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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ATF4

Z-value: 1.39

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.17 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg38_v1_chr22_+_39520553_395206040.482.3e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_40953463 1.37 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr21_-_6467509 1.15 ENST00000624406.3
ENST00000398168.5
ENST00000624934.3
CBSL
cystathionine beta-synthase like
chr16_-_28539004 1.14 ENST00000395641.2
NUPR1
nuclear protein 1, transcriptional regulator
chr21_-_43075831 1.12 ENST00000398158.5
ENST00000398165.8
CBS
cystathionine beta-synthase
chr16_-_28538951 1.11 ENST00000324873.8
NUPR1
nuclear protein 1, transcriptional regulator
chr7_-_56034133 0.81 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr3_+_148697784 0.71 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chr1_+_162632454 0.67 ENST00000367921.8
ENST00000367922.7
DDR2
discoidin domain receptor tyrosine kinase 2
chr14_-_91946989 0.59 ENST00000556154.5
FBLN5
fibulin 5
chr12_-_24949026 0.58 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr14_+_24094301 0.50 ENST00000545054.6
ENST00000561286.5
ENST00000216780.9
ENST00000558096.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr14_-_91947383 0.50 ENST00000267620.14
FBLN5
fibulin 5
chr17_+_1762052 0.44 ENST00000254722.9
ENST00000576406.5
ENST00000571149.5
SERPINF1
serpin family F member 1
chr9_+_78297143 0.43 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr1_-_37947010 0.38 ENST00000458109.6
ENST00000373024.8
ENST00000373023.6
INPP5B
inositol polyphosphate-5-phosphatase B
chr7_+_48171451 0.38 ENST00000435803.6
ABCA13
ATP binding cassette subfamily A member 13
chr14_+_24094053 0.38 ENST00000559250.5
ENST00000560736.5
ENST00000396973.8
ENST00000559837.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr9_+_78297117 0.35 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr22_+_35381086 0.34 ENST00000216117.9
ENST00000677931.1
ENST00000679074.1
HMOX1
heme oxygenase 1
chr14_-_100375602 0.33 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
WARS1
tryptophanyl-tRNA synthetase 1
chr14_-_100375333 0.32 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
WARS1
tryptophanyl-tRNA synthetase 1
chr16_+_46884323 0.31 ENST00000340124.9
GPT2
glutamic--pyruvic transaminase 2
chr12_-_49904217 0.29 ENST00000550635.6
FAIM2
Fas apoptotic inhibitory molecule 2
chr12_+_57230301 0.27 ENST00000553474.5
SHMT2
serine hydroxymethyltransferase 2
chr17_-_81937221 0.27 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chrX_-_15314543 0.27 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr16_+_67660946 0.26 ENST00000602551.5
ENST00000219255.3
ENST00000458121.7
PARD6A
par-6 family cell polarity regulator alpha
chr7_+_30594823 0.26 ENST00000675810.1
ENST00000674815.1
ENST00000454308.6
ENST00000389266.8
ENST00000675693.1
ENST00000675651.1
ENST00000674851.1
GARS1
glycyl-tRNA synthetase 1
chr17_-_81937277 0.26 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937320 0.26 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
PYCR1
pyrroline-5-carboxylate reductase 1
chr11_-_3057386 0.25 ENST00000529772.5
ENST00000278224.13
ENST00000380525.9
CARS1
cysteinyl-tRNA synthetase 1
chr1_-_44031352 0.24 ENST00000372306.7
ENST00000475075.6
SLC6A9
solute carrier family 6 member 9
chr14_+_75428011 0.22 ENST00000651602.1
ENST00000559060.5
JDP2
Jun dimerization protein 2
chr12_+_57230336 0.22 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
SHMT2
serine hydroxymethyltransferase 2
chr3_+_101849505 0.22 ENST00000326151.9
ENST00000326172.9
NFKBIZ
NFKB inhibitor zeta
chr1_-_44031446 0.21 ENST00000372310.8
ENST00000466926.1
SLC6A9
solute carrier family 6 member 9
chr6_+_72366730 0.20 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr17_-_79839387 0.19 ENST00000448310.1
ENST00000269397.9
CBX4
chromobox 4
chr1_-_32817311 0.19 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr11_-_33892010 0.19 ENST00000257818.3
LMO2
LIM domain only 2
chr12_+_57455266 0.19 ENST00000266646.3
INHBE
inhibin subunit beta E
chr19_+_33373694 0.19 ENST00000284000.9
CEBPG
CCAAT enhancer binding protein gamma
chr12_+_57230086 0.19 ENST00000414700.7
ENST00000557703.5
SHMT2
serine hydroxymethyltransferase 2
chr6_+_125781108 0.19 ENST00000368357.7
NCOA7
nuclear receptor coactivator 7
chr16_-_70289480 0.18 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr19_+_33374312 0.18 ENST00000585933.2
CEBPG
CCAAT enhancer binding protein gamma
chr10_+_94089034 0.18 ENST00000676102.1
ENST00000371385.8
PLCE1
phospholipase C epsilon 1
chr12_+_57229694 0.18 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
SHMT2
serine hydroxymethyltransferase 2
chr10_+_94089067 0.18 ENST00000371375.1
ENST00000675218.1
PLCE1
phospholipase C epsilon 1
chr12_-_116881062 0.17 ENST00000550505.5
HRK
harakiri, BCL2 interacting protein
chr17_-_42676980 0.15 ENST00000587627.1
ENST00000591022.6
ENST00000293349.10
PLEKHH3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr12_-_57520480 0.13 ENST00000642841.1
ENST00000547303.5
ENST00000552740.5
ENST00000547526.1
ENST00000346473.8
ENST00000551116.5
ENSG00000285133.1
DDIT3
novel protein
DNA damage inducible transcript 3
chr1_-_19923617 0.13 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr22_+_50481515 0.13 ENST00000395737.2
ENST00000395738.2
ADM2
adrenomedullin 2
chr10_+_110005804 0.13 ENST00000360162.7
ADD3
adducin 3
chr12_+_56468561 0.12 ENST00000338146.7
SPRYD4
SPRY domain containing 4
chr14_+_60981114 0.12 ENST00000354886.6
SLC38A6
solute carrier family 38 member 6
chr1_+_154272589 0.12 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr5_+_33440696 0.11 ENST00000502553.5
ENST00000514259.5
TARS1
threonyl-tRNA synthetase 1
chr19_-_46784733 0.11 ENST00000593713.1
ENST00000598022.1
ENST00000434726.6
SLC1A5
solute carrier family 1 member 5
chr19_-_46784905 0.11 ENST00000594991.5
SLC1A5
solute carrier family 1 member 5
chr9_-_92293674 0.10 ENST00000683679.1
ENST00000683565.1
ENST00000684557.1
ENST00000682578.1
ENST00000443024.7
ENST00000375643.7
ENST00000683469.1
IARS1
isoleucyl-tRNA synthetase 1
chr14_+_60981183 0.10 ENST00000267488.9
ENST00000451406.5
SLC38A6
solute carrier family 38 member 6
chr3_-_48089203 0.10 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr5_+_68290637 0.10 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr1_-_220046432 0.10 ENST00000609181.5
ENST00000366923.8
EPRS1
glutamyl-prolyl-tRNA synthetase 1
chr12_+_93569814 0.10 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr5_+_33440947 0.10 ENST00000455217.6
ENST00000265112.8
TARS1
threonyl-tRNA synthetase 1
chr2_+_46542474 0.10 ENST00000238738.9
RHOQ
ras homolog family member Q
chr1_+_212608628 0.10 ENST00000613954.4
ENST00000341491.9
ENST00000366985.5
ATF3
activating transcription factor 3
chr3_-_48088824 0.09 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr3_-_48088800 0.09 ENST00000423088.5
MAP4
microtubule associated protein 4
chr5_+_174724549 0.09 ENST00000239243.7
ENST00000507785.2
MSX2
msh homeobox 2
chr14_-_24576240 0.09 ENST00000216336.3
CTSG
cathepsin G
chr12_-_46268989 0.09 ENST00000549049.5
ENST00000439706.5
ENST00000398637.10
SLC38A1
solute carrier family 38 member 1
chr7_+_99408609 0.08 ENST00000403633.6
BUD31
BUD31 homolog
chr2_-_55334529 0.08 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr7_+_99408958 0.08 ENST00000222969.10
BUD31
BUD31 homolog
chr19_+_11239602 0.08 ENST00000252453.12
ANGPTL8
angiopoietin like 8
chr10_-_99430617 0.07 ENST00000370508.7
GOT1
glutamic-oxaloacetic transaminase 1
chr7_-_18027839 0.06 ENST00000506618.5
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1 like 1
chr2_-_46542555 0.05 ENST00000522587.6
ATP6V1E2
ATPase H+ transporting V1 subunit E2
chr1_+_52056255 0.05 ENST00000489308.6
BTF3L4
basic transcription factor 3 like 4
chr11_-_77474041 0.05 ENST00000278568.8
PAK1
p21 (RAC1) activated kinase 1
chr1_-_206970457 0.05 ENST00000324852.9
ENST00000450945.3
ENST00000400962.8
FCAMR
Fc fragment of IgA and IgM receptor
chrX_+_48539665 0.05 ENST00000376771.9
ENST00000418627.1
TBC1D25
TBC1 domain family member 25
chr11_-_77474087 0.05 ENST00000356341.8
PAK1
p21 (RAC1) activated kinase 1
chr10_+_61901678 0.04 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr18_-_57621741 0.04 ENST00000587194.1
ENST00000591599.5
ENST00000588661.5
ENST00000256854.10
NARS1
asparaginyl-tRNA synthetase 1
chr11_+_62881686 0.04 ENST00000536981.6
ENST00000539891.6
SLC3A2
solute carrier family 3 member 2
chr5_-_146182475 0.04 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
LARS1
leucyl-tRNA synthetase 1
chr9_+_97983332 0.03 ENST00000339399.5
ANP32B
acidic nuclear phosphoprotein 32 family member B
chr1_+_241652275 0.03 ENST00000366552.6
ENST00000437684.7
WDR64
WD repeat domain 64
chr7_-_99408548 0.03 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr2_-_177264686 0.03 ENST00000397062.8
ENST00000430047.1
NFE2L2
nuclear factor, erythroid 2 like 2
chr1_-_167914089 0.03 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr15_+_40594241 0.02 ENST00000532056.5
ENST00000527044.5
ENST00000399668.7
KNL1
kinetochore scaffold 1
chr11_+_119085200 0.02 ENST00000650101.1
HMBS
hydroxymethylbilane synthase
chr11_+_119084873 0.02 ENST00000652429.1
ENST00000442944.7
ENST00000537841.5
ENST00000542729.5
ENST00000546302.6
ENST00000536813.6
ENST00000544387.5
ENST00000543090.5
HMBS
hydroxymethylbilane synthase
chr5_-_146182591 0.02 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
LARS1
leucyl-tRNA synthetase 1
chr6_+_150865815 0.02 ENST00000367308.8
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr1_+_32817442 0.02 ENST00000373476.5
ENST00000529027.5
S100PBP
S100P binding protein
chr2_-_240820205 0.02 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
KIF1A
kinesin family member 1A
chr15_+_40594001 0.01 ENST00000346991.9
ENST00000528975.5
KNL1
kinetochore scaffold 1
chr3_-_33645433 0.01 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr17_-_48626325 0.01 ENST00000311177.7
HOXB9
homeobox B9
chr9_-_34665985 0.01 ENST00000416454.5
ENST00000544078.2
ENST00000421828.7
ENST00000423809.5
ENSG00000187186.15
novel protein
chr10_+_100347225 0.00 ENST00000370355.3
SCD
stearoyl-CoA desaturase
chr5_+_154755272 0.00 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.3 0.8 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.2 0.7 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 1.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.5 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.6 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.3 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1 2.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.9 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.7 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 1.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.3 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.1 0.2 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.4 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.3 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:0006532 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.0 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0071953 elastic fiber(GO:0071953)
0.1 0.9 GO:0070552 BRISC complex(GO:0070552)
0.1 0.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.4 GO:0043203 axon hillock(GO:0043203)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.2 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.3 1.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 0.9 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 0.7 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.2 0.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.9 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.6 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.1 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.0 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle