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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for DMC1

Z-value: 0.44

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.10 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg38_v1_chr22_-_38570167_385702040.611.1e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_31414694 0.53 ENST00000379416.4
XDH
xanthine dehydrogenase
chr14_+_21057822 0.52 ENST00000308227.2
RNASE8
ribonuclease A family member 8
chr21_-_44928711 0.49 ENST00000517563.5
ITGB2
integrin subunit beta 2
chr7_+_90154442 0.28 ENST00000297205.7
STEAP1
STEAP family member 1
chr5_-_83673544 0.27 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr7_-_22500152 0.26 ENST00000406890.6
ENST00000678116.1
ENST00000424363.5
STEAP1B
STEAP family member 1B
chr12_-_70637405 0.21 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
PTPRB
protein tyrosine phosphatase receptor type B
chr4_+_153684241 0.21 ENST00000646219.1
ENST00000642580.1
ENST00000643501.1
ENST00000642700.2
TLR2
toll like receptor 2
chr4_-_76023489 0.20 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr17_+_59220446 0.19 ENST00000284116.9
ENST00000581140.5
ENST00000581276.5
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr10_-_96271508 0.18 ENST00000427367.6
ENST00000413476.6
ENST00000371176.6
BLNK
B cell linker
chr21_-_44928824 0.18 ENST00000355153.8
ENST00000397850.6
ITGB2
integrin subunit beta 2
chr13_-_75366973 0.18 ENST00000648194.1
TBC1D4
TBC1 domain family member 4
chr1_-_205994439 0.17 ENST00000617991.4
RAB7B
RAB7B, member RAS oncogene family
chr2_-_162152404 0.17 ENST00000375497.3
GCG
glucagon
chr6_+_116461364 0.16 ENST00000368606.7
ENST00000368605.3
CALHM6
calcium homeostasis modulator family member 6
chr10_-_96271553 0.16 ENST00000224337.10
BLNK
B cell linker
chr1_+_81306096 0.14 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr14_-_21023318 0.12 ENST00000298684.9
ENST00000557169.5
ENST00000553563.5
NDRG2
NDRG family member 2
chr6_-_131701401 0.12 ENST00000315453.4
OR2A4
olfactory receptor family 2 subfamily A member 4
chrX_-_135171398 0.12 ENST00000276241.11
ENST00000344129.2
CT55
cancer/testis antigen 55
chr5_+_55853528 0.12 ENST00000490985.5
IL31RA
interleukin 31 receptor A
chr10_-_60572599 0.11 ENST00000503366.5
ANK3
ankyrin 3
chr11_+_71527267 0.11 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr6_-_29368865 0.11 ENST00000641768.1
OR5V1
olfactory receptor family 5 subfamily V member 1
chrX_-_64230600 0.10 ENST00000362002.3
ASB12
ankyrin repeat and SOCS box containing 12
chr7_-_151187212 0.10 ENST00000420175.3
ENST00000275838.5
ASB10
ankyrin repeat and SOCS box containing 10
chr17_+_32991867 0.09 ENST00000394638.1
SPACA3
sperm acrosome associated 3
chrX_+_106611930 0.09 ENST00000372544.6
ENST00000372548.9
RADX
RPA1 related single stranded DNA binding protein, X-linked
chrX_-_50200988 0.08 ENST00000358526.7
AKAP4
A-kinase anchoring protein 4
chr7_+_92057602 0.08 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr11_-_86069043 0.08 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_+_73851809 0.08 ENST00000555661.6
ENST00000555228.5
PTGR2
prostaglandin reductase 2
chr14_+_73851908 0.08 ENST00000267568.8
PTGR2
prostaglandin reductase 2
chr8_-_100722731 0.07 ENST00000521865.6
ENST00000520804.2
ENST00000522720.2
ENST00000521067.1
PABPC1
poly(A) binding protein cytoplasmic 1
chr10_+_60778331 0.07 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr8_-_100722587 0.07 ENST00000523555.6
PABPC1
poly(A) binding protein cytoplasmic 1
chrX_-_50200358 0.07 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
AKAP4
A-kinase anchoring protein 4
chr6_+_35342614 0.06 ENST00000337400.6
ENST00000311565.4
PPARD
peroxisome proliferator activated receptor delta
chr11_+_134331874 0.06 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr1_+_166989254 0.06 ENST00000367872.9
ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr1_+_166989089 0.06 ENST00000367870.6
MAEL
maelstrom spermatogenic transposon silencer
chr12_-_108632073 0.06 ENST00000228463.6
SELPLG
selectin P ligand
chr2_-_162152239 0.06 ENST00000418842.7
GCG
glucagon
chr3_+_101827982 0.06 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr18_+_59225492 0.06 ENST00000456142.3
ENST00000530323.1
GRP
gastrin releasing peptide
chr2_+_119429889 0.05 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr6_+_26383176 0.05 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr10_+_60778490 0.05 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr7_-_5970632 0.04 ENST00000455618.2
ENST00000405415.5
ENST00000404406.5
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B
chr2_-_18560616 0.04 ENST00000381249.4
RDH14
retinol dehydrogenase 14
chr2_+_61017562 0.04 ENST00000401576.1
ENST00000295030.6
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr1_-_110519175 0.03 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr6_+_26383090 0.03 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr1_+_9539431 0.03 ENST00000302692.7
SLC25A33
solute carrier family 25 member 33
chr7_-_151187772 0.03 ENST00000377867.7
ASB10
ankyrin repeat and SOCS box containing 10
chr17_+_32991844 0.03 ENST00000269053.8
SPACA3
sperm acrosome associated 3
chr5_-_150086511 0.03 ENST00000675795.1
CSF1R
colony stimulating factor 1 receptor
chr22_+_20116099 0.02 ENST00000430524.6
RANBP1
RAN binding protein 1
chr17_+_79022814 0.02 ENST00000578229.5
C1QTNF1
C1q and TNF related 1
chr11_+_6863057 0.02 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr2_-_75199511 0.02 ENST00000305249.10
TACR1
tachykinin receptor 1
chr6_+_35342535 0.02 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
PPARD
peroxisome proliferator activated receptor delta
chr7_+_6754109 0.02 ENST00000403107.5
ENST00000404077.5
ENST00000435395.5
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2
chr2_+_186590022 0.02 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr11_-_86068929 0.01 ENST00000630913.2
PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_+_22040576 0.01 ENST00000390448.3
TRAV20
T cell receptor alpha variable 20
chr1_-_11803383 0.01 ENST00000641407.1
ENST00000376583.7
ENST00000423400.7
MTHFR
methylenetetrahydrofolate reductase
chr3_-_46812558 0.01 ENST00000641183.1
ENST00000460241.2
ENSG00000284672.1
ENSG00000206549.13
novel transcript
novel protein identical to PRSS50
chr1_+_12230006 0.01 ENST00000620676.6
VPS13D
vacuolar protein sorting 13 homolog D
chr17_+_4942805 0.01 ENST00000576965.1
RNF167
ring finger protein 167
chr6_-_62286161 0.01 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr15_-_33068143 0.01 ENST00000558197.1
FMN1
formin 1
chr15_+_41286011 0.00 ENST00000661438.1
ENSG00000285920.2
novel protein
chr17_+_79022908 0.00 ENST00000354124.7
ENST00000580454.5
C1QTNF1
C1q and TNF related 1
chr11_-_74009077 0.00 ENST00000314032.9
ENST00000426995.2
UCP3
uncoupling protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.5 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.5 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.2 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.1 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.7 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
0.0 0.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.0 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 0.2 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.1 GO:0030849 autosome(GO:0030849)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:0044307 dendritic branch(GO:0044307)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.5 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 0.5 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.7 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin