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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GRHL1

Z-value: 1.01

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.18 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg38_v1_chr2_+_9951653_99517340.373.7e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_201399302 2.40 ENST00000633953.1
ENST00000391967.7
LAD1
ladinin 1
chr1_+_34782259 1.90 ENST00000373362.3
GJB3
gap junction protein beta 3
chr19_-_291132 1.75 ENST00000327790.7
PLPP2
phospholipid phosphatase 2
chr19_+_44809053 1.56 ENST00000611077.5
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr1_+_156061142 1.42 ENST00000361084.10
RAB25
RAB25, member RAS oncogene family
chr2_+_95274439 1.31 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
PROM2
prominin 2
chr20_-_18057841 1.30 ENST00000278780.7
OVOL2
ovo like zinc finger 2
chr19_+_44809089 1.22 ENST00000270233.12
ENST00000591520.6
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr11_-_120138104 1.13 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr3_-_172523460 1.13 ENST00000420541.6
TNFSF10
TNF superfamily member 10
chr3_-_172523423 1.13 ENST00000241261.7
TNFSF10
TNF superfamily member 10
chr19_-_4338786 0.75 ENST00000601482.1
ENST00000600324.5
ENST00000594605.6
STAP2
signal transducing adaptor family member 2
chr1_-_24143112 0.74 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr11_+_65787056 0.69 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chr8_-_129786617 0.67 ENST00000276708.9
GSDMC
gasdermin C
chr11_+_76782250 0.55 ENST00000533752.1
ENST00000612930.1
TSKU
tsukushi, small leucine rich proteoglycan
chr1_-_32901330 0.54 ENST00000329151.5
ENST00000373463.8
TMEM54
transmembrane protein 54
chr17_-_4560564 0.52 ENST00000574584.1
ENST00000381550.8
ENST00000301395.7
GGT6
gamma-glutamyltransferase 6
chr5_+_181040260 0.47 ENST00000515271.1
ENST00000327705.14
BTNL9
butyrophilin like 9
chr9_+_5450503 0.42 ENST00000381573.8
ENST00000381577.4
CD274
CD274 molecule
chr19_+_1491140 0.42 ENST00000233596.8
ENST00000395479.10
REEP6
receptor accessory protein 6
chr19_-_15479469 0.40 ENST00000292609.8
ENST00000340880.5
PGLYRP2
peptidoglycan recognition protein 2
chr1_+_43974902 0.36 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATP6V0B
ATPase H+ transporting V0 subunit b
chr19_-_35490456 0.34 ENST00000338897.4
ENST00000484218.6
KRTDAP
keratinocyte differentiation associated protein
chr1_-_16212598 0.34 ENST00000270747.8
ARHGEF19
Rho guanine nucleotide exchange factor 19
chr12_+_56104527 0.32 ENST00000552766.5
ENST00000303305.11
PA2G4
proliferation-associated 2G4
chr7_-_80922354 0.31 ENST00000419255.6
SEMA3C
semaphorin 3C
chr7_-_124765753 0.29 ENST00000303921.3
GPR37
G protein-coupled receptor 37
chr11_+_706117 0.28 ENST00000533256.5
ENST00000614442.4
EPS8L2
EPS8 like 2
chr19_+_57527316 0.28 ENST00000240719.7
ENST00000376233.8
ENST00000594943.1
ENST00000602149.1
ZNF549
zinc finger protein 549
chr19_-_17245889 0.27 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr2_+_113058637 0.27 ENST00000346807.7
IL36RN
interleukin 36 receptor antagonist
chr11_+_706595 0.26 ENST00000531348.5
ENST00000530636.5
EPS8L2
EPS8 like 2
chr15_+_66386902 0.25 ENST00000307102.10
MAP2K1
mitogen-activated protein kinase kinase 1
chr6_+_32153441 0.24 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
PPT2
palmitoyl-protein thioesterase 2
chr13_+_48232609 0.23 ENST00000649266.1
ITM2B
integral membrane protein 2B
chr15_+_41838839 0.22 ENST00000458483.4
PLA2G4B
phospholipase A2 group IVB
chr9_+_127803208 0.21 ENST00000373225.7
ENST00000431857.5
FPGS
folylpolyglutamate synthase
chr3_-_49104745 0.20 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
QARS1
glutaminyl-tRNA synthetase 1
chr16_-_23557331 0.20 ENST00000563232.1
ENST00000449606.7
EARS2
glutamyl-tRNA synthetase 2, mitochondrial
chr2_+_112542413 0.19 ENST00000417433.6
ENST00000263331.10
POLR1B
RNA polymerase I subunit B
chr18_-_37565825 0.17 ENST00000603232.6
CELF4
CUGBP Elav-like family member 4
chr18_-_37565765 0.16 ENST00000361795.9
ENST00000420428.7
CELF4
CUGBP Elav-like family member 4
chr3_+_52211442 0.16 ENST00000459884.1
ALAS1
5'-aminolevulinate synthase 1
chr18_+_9475494 0.16 ENST00000383432.8
RALBP1
ralA binding protein 1
chr3_-_49104457 0.16 ENST00000635292.1
ENST00000635541.1
ENST00000464962.6
QARS1
glutaminyl-tRNA synthetase 1
chr1_-_28058087 0.15 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr13_+_48233171 0.15 ENST00000378549.5
ENST00000647800.2
ITM2B
integral membrane protein 2B
chr18_-_37565714 0.15 ENST00000591287.5
ENST00000601019.5
ENST00000601392.5
CELF4
CUGBP Elav-like family member 4
chr11_-_67674725 0.15 ENST00000525827.6
ENST00000673966.1
ENST00000673873.1
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr18_-_37565628 0.15 ENST00000334919.9
ENST00000591282.5
ENST00000588597.5
CELF4
CUGBP Elav-like family member 4
chrX_+_147911910 0.14 ENST00000370475.9
FMR1
FMRP translational regulator 1
chr11_-_67674606 0.13 ENST00000674110.1
ENST00000349015.7
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr11_+_119168705 0.12 ENST00000409109.6
ENST00000409991.5
ENST00000292199.6
NLRX1
NLR family member X1
chr9_+_69121259 0.12 ENST00000643713.1
ENST00000606364.5
TJP2
tight junction protein 2
chr22_+_18077976 0.12 ENST00000399744.8
PEX26
peroxisomal biogenesis factor 26
chr4_+_155666718 0.12 ENST00000621234.4
ENST00000511108.5
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr9_+_69123009 0.11 ENST00000647986.1
TJP2
tight junction protein 2
chr11_+_119168188 0.11 ENST00000454811.5
ENST00000409265.8
ENST00000449394.5
NLRX1
NLR family member X1
chr14_+_23469681 0.10 ENST00000408901.8
ENST00000397154.7
ENST00000555128.5
NGDN
neuroguidin
chr4_+_155666827 0.10 ENST00000511507.5
ENST00000506455.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr18_+_9474994 0.10 ENST00000019317.8
RALBP1
ralA binding protein 1
chr1_+_244352627 0.10 ENST00000366537.5
ENST00000308105.5
C1orf100
chromosome 1 open reading frame 100
chr10_-_50885619 0.09 ENST00000373997.8
A1CF
APOBEC1 complementation factor
chr16_+_2514253 0.09 ENST00000565223.1
ATP6V0C
ATPase H+ transporting V0 subunit c
chr17_-_62806632 0.09 ENST00000583803.1
ENST00000456609.6
MARCHF10
membrane associated ring-CH-type finger 10
chr2_+_167248638 0.09 ENST00000295237.10
XIRP2
xin actin binding repeat containing 2
chrX_+_147912039 0.08 ENST00000334557.10
ENST00000439526.6
FMR1
FMRP translational regulator 1
chr17_+_7572818 0.07 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
EIF4A1
ENSG00000264772.6
eukaryotic translation initiation factor 4A1
novel transcript
chr11_-_11353241 0.07 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr3_-_113696624 0.07 ENST00000316407.9
ENST00000491165.5
USF3
upstream transcription factor family member 3
chr20_-_62427528 0.07 ENST00000252998.2
RBBP8NL
RBBP8 N-terminal like
chr10_-_50885656 0.06 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr19_+_10625507 0.06 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
SLC44A2
solute carrier family 44 member 2
chr1_-_52055156 0.06 ENST00000371626.9
ENST00000610127.2
TXNDC12
thioredoxin domain containing 12
chr4_+_109815734 0.06 ENST00000226796.7
GAR1
GAR1 ribonucleoprotein
chr6_-_46921926 0.05 ENST00000283296.12
ADGRF5
adhesion G protein-coupled receptor F5
chr4_+_155667198 0.05 ENST00000296518.11
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr11_-_64166102 0.05 ENST00000255681.7
ENST00000675777.1
MACROD1
mono-ADP ribosylhydrolase 1
chr12_-_3753091 0.05 ENST00000252322.1
ENST00000440314.7
CRACR2A
calcium release activated channel regulator 2A
chr4_+_155666963 0.05 ENST00000455639.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155667096 0.04 ENST00000393832.7
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_109815503 0.04 ENST00000394631.7
GAR1
GAR1 ribonucleoprotein
chr10_-_92243246 0.04 ENST00000412050.8
ENST00000614585.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_126423176 0.03 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr1_+_40258202 0.03 ENST00000372759.4
ZMPSTE24
zinc metallopeptidase STE24
chr21_+_32298945 0.03 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr5_+_126423122 0.02 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr5_+_126423363 0.00 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr2_+_190408324 0.00 ENST00000417958.5
ENST00000432036.5
ENST00000392328.6
MFSD6
major facilitator superfamily domain containing 6
chr15_+_41559189 0.00 ENST00000263798.8
TYRO3
TYRO3 protein tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.2 0.7 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 1.3 GO:0060214 endocardium formation(GO:0060214)
0.1 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.4 GO:0032827 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 2.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.6 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0031268 pseudopodium organization(GO:0031268)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.3 GO:0019732 antifungal humoral response(GO:0019732)
0.0 1.8 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.3 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0044393 microspike(GO:0044393)
0.1 0.2 GO:1902737 dendritic filopodium(GO:1902737)
0.1 1.9 GO:0005922 connexon complex(GO:0005922)
0.0 1.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0005055 laminin receptor activity(GO:0005055)
0.3 1.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.6 GO:0042835 BRE binding(GO:0042835)
0.1 0.4 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.3 GO:0036505 prosaposin receptor activity(GO:0036505)
0.1 1.9 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 2.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0004030 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling