ISMARA results: GAGGUAG

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GAGGUAG

Z-value: 1.11

Motif logo

miRNA associated with seed GAGGUAG

Name	miRBASE accession
hsa-let-7a-5p miRBase	MIMAT0000062
hsa-let-7b-5p miRBase	MIMAT0000063
hsa-let-7c-5p miRBase	MIMAT0000064
hsa-let-7d-5p miRBase	MIMAT0000065
hsa-let-7e-5p miRBase	MIMAT0000066
hsa-let-7f-5p miRBase	MIMAT0000067
hsa-let-7g-5p miRBase	MIMAT0000414
hsa-let-7i-5p miRBase	MIMAT0000415
hsa-miR-4458 miRBase	MIMAT0018980
hsa-miR-4500 miRBase	MIMAT0019036
hsa-miR-98-5p miRBase	MIMAT0000096

Activity profile of GAGGUAG motif

Sorted Z-values of GAGGUAG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_98268186 Show fit	2.61	ENST00000260702.4	LOXL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	lysyl oxidase like 4
chr1_-_242524687 Show fit	1.15	ENST00000442594.6 ENST00000536534.7	PLD5 Ensembl NCBI GeneCards UniProt NextProt Show fit	phospholipase D family member 5
chr5_+_167754918 Show fit	1.00	ENST00000519204.5	TENM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	teneurin transmembrane protein 2
chr12_+_72272360 Show fit	0.92	ENST00000547300.2 ENST00000261180.10	TRHDE Ensembl NCBI GeneCards UniProt NextProt Show fit	thyrotropin releasing hormone degrading enzyme
chr3_-_69386079 Show fit	0.89	ENST00000398540.8	FRMD4B Ensembl NCBI GeneCards UniProt NextProt Show fit	FERM domain containing 4B
chr1_-_9129085 Show fit	0.87	ENST00000377411.5	GPR157 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 157
chr1_-_153390976 Show fit	0.87	ENST00000368732.5 ENST00000368733.4	S100A8 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A8
chr1_+_59814939 Show fit	0.87	ENST00000371208.5	HOOK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hook microtubule tethering protein 1
chrX_+_37685773 Show fit	0.86	ENST00000378616.5	XK Ensembl NCBI GeneCards UniProt NextProt Show fit	X-linked Kx blood group
chr19_-_51020019 Show fit	0.82	ENST00000309958.7	KLK10 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein related peptidase 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GAGGUAG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0032119	sequestering of zinc ion(GO:0032119)
0.2	1.2	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.2	1.1	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0	1.1	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0	1.1	GO:0045022	early endosome to late endosome transport(GO:0045022)
0.2	1.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	1.0	GO:0097264	self proteolysis(GO:0097264)
0.1	0.9	GO:0031133	regulation of axon diameter(GO:0031133)
0.0	0.9	GO:0060019	radial glial cell differentiation(GO:0060019)
0.0	0.9	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)

Showing 1 to 10 of 149 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0070695	FHF complex(GO:0070695)
0.0	0.9	GO:0032433	filopodium tip(GO:0032433)
0.0	0.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.2	0.6	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	0.6	GO:0045179	apical cortex(GO:0045179)
0.1	0.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	0.5	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.5	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.5	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	0.4	GO:1990723	cytoplasmic periphery of the nuclear pore complex(GO:1990723)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	1.3	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	1.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.2	0.9	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1	0.9	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.9	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.9	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.1	0.8	GO:0070700	BMP receptor binding(GO:0070700)
0.2	0.7	GO:0008523	sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2	0.7	GO:0004939	beta-adrenergic receptor activity(GO:0004939)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.6	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
1.2	PID BMP PATHWAY	BMP receptor signaling
1.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.9	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.8	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.6	PID S1P S1P1 PATHWAY	S1P1 pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.5	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	1.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	0.8	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.7	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.7	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.7	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.7	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.6	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex

Showing 1 to 10 of 33 entries

Results for GAGGUAG

Z-value: 1.11

Motif logo

miRNA associated with seed GAGGUAG

Activity profile of GAGGUAG motif

Sorted Z-values of GAGGUAG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GAGGUAG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: