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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for BBX

Z-value: 0.51

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.19 BBX high mobility group box domain containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg38_v1_chr3_+_107525378_1075254070.866.3e-03Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_78620722 0.58 ENST00000679848.1
IFI44L
interferon induced protein 44 like
chr4_-_158159657 0.56 ENST00000590648.5
GASK1B
golgi associated kinase 1B
chr6_+_72212802 0.44 ENST00000401910.7
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_92482350 0.44 ENST00000375543.2
ASPN
asporin
chr6_+_72212887 0.41 ENST00000523963.5
RIMS1
regulating synaptic membrane exocytosis 1
chr8_-_107497909 0.37 ENST00000517746.6
ANGPT1
angiopoietin 1
chr8_-_107498041 0.37 ENST00000297450.7
ANGPT1
angiopoietin 1
chr9_-_92482499 0.36 ENST00000375544.7
ASPN
asporin
chrX_+_54807599 0.31 ENST00000375053.6
ENST00000627068.2
ENST00000375068.6
ENST00000347546.8
MAGED2
MAGE family member D2
chr9_-_92404559 0.30 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr4_-_185775271 0.27 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr9_-_90642855 0.22 ENST00000637905.1
DIRAS2
DIRAS family GTPase 2
chr15_+_72118392 0.21 ENST00000340912.6
SENP8
SUMO peptidase family member, NEDD8 specific
chr4_-_185775890 0.18 ENST00000437304.6
SORBS2
sorbin and SH3 domain containing 2
chr20_-_31722854 0.17 ENST00000307677.5
BCL2L1
BCL2 like 1
chr2_+_209653171 0.17 ENST00000447185.5
MAP2
microtubule associated protein 2
chr20_-_31722533 0.16 ENST00000677194.1
ENST00000434194.2
ENST00000376062.6
BCL2L1
BCL2 like 1
chr20_-_31722949 0.16 ENST00000376055.9
BCL2L1
BCL2 like 1
chr2_-_119366682 0.16 ENST00000409877.5
ENST00000409523.1
ENST00000409466.6
C2orf76
chromosome 2 open reading frame 76
chr10_+_110005804 0.15 ENST00000360162.7
ADD3
adducin 3
chr4_-_185812209 0.15 ENST00000393523.6
ENST00000393528.7
ENST00000449407.6
SORBS2
sorbin and SH3 domain containing 2
chr4_-_993430 0.14 ENST00000361661.6
ENST00000622731.4
SLC26A1
solute carrier family 26 member 1
chr2_-_110473041 0.12 ENST00000632897.1
ENST00000413601.3
LIMS4
LIM zinc finger domain containing 4
chr4_-_993376 0.12 ENST00000398520.6
ENST00000398516.3
SLC26A1
solute carrier family 26 member 1
chr4_-_103099811 0.12 ENST00000504285.5
ENST00000296424.9
BDH2
3-hydroxybutyrate dehydrogenase 2
chr2_+_200440649 0.12 ENST00000366118.2
SPATS2L
spermatogenesis associated serine rich 2 like
chr3_+_122680802 0.12 ENST00000474629.7
PARP14
poly(ADP-ribose) polymerase family member 14
chr6_-_117573571 0.11 ENST00000467125.1
ENSG00000282218.1
novel protein, GOPC-ROS1 readthrough
chr2_-_61854119 0.11 ENST00000405894.3
FAM161A
FAM161 centrosomal protein A
chr2_-_61854013 0.11 ENST00000404929.6
FAM161A
FAM161 centrosomal protein A
chr3_-_58666765 0.11 ENST00000358781.7
FAM3D
FAM3 metabolism regulating signaling molecule D
chr22_+_32475235 0.10 ENST00000452138.3
FBXO7
F-box protein 7
chr10_-_13972355 0.10 ENST00000264546.10
FRMD4A
FERM domain containing 4A
chr21_+_46635595 0.09 ENST00000451211.6
ENST00000458387.6
ENST00000397638.6
ENST00000291705.11
ENST00000397637.5
ENST00000334494.8
ENST00000397628.5
ENST00000355680.8
ENST00000440086.5
PRMT2
protein arginine methyltransferase 2
chr11_+_58622659 0.09 ENST00000361987.6
CNTF
ciliary neurotrophic factor
chr5_+_141135199 0.09 ENST00000231134.8
ENST00000623915.1
PCDHB5
protocadherin beta 5
chr22_+_32475257 0.09 ENST00000397426.5
FBXO7
F-box protein 7
chr6_+_52420107 0.09 ENST00000636489.1
ENST00000637089.1
ENST00000637353.1
ENST00000637263.1
EFHC1
EF-hand domain containing 1
chr3_-_146528750 0.09 ENST00000483300.5
PLSCR1
phospholipid scramblase 1
chr6_+_117482634 0.08 ENST00000296955.12
ENST00000338728.10
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr3_+_151814102 0.08 ENST00000232892.12
AADAC
arylacetamide deacetylase
chr9_+_35161951 0.08 ENST00000617908.4
ENST00000619578.4
UNC13B
unc-13 homolog B
chr1_-_686673 0.08 ENST00000332831.4
OR4F16
olfactory receptor family 4 subfamily F member 16
chr4_+_70592253 0.08 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr17_-_44066595 0.08 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr12_-_8612850 0.07 ENST00000229335.11
ENST00000537228.5
AICDA
activation induced cytidine deaminase
chr5_+_141430499 0.07 ENST00000252085.4
PCDHGA12
protocadherin gamma subfamily A, 12
chr19_+_7763210 0.06 ENST00000359059.10
ENST00000596363.5
ENST00000394122.7
ENST00000327325.10
CLEC4M
C-type lectin domain family 4 member M
chr20_+_23440248 0.06 ENST00000246020.2
CSTL1
cystatin like 1
chr2_-_230219902 0.06 ENST00000409815.6
SP110
SP110 nuclear body protein
chr3_-_112499457 0.06 ENST00000334529.10
BTLA
B and T lymphocyte associated
chr7_+_117480011 0.06 ENST00000649406.1
ENST00000648260.1
ENST00000003084.11
CFTR
CF transmembrane conductance regulator
chr7_-_16881967 0.06 ENST00000402239.7
ENST00000310398.7
ENST00000414935.1
AGR3
anterior gradient 3, protein disulphide isomerase family member
chr5_+_181367268 0.06 ENST00000456475.1
OR4F3
olfactory receptor family 4 subfamily F member 3
chr12_+_18262730 0.06 ENST00000675017.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr6_-_135497230 0.06 ENST00000681365.1
AHI1
Abelson helper integration site 1
chr21_+_30396030 0.05 ENST00000355459.4
KRTAP13-1
keratin associated protein 13-1
chr6_-_29375291 0.05 ENST00000396806.3
OR12D3
olfactory receptor family 12 subfamily D member 3
chr12_-_99984227 0.05 ENST00000547776.6
ENST00000547010.5
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_-_75785486 0.05 ENST00000586607.5
H3-3B
H3.3 histone B
chr19_-_18397596 0.05 ENST00000595840.1
ENST00000339007.4
LRRC25
leucine rich repeat containing 25
chr9_+_35162000 0.05 ENST00000396787.5
ENST00000378495.7
ENST00000635942.1
ENST00000378496.8
UNC13B
unc-13 homolog B
chr9_+_65700287 0.05 ENST00000489273.1
CBWD5
COBW domain containing 5
chr1_+_95151377 0.05 ENST00000604203.1
TLCD4-RWDD3
TLCD4-RWDD3 readthrough
chr2_+_112181788 0.04 ENST00000272559.4
FBLN7
fibulin 7
chr1_-_37514743 0.04 ENST00000448519.2
ENST00000373075.6
ENST00000373073.8
ENST00000296214.10
MEAF6
MYST/Esa1 associated factor 6
chr1_+_54998927 0.04 ENST00000651561.1
BSND
barttin CLCNK type accessory subunit beta
chr7_+_117480052 0.04 ENST00000426809.5
ENST00000649781.1
CFTR
CF transmembrane conductance regulator
chr9_-_13175824 0.04 ENST00000545857.5
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr13_+_76948500 0.04 ENST00000377462.6
ACOD1
aconitate decarboxylase 1
chr15_-_75455767 0.04 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr16_+_56638659 0.03 ENST00000290705.12
MT1A
metallothionein 1A
chr2_+_33436304 0.03 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr5_-_149550284 0.03 ENST00000504676.5
ENST00000515435.5
CSNK1A1
casein kinase 1 alpha 1
chr7_+_66075876 0.03 ENST00000395332.8
ASL
argininosuccinate lyase
chr6_-_160664270 0.03 ENST00000316300.10
LPA
lipoprotein(a)
chr6_+_29457155 0.03 ENST00000377133.6
ENST00000377136.5
OR2H1
olfactory receptor family 2 subfamily H member 1
chr1_+_152811971 0.03 ENST00000360090.4
LCE1B
late cornified envelope 1B
chr3_+_111542178 0.03 ENST00000283285.10
ENST00000352690.9
CD96
CD96 molecule
chr9_-_146140 0.03 ENST00000475990.5
CBWD1
COBW domain containing 1
chr5_+_40841308 0.03 ENST00000381677.4
ENST00000254691.10
CARD6
caspase recruitment domain family member 6
chr11_+_56176618 0.03 ENST00000312298.1
OR5J2
olfactory receptor family 5 subfamily J member 2
chr17_-_61591192 0.02 ENST00000521764.3
NACA2
nascent polypeptide associated complex subunit alpha 2
chr7_-_140924900 0.02 ENST00000646891.1
ENST00000644969.2
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr1_+_117420597 0.02 ENST00000449370.6
MAN1A2
mannosidase alpha class 1A member 2
chr1_-_13285154 0.02 ENST00000357367.6
ENST00000614831.1
PRAMEF8
PRAME family member 8
chr5_+_141182369 0.02 ENST00000609684.3
ENST00000625044.1
ENST00000623407.1
ENST00000623884.1
PCDHB16
ENSG00000279068.1
protocadherin beta 16
novel transcript
chr5_+_148394712 0.02 ENST00000513826.1
FBXO38
F-box protein 38
chr1_+_192575765 0.02 ENST00000469578.2
ENST00000367459.8
RGS1
regulator of G protein signaling 1
chr10_-_92243246 0.02 ENST00000412050.8
ENST00000614585.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_126423122 0.02 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr5_+_150660841 0.02 ENST00000297130.4
MYOZ3
myozenin 3
chr8_-_28490220 0.02 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
FBXO16
F-box protein 16
chr4_+_94489030 0.02 ENST00000510099.5
PDLIM5
PDZ and LIM domain 5
chrX_-_126166273 0.02 ENST00000360028.4
DCAF12L2
DDB1 and CUL4 associated factor 12 like 2
chr5_+_150661243 0.01 ENST00000517768.6
MYOZ3
myozenin 3
chrX_-_141698739 0.01 ENST00000370515.3
SPANXD
SPANX family member D
chr14_+_94026314 0.01 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr1_-_153150884 0.01 ENST00000368748.5
SPRR2G
small proline rich protein 2G
chr19_+_6887560 0.01 ENST00000250572.12
ENST00000381407.9
ENST00000450315.7
ENST00000312053.9
ENST00000381404.8
ADGRE1
adhesion G protein-coupled receptor E1
chr5_-_176034680 0.01 ENST00000514861.5
THOC3
THO complex 3
chr6_+_54308429 0.01 ENST00000259782.9
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr5_-_56116946 0.01 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr16_-_28363508 0.00 ENST00000532254.1
NPIPB6
nuclear pore complex interacting protein family member B6
chr5_-_135399863 0.00 ENST00000510038.1
ENST00000304332.8
MACROH2A1
macroH2A.1 histone
chr20_-_46684467 0.00 ENST00000372121.5
SLC13A3
solute carrier family 13 member 3
chr19_+_9250930 0.00 ENST00000456448.3
OR7E24
olfactory receptor family 7 subfamily E member 24

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.1 0.8 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.5 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.9 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0070121 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:0046968 peptide antigen transport(GO:0046968)
0.0 0.6 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.0 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990038 glial cytoplasmic inclusion(GO:0097409) classical Lewy body(GO:0097414) Lewy neurite(GO:0097462) Lewy body corona(GO:1990038)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.0 GO:0004056 argininosuccinate lyase activity(GO:0004056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes