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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ATF2_ATF1_ATF3
Z-value: 1.07
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Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115966.17 | activating transcription factor 2 | |
| ENSG00000123268.9 | activating transcription factor 1 | |
| ENSG00000162772.17 | activating transcription factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg38_v1_chr1_+_212565334_212565414 | 0.67 | 6.8e-02 | Click! |
| ATF1 | hg38_v1_chr12_+_50764509_50764613 | 0.34 | 4.1e-01 | Click! |
| ATF2 | hg38_v1_chr2_-_175168159_175168213 | 0.25 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_67619911 Show fit | 1.43 |
ENST00000261783.4
|
arginase 2 |
|
| chr1_+_156061142 Show fit | 0.98 |
ENST00000361084.10
|
RAB25, member RAS oncogene family |
|
| chr9_+_12693327 Show fit | 0.88 |
ENST00000388918.10
|
tyrosinase related protein 1 |
|
| chr20_+_59604527 Show fit | 0.80 |
ENST00000371015.6
|
phosphatase and actin regulator 3 |
|
| chr12_+_22625357 Show fit | 0.78 |
ENST00000545979.2
|
ethanolamine kinase 1 |
|
| chr12_-_84911178 Show fit | 0.77 |
ENST00000681688.1
|
solute carrier family 6 member 15 |
|
| chr4_+_74445302 Show fit | 0.75 |
ENST00000502307.1
|
amphiregulin |
|
| chr16_+_19067639 Show fit | 0.71 |
ENST00000568985.5
ENST00000566110.5 |
coenzyme Q7, hydroxylase |
|
| chr12_-_64222239 Show fit | 0.70 |
ENST00000311915.12
ENST00000398055.8 ENST00000544871.1 |
chromosome 12 open reading frame 66 |
|
| chr22_+_24607602 Show fit | 0.69 |
ENST00000447416.5
|
gamma-glutamyltransferase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 1.6 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.1 | 1.5 | GO:0015820 | leucine transport(GO:0015820) |
| 0.2 | 1.4 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) |
| 0.1 | 1.4 | GO:0000050 | urea cycle(GO:0000050) |
| 0.1 | 1.3 | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
| 0.1 | 1.3 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
| 0.0 | 1.2 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.0 | 1.2 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 1.0 | GO:0031268 | pseudopodium organization(GO:0031268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 1.2 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 1.2 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 1.1 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 1.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.9 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 0.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.1 | 1.7 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 1.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 1.2 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 0.1 | 1.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.2 | 1.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.1 | 1.1 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 1.1 | GO:0048365 | Rac GTPase binding(GO:0048365) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.9 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |