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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GLI2

Z-value: 1.19

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Transcription factors associated with GLI2

Gene Symbol Gene ID Gene Info
GLI2
ENSG00000074047.22 GLI family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLI2hg38_v1_chr2_+_120735848_1207358990.821.2e-02Click!

Activity profile of GLI2 motif

Sorted Z-values of GLI2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_118679637 1.88 ENST00000264029.9
ENST00000397925.2
TREH
trehalase
chr3_+_45026296 1.29 ENST00000296130.5
CLEC3B
C-type lectin domain family 3 member B
chr9_+_87497852 1.12 ENST00000408954.8
DAPK1
death associated protein kinase 1
chr9_+_87497675 1.05 ENST00000472284.5
ENST00000469640.6
DAPK1
death associated protein kinase 1
chr13_-_113410938 0.92 ENST00000682618.1
ADPRHL1
ADP-ribosylhydrolase like 1
chr2_+_200585987 0.92 ENST00000374700.7
AOX1
aldehyde oxidase 1
chrX_+_52184874 0.86 ENST00000599522.7
ENST00000471932.6
MAGED4
MAGE family member D4
chrX_+_52184904 0.85 ENST00000375626.7
ENST00000467526.1
MAGED4
MAGE family member D4
chrX_-_52069172 0.83 ENST00000486010.1
ENST00000497164.5
ENST00000360134.10
ENST00000485287.5
ENST00000335504.9
MAGED4B
MAGE family member D4B
chr12_-_55707865 0.82 ENST00000347027.10
ENST00000257879.11
ENST00000553804.6
ITGA7
integrin subunit alpha 7
chr21_-_43659460 0.81 ENST00000443485.1
ENST00000291560.7
HSF2BP
heat shock transcription factor 2 binding protein
chr14_-_52069228 0.78 ENST00000617139.4
NID2
nidogen 2
chr16_+_2830155 0.78 ENST00000382280.7
ZG16B
zymogen granule protein 16B
chr14_-_52069039 0.78 ENST00000216286.10
NID2
nidogen 2
chrX_-_107775951 0.72 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chr9_+_4490388 0.69 ENST00000262352.8
SLC1A1
solute carrier family 1 member 1
chr5_-_168883333 0.69 ENST00000404867.7
SLIT3
slit guidance ligand 3
chr16_+_2830179 0.64 ENST00000570670.5
ZG16B
zymogen granule protein 16B
chr6_+_71886900 0.63 ENST00000517960.5
ENST00000518273.5
ENST00000522291.5
ENST00000521978.5
ENST00000520567.5
ENST00000264839.11
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_132777371 0.61 ENST00000620483.4
SEPTIN8
septin 8
chr22_+_38982370 0.61 ENST00000402182.7
APOBEC3B
apolipoprotein B mRNA editing enzyme catalytic subunit 3B
chr18_-_28177934 0.60 ENST00000676445.1
CDH2
cadherin 2
chr17_-_5500997 0.60 ENST00000568641.2
ENSG00000286190.2
novel protein
chr9_-_111038425 0.59 ENST00000441240.1
ENST00000683809.1
LPAR1
lysophosphatidic acid receptor 1
chr16_+_2830295 0.58 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr16_+_2830368 0.58 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr21_-_26843063 0.56 ENST00000678221.1
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr21_-_26843012 0.56 ENST00000517777.6
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr16_+_88382950 0.56 ENST00000565624.3
ZNF469
zinc finger protein 469
chr10_-_48493641 0.53 ENST00000417247.6
ARHGAP22
Rho GTPase activating protein 22
chrX_+_9465011 0.53 ENST00000645353.2
TBL1X
transducin beta like 1 X-linked
chr15_+_41621134 0.52 ENST00000566718.6
MGA
MAX dimerization protein MGA
chr17_+_83079595 0.52 ENST00000320095.12
METRNL
meteorin like, glial cell differentiation regulator
chr9_-_111038061 0.51 ENST00000358883.8
LPAR1
lysophosphatidic acid receptor 1
chr22_-_24226112 0.51 ENST00000425408.5
GGT5
gamma-glutamyltransferase 5
chr5_-_132777215 0.51 ENST00000458488.2
SEPTIN8
septin 8
chr6_+_71886703 0.51 ENST00000491071.6
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_20382461 0.50 ENST00000380321.5
ENST00000629733.3
MLLT3
MLLT3 super elongation complex subunit
chr11_+_124739927 0.50 ENST00000284292.11
ENST00000412681.2
NRGN
neurogranin
chr20_-_31722854 0.49 ENST00000307677.5
BCL2L1
BCL2 like 1
chr9_-_111038037 0.49 ENST00000374431.7
LPAR1
lysophosphatidic acid receptor 1
chr19_+_18097763 0.48 ENST00000262811.10
MAST3
microtubule associated serine/threonine kinase 3
chr11_-_74311609 0.48 ENST00000331597.9
ENST00000427714.2
P4HA3
prolyl 4-hydroxylase subunit alpha 3
chr22_-_32255344 0.48 ENST00000266086.6
SLC5A4
solute carrier family 5 member 4
chr6_-_52577012 0.47 ENST00000182527.4
TRAM2
translocation associated membrane protein 2
chr9_-_136764515 0.47 ENST00000316144.6
LCN15
lipocalin 15
chr5_-_132777229 0.46 ENST00000378721.8
ENST00000378719.7
ENST00000378701.5
SEPTIN8
septin 8
chr10_-_37976589 0.46 ENST00000302609.8
ZNF25
zinc finger protein 25
chr5_-_132777344 0.46 ENST00000378706.5
SEPTIN8
septin 8
chr18_-_63319987 0.46 ENST00000398117.1
BCL2
BCL2 apoptosis regulator
chr17_-_19745369 0.46 ENST00000573368.5
ENST00000457500.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr16_+_31472130 0.45 ENST00000394863.8
ENST00000565360.5
ENST00000361773.7
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr22_+_38982341 0.45 ENST00000407298.7
ENST00000333467.4
APOBEC3B
apolipoprotein B mRNA editing enzyme catalytic subunit 3B
chr19_+_55647995 0.45 ENST00000593069.1
ENST00000308964.7
CCDC106
coiled-coil domain containing 106
chr3_-_120450981 0.44 ENST00000424703.6
ENST00000469005.1
ENST00000295633.8
FSTL1
follistatin like 1
chr15_+_41621492 0.44 ENST00000570161.6
MGA
MAX dimerization protein MGA
chr10_-_43574555 0.43 ENST00000374446.7
ENST00000535642.5
ENST00000426961.1
ZNF239
zinc finger protein 239
chr2_+_216633411 0.43 ENST00000233809.9
IGFBP2
insulin like growth factor binding protein 2
chr5_-_132777866 0.43 ENST00000448933.5
SEPTIN8
septin 8
chr19_+_55648198 0.43 ENST00000586790.6
ENST00000588740.5
ENST00000591578.5
CCDC106
coiled-coil domain containing 106
chr5_-_177497561 0.42 ENST00000359895.6
ENST00000355572.6
ENST00000393551.5
ENST00000505074.5
ENST00000393546.8
ENST00000355841.7
PDLIM7
PDZ and LIM domain 7
chr2_-_223838022 0.42 ENST00000444408.1
AP1S3
adaptor related protein complex 1 subunit sigma 3
chrX_+_7147819 0.41 ENST00000660000.2
STS
steroid sulfatase
chr1_-_241357085 0.41 ENST00000366564.5
RGS7
regulator of G protein signaling 7
chr17_-_75765136 0.40 ENST00000592997.6
ENST00000588479.6
ENST00000225614.6
GALK1
galactokinase 1
chr17_+_43006740 0.40 ENST00000438323.2
ENST00000415816.7
IFI35
interferon induced protein 35
chr11_+_65833944 0.40 ENST00000308342.7
SNX32
sorting nexin 32
chr5_-_132777404 0.39 ENST00000296873.11
SEPTIN8
septin 8
chr5_-_10761156 0.39 ENST00000432074.2
ENST00000230895.11
DAP
death associated protein
chr11_-_414948 0.38 ENST00000530494.1
ENST00000528209.5
ENST00000528058.1
ENST00000431843.7
SIGIRR
single Ig and TIR domain containing
chr5_+_134905100 0.38 ENST00000512783.5
ENST00000254908.11
PCBD2
pterin-4 alpha-carbinolamine dehydratase 2
chr19_+_40601342 0.37 ENST00000396819.8
LTBP4
latent transforming growth factor beta binding protein 4
chr3_-_165196689 0.37 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr10_+_102743938 0.37 ENST00000448841.7
WBP1L
WW domain binding protein 1 like
chrX_-_153446051 0.37 ENST00000370231.3
TREX2
three prime repair exonuclease 2
chr5_-_178627001 0.37 ENST00000611575.4
ENST00000520957.1
ENST00000316308.9
ENST00000611733.4
CLK4
CDC like kinase 4
chr17_-_35089212 0.35 ENST00000584655.5
ENST00000447669.6
ENST00000315249.11
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr19_+_57614211 0.35 ENST00000600344.1
ENST00000396161.10
ENST00000600883.1
ZNF134
zinc finger protein 134
chr10_-_13300051 0.35 ENST00000479604.1
ENST00000263038.9
PHYH
phytanoyl-CoA 2-hydroxylase
chr19_-_53254841 0.35 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
ZNF677
zinc finger protein 677
chr1_-_241357225 0.35 ENST00000366565.5
RGS7
regulator of G protein signaling 7
chr2_+_127423265 0.35 ENST00000402125.2
PROC
protein C, inactivator of coagulation factors Va and VIIIa
chr4_+_61202142 0.35 ENST00000514591.5
ADGRL3
adhesion G protein-coupled receptor L3
chr1_-_241357171 0.35 ENST00000440928.6
RGS7
regulator of G protein signaling 7
chr9_-_90642855 0.34 ENST00000637905.1
DIRAS2
DIRAS family GTPase 2
chr7_-_131556602 0.34 ENST00000322985.9
ENST00000378555.8
PODXL
podocalyxin like
chr20_+_36154630 0.34 ENST00000338074.7
ENST00000636016.2
ENST00000373945.5
EPB41L1
erythrocyte membrane protein band 4.1 like 1
chr5_+_173918186 0.34 ENST00000657000.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr19_-_53254688 0.34 ENST00000594517.5
ENST00000601413.5
ENST00000594681.5
ZNF677
zinc finger protein 677
chr2_-_43676406 0.34 ENST00000475092.4
C1GALT1C1L
C1GALT1 specific chaperone 1 like
chr17_+_7580442 0.34 ENST00000584180.1
CD68
CD68 molecule
chr5_-_88823763 0.33 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr1_-_25906457 0.33 ENST00000426559.6
STMN1
stathmin 1
chr5_+_141338753 0.33 ENST00000528330.2
ENST00000394576.3
PCDHGA2
protocadherin gamma subfamily A, 2
chr10_+_45000898 0.32 ENST00000298299.4
ZNF22
zinc finger protein 22
chr10_+_93993897 0.32 ENST00000371380.8
PLCE1
phospholipase C epsilon 1
chr5_+_149960719 0.32 ENST00000286298.5
ENST00000433184.1
SLC26A2
solute carrier family 26 member 2
chr2_-_70790643 0.32 ENST00000332372.6
FIGLA
folliculogenesis specific bHLH transcription factor
chr19_+_40611863 0.32 ENST00000601032.5
LTBP4
latent transforming growth factor beta binding protein 4
chr10_+_134465 0.32 ENST00000439456.5
ENST00000397962.8
ENST00000309776.8
ENST00000397959.7
ZMYND11
zinc finger MYND-type containing 11
chr20_+_45833792 0.32 ENST00000491381.6
ENST00000614929.4
ENST00000462307.5
SNX21
sorting nexin family member 21
chr3_-_9878765 0.31 ENST00000430427.6
ENST00000383817.5
ENST00000679265.1
CIDEC
cell death inducing DFFA like effector c
chr2_+_130611440 0.31 ENST00000409602.2
POTEJ
POTE ankyrin domain family member J
chr2_+_200440649 0.31 ENST00000366118.2
SPATS2L
spermatogenesis associated serine rich 2 like
chr19_+_48325323 0.30 ENST00000596315.5
EMP3
epithelial membrane protein 3
chr3_+_54123452 0.30 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr12_+_76764241 0.30 ENST00000550876.1
ZDHHC17
zinc finger DHHC-type palmitoyltransferase 17
chr5_+_173918216 0.30 ENST00000519467.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr5_-_177496802 0.30 ENST00000506161.5
PDLIM7
PDZ and LIM domain 7
chr4_+_678189 0.29 ENST00000507804.1
MYL5
myosin light chain 5
chr6_-_24910695 0.29 ENST00000643623.1
ENST00000538035.6
ENST00000647136.1
RIPOR2
RHO family interacting cell polarization regulator 2
chrX_+_9560465 0.29 ENST00000647060.1
TBL1X
transducin beta like 1 X-linked
chr20_-_41366805 0.29 ENST00000332312.4
EMILIN3
elastin microfibril interfacer 3
chr5_-_177496845 0.29 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7
chr6_-_53665748 0.29 ENST00000370905.4
KLHL31
kelch like family member 31
chr2_+_11155498 0.28 ENST00000402361.5
ENST00000428481.1
SLC66A3
solute carrier family 66 member 3
chr8_+_232416 0.28 ENST00000518414.5
ENST00000521270.5
ENST00000518320.6
ENST00000398612.3
ZNF596
zinc finger protein 596
chr12_+_122980060 0.28 ENST00000543566.6
ENST00000453766.7
ENST00000392435.7
ENST00000413381.6
ENST00000426960.6
ARL6IP4
ADP ribosylation factor like GTPase 6 interacting protein 4
chr1_-_38005484 0.28 ENST00000373016.4
FHL3
four and a half LIM domains 3
chr19_+_49114324 0.27 ENST00000391864.7
LIN7B
lin-7 homolog B, crumbs cell polarity complex component
chrX_+_51893533 0.27 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGED1
MAGE family member D1
chr11_+_77066985 0.27 ENST00000456580.6
CAPN5
calpain 5
chr12_-_89630552 0.27 ENST00000393164.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr19_+_15944299 0.26 ENST00000641275.1
OR10H4
olfactory receptor family 10 subfamily H member 4
chr8_+_1973668 0.26 ENST00000320248.4
KBTBD11
kelch repeat and BTB domain containing 11
chr12_+_2890907 0.26 ENST00000397132.6
TULP3
TUB like protein 3
chr19_-_7874361 0.26 ENST00000618550.5
PRR36
proline rich 36
chr12_-_13095798 0.26 ENST00000396302.7
GSG1
germ cell associated 1
chr22_-_30387078 0.26 ENST00000215798.10
RNF215
ring finger protein 215
chr4_-_118352967 0.26 ENST00000296498.3
PRSS12
serine protease 12
chr2_+_127418420 0.25 ENST00000234071.8
ENST00000429925.5
ENST00000442644.5
PROC
protein C, inactivator of coagulation factors Va and VIIIa
chr17_+_44846318 0.25 ENST00000591513.5
HIGD1B
HIG1 hypoxia inducible domain family member 1B
chrX_+_152917830 0.25 ENST00000318529.12
ZNF185
zinc finger protein 185 with LIM domain
chr3_-_51968387 0.25 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
PCBP4
poly(rC) binding protein 4
chr5_+_154858482 0.25 ENST00000519211.5
ENST00000522458.5
ENST00000519903.5
ENST00000521450.5
ENST00000403027.6
CNOT8
CCR4-NOT transcription complex subunit 8
chrX_+_154144242 0.25 ENST00000369951.9
OPN1LW
opsin 1, long wave sensitive
chr17_-_65826445 0.25 ENST00000317442.12
CEP112
centrosomal protein 112
chr5_-_132963598 0.25 ENST00000378595.7
AFF4
AF4/FMR2 family member 4
chr1_-_165445220 0.25 ENST00000619224.1
RXRG
retinoid X receptor gamma
chrX_+_153517672 0.25 ENST00000349466.6
ENST00000370186.5
ENST00000359149.8
ATP2B3
ATPase plasma membrane Ca2+ transporting 3
chr19_+_3314403 0.25 ENST00000641145.1
NFIC
nuclear factor I C
chr19_+_50358571 0.24 ENST00000652203.1
NR1H2
nuclear receptor subfamily 1 group H member 2
chr6_+_122610391 0.24 ENST00000368452.7
PKIB
cAMP-dependent protein kinase inhibitor beta
chr1_+_2019379 0.24 ENST00000638771.1
ENST00000640949.1
ENST00000640030.1
GABRD
gamma-aminobutyric acid type A receptor subunit delta
chr12_-_13095628 0.24 ENST00000457134.6
ENST00000537302.5
GSG1
germ cell associated 1
chr19_+_48321454 0.24 ENST00000599704.5
EMP3
epithelial membrane protein 3
chr3_+_156290982 0.24 ENST00000618897.4
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr11_-_55936400 0.24 ENST00000301532.3
OR5I1
olfactory receptor family 5 subfamily I member 1
chr8_+_22570944 0.24 ENST00000517962.1
SORBS3
sorbin and SH3 domain containing 3
chr17_-_31858927 0.24 ENST00000579741.1
COPRS
coordinator of PRMT5 and differentiation stimulator
chr4_-_106316216 0.24 ENST00000361687.8
ENST00000507696.1
ENST00000509532.5
TBCK
TBC1 domain containing kinase
chr22_+_20021069 0.24 ENST00000420290.6
ENST00000432883.5
ENST00000434570.6
ENST00000447208.6
ENST00000456048.5
ENST00000398042.6
ENST00000450664.5
ENST00000327374.9
TANGO2
transport and golgi organization 2 homolog
chr1_+_65525641 0.24 ENST00000344610.12
ENST00000616738.4
LEPR
leptin receptor
chr5_-_178232759 0.24 ENST00000308158.10
PHYKPL
5-phosphohydroxy-L-lysine phospho-lyase
chr3_+_156291020 0.24 ENST00000302490.12
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr19_+_55640966 0.24 ENST00000590190.1
ENST00000325333.10
ENST00000585995.1
ENST00000592996.5
ZNF580
ZNF581
CCDC106
zinc finger protein 580
zinc finger protein 581
coiled-coil domain containing 106
chr17_+_28662183 0.24 ENST00000347486.8
ENST00000314616.11
SUPT6H
SPT6 homolog, histone chaperone and transcription elongation factor
chr6_+_158168342 0.23 ENST00000648328.1
ENST00000607778.2
GTF2H5
general transcription factor IIH subunit 5
chr10_-_24723185 0.23 ENST00000376410.7
ENST00000446003.5
ARHGAP21
Rho GTPase activating protein 21
chr22_+_37051787 0.23 ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr9_-_113056670 0.23 ENST00000553380.1
ENST00000374227.8
ZFP37
ZFP37 zinc finger protein
chr3_+_133400046 0.23 ENST00000302334.3
BFSP2
beaded filament structural protein 2
chr1_+_22052627 0.23 ENST00000400259.5
ENST00000344548.7
ENST00000315554.13
ENST00000656825.1
ENST00000651171.1
ENST00000652582.1
ENST00000667384.1
CDC42
cell division cycle 42
chr15_-_63157464 0.23 ENST00000330964.10
ENST00000635699.1
ENST00000439025.1
RPS27L
ribosomal protein S27 like
chr19_+_40586774 0.23 ENST00000594298.5
ENST00000597396.5
SHKBP1
SH3KBP1 binding protein 1
chr5_+_154858537 0.23 ENST00000517568.5
ENST00000524105.5
CNOT8
CCR4-NOT transcription complex subunit 8
chr22_-_30471986 0.23 ENST00000401751.5
ENST00000402286.5
ENST00000403066.5
ENST00000215812.9
SEC14L3
SEC14 like lipid binding 3
chr1_+_150549734 0.22 ENST00000674043.1
ENST00000674058.1
ADAMTSL4
ADAMTS like 4
chrX_+_154182596 0.22 ENST00000595290.6
OPN1MW
opsin 1, medium wave sensitive
chr12_+_53295506 0.22 ENST00000549759.2
ENST00000628881.2
ENST00000351500.7
ENST00000550846.5
ENST00000334478.9
ENST00000547130.6
ENST00000552742.6
PFDN5
prefoldin subunit 5
chr11_+_77066948 0.22 ENST00000527066.5
ENST00000648180.1
ENST00000529629.5
CAPN5
calpain 5
chr1_-_25906411 0.22 ENST00000455785.7
STMN1
stathmin 1
chr18_-_63319729 0.22 ENST00000333681.5
BCL2
BCL2 apoptosis regulator
chrX_-_49043345 0.22 ENST00000315869.8
TFE3
transcription factor binding to IGHM enhancer 3
chr8_-_133571909 0.22 ENST00000521180.5
ENST00000517668.5
ENST00000399640.3
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_53945584 0.22 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr16_+_53054973 0.21 ENST00000447540.6
ENST00000615216.4
ENST00000566029.5
CHD9
chromodomain helicase DNA binding protein 9
chr17_-_81911350 0.21 ENST00000570388.5
PCYT2
phosphate cytidylyltransferase 2, ethanolamine
chr11_+_68008542 0.21 ENST00000614849.4
ALDH3B1
aldehyde dehydrogenase 3 family member B1
chr12_+_51239278 0.21 ENST00000551313.1
DAZAP2
DAZ associated protein 2
chr9_-_35684766 0.21 ENST00000644325.1
TPM2
tropomyosin 2
chr5_-_157142745 0.21 ENST00000420343.1
MED7
mediator complex subunit 7
chr4_-_106316181 0.21 ENST00000394706.7
ENST00000394708.7
TBCK
TBC1 domain containing kinase
chr12_-_81758641 0.21 ENST00000552948.5
ENST00000548586.5
PPFIA2
PTPRF interacting protein alpha 2
chr15_+_31366138 0.21 ENST00000558844.1
KLF13
Kruppel like factor 13
chr14_-_106811131 0.20 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr8_-_66613208 0.20 ENST00000522677.8
MYBL1
MYB proto-oncogene like 1
chr20_-_31723491 0.20 ENST00000676582.1
ENST00000422920.2
BCL2L1
BCL2 like 1
chr3_-_71493500 0.20 ENST00000648380.1
ENST00000650295.1
FOXP1
forkhead box P1
chr5_+_154858218 0.20 ENST00000523698.5
ENST00000517876.5
ENST00000520472.5
CNOT8
CCR4-NOT transcription complex subunit 8
chrX_+_7147675 0.20 ENST00000674429.1
STS
steroid sulfatase
chr1_-_53945567 0.20 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr7_+_143288215 0.20 ENST00000619992.4
ENST00000310447.10
CASP2
caspase 2
chr5_+_119071358 0.20 ENST00000311085.8
DMXL1
Dmx like 1
chr8_-_29263063 0.20 ENST00000524189.6
KIF13B
kinesin family member 13B
chr19_-_10568968 0.20 ENST00000393599.3
CDKN2D
cyclin dependent kinase inhibitor 2D
chr19_+_46602050 0.20 ENST00000599839.5
ENST00000596362.1
CALM3
calmodulin 3
chr5_-_65624288 0.20 ENST00000381018.7
ENST00000274327.11
ENST00000231524.14
TRIM23
tripartite motif containing 23
chr11_+_123430259 0.20 ENST00000533341.3
ENST00000635736.2
GRAMD1B
GRAM domain containing 1B
chr5_+_154858594 0.20 ENST00000519430.5
ENST00000520671.5
ENST00000521583.5
ENST00000285896.11
ENST00000518028.5
ENST00000519404.5
ENST00000519394.5
ENST00000518775.5
CNOT8
CCR4-NOT transcription complex subunit 8

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3 0.9 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 0.6 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.2 0.7 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 0.5 GO:0060434 bronchus morphogenesis(GO:0060434)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 1.9 GO:0005984 disaccharide metabolic process(GO:0005984)
0.1 1.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 0.3 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.1 0.9 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 0.3 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.1 0.7 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) apoptotic process involved in luteolysis(GO:0061364)
0.1 0.5 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.4 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.1 0.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.7 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.2 GO:0071335 submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.8 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 2.2 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 1.1 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 0.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 1.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.2 GO:0001554 luteolysis(GO:0001554)
0.1 0.6 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.5 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.3 GO:0006550 isoleucine catabolic process(GO:0006550)
0.1 0.7 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.2 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.6 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.2 GO:0032712 negative regulation of interleukin-3 production(GO:0032712) negative regulation of granulocyte colony-stimulating factor production(GO:0071656) negative regulation of macrophage colony-stimulating factor production(GO:1901257)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.3 GO:1902613 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 1.1 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:0036018 response to cobalamin(GO:0033590) cellular response to erythropoietin(GO:0036018)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.4 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.5 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.1 GO:1904349 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) regulation of small intestine smooth muscle contraction(GO:1904347) positive regulation of small intestine smooth muscle contraction(GO:1904349) small intestine smooth muscle contraction(GO:1990770) negative regulation of energy homeostasis(GO:2000506)
0.0 0.4 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.3 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.4 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.6 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 1.6 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.2 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0070256 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.0 0.1 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0002554 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.0 0.5 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.2 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 2.8 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.1 GO:0071110 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.0 0.1 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:1990009 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)
0.0 0.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.2 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.1 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.9 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining(GO:2001033)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.0 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.0 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.0 0.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.0 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.0 GO:1901388 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.3 GO:0014041 regulation of neuron maturation(GO:0014041)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.1 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.1 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.0 0.1 GO:0090298 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0006554 lysine catabolic process(GO:0006554)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0071393 propionate metabolic process(GO:0019541) cellular response to progesterone stimulus(GO:0071393) tolerance induction to lipopolysaccharide(GO:0072573)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999)
0.0 0.3 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.0 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) negative regulation of glial cell migration(GO:1903976)
0.0 0.4 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.0 0.3 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0 0.2 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.1 GO:0032482 Rab protein signal transduction(GO:0032482)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0001652 granular component(GO:0001652)
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 1.0 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.5 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.0 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.0 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 1.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 0.9 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.2 1.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 0.7 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.2 0.6 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.4 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.4 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.5 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.4 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.1 0.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.7 GO:0043426 MRF binding(GO:0043426)
0.1 0.5 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.3 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.4 GO:0070513 death domain binding(GO:0070513)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.2 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.3 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.2 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0030395 lactose binding(GO:0030395)
0.0 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0016154 thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0015489 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.6 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0004079 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.1 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.1 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.0 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.0 GO:0002135 CTP binding(GO:0002135)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.0 GO:0070704 C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704)
0.0 0.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0070004 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 1.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 4.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.3 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock