complex(GO:0071564)
0.4	5.5	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.6	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.7	16.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.3	15.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.6	10.2	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
3.2	9.7	GO:0016964	alpha-2 macroglobulin receptor activity(GO:0016964)
0.1	9.1	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	8.7	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	8.1	GO:0003697	single-stranded DNA binding(GO:0003697)
0.2	7.5	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.2	7.4	GO:0046966	thyroid hormone receptor binding(GO:0046966)

Showing 1 to 10 of 170 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	18.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	13.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	13.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	10.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	6.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	5.9	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	5.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	5.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	4.6	PID TGFBR PATHWAY	TGF-beta receptor signaling

Showing 1 to 10 of 51 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	16.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.5	7.5	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	7.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	6.7	REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	Genes involved in trans-Golgi Network Vesicle Budding
0.1	6.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	5.8	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	4.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	4.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	4.2	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1	4.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation

Showing 1 to 10 of 68 entries

Results for ZNF740_ZNF219

Z-value: 2.28

Motif logo

Transcription factors associated with ZNF740_ZNF219

Activity-expression correlation:

Activity profile of ZNF740_ZNF219 motif

Sorted Z-values of ZNF740_ZNF219 motif

No targets for ZNF740_ZNF219

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: