ISMARA results: E2F7

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for E2F7_E2F1

Z-value: 2.71

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Transcription factors associated with E2F7_E2F1

Gene Symbol	Gene ID	Gene Info
E2F7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000165891.16	E2F transcription factor 7
E2F1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000101412.13	E2F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F7	hg38_v1_chr12_-_77065526_77065586	0.93	7.7e-04	Click!
E2F1	hg38_v1_chr20_-_33686371_33686407	0.52	1.9e-01	Click!

Activity profile of E2F7_E2F1 motif

Sorted Z-values of E2F7_E2F1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_35769928 Show fit	1.71	ENST00000373220.7 ENST00000520551.1	CLSPN Ensembl NCBI GeneCards UniProt NextProt Show fit	claspin
chr1_-_35769958 Show fit	1.39	ENST00000251195.9 ENST00000318121.8	CLSPN Ensembl NCBI GeneCards UniProt NextProt Show fit	claspin
chr12_-_77065526 Show fit	1.30	ENST00000547316.1 ENST00000416496.6 ENST00000550669.5 ENST00000322886.12	E2F7 Ensembl NCBI GeneCards UniProt NextProt Show fit	E2F transcription factor 7
chr13_+_32315468 Show fit	1.27	ENST00000530893.6 ENST00000380152.8	BRCA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	BRCA2 DNA repair associated
chr13_-_109786567 Show fit	1.05	ENST00000375856.5	IRS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin receptor substrate 2
chr1_-_52404387 Show fit	1.05	ENST00000371566.1 ENST00000371568.8	ORC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	origin recognition complex subunit 1
chr11_-_19241598 Show fit	1.04	ENST00000532666.1 ENST00000527884.5 ENST00000620009.4	E2F8 Ensembl NCBI GeneCards UniProt NextProt Show fit	E2F transcription factor 8
chr5_+_126777112 Show fit	1.00	ENST00000261366.10 ENST00000492190.5 ENST00000395354.1	LMNB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin B1
chr7_-_73522278 Show fit	0.95	ENST00000404251.1 ENST00000339594.9	BAZ1B Ensembl NCBI GeneCards UniProt NextProt Show fit	bromodomain adjacent to zinc finger domain 1B
chr11_-_19240936 Show fit	0.90	ENST00000250024.9	E2F8 Ensembl NCBI GeneCards UniProt NextProt Show fit	E2F transcription factor 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F7_E2F1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
0.3	3.2	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.3	2.8	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.1	2.6	GO:0006270	DNA replication initiation(GO:0006270)
0.4	2.2	GO:1990426	homologous recombination-dependent replication fork processing(GO:1990426)
0.1	2.2	GO:0031055	chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.7	2.1	GO:0070510	regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.1	2.0	GO:0051290	protein heterotetramerization(GO:0051290)
0.3	1.9	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	1.8	GO:0007080	mitotic metaphase plate congression(GO:0007080)

Showing 1 to 10 of 409 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.8	GO:0042555	MCM complex(GO:0042555)
0.6	2.8	GO:0031436	BRCA1-BARD1 complex(GO:0031436)
0.2	2.5	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.7	2.2	GO:0033593	BRCA2-MAGE-D1 complex(GO:0033593)
0.3	2.2	GO:0000796	condensin complex(GO:0000796)
0.1	2.1	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	2.0	GO:0000776	kinetochore(GO:0000776)
0.3	1.6	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	1.6	GO:0015030	Cajal body(GO:0015030)
0.0	1.6	GO:0010494	cytoplasmic stress granule(GO:0010494)

Showing 1 to 10 of 180 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	2.9	GO:0001047	core promoter binding(GO:0001047)
0.3	2.7	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	2.5	GO:0003684	damaged DNA binding(GO:0003684)
0.3	2.2	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.2	2.0	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	1.9	GO:0004386	helicase activity(GO:0004386)
0.3	1.6	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	1.6	GO:0031491	nucleosome binding(GO:0031491)
0.1	1.4	GO:0035173	histone kinase activity(GO:0035173)

Showing 1 to 10 of 265 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	6.1	PID ATR PATHWAY	ATR signaling pathway
0.0	5.6	PID E2F PATHWAY	E2F transcription factor network
0.1	1.8	PID ATM PATHWAY	ATM pathway
0.0	1.7	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.5	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.1	PID EPO PATHWAY	EPO signaling pathway
0.0	1.0	PID BARD1 PATHWAY	BARD1 signaling events

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2	3.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	3.1	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	3.0	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	2.1	REACTOME MEIOSIS	Genes involved in Meiosis
0.0	2.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	2.0	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.1	1.9	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	1.8	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	1.7	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere

Showing 1 to 10 of 80 entries

Results for E2F7_E2F1

Z-value: 2.71

Motif logo

Transcription factors associated with E2F7_E2F1

Activity-expression correlation:

Activity profile of E2F7_E2F1 motif

Sorted Z-values of E2F7_E2F1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F7_E2F1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: