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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for DLX5

Z-value: 0.45

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
ENSG00000105880.7 distal-less homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg38_v1_chr7_-_97024821_97024950-0.695.6e-02Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_53099100 0.78 ENST00000565832.5
chromodomain helicase DNA binding protein 9
chr5_-_20575850 0.46 ENST00000507958.5
cadherin 18
chr15_+_89088417 0.43 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr19_+_49513353 0.36 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr4_-_137532452 0.29 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr7_+_101127095 0.27 ENST00000223095.5
serpin family E member 1
chr3_+_186842687 0.26 ENST00000444204.2
ENST00000320741.7
adiponectin, C1Q and collagen domain containing
chr5_+_172641241 0.25 ENST00000369800.6
ENST00000520919.5
ENST00000522853.5
neuralized E3 ubiquitin protein ligase 1B
chr15_+_41621134 0.24 ENST00000566718.6
MAX dimerization protein MGA
chr15_+_41621492 0.23 ENST00000570161.6
MAX dimerization protein MGA
chr7_+_100119607 0.22 ENST00000262932.5
canopy FGF signaling regulator 4
chr12_+_51424965 0.20 ENST00000514353.7
solute carrier family 4 member 8
chr17_+_44187190 0.19 ENST00000319511.6
transmembrane and ubiquitin like domain containing 2
chr17_+_44187210 0.19 ENST00000589785.1
ENST00000592825.1
ENST00000589184.5
transmembrane and ubiquitin like domain containing 2
chr19_+_1266653 0.18 ENST00000586472.5
ENST00000589266.5
cold inducible RNA binding protein
chr12_+_119668109 0.18 ENST00000229328.10
ENST00000630317.1
protein kinase AMP-activated non-catalytic subunit beta 1
chr5_+_141150012 0.18 ENST00000231136.4
ENST00000622991.1
protocadherin beta 6
chr3_+_158801926 0.18 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr3_+_11137093 0.16 ENST00000438284.2
histamine receptor H1
chr15_+_76336755 0.16 ENST00000290759.9
ISL LIM homeobox 2
chr7_+_71132123 0.15 ENST00000333538.10
polypeptide N-acetylgalactosaminyltransferase 17
chr6_-_41733690 0.13 ENST00000419396.6
ENST00000678831.1
ENST00000394283.5
transcription factor EB
chr17_+_75110021 0.13 ENST00000584947.1
armadillo repeat containing 7
chrX_-_16869840 0.12 ENST00000380084.8
RB binding protein 7, chromatin remodeling factor
chr13_-_36214584 0.12 ENST00000317764.6
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr4_-_73988179 0.12 ENST00000296028.4
pro-platelet basic protein
chr2_+_95297304 0.11 ENST00000295225.10
potassium voltage-gated channel interacting protein 3
chr12_+_51424802 0.11 ENST00000453097.7
solute carrier family 4 member 8
chr7_-_13989658 0.11 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETS variant transcription factor 1
chr5_-_160852200 0.10 ENST00000327245.10
ATPase phospholipid transporting 10B (putative)
chr11_-_33892010 0.10 ENST00000257818.3
LIM domain only 2
chr6_+_122717544 0.10 ENST00000354275.2
ENST00000368446.1
cAMP-dependent protein kinase inhibitor beta
chr14_+_32329256 0.09 ENST00000280979.9
A-kinase anchoring protein 6
chr19_-_45782388 0.09 ENST00000458663.6
DM1 protein kinase
chr1_-_113904789 0.08 ENST00000369569.6
ENST00000369567.5
adaptor related protein complex 4 subunit beta 1
chr7_-_7535863 0.08 ENST00000399429.8
collagen type XXVIII alpha 1 chain
chr4_-_65670478 0.08 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr19_+_36115439 0.08 ENST00000629269.2
ENST00000221855.8
ENST00000651435.1
ENST00000589996.5
ENST00000591296.1
tubulin folding cofactor B
chr6_-_77463485 0.08 ENST00000369947.5
5-hydroxytryptamine receptor 1B
chr19_-_46634685 0.08 ENST00000300873.4
G protein subunit gamma 8
chr4_-_65670339 0.08 ENST00000273854.7
EPH receptor A5
chr6_+_106360668 0.07 ENST00000633556.3
crystallin beta-gamma domain containing 1
chr11_+_76381303 0.07 ENST00000662483.1
ENST00000663165.1
ENST00000529331.2
ENST00000321844.6
ENST00000667240.1
GVQW motif containing 3
chr2_-_182522703 0.07 ENST00000410103.1
phosphodiesterase 1A
chr11_-_26572130 0.07 ENST00000527569.1
mucin 15, cell surface associated
chr2_+_169584779 0.07 ENST00000678638.1
peptidylprolyl isomerase G
chr4_-_145180496 0.06 ENST00000447906.8
OTU deubiquitinase 4
chr19_+_58059236 0.06 ENST00000359978.10
ENST00000401053.8
ENST00000511556.5
ENST00000506786.1
ENST00000313434.10
zinc finger protein 135
chr1_+_160190567 0.06 ENST00000368078.8
calsequestrin 1
chr7_-_130441136 0.06 ENST00000675596.1
ENST00000676312.1
centrosomal protein 41
chr11_-_26722051 0.06 ENST00000396005.8
solute carrier family 5 member 12
chr10_+_97446194 0.06 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr6_-_27893175 0.06 ENST00000359611.4
H2A clustered histone 17
chr17_+_45161070 0.06 ENST00000593138.6
ENST00000586681.6
HEXIM P-TEFb complex subunit 2
chr8_-_7475082 0.06 ENST00000316169.2
defensin beta 104B
chrX_+_152831054 0.05 ENST00000370274.8
NAD(P) dependent steroid dehydrogenase-like
chr19_-_45782479 0.05 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chr3_-_186570308 0.05 ENST00000446782.5
TBCC domain containing 1
chr10_+_97446137 0.05 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
zinc finger DHHC-type palmitoyltransferase 16
chr13_+_35476740 0.05 ENST00000537702.5
neurobeachin
chrX_-_152830721 0.05 ENST00000370277.5
centrin 2
chr19_+_35748549 0.05 ENST00000301159.14
lin-37 DREAM MuvB core complex component
chr2_+_168901290 0.05 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
glucose-6-phosphatase catalytic subunit 2
chr3_+_2892199 0.05 ENST00000397459.6
contactin 4
chr1_+_202348727 0.04 ENST00000356764.6
protein phosphatase 1 regulatory subunit 12B
chr11_+_818906 0.04 ENST00000336615.9
patatin like phospholipase domain containing 2
chr3_-_180679468 0.04 ENST00000651046.1
ENST00000476379.6
coiled-coil domain containing 39
chr7_-_30550761 0.04 ENST00000598361.4
ENST00000440438.6
novel protein
GARS1 divergent transcript
chr1_-_197146620 0.04 ENST00000367409.9
ENST00000680265.1
assembly factor for spindle microtubules
chr14_-_67816574 0.03 ENST00000677026.1
ENST00000555452.1
ENST00000347230.9
ENST00000678386.1
ENST00000676620.1
ENST00000676512.1
zinc finger FYVE-type containing 26
chr11_-_94973541 0.03 ENST00000279839.8
CWC15 spliceosome associated protein homolog
chr1_-_23344314 0.03 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
heterogeneous nuclear ribonucleoprotein R
chr11_-_26572254 0.03 ENST00000529533.6
mucin 15, cell surface associated
chr1_+_202348687 0.03 ENST00000608999.6
ENST00000391959.5
ENST00000480184.5
protein phosphatase 1 regulatory subunit 12B
chr10_+_96832906 0.03 ENST00000675537.1
ENST00000675117.1
ENST00000356016.7
ENST00000371097.8
ligand dependent nuclear receptor corepressor
chr18_+_44700796 0.02 ENST00000677130.1
SET binding protein 1
chr10_+_114043858 0.02 ENST00000369295.4
adrenoceptor beta 1
chr7_-_100119323 0.02 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chr2_-_182522556 0.02 ENST00000435564.5
phosphodiesterase 1A
chr2_+_30146993 0.02 ENST00000261353.9
ENST00000402003.7
yippee like 5
chr19_-_14674886 0.02 ENST00000344373.8
ENST00000595472.1
adhesion G protein-coupled receptor E3
chr20_-_37261808 0.02 ENST00000373614.7
growth hormone releasing hormone
chr10_-_54801179 0.02 ENST00000373955.5
protocadherin related 15
chr19_-_14674829 0.02 ENST00000443157.6
ENST00000253673.6
adhesion G protein-coupled receptor E3
chr7_-_87220567 0.02 ENST00000433078.5
transmembrane protein 243
chr13_-_110242694 0.02 ENST00000648989.1
ENST00000647797.1
ENST00000648966.1
ENST00000649484.1
ENST00000648695.1
ENST00000650115.1
ENST00000650566.1
collagen type IV alpha 1 chain
chr17_+_29941605 0.02 ENST00000394835.7
EF-hand calcium binding domain 5
chr2_+_30146941 0.02 ENST00000379520.7
ENST00000379519.7
yippee like 5
chrX_+_101391000 0.02 ENST00000553110.8
ENST00000409338.5
ENST00000409170.3
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr7_-_100119840 0.02 ENST00000437822.6
TATA-box binding protein associated factor 6
chr1_-_23344259 0.02 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
heterogeneous nuclear ribonucleoprotein R
chr1_-_150697128 0.02 ENST00000427665.1
ENST00000271732.8
golgi phosphoprotein 3 like
chr10_-_54801221 0.02 ENST00000644397.2
ENST00000395445.6
ENST00000613657.5
ENST00000320301.11
protocadherin related 15
chrX_+_101390976 0.02 ENST00000392994.7
ribosomal protein L36a
chr1_+_50103903 0.02 ENST00000371827.5
ELAV like RNA binding protein 4
chr22_-_32464440 0.02 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPI fold containing family C
chr14_+_22271921 0.02 ENST00000390464.2
T cell receptor alpha variable 38-1
chr10_-_54801262 0.01 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
protocadherin related 15
chr13_-_35476682 0.01 ENST00000379919.6
mab-21 like 1
chr6_-_111873421 0.01 ENST00000368678.8
ENST00000523238.5
ENST00000354650.7
FYN proto-oncogene, Src family tyrosine kinase
chr22_-_30564889 0.01 ENST00000401975.5
ENST00000428682.5
ENST00000423299.5
galactose-3-O-sulfotransferase 1
chr21_-_14546297 0.01 ENST00000400566.6
ENST00000400564.5
SAM domain, SH3 domain and nuclear localization signals 1
chr12_-_10826358 0.01 ENST00000240619.2
taste 2 receptor member 10
chr3_+_186570663 0.01 ENST00000265028.8
DnaJ heat shock protein family (Hsp40) member B11
chr6_-_38703066 0.01 ENST00000373365.5
glyoxalase I
chrX_+_101390824 0.01 ENST00000427805.6
ENST00000614077.4
ribosomal protein L36a
chr12_+_52301833 0.01 ENST00000293525.5
keratin 86
chr1_+_67685170 0.01 ENST00000370985.4
ENST00000370986.9
ENST00000650283.1
ENST00000648742.1
growth arrest and DNA damage inducible alpha
chr5_-_59276109 0.00 ENST00000503258.5
phosphodiesterase 4D
chr9_+_113463697 0.00 ENST00000317613.10
regulator of G protein signaling 3

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.3 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.3 GO:2000583 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.2 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions