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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for BHLHE40

Z-value: 0.92

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.5 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg38_v1_chr3_+_4979428_4979495-0.482.3e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_136550819 1.60 ENST00000616617.4
ENST00000618822.4
MAP7
microtubule associated protein 7
chr8_+_32548303 1.39 ENST00000650967.1
NRG1
neuregulin 1
chr1_+_34782259 1.39 ENST00000373362.3
GJB3
gap junction protein beta 3
chr6_-_136550407 1.38 ENST00000354570.8
MAP7
microtubule associated protein 7
chr7_+_148133684 1.34 ENST00000628930.2
CNTNAP2
contactin associated protein 2
chr8_+_32548210 1.23 ENST00000523079.5
ENST00000650919.1
NRG1
neuregulin 1
chr10_-_5977589 1.00 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
IL15RA
interleukin 15 receptor subunit alpha
chr10_-_5977535 0.93 ENST00000379977.8
IL15RA
interleukin 15 receptor subunit alpha
chr19_-_55140922 0.88 ENST00000589745.5
TNNT1
troponin T1, slow skeletal type
chr17_-_17206264 0.84 ENST00000321560.4
PLD6
phospholipase D family member 6
chr8_+_32548267 0.63 ENST00000356819.7
NRG1
neuregulin 1
chr9_+_706841 0.60 ENST00000382293.7
KANK1
KN motif and ankyrin repeat domains 1
chr12_-_47904986 0.57 ENST00000549336.6
VDR
vitamin D receptor
chr9_-_114348966 0.56 ENST00000374079.8
AKNA
AT-hook transcription factor
chr5_+_90474848 0.55 ENST00000651687.1
POLR3G
RNA polymerase III subunit G
chr5_+_90474879 0.55 ENST00000504930.5
ENST00000514483.5
POLR3G
RNA polymerase III subunit G
chr12_-_47905003 0.52 ENST00000550325.5
ENST00000546653.5
ENST00000548664.1
VDR
vitamin D receptor
chr10_-_5977492 0.51 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
IL15RA
interleukin 15 receptor subunit alpha
chr2_-_228181669 0.48 ENST00000392056.8
SPHKAP
SPHK1 interactor, AKAP domain containing
chr2_-_228181612 0.47 ENST00000344657.5
SPHKAP
SPHK1 interactor, AKAP domain containing
chr14_+_77458032 0.43 ENST00000535854.6
ENST00000555517.1
ENST00000216479.8
AHSA1
activator of HSP90 ATPase activity 1
chr7_-_920884 0.41 ENST00000617043.4
ENST00000437486.5
ADAP1
ArfGAP with dual PH domains 1
chr12_-_24949026 0.40 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr18_+_58045683 0.39 ENST00000592846.5
ENST00000675801.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_+_75796867 0.38 ENST00000263187.4
MSH4
mutS homolog 4
chr18_+_58045642 0.38 ENST00000676223.1
ENST00000675147.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr2_-_135985568 0.36 ENST00000264161.9
DARS1
aspartyl-tRNA synthetase 1
chr11_+_60842095 0.35 ENST00000227520.10
CCDC86
coiled-coil domain containing 86
chr17_-_8079903 0.35 ENST00000649809.1
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chr7_-_36985060 0.33 ENST00000396040.6
ELMO1
engulfment and cell motility 1
chr20_-_45912047 0.32 ENST00000477313.5
ENST00000354050.8
ENST00000372431.8
ENST00000420868.2
PLTP
phospholipid transfer protein
chr9_+_127802858 0.32 ENST00000393706.6
ENST00000630236.2
ENST00000373247.7
ENST00000373228.5
FPGS
folylpolyglutamate synthase
chr9_+_127803208 0.31 ENST00000373225.7
ENST00000431857.5
FPGS
folylpolyglutamate synthase
chr1_-_206921987 0.30 ENST00000530505.1
ENST00000442471.4
FCMR
Fc fragment of IgM receptor
chr6_+_143843316 0.29 ENST00000367576.6
LTV1
LTV1 ribosome biogenesis factor
chr5_+_150357629 0.29 ENST00000650162.1
ENST00000377797.7
ENST00000445265.6
ENST00000323668.11
ENST00000643257.2
ENST00000646961.1
ENST00000513538.2
ENST00000439160.6
ENST00000394269.7
ENST00000427724.7
ENST00000504761.6
ENST00000513346.5
ENST00000515516.1
TCOF1
treacle ribosome biogenesis factor 1
chr5_+_36151989 0.27 ENST00000274254.9
SKP2
S-phase kinase associated protein 2
chr1_-_15585015 0.27 ENST00000375826.4
AGMAT
agmatinase
chr18_+_58196736 0.27 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr20_+_63861498 0.27 ENST00000369916.5
ABHD16B
abhydrolase domain containing 16B
chr14_+_22226711 0.26 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr5_+_36152077 0.26 ENST00000546211.6
ENST00000620197.5
ENST00000678270.1
ENST00000679015.1
ENST00000678580.1
ENST00000274255.11
ENST00000508514.5
SKP2
S-phase kinase associated protein 2
chr17_-_7290392 0.25 ENST00000571464.1
YBX2
Y-box binding protein 2
chr14_+_72926377 0.24 ENST00000353777.7
ENST00000358377.7
ENST00000394234.6
ENST00000509153.5
ENST00000555042.5
DCAF4
DDB1 and CUL4 associated factor 4
chr13_-_98977975 0.24 ENST00000376460.5
DOCK9
dedicator of cytokinesis 9
chr19_+_45406630 0.24 ENST00000309424.8
POLR1G
RNA polymerase I subunit G
chr2_+_102619531 0.23 ENST00000233969.3
SLC9A2
solute carrier family 9 member A2
chr6_+_5260992 0.23 ENST00000324331.10
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr13_-_98978022 0.23 ENST00000682017.1
ENST00000442173.5
ENST00000627024.2
DOCK9
dedicator of cytokinesis 9
chr8_+_98117285 0.22 ENST00000401707.7
ENST00000522319.5
POP1
POP1 homolog, ribonuclease P/MRP subunit
chr1_+_173824626 0.22 ENST00000648960.1
ENST00000648807.1
ENST00000649067.1
ENST00000649689.2
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr1_+_173824694 0.22 ENST00000647645.1
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr12_-_6568256 0.21 ENST00000382421.7
ENST00000545200.5
ENST00000399466.6
ENST00000322166.10
ENST00000536124.5
ENST00000540228.1
ENST00000542867.5
ENST00000545492.5
ENST00000545915.5
ENST00000620535.4
ENST00000617555.4
NOP2
NOP2 nucleolar protein
chr8_+_108443601 0.21 ENST00000524143.5
ENST00000220853.8
EMC2
ER membrane protein complex subunit 2
chrX_-_2968236 0.21 ENST00000684117.1
ENST00000672761.1
ENST00000672027.1
ENST00000672606.1
ENST00000673032.1
ENST00000540563.6
ARSL
arylsulfatase L
chr1_-_43172244 0.21 ENST00000236051.3
EBNA1BP2
EBNA1 binding protein 2
chr18_+_580367 0.20 ENST00000327228.5
CETN1
centrin 1
chr4_+_47485268 0.20 ENST00000273859.8
ENST00000504445.1
ATP10D
ATPase phospholipid transporting 10D (putative)
chr19_-_5720131 0.19 ENST00000587365.1
ENST00000360614.8
ENST00000585374.5
LONP1
lon peptidase 1, mitochondrial
chr19_-_5720159 0.19 ENST00000593119.5
LONP1
lon peptidase 1, mitochondrial
chr10_+_99732211 0.19 ENST00000370476.10
ENST00000370472.4
CUTC
cutC copper transporter
chr1_+_206897435 0.18 ENST00000391929.7
ENST00000294984.7
ENST00000611909.4
ENST00000367093.3
IL24
interleukin 24
chr15_-_74695987 0.18 ENST00000563009.5
ENST00000568176.5
ENST00000566243.5
ENST00000566219.1
ENST00000426797.7
ENST00000315127.9
ENST00000566119.5
EDC3
enhancer of mRNA decapping 3
chr1_+_209827964 0.18 ENST00000491415.7
UTP25
UTP25 small subunit processor component
chr5_+_177087412 0.18 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr6_-_111606260 0.18 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr19_-_3786363 0.17 ENST00000310132.11
MATK
megakaryocyte-associated tyrosine kinase
chr19_-_5719849 0.17 ENST00000590729.5
LONP1
lon peptidase 1, mitochondrial
chrX_+_54530201 0.17 ENST00000674225.1
ENST00000336470.8
ENST00000360845.3
ENST00000674238.1
ENST00000674420.1
ENST00000674311.1
ENST00000674508.1
GNL3L
G protein nucleolar 3 like
chr1_-_171652675 0.16 ENST00000037502.11
MYOC
myocilin
chr8_-_108443409 0.16 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr6_+_5261497 0.16 ENST00000274680.9
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr4_-_56435581 0.16 ENST00000264220.6
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr1_-_43172504 0.15 ENST00000431635.6
EBNA1BP2
EBNA1 binding protein 2
chr7_+_98211431 0.15 ENST00000609256.2
BHLHA15
basic helix-loop-helix family member a15
chr2_+_206765578 0.14 ENST00000403094.3
ENST00000402774.8
FASTKD2
FAST kinase domains 2
chr1_+_12019460 0.14 ENST00000235332.6
MIIP
migration and invasion inhibitory protein
chr22_-_30591850 0.14 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
PES1
pescadillo ribosomal biogenesis factor 1
chr1_-_200620729 0.13 ENST00000367350.5
KIF14
kinesin family member 14
chr1_+_117929720 0.13 ENST00000369441.7
ENST00000349139.6
WDR3
WD repeat domain 3
chr15_-_74695936 0.13 ENST00000647659.1
ENST00000566828.5
EDC3
enhancer of mRNA decapping 3
chr11_+_34642468 0.13 ENST00000527935.1
EHF
ETS homologous factor
chr19_-_45406327 0.13 ENST00000593226.5
ENST00000418234.6
PPP1R13L
protein phosphatase 1 regulatory subunit 13 like
chr16_+_68264501 0.12 ENST00000618043.4
ENST00000219343.11
ENST00000566834.5
ENST00000566454.5
SLC7A6
solute carrier family 7 member 6
chr14_-_55027045 0.12 ENST00000455555.1
ENST00000360586.8
ENST00000420358.2
WDHD1
WD repeat and HMG-box DNA binding protein 1
chr4_+_15681683 0.11 ENST00000504137.1
FAM200B
family with sequence similarity 200 member B
chr12_-_113335030 0.10 ENST00000552014.5
ENST00000680972.1
ENST00000548186.5
ENST00000202831.7
ENST00000549181.5
SLC8B1
solute carrier family 8 member B1
chr12_+_123762188 0.10 ENST00000409039.8
ENST00000673944.1
DNAH10
dynein axonemal heavy chain 10
chr6_-_5260883 0.10 ENST00000330636.9
LYRM4
LYR motif containing 4
chr2_-_111884117 0.10 ENST00000341068.8
ANAPC1
anaphase promoting complex subunit 1
chr16_+_19718264 0.10 ENST00000564186.5
IQCK
IQ motif containing K
chr8_-_144605699 0.09 ENST00000377307.6
ENST00000276826.5
ARHGAP39
Rho GTPase activating protein 39
chr21_+_33230375 0.09 ENST00000447980.1
IFNAR2
interferon alpha and beta receptor subunit 2
chr4_+_56435730 0.09 ENST00000514888.5
ENST00000264221.6
ENST00000505164.5
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr11_+_60327250 0.09 ENST00000684409.1
MS4A6E
membrane spanning 4-domains A6E
chr17_+_36949285 0.09 ENST00000681062.1
ENST00000679881.1
ENST00000680782.1
AATF
apoptosis antagonizing transcription factor
chr3_-_51499950 0.09 ENST00000423656.5
ENST00000504652.5
ENST00000684031.1
DCAF1
DDB1 and CUL4 associated factor 1
chr17_-_10697501 0.09 ENST00000577427.1
ENST00000255390.10
SCO1
synthesis of cytochrome C oxidase 1
chr6_+_122399621 0.09 ENST00000368455.9
HSF2
heat shock transcription factor 2
chr6_+_69866546 0.08 ENST00000620364.5
COL19A1
collagen type XIX alpha 1 chain
chr3_+_63652663 0.08 ENST00000343837.8
ENST00000469440.5
SNTN
sentan, cilia apical structure protein
chr22_+_48489546 0.08 ENST00000402357.6
TAFA5
TAFA chemokine like family member 5
chr19_-_3786254 0.08 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr10_-_103917657 0.08 ENST00000369764.1
STN1
STN1 subunit of CST complex
chr17_-_76737321 0.08 ENST00000359995.10
ENST00000508921.7
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
SRSF2
serine and arginine rich splicing factor 2
chr6_+_44247866 0.08 ENST00000371554.2
HSP90AB1
heat shock protein 90 alpha family class B member 1
chr6_+_122399536 0.07 ENST00000452194.5
HSF2
heat shock transcription factor 2
chr1_+_119414931 0.07 ENST00000543831.5
ENST00000433745.5
ENST00000369416.4
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_+_43979877 0.07 ENST00000356836.10
ENST00000309519.8
B4GALT2
beta-1,4-galactosyltransferase 2
chr4_+_56436131 0.07 ENST00000399688.7
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr22_-_50085331 0.07 ENST00000395876.6
MLC1
modulator of VRAC current 1
chrX_+_54530182 0.07 ENST00000674498.1
GNL3L
G protein nucleolar 3 like
chr21_+_36699100 0.06 ENST00000290399.11
SIM2
SIM bHLH transcription factor 2
chr6_-_5260730 0.06 ENST00000464010.5
ENST00000500576.4
ENST00000468929.5
ENST00000480566.5
LYRM4
LYR motif containing 4
chrX_+_129906146 0.06 ENST00000394422.8
UTP14A
UTP14A small subunit processome component
chr6_-_118651522 0.05 ENST00000368491.8
CEP85L
centrosomal protein 85 like
chr12_+_93467506 0.05 ENST00000549982.6
ENST00000552217.6
ENST00000393128.8
ENST00000547098.5
MRPL42
mitochondrial ribosomal protein L42
chr21_+_33230073 0.05 ENST00000342101.7
ENST00000413881.5
ENST00000443073.5
IFNAR2
interferon alpha and beta receptor subunit 2
chr6_-_154356735 0.05 ENST00000367220.8
ENST00000265198.8
ENST00000520261.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr2_+_189784435 0.05 ENST00000409985.5
ENST00000441310.7
ENST00000446877.5
ENST00000409823.7
ENST00000374826.8
ENST00000424766.5
ENST00000447232.6
PMS1
PMS1 homolog 1, mismatch repair system component
chrX_+_55075023 0.05 ENST00000374971.2
PAGE2B
PAGE family member 2B
chrX_+_55075062 0.05 ENST00000374974.7
PAGE2B
PAGE family member 2B
chrX_+_129906118 0.05 ENST00000425117.6
UTP14A
UTP14A small subunit processome component
chr17_+_74432079 0.05 ENST00000392627.7
ENST00000392628.7
ENST00000582473.2
GPRC5C
G protein-coupled receptor class C group 5 member C
chr2_+_105038036 0.05 ENST00000258455.8
MRPS9
mitochondrial ribosomal protein S9
chr20_+_23350755 0.04 ENST00000254998.3
NXT1
nuclear transport factor 2 like export factor 1
chr21_+_41370452 0.04 ENST00000680862.1
MX2
MX dynamin like GTPase 2
chr6_+_158560057 0.04 ENST00000684151.1
TMEM181
transmembrane protein 181
chr17_-_13601901 0.04 ENST00000284110.2
HS3ST3A1
heparan sulfate-glucosamine 3-sulfotransferase 3A1
chr5_-_72320217 0.04 ENST00000508863.6
ENST00000522095.1
ENST00000513900.5
ENST00000515404.5
ENST00000261413.10
ENST00000457646.8
MRPS27
mitochondrial ribosomal protein S27
chr3_+_111859796 0.04 ENST00000393925.7
PHLDB2
pleckstrin homology like domain family B member 2
chr21_+_32412648 0.04 ENST00000401402.7
ENST00000382699.7
ENST00000300255.7
EVA1C
eva-1 homolog C
chr14_-_45253402 0.04 ENST00000627697.1
MIS18BP1
MIS18 binding protein 1
chr3_+_108296489 0.04 ENST00000619531.4
HHLA2
HERV-H LTR-associating 2
chr22_-_30557586 0.04 ENST00000338911.6
ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_20139316 0.04 ENST00000375102.4
PLA2G2F
phospholipase A2 group IIF
chr15_+_77420880 0.03 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr10_-_95656643 0.03 ENST00000371221.3
ENST00000371224.7
ALDH18A1
aldehyde dehydrogenase 18 family member A1
chr7_-_155533837 0.03 ENST00000406197.5
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr16_-_3099228 0.02 ENST00000572431.1
ENST00000572548.1
ENST00000575108.5
ENST00000576985.6
ENST00000576483.1
ENST00000538082.5
ZSCAN10
zinc finger and SCAN domain containing 10
chr8_-_30912998 0.02 ENST00000643185.2
TEX15
testis expressed 15, meiosis and synapsis associated
chr11_-_6603571 0.02 ENST00000534343.1
ENST00000254605.11
RRP8
ribosomal RNA processing 8
chr12_+_64610458 0.02 ENST00000542104.6
RASSF3
Ras association domain family member 3
chr1_-_231241090 0.02 ENST00000451322.1
C1orf131
chromosome 1 open reading frame 131
chr2_-_240557957 0.01 ENST00000373318.6
ENST00000406958.5
ENST00000272972.7
ENST00000401804.5
ENST00000361678.8
ENST00000391987.5
ENST00000405523.7
ANKMY1
ankyrin repeat and MYND domain containing 1
chr4_+_41981745 0.01 ENST00000333141.7
DCAF4L1
DDB1 and CUL4 associated factor 4 like 1
chr1_-_231241121 0.00 ENST00000318906.6
ENST00000366649.7
ENST00000366651.7
C1orf131
chromosome 1 open reading frame 131
chr8_-_11853470 0.00 ENST00000679121.1
CTSB
cathepsin B
chr7_+_116672187 0.00 ENST00000318493.11
ENST00000397752.8
MET
MET proto-oncogene, receptor tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0007308 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.3 1.1 GO:0060057 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.3 1.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.3 3.4 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 0.6 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.2 0.6 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 0.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.4 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.9 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.5 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 1.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.2 GO:0009386 translational attenuation(GO:0009386)
0.1 0.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.0 0.3 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
0.0 0.4 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.2 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:1903412 response to bile acid(GO:1903412)
0.0 0.1 GO:1901389 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.0 2.9 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0055070 copper ion homeostasis(GO:0055070)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 GO:0030673 axolemma(GO:0030673)
0.1 0.4 GO:0005713 recombination nodule(GO:0005713)
0.1 1.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0034448 EGO complex(GO:0034448)
0.0 0.9 GO:0005861 troponin complex(GO:0005861)
0.0 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 3.2 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1902271 D3 vitamins binding(GO:1902271)
0.2 0.6 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.2 3.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.4 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 1.4 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.9 GO:0031014 troponin T binding(GO:0031014)
0.0 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0004638 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.0 0.4 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.1 GO:0004905 type I interferon receptor activity(GO:0004905)
0.0 0.1 GO:0002135 CTP binding(GO:0002135)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 2.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.3 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines