Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for EBF1
Z-value: 2.93
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg38_v1_chr5_-_159099684_159099698, hg38_v1_chr5_-_159099745_159099789 | -0.20 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_35115912 Show fit | 4.31 |
ENST00000603181.5
|
FXYD domain containing ion transport regulator 3 |
|
| chr19_-_50952942 Show fit | 4.07 |
ENST00000594846.1
ENST00000336334.8 |
kallikrein related peptidase 5 |
|
| chr19_+_35248994 Show fit | 2.66 |
ENST00000427250.5
ENST00000605618.6 |
lipolysis stimulated lipoprotein receptor |
|
| chr16_-_68236069 Show fit | 2.50 |
ENST00000473183.7
ENST00000565858.5 |
epithelial splicing regulatory protein 2 |
|
| chr19_+_35248879 Show fit | 2.50 |
ENST00000347609.8
|
lipolysis stimulated lipoprotein receptor |
|
| chr19_+_35248728 Show fit | 2.49 |
ENST00000602003.1
ENST00000360798.7 ENST00000354900.7 |
lipolysis stimulated lipoprotein receptor |
|
| chr19_+_35115872 Show fit | 2.45 |
ENST00000435734.6
|
FXYD domain containing ion transport regulator 3 |
|
| chr6_+_36130484 Show fit | 2.44 |
ENST00000373766.9
ENST00000211287.9 |
mitogen-activated protein kinase 13 |
|
| chr20_+_59628609 Show fit | 2.18 |
ENST00000541461.5
|
phosphatase and actin regulator 3 |
|
| chr12_-_57767057 Show fit | 2.11 |
ENST00000228606.9
|
cytochrome P450 family 27 subfamily B member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 10.9 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.7 | 9.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.1 | 7.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.6 | 5.5 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 5.1 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 4.0 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.6 | 3.8 | GO:1903284 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 3.4 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.1 | 3.2 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 2.9 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 12.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 1.0 | 9.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.3 | 6.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 6.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 6.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 6.3 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.1 | 4.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 3.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 3.7 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 3.5 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 9.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.5 | 6.8 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.8 | 5.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 4.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 4.4 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 4.0 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.6 | 3.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 3.4 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.1 | 3.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 4.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 3.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.0 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 2.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.7 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.6 | PID EPO PATHWAY | EPO signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.1 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 3.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 3.0 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.8 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.6 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 2.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.0 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |