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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for FOXA1

Z-value: 0.93

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Transcription factors associated with FOXA1

Gene Symbol Gene ID Gene Info
FOXA1
ENSG00000129514.8 forkhead box A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXA1hg38_v1_chr14_-_37595224_37595281-0.265.3e-01Click!

Activity profile of FOXA1 motif

Sorted Z-values of FOXA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_91178520 1.41 ENST00000425043.5
ENST00000420120.6
ENST00000441303.6
ENST00000456569.2
DCN
decorin
chr9_-_92424427 1.21 ENST00000375550.5
OMD
osteomodulin
chr2_-_144516154 0.87 ENST00000637304.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_144516397 0.86 ENST00000638128.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_144431001 0.80 ENST00000636413.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_144430934 0.79 ENST00000638087.1
ENST00000638007.1
ZEB2
zinc finger E-box binding homeobox 2
chr5_-_41510623 0.77 ENST00000328457.5
PLCXD3
phosphatidylinositol specific phospholipase C X domain containing 3
chr5_-_41510554 0.76 ENST00000377801.8
PLCXD3
phosphatidylinositol specific phospholipase C X domain containing 3
chr21_-_26843063 0.72 ENST00000678221.1
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr21_-_26843012 0.72 ENST00000517777.6
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr8_-_119673368 0.63 ENST00000427067.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr6_-_117425905 0.61 ENST00000368507.8
ROS1
ROS proto-oncogene 1, receptor tyrosine kinase
chr10_+_122560639 0.61 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
DMBT1
deleted in malignant brain tumors 1
chr6_-_117425855 0.60 ENST00000368508.7
ROS1
ROS proto-oncogene 1, receptor tyrosine kinase
chr10_+_122560679 0.59 ENST00000657942.1
DMBT1
deleted in malignant brain tumors 1
chr8_+_69492793 0.56 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr10_+_122560751 0.56 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
DMBT1
deleted in malignant brain tumors 1
chrX_+_16946862 0.56 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr18_-_63158208 0.52 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr2_-_213151590 0.49 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKZF2
IKAROS family zinc finger 2
chr13_+_75760362 0.46 ENST00000534657.5
LMO7
LIM domain 7
chr1_+_222928415 0.45 ENST00000284476.7
DISP1
dispatched RND transporter family member 1
chr6_-_87095059 0.44 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr6_-_56843153 0.42 ENST00000361203.7
ENST00000523817.1
DST
dystonin
chr17_-_19748355 0.39 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr5_-_128339191 0.38 ENST00000507835.5
FBN2
fibrillin 2
chr9_-_20622479 0.37 ENST00000380338.9
MLLT3
MLLT3 super elongation complex subunit
chr2_+_172085499 0.37 ENST00000361725.5
ENST00000341900.6
DLX1
distal-less homeobox 1
chr9_-_120477354 0.36 ENST00000416449.5
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr3_+_69936583 0.35 ENST00000314557.10
ENST00000394351.9
MITF
melanocyte inducing transcription factor
chr6_+_108656346 0.34 ENST00000540898.1
FOXO3
forkhead box O3
chr13_+_75760659 0.31 ENST00000526202.5
ENST00000465261.6
LMO7
LIM domain 7
chr20_-_47355657 0.31 ENST00000311275.11
ZMYND8
zinc finger MYND-type containing 8
chr5_+_150778733 0.31 ENST00000526627.2
SMIM3
small integral membrane protein 3
chr3_+_141387801 0.30 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr9_-_86947496 0.29 ENST00000298743.9
GAS1
growth arrest specific 1
chr2_+_168901290 0.29 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr1_-_177970213 0.28 ENST00000464631.6
SEC16B
SEC16 homolog B, endoplasmic reticulum export factor
chr3_-_146161167 0.28 ENST00000360060.7
ENST00000282903.10
PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
chr13_+_75760431 0.27 ENST00000321797.12
LMO7
LIM domain 7
chr8_+_94895813 0.26 ENST00000396113.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr3_+_148827800 0.26 ENST00000282957.9
ENST00000468341.1
CPB1
carboxypeptidase B1
chr1_+_40247926 0.25 ENST00000372766.4
TMCO2
transmembrane and coiled-coil domains 2
chr5_+_102865805 0.25 ENST00000346918.7
PAM
peptidylglycine alpha-amidating monooxygenase
chr5_+_148394712 0.25 ENST00000513826.1
FBXO38
F-box protein 38
chr2_-_233013228 0.24 ENST00000264051.8
NGEF
neuronal guanine nucleotide exchange factor
chr15_+_96325935 0.24 ENST00000421109.6
NR2F2
nuclear receptor subfamily 2 group F member 2
chrX_+_86714623 0.24 ENST00000484479.1
DACH2
dachshund family transcription factor 2
chr4_+_54229261 0.24 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
PDGFRA
platelet derived growth factor receptor alpha
chr22_+_35066136 0.23 ENST00000308700.6
ENST00000404699.7
ISX
intestine specific homeobox
chr6_+_52420992 0.23 ENST00000636954.1
ENST00000636566.1
ENST00000638075.1
EFHC1
EF-hand domain containing 1
chr1_-_26913964 0.22 ENST00000254227.4
NR0B2
nuclear receptor subfamily 0 group B member 2
chr5_-_138338325 0.22 ENST00000510119.1
ENST00000513970.5
CDC25C
cell division cycle 25C
chr8_+_76681208 0.22 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr12_-_71157872 0.21 ENST00000546561.2
TSPAN8
tetraspanin 8
chr12_-_71157992 0.21 ENST00000247829.8
TSPAN8
tetraspanin 8
chr20_+_33235987 0.21 ENST00000375422.6
ENST00000375413.8
ENST00000354297.9
BPIFA1
BPI fold containing family A member 1
chr10_+_102776237 0.21 ENST00000369889.5
WBP1L
WW domain binding protein 1 like
chr12_+_103587266 0.21 ENST00000388887.7
STAB2
stabilin 2
chr9_+_6413191 0.20 ENST00000276893.10
UHRF2
ubiquitin like with PHD and ring finger domains 2
chr5_+_98769273 0.20 ENST00000308234.11
RGMB
repulsive guidance molecule BMP co-receptor b
chr16_-_87936529 0.19 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
CA5A
carbonic anhydrase 5A
chr18_+_75210789 0.19 ENST00000580243.3
TSHZ1
teashirt zinc finger homeobox 1
chr3_-_71583713 0.19 ENST00000649528.3
ENST00000471386.3
ENST00000493089.7
FOXP1
forkhead box P1
chr1_+_61082398 0.18 ENST00000664149.1
NFIA
nuclear factor I A
chrX_+_136648138 0.18 ENST00000370629.7
CD40LG
CD40 ligand
chr2_+_87748087 0.18 ENST00000359481.9
PLGLB2
plasminogen like B2
chr18_+_3449413 0.17 ENST00000549253.5
TGIF1
TGFB induced factor homeobox 1
chr2_+_151410090 0.17 ENST00000430328.6
RIF1
replication timing regulatory factor 1
chr1_+_61081728 0.17 ENST00000371189.8
NFIA
nuclear factor I A
chr7_+_134891566 0.17 ENST00000424922.5
ENST00000495522.1
CALD1
caldesmon 1
chrX_+_22032301 0.17 ENST00000379374.5
PHEX
phosphate regulating endopeptidase homolog X-linked
chrX_+_136648214 0.17 ENST00000370628.2
CD40LG
CD40 ligand
chr14_-_94323324 0.17 ENST00000341584.4
SERPINA6
serpin family A member 6
chr7_+_134745460 0.17 ENST00000436461.6
CALD1
caldesmon 1
chr2_+_203936755 0.17 ENST00000316386.11
ENST00000435193.1
ICOS
inducible T cell costimulator
chr19_+_38390055 0.16 ENST00000587947.5
ENST00000338502.8
SPRED3
sprouty related EVH1 domain containing 3
chr20_+_33007695 0.16 ENST00000170150.4
BPIFB2
BPI fold containing family B member 2
chr3_-_71583683 0.16 ENST00000649631.1
ENST00000648718.1
FOXP1
forkhead box P1
chr12_+_77830886 0.15 ENST00000397909.7
ENST00000549464.5
NAV3
neuron navigator 3
chr5_+_96662969 0.15 ENST00000514845.5
ENST00000675663.1
CAST
calpastatin
chr20_-_44521989 0.15 ENST00000342374.5
ENST00000255175.5
SERINC3
serine incorporator 3
chr4_+_164754116 0.15 ENST00000507311.1
SMIM31
small integral membrane protein 31
chr15_+_75043263 0.14 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr16_-_4846196 0.14 ENST00000589389.5
GLYR1
glyoxylate reductase 1 homolog
chr10_-_79560386 0.14 ENST00000372327.9
ENST00000417041.1
ENST00000640627.1
ENST00000372325.7
SFTPA2
surfactant protein A2
chr7_+_135148041 0.14 ENST00000275767.3
TMEM140
transmembrane protein 140
chr11_-_9265302 0.14 ENST00000328194.8
DENND5A
DENN domain containing 5A
chr13_+_50015438 0.14 ENST00000312942.2
KCNRG
potassium channel regulator
chr8_+_94895837 0.14 ENST00000519136.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr1_+_116111395 0.14 ENST00000684484.1
ENST00000369500.4
MAB21L3
mab-21 like 3
chr13_+_50015254 0.14 ENST00000360473.8
KCNRG
potassium channel regulator
chr6_+_73696145 0.13 ENST00000287097.6
CD109
CD109 molecule
chr6_+_73695779 0.13 ENST00000422508.6
ENST00000437994.6
CD109
CD109 molecule
chr16_+_4846652 0.13 ENST00000592120.5
UBN1
ubinuclein 1
chr12_-_55729660 0.13 ENST00000546457.1
ENST00000549117.5
CD63
CD63 molecule
chr12_+_96194365 0.13 ENST00000228741.8
ENST00000547249.1
ELK3
ETS transcription factor ELK3
chr1_+_61082553 0.13 ENST00000403491.8
ENST00000371187.7
NFIA
nuclear factor I A
chr13_-_45201027 0.13 ENST00000379108.2
KCTD4
potassium channel tetramerization domain containing 4
chr7_+_134891400 0.12 ENST00000393118.6
CALD1
caldesmon 1
chr5_-_134174765 0.12 ENST00000520417.1
SKP1
S-phase kinase associated protein 1
chr12_-_48004496 0.12 ENST00000337299.7
COL2A1
collagen type II alpha 1 chain
chr14_+_64504574 0.12 ENST00000358738.3
ZBTB1
zinc finger and BTB domain containing 1
chr11_+_121102666 0.12 ENST00000264037.2
TECTA
tectorin alpha
chr7_-_93226449 0.12 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr11_-_116792386 0.12 ENST00000433069.2
ENST00000542499.5
APOA5
apolipoprotein A5
chr8_+_94895763 0.11 ENST00000523378.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr12_+_96194501 0.11 ENST00000552142.5
ELK3
ETS transcription factor ELK3
chr21_-_42315336 0.11 ENST00000398431.2
ENST00000518498.3
TFF3
trefoil factor 3
chr18_+_3449620 0.11 ENST00000405385.7
TGIF1
TGFB induced factor homeobox 1
chr10_+_113709261 0.11 ENST00000672138.1
ENST00000452490.3
CASP7
caspase 7
chrX_-_48003949 0.11 ENST00000396965.5
ENST00000376943.8
ZNF182
zinc finger protein 182
chr5_+_96663010 0.10 ENST00000506811.5
ENST00000514055.5
ENST00000508608.6
CAST
calpastatin
chr12_-_120327762 0.10 ENST00000308366.9
ENST00000423423.3
PLA2G1B
phospholipase A2 group IB
chr3_-_149792547 0.10 ENST00000446160.7
ENST00000462519.3
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr1_-_56966133 0.10 ENST00000535057.5
ENST00000543257.5
C8B
complement C8 beta chain
chr18_+_75210755 0.10 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr4_-_154612635 0.10 ENST00000407946.5
ENST00000405164.5
ENST00000336098.8
ENST00000393846.6
ENST00000404648.7
ENST00000443553.5
FGG
fibrinogen gamma chain
chr22_-_17219571 0.09 ENST00000610390.4
ADA2
adenosine deaminase 2
chr2_-_55334529 0.09 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr20_+_45791930 0.09 ENST00000372622.8
DNTTIP1
deoxynucleotidyltransferase terminal interacting protein 1
chr11_-_102530738 0.09 ENST00000260227.5
MMP7
matrix metallopeptidase 7
chr19_+_49877660 0.09 ENST00000535102.6
TBC1D17
TBC1 domain family member 17
chr14_+_64503943 0.09 ENST00000556965.1
ENST00000554015.5
ZBTB1
zinc finger and BTB domain containing 1
chr22_-_40533808 0.09 ENST00000422851.1
ENST00000651694.1
ENST00000652095.2
MRTFA
myocardin related transcription factor A
chr10_+_89332484 0.09 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
IFIT3
interferon induced protein with tetratricopeptide repeats 3
chr19_+_49877694 0.09 ENST00000221543.10
TBC1D17
TBC1 domain family member 17
chr11_-_124752247 0.09 ENST00000326621.10
VSIG2
V-set and immunoglobulin domain containing 2
chr19_-_48390847 0.09 ENST00000597017.5
KDELR1
KDEL endoplasmic reticulum protein retention receptor 1
chrX_+_130339941 0.09 ENST00000218197.9
SLC25A14
solute carrier family 25 member 14
chr1_-_56966006 0.09 ENST00000371237.9
C8B
complement C8 beta chain
chr1_-_152360004 0.08 ENST00000388718.5
FLG2
filaggrin family member 2
chr1_+_43389889 0.08 ENST00000562955.2
ENST00000634258.3
SZT2
SZT2 subunit of KICSTOR complex
chr2_-_87021844 0.08 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr11_-_26722051 0.08 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr12_+_120978537 0.08 ENST00000257555.11
ENST00000400024.6
HNF1A
HNF1 homeobox A
chr19_+_42302098 0.08 ENST00000598490.1
ENST00000341747.8
PRR19
proline rich 19
chr11_-_31812171 0.08 ENST00000639409.1
ENST00000640975.1
PAX6
paired box 6
chr10_-_31031911 0.08 ENST00000375311.1
ENST00000413025.5
ENST00000436087.6
ENST00000452305.5
ENST00000442986.5
ZNF438
zinc finger protein 438
chr22_-_17219424 0.08 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
ADA2
adenosine deaminase 2
chr3_-_52231190 0.08 ENST00000494383.1
ENSG00000173366.11
novel twinfilin, actin-binding protein, homolog 2 (Drosophila) (TWF2) and toll-like receptor 9 (TLR9) protein
chr1_-_244860376 0.08 ENST00000638716.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr1_+_200027605 0.08 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr17_-_41315706 0.08 ENST00000334202.5
KRTAP17-1
keratin associated protein 17-1
chr4_+_74308463 0.07 ENST00000413830.6
EPGN
epithelial mitogen
chr6_-_89315291 0.07 ENST00000402938.4
GABRR2
gamma-aminobutyric acid type A receptor subunit rho2
chr3_+_108602776 0.07 ENST00000497905.5
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chrX_+_38006551 0.07 ENST00000297875.7
SYTL5
synaptotagmin like 5
chr17_-_42745025 0.07 ENST00000592492.5
ENST00000585893.5
ENST00000593214.5
ENST00000590078.5
ENST00000428826.7
ENST00000586382.5
ENST00000415827.6
ENST00000592743.5
ENST00000586089.5
EZH1
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr11_+_35662739 0.07 ENST00000299413.7
TRIM44
tripartite motif containing 44
chr4_+_169660062 0.07 ENST00000507875.5
ENST00000613795.4
CLCN3
chloride voltage-gated channel 3
chr16_-_49664225 0.07 ENST00000535559.5
ZNF423
zinc finger protein 423
chr1_-_120100688 0.07 ENST00000652264.1
NOTCH2
notch receptor 2
chrX_+_130339886 0.07 ENST00000543953.5
ENST00000612248.4
ENST00000424447.5
ENST00000545805.6
SLC25A14
solute carrier family 25 member 14
chr15_+_71096941 0.07 ENST00000355327.7
THSD4
thrombospondin type 1 domain containing 4
chr2_+_102473219 0.07 ENST00000295269.5
SLC9A4
solute carrier family 9 member A4
chr2_+_151409878 0.07 ENST00000453091.6
ENST00000428287.6
ENST00000444746.7
ENST00000243326.9
ENST00000414861.6
RIF1
replication timing regulatory factor 1
chr7_+_77840122 0.07 ENST00000450574.5
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr2_+_65056382 0.07 ENST00000377990.7
ENST00000537589.1
ENST00000260569.4
CEP68
centrosomal protein 68
chr1_+_74235377 0.07 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chr3_+_138010143 0.07 ENST00000183605.10
CLDN18
claudin 18
chr14_+_55661272 0.07 ENST00000555573.5
KTN1
kinectin 1
chr20_+_33168148 0.07 ENST00000354932.6
BPIFA2
BPI fold containing family A member 2
chr3_+_69936629 0.06 ENST00000394348.2
ENST00000531774.1
MITF
melanocyte inducing transcription factor
chr7_-_100100716 0.06 ENST00000354230.7
ENST00000425308.5
MCM7
minichromosome maintenance complex component 7
chr12_+_120978686 0.06 ENST00000541395.5
ENST00000544413.2
HNF1A
HNF1 homeobox A
chr3_+_137998735 0.06 ENST00000343735.8
CLDN18
claudin 18
chr4_+_55853639 0.06 ENST00000381295.7
ENST00000346134.11
ENST00000349598.6
EXOC1
exocyst complex component 1
chr1_-_216423396 0.06 ENST00000366942.3
ENST00000674083.1
ENST00000307340.8
USH2A
usherin
chr6_-_89217339 0.06 ENST00000454853.7
GABRR1
gamma-aminobutyric acid type A receptor subunit rho1
chr5_-_149379286 0.06 ENST00000261796.4
IL17B
interleukin 17B
chr2_-_171160833 0.06 ENST00000360843.7
ENST00000431350.7
TLK1
tousled like kinase 1
chr4_+_67558719 0.06 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr19_-_18791297 0.06 ENST00000542601.6
ENST00000222271.7
ENST00000425807.1
COMP
cartilage oligomeric matrix protein
chr19_+_49877425 0.06 ENST00000622860.4
TBC1D17
TBC1 domain family member 17
chr4_-_110198579 0.06 ENST00000302274.8
ELOVL6
ELOVL fatty acid elongase 6
chr11_+_844406 0.05 ENST00000397404.5
TSPAN4
tetraspanin 4
chr10_+_18400562 0.05 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr4_-_110198650 0.05 ENST00000394607.7
ELOVL6
ELOVL fatty acid elongase 6
chr5_+_96936071 0.05 ENST00000231368.10
LNPEP
leucyl and cystinyl aminopeptidase
chr1_+_43389874 0.05 ENST00000372450.8
SZT2
SZT2 subunit of KICSTOR complex
chr4_+_186266183 0.05 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
F11
coagulation factor XI
chr5_-_40755885 0.05 ENST00000636863.1
ENST00000637375.1
ENST00000337702.5
ENST00000636106.1
TTC33
tetratricopeptide repeat domain 33
chr4_-_163613505 0.05 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr7_+_117014881 0.05 ENST00000422922.5
ENST00000432298.5
ST7
suppression of tumorigenicity 7
chr1_-_94925759 0.05 ENST00000415017.1
ENST00000545882.5
CNN3
calponin 3
chr11_-_6440980 0.05 ENST00000265983.8
ENST00000615166.1
HPX
hemopexin
chr7_+_106865263 0.05 ENST00000440650.6
ENST00000496166.6
ENST00000473541.5
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr13_-_99258366 0.05 ENST00000397470.5
ENST00000397473.7
GPR18
G protein-coupled receptor 18
chr14_+_64504743 0.05 ENST00000683701.1
ZBTB1
zinc finger and BTB domain containing 1
chr6_-_42048648 0.05 ENST00000502771.1
ENST00000508143.5
ENST00000514588.1
ENST00000510503.5
CCND3
cyclin D3
chr22_-_21227637 0.05 ENST00000401924.5
GGT2
gamma-glutamyltransferase 2
chr3_-_45915698 0.04 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1
chr20_-_54070520 0.04 ENST00000371435.6
ENST00000395961.7
BCAS1
brain enriched myelin associated protein 1
chr9_-_14910421 0.04 ENST00000380880.4
FREM1
FRAS1 related extracellular matrix 1
chr11_+_1157946 0.04 ENST00000621226.2
MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr1_-_43389768 0.04 ENST00000372455.4
ENST00000372457.9
ENST00000290663.10
MED8
mediator complex subunit 8
chr12_-_68253502 0.04 ENST00000328087.6
ENST00000538666.6
IL22
interleukin 22
chr1_-_66801276 0.04 ENST00000304526.3
INSL5
insulin like 5
chr3_+_148730100 0.04 ENST00000474935.5
ENST00000475347.5
ENST00000461609.1
AGTR1
angiotensin II receptor type 1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.2 GO:0010966 regulation of phosphate transport(GO:0010966)
0.2 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.5 GO:0035638 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.1 0.5 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.4 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) regulation of amacrine cell differentiation(GO:1902869) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 0.3 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 1.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.3 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1 1.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.2 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.2 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.2 GO:0018032 protein amidation(GO:0018032)
0.1 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 0.3 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 0.2 GO:1900190 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0035565 regulation of pronephros size(GO:0035565)
0.0 0.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.4 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.4 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.2 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 0.3 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) regulation of microglial cell activation(GO:1903978)
0.0 0.1 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.0 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.5 GO:0072189 ureter development(GO:0072189)
0.0 0.0 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.0 0.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.0 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.3 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.0 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.0 GO:0051919 positive regulation of fibrinolysis(GO:0051919)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.4 GO:0031673 H zone(GO:0031673)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0001939 female pronucleus(GO:0001939) male pronucleus(GO:0001940)
0.0 0.7 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139) periciliary membrane compartment(GO:1990075)
0.0 0.0 GO:0070701 mucus layer(GO:0070701)
0.0 0.4 GO:0097431 pericentriolar material(GO:0000242) mitotic spindle pole(GO:0097431)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0032302 MutSalpha complex(GO:0032301) MutSbeta complex(GO:0032302)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0035375 zymogen binding(GO:0035375)
0.2 0.6 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 3.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0005046 KDEL sequence binding(GO:0005046)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.5 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 1.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0032143 double-strand/single-strand DNA junction binding(GO:0000406) single thymine insertion binding(GO:0032143) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide