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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for DMBX1

Z-value: 0.42

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.11 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg38_v1_chr1_+_46489800_464898420.049.3e-01Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_70553638 0.76 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
TGFA
transforming growth factor alpha
chr10_+_116427839 0.66 ENST00000369230.4
PNLIPRP3
pancreatic lipase related protein 3
chr18_+_31447732 0.63 ENST00000257189.5
DSG3
desmoglein 3
chr6_-_106975616 0.57 ENST00000610952.1
CD24
CD24 molecule
chr2_-_70553440 0.55 ENST00000450929.5
TGFA
transforming growth factor alpha
chrX_-_103311004 0.53 ENST00000372674.5
BEX2
brain expressed X-linked 2
chr8_-_124565699 0.40 ENST00000519168.5
MTSS1
MTSS I-BAR domain containing 1
chrX_-_32155462 0.33 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr7_+_148339452 0.26 ENST00000463592.3
CNTNAP2
contactin associated protein 2
chr17_-_4739866 0.26 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr6_+_130018565 0.23 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr4_+_139665768 0.19 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
MGST2
microsomal glutathione S-transferase 2
chr14_-_21022817 0.16 ENST00000554104.5
NDRG2
NDRG family member 2
chr11_+_121576760 0.14 ENST00000532694.5
ENST00000534286.5
SORL1
sortilin related receptor 1
chr17_+_9825906 0.14 ENST00000262441.10
GLP2R
glucagon like peptide 2 receptor
chr11_+_61481110 0.13 ENST00000338608.7
ENST00000432063.6
PPP1R32
protein phosphatase 1 regulatory subunit 32
chr3_+_188947199 0.13 ENST00000433971.5
TPRG1
tumor protein p63 regulated 1
chr11_-_36598221 0.13 ENST00000311485.8
ENST00000527033.5
ENST00000532616.1
ENST00000618712.4
RAG2
recombination activating 2
chrX_-_15854743 0.12 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr6_-_138572523 0.12 ENST00000427025.6
NHSL1
NHS like 1
chr20_+_33217325 0.11 ENST00000375452.3
ENST00000375454.8
BPIFA3
BPI fold containing family A member 3
chr18_-_55587335 0.10 ENST00000638154.3
TCF4
transcription factor 4
chr2_-_219387784 0.10 ENST00000520694.6
DNPEP
aspartyl aminopeptidase
chr1_+_19882374 0.09 ENST00000375120.4
OTUD3
OTU deubiquitinase 3
chr7_+_1688119 0.09 ENST00000424383.4
ELFN1
extracellular leucine rich repeat and fibronectin type III domain containing 1
chr1_-_121184292 0.08 ENST00000452190.2
ENST00000619376.4
ENST00000369390.7
FAM72B
family with sequence similarity 72 member B
chr3_+_49020443 0.08 ENST00000326912.8
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr17_+_17042433 0.08 ENST00000651222.2
MPRIP
myosin phosphatase Rho interacting protein
chr1_-_143971965 0.08 ENST00000369175.4
ENST00000584486.6
FAM72C
family with sequence similarity 72 member C
chr1_+_145095967 0.08 ENST00000400889.3
FAM72D
family with sequence similarity 72 member D
chr1_-_206202827 0.08 ENST00000431655.2
ENST00000367128.8
FAM72A
family with sequence similarity 72 member A
chr17_+_4740042 0.08 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr10_+_72692125 0.07 ENST00000373053.7
ENST00000357157.10
MCU
mitochondrial calcium uniporter
chr17_+_4740005 0.07 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr19_-_3761657 0.07 ENST00000316757.4
APBA3
amyloid beta precursor protein binding family A member 3
chr3_+_49021071 0.07 ENST00000395458.6
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr19_-_42412347 0.07 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chr7_-_135728177 0.07 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr12_-_118190510 0.06 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr3_-_11643871 0.06 ENST00000430365.7
VGLL4
vestigial like family member 4
chr1_-_28058087 0.06 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr15_+_73873557 0.06 ENST00000300504.7
TBC1D21
TBC1 domain family member 21
chr20_-_45101112 0.06 ENST00000306117.5
ENST00000537075.3
KCNS1
potassium voltage-gated channel modifier subfamily S member 1
chr10_+_102132994 0.05 ENST00000413464.6
ENST00000278070.7
PPRC1
PPARG related coactivator 1
chr20_+_35968566 0.05 ENST00000373973.7
ENST00000349339.5
ENST00000489667.1
ENST00000538900.1
CNBD2
cyclic nucleotide binding domain containing 2
chr12_-_21334858 0.05 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
SLCO1A2
solute carrier organic anion transporter family member 1A2
chr17_-_40703744 0.05 ENST00000264651.3
KRT24
keratin 24
chr14_+_96797304 0.05 ENST00000553683.2
ENST00000680538.1
ENST00000681195.1
ENST00000679727.1
ENST00000680509.1
ENST00000557222.6
ENST00000680683.1
ENST00000680335.1
ENST00000216639.8
ENST00000679736.1
ENST00000681176.1
ENST00000557352.2
ENST00000679903.1
ENST00000681419.1
ENST00000680849.1
ENST00000681493.1
ENST00000679770.1
ENST00000681355.1
ENST00000681344.1
VRK1
VRK serine/threonine kinase 1
chr7_+_726682 0.05 ENST00000297440.11
DNAAF5
dynein axonemal assembly factor 5
chr17_+_70104848 0.05 ENST00000392670.5
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr19_+_17337539 0.04 ENST00000324894.13
ENST00000358792.11
ENST00000600625.5
GTPBP3
GTP binding protein 3, mitochondrial
chr19_-_6459735 0.04 ENST00000334510.9
ENST00000301454.9
SLC25A23
solute carrier family 25 member 23
chr19_-_17075038 0.04 ENST00000593360.1
HAUS8
HAUS augmin like complex subunit 8
chr4_+_41935114 0.04 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
TMEM33
transmembrane protein 33
chr17_-_7239279 0.04 ENST00000613632.4
ENST00000571362.5
ENST00000576955.5
ENST00000320316.8
PHF23
PHD finger protein 23
chr19_-_17075418 0.03 ENST00000253669.10
HAUS8
HAUS augmin like complex subunit 8
chr15_+_73873604 0.03 ENST00000535547.6
ENST00000562056.1
TBC1D21
TBC1 domain family member 21
chr2_-_207624983 0.03 ENST00000448007.6
ENST00000432416.5
ENST00000411432.5
ENST00000458426.5
ENST00000406927.6
ENST00000425132.5
METTL21A
methyltransferase like 21A
chr19_+_45498439 0.03 ENST00000451287.7
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr4_-_53365976 0.03 ENST00000401642.8
ENST00000388940.8
ENST00000503450.1
SCFD2
sec1 family domain containing 2
chr2_+_73234236 0.03 ENST00000540468.5
ENST00000539919.5
CCT7
chaperonin containing TCP1 subunit 7
chr3_-_138132381 0.03 ENST00000236709.4
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr18_-_37565765 0.03 ENST00000361795.9
ENST00000420428.7
CELF4
CUGBP Elav-like family member 4
chr2_+_73234282 0.02 ENST00000399032.2
ENST00000398422.2
ENST00000258091.10
CCT7
chaperonin containing TCP1 subunit 7
chr16_-_20327426 0.02 ENST00000575582.5
ENST00000341642.9
ENST00000381362.8
ENST00000572347.5
ENST00000572478.5
ENST00000302555.10
GP2
glycoprotein 2
chr18_-_37565714 0.02 ENST00000591287.5
ENST00000601019.5
ENST00000601392.5
CELF4
CUGBP Elav-like family member 4
chr1_+_109213887 0.02 ENST00000234677.7
ENST00000369923.4
SARS1
seryl-tRNA synthetase 1
chr18_-_37565628 0.02 ENST00000334919.9
ENST00000591282.5
ENST00000588597.5
CELF4
CUGBP Elav-like family member 4
chr11_+_124185216 0.02 ENST00000318666.6
OR10D3
olfactory receptor family 10 subfamily D member 3
chr4_-_75990919 0.02 ENST00000395711.8
ENST00000356260.10
SDAD1
SDA1 domain containing 1
chr14_-_106875069 0.02 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr9_-_21995262 0.01 ENST00000494262.5
CDKN2A
cyclin dependent kinase inhibitor 2A
chr18_-_37565825 0.01 ENST00000603232.6
CELF4
CUGBP Elav-like family member 4
chr11_-_45918789 0.01 ENST00000532681.5
PEX16
peroxisomal biogenesis factor 16
chr14_-_106511856 0.01 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr19_-_50637939 0.01 ENST00000338916.8
SYT3
synaptotagmin 3
chr12_-_54981838 0.01 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr3_+_136930469 0.01 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr4_+_168631597 0.01 ENST00000504519.5
ENST00000512127.5
PALLD
palladin, cytoskeletal associated protein
chr12_-_62192762 0.01 ENST00000416284.8
TAFA2
TAFA chemokine like family member 2
chr1_-_13347134 0.01 ENST00000334600.7
PRAMEF14
PRAME family member 14
chr7_-_100177336 0.01 ENST00000292377.4
GPC2
glypican 2
chr7_+_29122274 0.01 ENST00000582692.2
ENST00000644824.1
ENSG00000285412.1
ENSG00000285162.1
novel transcript, antisense to CPVL
chimerin 2
chr18_-_24272179 0.01 ENST00000399443.7
OSBPL1A
oxysterol binding protein like 1A
chr1_-_47314089 0.01 ENST00000360380.7
ENST00000371877.8
ENST00000447475.7
STIL
STIL centriolar assembly protein
chr9_-_21995301 0.00 ENST00000498628.6
CDKN2A
cyclin dependent kinase inhibitor 2A
chr18_+_44680875 0.00 ENST00000649279.2
ENST00000677699.1
SETBP1
SET binding protein 1
chr10_+_84245038 0.00 ENST00000650682.1
ENST00000358110.7
ENST00000651237.1
ENST00000652122.1
ENST00000652092.2
ENST00000359452.9
ENST00000483744.6
RGR
retinal G protein coupled receptor
chr5_+_170232912 0.00 ENST00000524171.5
ENST00000517575.4
ENST00000518395.2
ENST00000593851.5
C5orf58
chromosome 5 open reading frame 58

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0032913 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.1 0.4 GO:0030035 microspike assembly(GO:0030035)
0.1 1.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 0.1 GO:1902960 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:1990167 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0042835 BRE binding(GO:0042835)
0.0 0.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins