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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for AR_NR3C2

Z-value: 0.68

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.18 androgen receptor
NR3C2
ENSG00000151623.15 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg38_v1_chrX_+_67543973_675440540.571.4e-01Click!
NR3C2hg38_v1_chr4_-_148444674_148444756,
hg38_v1_chr4_-_148442508_148442526,
hg38_v1_chr4_-_148442342_148442431		-0.039.4e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_19386785 1.21 ENST00000497081.6
MFAP4
microfibril associated protein 4
chr17_-_19387170 1.16 ENST00000395592.6
ENST00000299610.5
MFAP4
microfibril associated protein 4
chr12_+_53050179 0.66 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
TNS2
tensin 2
chr12_+_53050014 0.66 ENST00000314250.11
TNS2
tensin 2
chr16_+_56632651 0.56 ENST00000379818.4
ENST00000570233.1
MT1M
metallothionein 1M
chr3_-_58577367 0.54 ENST00000464064.5
ENST00000360997.7
FAM107A
family with sequence similarity 107 member A
chr3_-_58577648 0.49 ENST00000394481.5
FAM107A
family with sequence similarity 107 member A
chr1_+_22653189 0.46 ENST00000432749.6
C1QB
complement C1q B chain
chr8_+_90001448 0.39 ENST00000519410.5
ENST00000522161.5
ENST00000220764.7
ENST00000517761.5
ENST00000520227.1
DECR1
2,4-dienoyl-CoA reductase 1
chr19_+_35140022 0.30 ENST00000588081.5
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35139724 0.29 ENST00000588715.5
ENST00000588607.5
FXYD1
FXYD domain containing ion transport regulator 1
chr15_+_31366138 0.28 ENST00000558844.1
KLF13
Kruppel like factor 13
chr7_+_94656325 0.28 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
PEG10
paternally expressed 10
chr16_+_67173935 0.26 ENST00000566871.5
NOL3
nucleolar protein 3
chr16_+_56682461 0.26 ENST00000562939.1
ENST00000394485.5
ENST00000567563.1
MT1X
ENSG00000259827.1
metallothionein 1X
novel transcript
chr1_+_22653228 0.25 ENST00000509305.6
C1QB
complement C1q B chain
chr19_+_35139440 0.24 ENST00000455515.6
FXYD1
FXYD domain containing ion transport regulator 1
chr5_-_142012973 0.24 ENST00000503794.5
ENST00000510194.5
ENST00000504424.1
ENST00000513454.5
ENST00000311337.11
ENST00000503229.5
ENST00000500692.6
ENST00000504139.5
ENST00000505689.5
GNPDA1
glucosamine-6-phosphate deaminase 1
chr1_-_1214146 0.21 ENST00000379236.4
TNFRSF4
TNF receptor superfamily member 4
chr22_+_22704265 0.21 ENST00000390307.2
IGLV3-22
immunoglobulin lambda variable 3-22
chr16_+_67173971 0.20 ENST00000563258.1
ENST00000568146.1
NOL3
nucleolar protein 3
chr16_+_56625775 0.19 ENST00000330439.7
ENST00000568293.1
MT1E
metallothionein 1E
chr2_+_237487239 0.19 ENST00000338530.8
ENST00000264605.8
ENST00000409373.5
MLPH
melanophilin
chr9_+_128920966 0.17 ENST00000428610.5
ENST00000372592.8
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr3_+_52245721 0.17 ENST00000323588.9
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent 1M
chr8_-_71844402 0.15 ENST00000325509.5
MSC
musculin
chr20_+_15196834 0.15 ENST00000402914.5
MACROD2
mono-ADP ribosylhydrolase 2
chr11_-_236326 0.14 ENST00000525237.1
ENST00000382743.9
ENST00000532956.5
ENST00000525319.5
ENST00000524564.5
SIRT3
sirtuin 3
chr13_+_113759219 0.14 ENST00000375353.5
ENST00000488362.5
TMEM255B
transmembrane protein 255B
chr7_+_20615653 0.13 ENST00000404938.7
ABCB5
ATP binding cassette subfamily B member 5
chr1_+_111619751 0.13 ENST00000433097.5
ENST00000369709.3
RAP1A
RAP1A, member of RAS oncogene family
chr12_+_66189178 0.13 ENST00000545837.1
IRAK3
interleukin 1 receptor associated kinase 3
chr12_-_56221701 0.12 ENST00000615206.4
ENST00000549038.5
ENST00000552244.5
RNF41
ring finger protein 41
chr8_+_61287950 0.12 ENST00000519846.5
ENST00000325897.5
ENST00000523868.2
ENST00000518592.5
CLVS1
clavesin 1
chr4_-_68951763 0.12 ENST00000251566.9
UGT2A3
UDP glucuronosyltransferase family 2 member A3
chr16_-_66550142 0.12 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
TK2
thymidine kinase 2
chr18_-_50819982 0.12 ENST00000398439.8
ENST00000431965.6
ENST00000436348.6
MRO
maestro
chr3_-_15341368 0.11 ENST00000408919.7
SH3BP5
SH3 domain binding protein 5
chr17_-_8152380 0.11 ENST00000317276.9
PER1
period circadian regulator 1
chr14_-_106675544 0.11 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr17_+_39667964 0.11 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chrY_-_13986473 0.11 ENST00000250825.5
VCY
variable charge Y-linked
chr12_+_50925007 0.11 ENST00000332160.5
METTL7A
methyltransferase like 7A
chrY_+_14056226 0.10 ENST00000250823.5
VCY1B
variable charge Y-linked 1B
chr12_-_56221909 0.10 ENST00000394013.6
ENST00000345093.9
ENST00000551711.5
ENST00000552656.5
RNF41
ring finger protein 41
chr11_-_114400417 0.10 ENST00000325636.8
ENST00000623205.2
C11orf71
chromosome 11 open reading frame 71
chr11_+_8911154 0.10 ENST00000309357.8
ENST00000529876.5
ENST00000309377.9
ENST00000525005.5
ENST00000524577.5
ENST00000534506.5
AKIP1
A-kinase interacting protein 1
chr4_-_8440712 0.09 ENST00000356406.10
ENST00000413009.6
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr11_+_8911106 0.09 ENST00000299576.9
AKIP1
A-kinase interacting protein 1
chr19_-_42412347 0.09 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chr11_+_8911280 0.09 ENST00000530281.5
ENST00000396648.6
ENST00000534147.5
ENST00000529942.1
AKIP1
A-kinase interacting protein 1
chr6_-_26234978 0.08 ENST00000244534.7
H1-3
H1.3 linker histone, cluster member
chr22_+_21567705 0.08 ENST00000342192.9
UBE2L3
ubiquitin conjugating enzyme E2 L3
chr19_+_55676621 0.08 ENST00000411543.6
EPN1
epsin 1
chr19_-_14835162 0.08 ENST00000322301.5
OR7A5
olfactory receptor family 7 subfamily A member 5
chrX_-_8171267 0.08 ENST00000317103.5
VCX2
variable charge X-linked 2
chr3_-_119677346 0.07 ENST00000484810.5
ENST00000497116.1
ENST00000261070.7
COX17
cytochrome c oxidase copper chaperone COX17
chr20_-_37158904 0.07 ENST00000417458.5
MROH8
maestro heat like repeat family member 8
chrX_-_18220878 0.07 ENST00000380033.9
BEND2
BEN domain containing 2
chr17_-_16569169 0.07 ENST00000395824.5
ZNF287
zinc finger protein 287
chr14_-_106411021 0.07 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chr18_-_50819764 0.06 ENST00000592966.5
MRO
maestro
chr5_-_173616588 0.06 ENST00000285908.5
ENST00000311086.9
ENST00000480951.1
BOD1
biorientation of chromosomes in cell division 1
chr4_-_75672868 0.06 ENST00000678123.1
ENST00000678578.1
ENST00000677876.1
ENST00000676839.1
ENST00000678265.1
G3BP2
G3BP stress granule assembly factor 2
chr17_-_16569184 0.06 ENST00000448349.2
ENST00000395825.4
ZNF287
zinc finger protein 287
chr4_+_37891060 0.06 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1D1
TBC1 domain family member 1
chr10_-_27983103 0.06 ENST00000672841.1
ODAD2
outer dynein arm docking complex subunit 2
chr11_-_75669028 0.06 ENST00000304771.8
MAP6
microtubule associated protein 6
chr14_-_106538331 0.06 ENST00000390624.3
IGHV3-48
immunoglobulin heavy variable 3-48
chr6_+_18387326 0.05 ENST00000259939.4
RNF144B
ring finger protein 144B
chr17_-_63918817 0.05 ENST00000458650.6
ENST00000351388.8
ENST00000342364.8
ENST00000617086.1
ENST00000323322.10
ENST00000392824.8
GH1
CSHL1
growth hormone 1
chorionic somatomammotropin hormone like 1
chr18_+_58862904 0.05 ENST00000591083.5
ZNF532
zinc finger protein 532
chr4_-_185425941 0.05 ENST00000264689.11
ENST00000505357.1
UFSP2
UFM1 specific peptidase 2
chr16_-_4802615 0.05 ENST00000591392.5
ENST00000587711.5
ENST00000322048.12
ROGDI
rogdi atypical leucine zipper
chr17_+_43171187 0.05 ENST00000542611.5
ENST00000590996.6
ENST00000589872.1
NBR1
NBR1 autophagy cargo receptor
chr1_+_145719483 0.05 ENST00000369288.7
CD160
CD160 molecule
chr9_-_35563867 0.05 ENST00000399742.7
ENST00000619051.4
FAM166B
family with sequence similarity 166 member B
chr2_-_37324826 0.05 ENST00000234179.8
PRKD3
protein kinase D3
chr18_+_7754959 0.04 ENST00000400053.8
PTPRM
protein tyrosine phosphatase receptor type M
chr16_+_8642375 0.04 ENST00000562973.1
METTL22
methyltransferase like 22
chr11_-_506739 0.04 ENST00000529306.5
ENST00000438658.6
ENST00000527485.5
ENST00000397615.6
ENST00000397614.5
RNH1
ribonuclease/angiogenin inhibitor 1
chr2_+_241637682 0.04 ENST00000419606.5
ENST00000404914.8
ENST00000400771.7
ATG4B
autophagy related 4B cysteine peptidase
chr1_+_1915080 0.04 ENST00000378604.3
CALML6
calmodulin like 6
chr1_+_75796867 0.04 ENST00000263187.4
MSH4
mutS homolog 4
chr8_+_24440930 0.04 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM7
ADAM metallopeptidase domain 7
chr15_-_19988117 0.03 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr19_+_58059236 0.03 ENST00000359978.10
ENST00000401053.8
ENST00000511556.5
ENST00000506786.1
ENST00000313434.10
ZNF135
zinc finger protein 135
chr1_+_93345893 0.03 ENST00000370272.9
ENST00000370267.1
DR1
down-regulator of transcription 1
chr17_+_20579724 0.03 ENST00000661883.1
ENST00000399044.1
CDRT15L2
CMT1A duplicated region transcript 15 like 2
chr11_+_114400592 0.03 ENST00000541475.5
RBM7
RNA binding motif protein 7
chr2_-_230960954 0.03 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr11_+_114400646 0.02 ENST00000375490.10
ENST00000544582.1
ENST00000545678.1
RBM7
RNA binding motif protein 7
chr16_+_56638659 0.02 ENST00000290705.12
MT1A
metallothionein 1A
chrX_+_8465426 0.02 ENST00000381029.4
VCX3B
variable charge X-linked 3B
chr12_-_10098977 0.02 ENST00000315330.8
ENST00000457018.6
CLEC1A
C-type lectin domain family 1 member A
chr14_-_45253402 0.02 ENST00000627697.1
MIS18BP1
MIS18 binding protein 1
chr14_+_73886617 0.02 ENST00000540593.5
ENST00000555730.6
ZNF410
zinc finger protein 410
chr2_-_108989206 0.02 ENST00000258443.7
ENST00000409271.5
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr16_+_56608577 0.02 ENST00000245185.6
ENST00000561491.1
MT2A
metallothionein 2A
chr14_-_106658251 0.02 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr19_+_8052752 0.01 ENST00000315626.6
ENST00000253451.9
CCL25
C-C motif chemokine ligand 25
chr6_+_127577168 0.01 ENST00000329722.8
C6orf58
chromosome 6 open reading frame 58
chr11_+_114400030 0.01 ENST00000540163.5
RBM7
RNA binding motif protein 7
chr17_-_63873676 0.01 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
CSH2
chorionic somatomammotropin hormone 2
chr1_-_48776811 0.01 ENST00000371833.4
BEND5
BEN domain containing 5
chrX_+_2691270 0.01 ENST00000381187.8
ENST00000381184.6
CD99
CD99 molecule (Xg blood group)
chr19_+_8053000 0.01 ENST00000390669.7
CCL25
C-C motif chemokine ligand 25
chr3_+_13480215 0.01 ENST00000446613.6
ENST00000402259.5
ENST00000402271.5
ENST00000295757.8
ENST00000404548.5
ENST00000404040.5
HDAC11
histone deacetylase 11
chr16_-_67944113 0.01 ENST00000264005.10
LCAT
lecithin-cholesterol acyltransferase
chr2_+_190180930 0.01 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chrX_-_24027186 0.01 ENST00000328046.8
KLHL15
kelch like family member 15
chr22_+_23688133 0.01 ENST00000401461.5
RGL4
ral guanine nucleotide dissociation stimulator like 4
chr8_-_48921419 0.01 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chrX_+_2691310 0.01 ENST00000482405.7
ENST00000624481.4
ENST00000381180.9
CD99
CD99 molecule (Xg blood group)
chr16_+_32066065 0.01 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr17_-_63896621 0.00 ENST00000453363.7
CSH1
chorionic somatomammotropin hormone 1
chrX_+_2691164 0.00 ENST00000611428.5
CD99
CD99 molecule (Xg blood group)
chr4_+_87006988 0.00 ENST00000307808.10
AFF1
AF4/FMR2 family member 1
chr8_-_22156789 0.00 ENST00000306317.7
LGI3
leucine rich repeat LGI family member 3
chrX_+_2691284 0.00 ENST00000381192.10
CD99
CD99 molecule (Xg blood group)
chr2_-_74648307 0.00 ENST00000421985.2
ENST00000536235.5
M1AP
meiosis 1 associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 0.5 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.1 0.8 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.2 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.1 GO:0048058 compound eye corneal lens development(GO:0048058)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 1.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0042414 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.0 1.3 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:1904732 regulation of electron carrier activity(GO:1904732)
0.0 0.1 GO:0010932 macrophage tolerance induction(GO:0010931) regulation of macrophage tolerance induction(GO:0010932) positive regulation of macrophage tolerance induction(GO:0010933)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0071953 elastic fiber(GO:0071953)
0.2 0.7 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.5 GO:0089720 death effector domain binding(GO:0035877) caspase binding(GO:0089720)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation