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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for EVX2

Z-value: 0.50

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 even-skipped homeobox 2

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_115504389 0.41 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr3_+_111999189 0.39 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111998915 0.37 ENST00000478951.6
TAGLN3
transgelin 3
chr3_+_111998739 0.36 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr1_+_27934980 0.36 ENST00000373894.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr3_+_111999326 0.35 ENST00000494932.1
TAGLN3
transgelin 3
chr1_+_27935110 0.34 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr6_+_132538290 0.32 ENST00000434551.2
TAAR9
trace amine associated receptor 9
chr4_+_76435216 0.31 ENST00000296043.7
SHROOM3
shroom family member 3
chr1_-_99766620 0.29 ENST00000646001.2
FRRS1
ferric chelate reductase 1
chr11_+_65787056 0.25 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chr4_+_143433491 0.24 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr20_-_51802433 0.18 ENST00000395997.3
SALL4
spalt like transcription factor 4
chr20_-_51802509 0.18 ENST00000371539.7
ENST00000217086.9
SALL4
spalt like transcription factor 4
chr1_+_27935022 0.18 ENST00000411604.5
ENST00000373888.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr4_+_112860981 0.17 ENST00000671704.1
ANK2
ankyrin 2
chr4_+_112861053 0.17 ENST00000672221.1
ANK2
ankyrin 2
chr4_+_112860912 0.16 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_94974984 0.15 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr4_-_73620629 0.15 ENST00000342081.7
RASSF6
Ras association domain family member 6
chr6_-_111606260 0.09 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr1_+_160190567 0.06 ENST00000368078.8
CASQ1
calsequestrin 1
chr17_+_18183803 0.05 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr6_-_111605859 0.04 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr12_+_28257195 0.04 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr12_-_53336342 0.03 ENST00000537210.2
ENST00000536324.4
SP7
Sp7 transcription factor
chr17_-_42185452 0.02 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr21_-_31160904 0.01 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr20_+_31879798 0.01 ENST00000620043.4
TTLL9
tubulin tyrosine ligase like 9
chr5_-_97142579 0.01 ENST00000274382.9
LIX1
limb and CNS expressed 1
chr17_-_10026265 0.00 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr8_+_91249307 0.00 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7

Network of associatons between targets according to the STRING database.

First level regulatory network of EVX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1901993 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0045176 apical protein localization(GO:0045176)
0.0 0.2 GO:1902731 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.0 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)