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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for FOSL1

Z-value: 2.03

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Transcription factors associated with FOSL1

Gene Symbol Gene ID Gene Info
ENSG00000175592.9 FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOSL1hg38_v1_chr11_-_65900375_659003970.561.5e-01Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_23873000 9.64 ENST00000269217.11
ENST00000587184.5
laminin subunit alpha 3
chr1_+_183186238 6.61 ENST00000493293.5
ENST00000264144.5
laminin subunit gamma 2
chr3_-_151316795 6.54 ENST00000260843.5
G protein-coupled receptor 87
chr18_+_63887698 4.54 ENST00000457692.5
ENST00000299502.9
ENST00000413956.5
serpin family B member 2
chr19_-_35513641 4.41 ENST00000339686.8
ENST00000447113.6
dermokine
chr19_-_35501878 4.35 ENST00000593342.5
ENST00000601650.1
ENST00000408915.6
dermokine
chr19_-_51020154 4.35 ENST00000391805.5
ENST00000599077.1
kallikrein related peptidase 10
chr11_+_394196 4.31 ENST00000331563.7
ENST00000531857.1
plakophilin 3
chr1_+_153031195 4.30 ENST00000307098.5
small proline rich protein 1B
chr19_-_51020019 4.17 ENST00000309958.7
kallikrein related peptidase 10
chr2_+_47369301 4.15 ENST00000263735.9
epithelial cell adhesion molecule
chr17_-_41612757 3.96 ENST00000301653.9
ENST00000593067.1
keratin 16
chr15_+_40239042 3.70 ENST00000558055.5
ENST00000455577.6
p21 (RAC1) activated kinase 6
chr15_+_40239420 3.59 ENST00000560346.5
p21 (RAC1) activated kinase 6
chr1_+_34755039 3.42 ENST00000338513.1
gap junction protein beta 5
chr6_+_47698574 3.37 ENST00000283303.3
adhesion G protein-coupled receptor F4
chr17_-_41518878 3.36 ENST00000254043.8
keratin 15
chr6_+_47698538 3.32 ENST00000327753.7
adhesion G protein-coupled receptor F4
chr20_+_46008900 3.12 ENST00000372330.3
matrix metallopeptidase 9
chr11_-_102798148 3.04 ENST00000315274.7
matrix metallopeptidase 1
chr18_+_63775369 2.96 ENST00000540675.5
serpin family B member 7
chr18_+_63775395 2.91 ENST00000398019.7
serpin family B member 7
chr15_+_40239857 2.76 ENST00000260404.8
p21 (RAC1) activated kinase 6
chr6_+_125219804 2.69 ENST00000524679.1
TPD52 like 1
chr19_-_291132 2.53 ENST00000327790.7
phospholipid phosphatase 2
chr8_+_119208322 2.41 ENST00000614891.5
mal, T cell differentiation protein 2
chr6_+_130366281 2.36 ENST00000617887.4
transmembrane protein 200A
chr5_+_148203024 2.33 ENST00000325630.3
serine peptidase inhibitor Kazal type 6
chr14_-_94388589 2.28 ENST00000402629.1
ENST00000556091.1
ENST00000393087.9
ENST00000554720.1
serpin family A member 1
chr6_+_130365958 2.27 ENST00000296978.4
transmembrane protein 200A
chr2_+_219627565 2.23 ENST00000273063.10
solute carrier family 4 member 3
chr2_+_219627650 2.19 ENST00000317151.7
solute carrier family 4 member 3
chr2_+_219627394 2.16 ENST00000373760.6
solute carrier family 4 member 3
chr2_+_219627622 2.16 ENST00000358055.8
solute carrier family 4 member 3
chr7_+_73830988 2.13 ENST00000340958.4
claudin 4
chr4_+_83535914 2.12 ENST00000611707.4
glycerol-3-phosphate acyltransferase 3
chr1_-_12616762 2.08 ENST00000464917.5
dehydrogenase/reductase 3
chr9_+_35673917 2.07 ENST00000617161.1
ENST00000378357.9
carbonic anhydrase 9
chr4_+_83536097 2.05 ENST00000395226.6
ENST00000264409.5
glycerol-3-phosphate acyltransferase 3
chr1_-_161021096 2.04 ENST00000537746.1
ENST00000368026.11
F11 receptor
chr11_+_10455292 2.03 ENST00000396553.6
adenosine monophosphate deaminase 3
chr5_+_145937793 2.03 ENST00000511217.1
SH3 domain containing ring finger 2
chr10_+_24466487 2.01 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr6_-_138107412 1.99 ENST00000421351.4
p53 apoptosis effector related to PMP22
chr1_-_28193873 1.98 ENST00000305392.3
ENST00000539896.1
platelet activating factor receptor
chr1_-_209651291 1.94 ENST00000391911.5
ENST00000415782.1
laminin subunit beta 3
chr10_-_5978022 1.93 ENST00000525219.6
interleukin 15 receptor subunit alpha
chr17_-_8118489 1.92 ENST00000380149.6
ENST00000448843.7
arachidonate lipoxygenase 3
chr1_+_152908538 1.88 ENST00000368764.4
involucrin
chr1_+_61952283 1.88 ENST00000307297.8
PATJ crumbs cell polarity complex component
chr1_+_61952036 1.86 ENST00000646453.1
ENST00000635137.1
PATJ crumbs cell polarity complex component
chr10_-_5977589 1.84 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
interleukin 15 receptor subunit alpha
chr13_+_77535669 1.79 ENST00000535157.5
sciellin
chr10_-_5977535 1.75 ENST00000379977.8
interleukin 15 receptor subunit alpha
chr6_+_106098933 1.74 ENST00000369089.3
PR/SET domain 1
chr11_+_35176575 1.71 ENST00000526000.6
CD44 molecule (Indian blood group)
chr15_+_40844018 1.71 ENST00000344051.8
ENST00000562057.6
serine peptidase inhibitor, Kunitz type 1
chr13_+_77535681 1.70 ENST00000349847.4
sciellin
chr13_+_77535742 1.69 ENST00000377246.7
sciellin
chr18_+_58221535 1.69 ENST00000431212.6
ENST00000586268.5
ENST00000587190.5
NEDD4 like E3 ubiquitin protein ligase
chr16_+_30740621 1.67 ENST00000615541.3
ENST00000483578.1
transmembrane protein 265
novel transcript
chr18_-_76495191 1.62 ENST00000443185.7
zinc finger protein 516
chr4_-_36244438 1.61 ENST00000303965.9
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_52949818 1.59 ENST00000546897.5
ENST00000552551.5
keratin 8
chr14_-_23155302 1.56 ENST00000529705.6
solute carrier family 7 member 8
chr6_+_137867241 1.54 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr5_+_35856883 1.54 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
interleukin 7 receptor
chr6_+_137867414 1.53 ENST00000237289.8
ENST00000433680.1
TNF alpha induced protein 3
chr22_+_44677044 1.52 ENST00000006251.11
proline rich 5
chr22_+_44677077 1.50 ENST00000403581.5
proline rich 5
chrX_-_33211540 1.49 ENST00000357033.9
dystrophin
chr22_+_44676808 1.48 ENST00000624862.3
proline rich 5
chr16_+_50266530 1.46 ENST00000566433.6
ENST00000394697.7
ENST00000673801.1
adenylate cyclase 7
chr5_-_1882902 1.45 ENST00000231357.7
iroquois homeobox 4
chr8_+_24913752 1.44 ENST00000518131.5
ENST00000221166.10
ENST00000437366.2
neurofilament medium
chr2_+_102001966 1.41 ENST00000457817.5
interleukin 1 receptor type 2
chr9_-_122228845 1.41 ENST00000394319.8
ENST00000340587.7
LIM homeobox 6
chr6_+_47656436 1.40 ENST00000507065.5
ENST00000296862.5
adhesion G protein-coupled receptor F2
chr3_-_98522514 1.36 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
claudin domain containing 1
chr2_+_113117889 1.35 ENST00000361779.7
ENST00000259206.9
ENST00000354115.6
interleukin 1 receptor antagonist
chr1_-_153549120 1.35 ENST00000368712.1
S100 calcium binding protein A3
chr17_-_41624541 1.34 ENST00000540235.5
ENST00000311208.13
keratin 17
chr9_-_23826299 1.33 ENST00000380117.5
ELAV like RNA binding protein 2
chr1_-_153057504 1.33 ENST00000392653.3
small proline rich protein 2A
chr16_+_57628507 1.30 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
adhesion G protein-coupled receptor G1
chr5_+_136059151 1.29 ENST00000503087.1
transforming growth factor beta induced
chr5_-_135578983 1.29 ENST00000512158.6
C-X-C motif chemokine ligand 14
chr5_+_148202771 1.29 ENST00000514389.5
ENST00000621437.4
serine peptidase inhibitor Kazal type 6
chr1_-_153549238 1.28 ENST00000368713.8
S100 calcium binding protein A3
chr12_-_94616061 1.28 ENST00000551457.1
transmembrane and coiled-coil domain family 3
chr9_-_137054016 1.28 ENST00000312665.7
ENST00000355097.7
ectonucleoside triphosphate diphosphohydrolase 2
chr17_+_75721471 1.25 ENST00000450894.7
integrin subunit beta 4
chr1_-_153041111 1.25 ENST00000360379.4
small proline rich protein 2D
chr6_+_41637005 1.24 ENST00000419164.6
ENST00000373051.6
MyoD family inhibitor
chr17_-_41586887 1.23 ENST00000167586.7
keratin 14
chr19_+_7888499 1.22 ENST00000618098.4
ENST00000306708.11
ENST00000600345.1
ENST00000598224.5
leucine rich repeat containing 8 VRAC subunit E
chr14_+_96256194 1.19 ENST00000216629.11
ENST00000553356.1
bradykinin receptor B1
chr17_+_75721327 1.16 ENST00000579662.5
integrin subunit beta 4
chr12_+_56079843 1.15 ENST00000549282.5
ENST00000549061.5
ENST00000683059.1
erb-b2 receptor tyrosine kinase 3
chr16_+_57628684 1.15 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
adhesion G protein-coupled receptor G1
chr19_+_38789198 1.15 ENST00000314980.5
galectin 7B
chr15_+_88639009 1.14 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr1_+_24319511 1.14 ENST00000356046.6
grainyhead like transcription factor 3
chr17_+_57085092 1.13 ENST00000575322.1
ENST00000337714.8
A-kinase anchoring protein 1
chr1_+_24319342 1.13 ENST00000361548.9
grainyhead like transcription factor 3
chr15_-_44194407 1.13 ENST00000484674.5
FERM domain containing 5
chr19_-_35528221 1.11 ENST00000588674.5
ENST00000452271.7
ENST00000518157.1
suprabasin
chr6_+_150721073 1.11 ENST00000358517.6
pleckstrin homology and RhoGEF domain containing G1
chr1_-_6602885 1.08 ENST00000377663.3
kelch like family member 21
chr12_+_56338873 1.07 ENST00000228534.6
interleukin 23 subunit alpha
chr15_+_88638947 1.06 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr1_-_94541636 1.06 ENST00000370207.4
coagulation factor III, tissue factor
chr1_-_6602859 1.02 ENST00000377658.8
kelch like family member 21
chr17_-_41786688 1.01 ENST00000310706.9
ENST00000393931.8
ENST00000424457.5
ENST00000591690.5
junction plakoglobin
chr12_-_95116967 0.98 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr11_+_128694052 0.98 ENST00000527786.7
ENST00000534087.3
Fli-1 proto-oncogene, ETS transcription factor
chr4_+_75556048 0.98 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
odontogenesis associated phosphoprotein
chr11_+_128693887 0.96 ENST00000281428.12
Fli-1 proto-oncogene, ETS transcription factor
chr2_-_142131004 0.96 ENST00000434794.1
ENST00000389484.8
LDL receptor related protein 1B
chr1_-_94541746 0.95 ENST00000334047.12
coagulation factor III, tissue factor
chr16_-_2858154 0.95 ENST00000571228.1
ENST00000161006.8
serine protease 22
chr5_+_136058849 0.93 ENST00000508076.5
transforming growth factor beta induced
chr17_+_32444379 0.93 ENST00000578213.5
ENST00000649012.1
ENST00000457654.6
ENST00000579451.1
ENST00000261712.8
proteasome 26S subunit, non-ATPase 11
chr7_+_48088596 0.91 ENST00000416681.5
ENST00000331803.8
ENST00000432131.5
uridine phosphorylase 1
chr17_+_76385256 0.91 ENST00000392496.3
sphingosine kinase 1
chr17_-_29176752 0.91 ENST00000533112.5
myosin XVIIIA
chr11_+_35176611 0.90 ENST00000279452.10
CD44 molecule (Indian blood group)
chr18_+_58196736 0.87 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr17_+_21288029 0.86 ENST00000526076.6
ENST00000361818.9
ENST00000316920.10
mitogen-activated protein kinase kinase 3
chr10_-_5977492 0.85 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
interleukin 15 receptor subunit alpha
chr18_+_31376777 0.84 ENST00000308128.9
ENST00000359747.4
desmoglein 4
chr17_-_41140487 0.84 ENST00000345847.4
keratin associated protein 4-6
chr4_-_122621011 0.83 ENST00000611104.2
ENST00000648588.1
interleukin 21
chr17_-_19004727 0.81 ENST00000388995.11
family with sequence similarity 83 member G
chr11_-_75490725 0.80 ENST00000529721.5
glycerophosphodiester phosphodiesterase domain containing 5
chr12_-_104958268 0.78 ENST00000432951.1
ENST00000258538.8
ENST00000415674.1
ENST00000424946.1
ENST00000433540.5
solute carrier family 41 member 2
chr1_+_26863140 0.78 ENST00000339276.6
stratifin
chr2_+_86441341 0.76 ENST00000312912.10
ENST00000409064.5
lysine demethylase 3A
chr3_+_113211539 0.76 ENST00000682979.1
ENST00000485230.5
BOC cell adhesion associated, oncogene regulated
chr6_+_106086316 0.75 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr1_-_43285559 0.75 ENST00000523677.6
chromosome 1 open reading frame 210
chr6_-_44265541 0.74 ENST00000619360.6
NFKB inhibitor epsilon
chr2_-_165794190 0.74 ENST00000392701.8
ENST00000422973.1
polypeptide N-acetylgalactosaminyltransferase 3
chrX_-_155334580 0.72 ENST00000369449.7
ENST00000321926.4
chloride intracellular channel 2
chr7_-_945799 0.72 ENST00000611167.4
ArfGAP with dual PH domains 1
chr18_-_31162849 0.72 ENST00000257197.7
ENST00000257198.6
desmocollin 1
chr5_-_79514127 0.71 ENST00000334082.11
homer scaffold protein 1
chr3_-_122793772 0.68 ENST00000306103.3
HSPB1 associated protein 1
chr16_-_72172135 0.68 ENST00000537465.5
ENST00000237353.15
polyamine modulated factor 1 binding protein 1
chr21_-_35049238 0.66 ENST00000416754.1
ENST00000437180.5
ENST00000455571.5
ENST00000675419.1
RUNX family transcription factor 1
chr9_+_121567057 0.64 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr5_-_140633690 0.64 ENST00000512545.1
ENST00000401743.6
CD14 molecule
chr2_+_232697362 0.64 ENST00000482666.5
ENST00000483164.5
ENST00000490229.5
ENST00000464805.5
ENST00000489328.1
GRB10 interacting GYF protein 2
chr17_-_45425620 0.64 ENST00000376922.6
Rho GTPase activating protein 27
chr1_+_22007450 0.64 ENST00000400271.2
chymotrypsin like elastase 3A
chr1_-_155978144 0.63 ENST00000313695.11
ENST00000497907.5
Rho/Rac guanine nucleotide exchange factor 2
chr11_+_34622053 0.62 ENST00000530286.5
ENST00000533754.5
ETS homologous factor
chr11_+_706222 0.61 ENST00000318562.13
ENST00000533500.5
EPS8 like 2
chr19_-_43781249 0.61 ENST00000615047.4
potassium calcium-activated channel subfamily N member 4
chr10_+_102395693 0.61 ENST00000652277.1
ENST00000189444.11
ENST00000661543.1
nuclear factor kappa B subunit 2
chr17_-_31314040 0.61 ENST00000330927.5
ecotropic viral integration site 2B
chr6_+_32153441 0.60 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr8_-_142769785 0.59 ENST00000521396.1
ENST00000317543.12
secreted LY6/PLAUR domain containing 2
chr11_+_706117 0.59 ENST00000533256.5
ENST00000614442.4
EPS8 like 2
chr21_-_35049327 0.58 ENST00000300305.7
RUNX family transcription factor 1
chr22_+_39520553 0.58 ENST00000674920.3
ENST00000679776.1
ENST00000675582.2
ENST00000337304.2
ENST00000676346.2
ENST00000396680.3
ENST00000680446.1
ENST00000674568.2
ENST00000680748.1
ENST00000674835.2
activating transcription factor 4
chr2_-_164841410 0.57 ENST00000342193.8
ENST00000375458.6
cordon-bleu WH2 repeat protein like 1
chr8_-_124372686 0.57 ENST00000297632.8
transmembrane protein 65
chr13_-_35855627 0.57 ENST00000379893.5
doublecortin like kinase 1
chr11_-_129024157 0.56 ENST00000392657.7
Rho GTPase activating protein 32
chr16_-_30113528 0.56 ENST00000406256.8
glycerophosphodiester phosphodiesterase domain containing 3
chr19_-_55370455 0.56 ENST00000264563.7
ENST00000585513.1
ENST00000590625.5
interleukin 11
chr13_-_103066411 0.55 ENST00000245312.5
solute carrier family 10 member 2
chr11_+_35176696 0.55 ENST00000528455.5
CD44 molecule (Indian blood group)
chr12_-_8066331 0.55 ENST00000546241.1
ENST00000307637.5
complement C3a receptor 1
chr22_-_32464440 0.55 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPI fold containing family C
chr19_-_35490456 0.54 ENST00000338897.4
ENST00000484218.6
keratinocyte differentiation associated protein
chr3_+_57060658 0.54 ENST00000334325.2
spermatogenesis associated 12
chr3_-_191282383 0.54 ENST00000427544.6
urotensin 2B
chr19_-_43780957 0.54 ENST00000648319.1
potassium calcium-activated channel subfamily N member 4
chr11_+_35176639 0.53 ENST00000527889.6
CD44 molecule (Indian blood group)
chr11_+_706196 0.52 ENST00000534755.5
ENST00000650127.1
EPS8 like 2
chr12_+_8989612 0.51 ENST00000266551.8
killer cell lectin like receptor G1
chr12_+_8989535 0.50 ENST00000356986.8
killer cell lectin like receptor G1
chr1_-_100132892 0.49 ENST00000287482.6
SAS-6 centriolar assembly protein
chr15_-_48963912 0.49 ENST00000332408.9
SHC adaptor protein 4
chr3_+_4814528 0.49 ENST00000478515.2
ENST00000649139.1
ENST00000647685.1
ENST00000649908.1
inositol 1,4,5-trisphosphate receptor type 1
chr12_-_53232182 0.49 ENST00000425354.7
ENST00000546717.1
ENST00000394426.5
retinoic acid receptor gamma
chr17_-_47851155 0.48 ENST00000536300.2
Sp6 transcription factor
chr6_-_30717264 0.47 ENST00000376406.8
mediator of DNA damage checkpoint 1
chr12_-_39443390 0.47 ENST00000361961.7
kinesin family member 21A
chr2_-_18589536 0.47 ENST00000416783.1
ENST00000359846.6
ENST00000304081.8
ENST00000532967.5
ENST00000444297.2
5'-nucleotidase, cytosolic IB
NT5C1B-RDH14 readthrough
chr2_+_219253243 0.46 ENST00000490341.3
tubulin alpha 4b
chr11_+_20599602 0.45 ENST00000525748.6
solute carrier family 6 member 5
chr6_+_138161932 0.44 ENST00000251691.5
ARFGEF family member 3
chr18_+_44700796 0.44 ENST00000677130.1
SET binding protein 1
chr3_-_98522869 0.43 ENST00000502288.5
ENST00000512147.5
ENST00000341181.11
ENST00000510541.5
ENST00000503621.5
ENST00000511081.5
ENST00000507874.5
ENST00000502299.5
ENST00000508659.5
ENST00000510545.5
ENST00000511667.5
ENST00000394185.6
claudin domain containing 1
chr6_+_31114793 0.43 ENST00000259881.10
psoriasis susceptibility 1 candidate 1
chr11_-_47185840 0.43 ENST00000539589.5
ENST00000528462.5
protein kinase C and casein kinase substrate in neurons 3
chr14_+_93997296 0.43 ENST00000636493.2
coiled-coil domain containing 197

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:1903575 cornified envelope assembly(GO:1903575)
1.3 5.3 GO:0002159 desmosome assembly(GO:0002159)
1.2 5.9 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
1.0 3.1 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.8 3.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.8 2.5 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.8 21.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 4.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 2.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.5 2.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.5 1.4 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.5 1.9 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.4 2.0 GO:1903238 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of leukocyte tethering or rolling(GO:1903238)
0.4 3.1 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.4 1.4 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.4 1.4 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.3 2.0 GO:0006196 AMP catabolic process(GO:0006196)
0.3 2.0 GO:0002934 desmosome organization(GO:0002934)
0.3 4.6 GO:0038203 TORC2 signaling(GO:0038203)
0.3 10.9 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 6.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 0.9 GO:0046108 uridine metabolic process(GO:0046108)
0.3 0.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 0.9 GO:1903028 positive regulation of opsonization(GO:1903028)
0.3 3.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 1.3 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.3 0.8 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.2 3.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 0.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 0.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.2 0.7 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
0.2 1.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 1.1 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.2 4.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 0.6 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 2.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 0.7 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 1.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 2.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 0.6 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.2 9.6 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.5 GO:0036233 glycine import(GO:0036233)
0.1 17.9 GO:0070268 cornification(GO:0070268)
0.1 0.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 4.0 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.6 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 0.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 1.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.3 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.1 0.4 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.1 0.6 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 1.2 GO:0046541 saliva secretion(GO:0046541)
0.1 1.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.9 GO:0035897 proteolysis in other organism(GO:0035897)
0.1 1.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.3 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 1.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.4 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.2 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.1 0.7 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.1 0.3 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.1 1.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 2.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.0 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 0.1 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.2 GO:0002368 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) B cell selection(GO:0002339) B cell cytokine production(GO:0002368) type I hypersensitivity(GO:0016068)
0.1 0.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.1 1.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.4 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.2 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.2 GO:2000547 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 0.2 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.1 0.7 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.2 GO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.1 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 1.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.9 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.1 0.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.6 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.7 GO:0032329 serine transport(GO:0032329)
0.0 0.5 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:1901093 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.5 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669)
0.0 2.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0010265 SCF complex assembly(GO:0010265)
0.0 1.6 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 2.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.8 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 1.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.4 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 1.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741) regulation of NADP metabolic process(GO:1902031)
0.0 1.2 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.6 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 2.3 GO:0006953 acute-phase response(GO:0006953)
0.0 0.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 4.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.7 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.0 GO:1902688 regulation of NAD metabolic process(GO:1902688)
0.0 2.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.3 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.5 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0 0.6 GO:0098926 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)
0.0 4.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.5 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
0.0 0.4 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.5 GO:0007099 centriole replication(GO:0007099)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 11.6 GO:0005610 laminin-5 complex(GO:0005610)
1.3 6.6 GO:0043256 laminin complex(GO:0043256)
0.4 20.2 GO:0001533 cornified envelope(GO:0001533)
0.3 3.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 2.4 GO:0097451 glial limiting end-foot(GO:0097451)
0.3 2.1 GO:0005827 polar microtubule(GO:0005827)
0.2 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 4.6 GO:0031932 TORC2 complex(GO:0031932)
0.2 2.0 GO:0030057 desmosome(GO:0030057)
0.2 0.6 GO:1990032 parallel fiber(GO:1990032)
0.2 0.6 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.4 GO:0005922 connexon complex(GO:0005922)
0.1 1.5 GO:0016013 syntrophin complex(GO:0016013)
0.1 2.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 3.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.4 GO:0005883 neurofilament(GO:0005883)
0.1 0.3 GO:0034515 proteasome storage granule(GO:0034515)
0.1 1.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 0.3 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.2 GO:0033565 ESCRT-0 complex(GO:0033565)
0.1 0.5 GO:0098536 deuterosome(GO:0098536)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.3 GO:0005605 basal lamina(GO:0005605)
0.1 0.2 GO:0097444 spine apparatus(GO:0097444)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.1 4.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:1990917 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.0 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 8.5 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.1 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 4.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 1.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0005771 multivesicular body(GO:0005771)
0.0 1.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0008859 exoribonuclease II activity(GO:0008859)
0.7 4.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.5 1.4 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.4 2.5 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.4 8.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 1.9 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.4 8.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 0.9 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.3 3.6 GO:0038132 neuregulin binding(GO:0038132)
0.3 1.4 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.3 0.8 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.3 8.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 2.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 0.8 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.2 1.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 3.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 2.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 0.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.0 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 17.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 3.0 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 1.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.6 GO:0019534 toxin transporter activity(GO:0019534)
0.1 10.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.6 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 1.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 13.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.7 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 1.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 1.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.3 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 1.0 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0002135 CTP binding(GO:0002135)
0.0 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 8.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.4 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.4 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 8.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0019956 chemokine binding(GO:0019956)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.9 GO:0043531 ADP binding(GO:0043531)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 2.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 3.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.0 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 20.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 2.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 9.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 6.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 4.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.3 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 4.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 4.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 5.2 PID P73PATHWAY p73 transcription factor network
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.5 ST ADRENERGIC Adrenergic Pathway
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 0.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 0.9 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 23.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.2 3.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 3.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 0.6 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 2.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 8.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 2.0 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome