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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GRHL1

Z-value: 1.01

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
ENSG00000134317.18 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg38_v1_chr2_+_9951653_99517340.373.7e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_201399302 2.40 ENST00000633953.1
ENST00000391967.7
ladinin 1
chr1_+_34782259 1.90 ENST00000373362.3
gap junction protein beta 3
chr19_-_291132 1.75 ENST00000327790.7
phospholipid phosphatase 2
chr19_+_44809053 1.56 ENST00000611077.5
basal cell adhesion molecule (Lutheran blood group)
chr1_+_156061142 1.42 ENST00000361084.10
RAB25, member RAS oncogene family
chr2_+_95274439 1.31 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
prominin 2
chr20_-_18057841 1.30 ENST00000278780.7
ovo like zinc finger 2
chr19_+_44809089 1.22 ENST00000270233.12
ENST00000591520.6
basal cell adhesion molecule (Lutheran blood group)
chr11_-_120138104 1.13 ENST00000341846.10
tripartite motif containing 29
chr3_-_172523460 1.13 ENST00000420541.6
TNF superfamily member 10
chr3_-_172523423 1.13 ENST00000241261.7
TNF superfamily member 10
chr19_-_4338786 0.75 ENST00000601482.1
ENST00000600324.5
ENST00000594605.6
signal transducing adaptor family member 2
chr1_-_24143112 0.74 ENST00000270800.2
interleukin 22 receptor subunit alpha 1
chr11_+_65787056 0.69 ENST00000335987.8
ovo like transcriptional repressor 1
chr8_-_129786617 0.67 ENST00000276708.9
gasdermin C
chr11_+_76782250 0.55 ENST00000533752.1
ENST00000612930.1
tsukushi, small leucine rich proteoglycan
chr1_-_32901330 0.54 ENST00000329151.5
ENST00000373463.8
transmembrane protein 54
chr17_-_4560564 0.52 ENST00000574584.1
ENST00000381550.8
ENST00000301395.7
gamma-glutamyltransferase 6
chr5_+_181040260 0.47 ENST00000515271.1
ENST00000327705.14
butyrophilin like 9
chr9_+_5450503 0.42 ENST00000381573.8
ENST00000381577.4
CD274 molecule
chr19_+_1491140 0.42 ENST00000233596.8
ENST00000395479.10
receptor accessory protein 6
chr19_-_15479469 0.40 ENST00000292609.8
ENST00000340880.5
peptidoglycan recognition protein 2
chr1_+_43974902 0.36 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATPase H+ transporting V0 subunit b
chr19_-_35490456 0.34 ENST00000338897.4
ENST00000484218.6
keratinocyte differentiation associated protein
chr1_-_16212598 0.34 ENST00000270747.8
Rho guanine nucleotide exchange factor 19
chr12_+_56104527 0.32 ENST00000552766.5
ENST00000303305.11
proliferation-associated 2G4
chr7_-_80922354 0.31 ENST00000419255.6
semaphorin 3C
chr7_-_124765753 0.29 ENST00000303921.3
G protein-coupled receptor 37
chr11_+_706117 0.28 ENST00000533256.5
ENST00000614442.4
EPS8 like 2
chr19_+_57527316 0.28 ENST00000240719.7
ENST00000376233.8
ENST00000594943.1
ENST00000602149.1
zinc finger protein 549
chr19_-_17245889 0.27 ENST00000291442.4
nuclear receptor subfamily 2 group F member 6
chr2_+_113058637 0.27 ENST00000346807.7
interleukin 36 receptor antagonist
chr11_+_706595 0.26 ENST00000531348.5
ENST00000530636.5
EPS8 like 2
chr15_+_66386902 0.25 ENST00000307102.10
mitogen-activated protein kinase kinase 1
chr6_+_32153441 0.24 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr13_+_48232609 0.23 ENST00000649266.1
integral membrane protein 2B
chr15_+_41838839 0.22 ENST00000458483.4
phospholipase A2 group IVB
chr9_+_127803208 0.21 ENST00000373225.7
ENST00000431857.5
folylpolyglutamate synthase
chr3_-_49104745 0.20 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
glutaminyl-tRNA synthetase 1
chr16_-_23557331 0.20 ENST00000563232.1
ENST00000449606.7
glutamyl-tRNA synthetase 2, mitochondrial
chr2_+_112542413 0.19 ENST00000417433.6
ENST00000263331.10
RNA polymerase I subunit B
chr18_-_37565825 0.17 ENST00000603232.6
CUGBP Elav-like family member 4
chr18_-_37565765 0.16 ENST00000361795.9
ENST00000420428.7
CUGBP Elav-like family member 4
chr3_+_52211442 0.16 ENST00000459884.1
5'-aminolevulinate synthase 1
chr18_+_9475494 0.16 ENST00000383432.8
ralA binding protein 1
chr3_-_49104457 0.16 ENST00000635292.1
ENST00000635541.1
ENST00000464962.6
glutaminyl-tRNA synthetase 1
chr1_-_28058087 0.15 ENST00000373864.5
EYA transcriptional coactivator and phosphatase 3
chr13_+_48233171 0.15 ENST00000378549.5
ENST00000647800.2
integral membrane protein 2B
chr18_-_37565714 0.15 ENST00000591287.5
ENST00000601019.5
ENST00000601392.5
CUGBP Elav-like family member 4
chr11_-_67674725 0.15 ENST00000525827.6
ENST00000673966.1
ENST00000673873.1
aldehyde dehydrogenase 3 family member B2
chr18_-_37565628 0.15 ENST00000334919.9
ENST00000591282.5
ENST00000588597.5
CUGBP Elav-like family member 4
chrX_+_147911910 0.14 ENST00000370475.9
FMRP translational regulator 1
chr11_-_67674606 0.13 ENST00000674110.1
ENST00000349015.7
aldehyde dehydrogenase 3 family member B2
chr11_+_119168705 0.12 ENST00000409109.6
ENST00000409991.5
ENST00000292199.6
NLR family member X1
chr9_+_69121259 0.12 ENST00000643713.1
ENST00000606364.5
tight junction protein 2
chr22_+_18077976 0.12 ENST00000399744.8
peroxisomal biogenesis factor 26
chr4_+_155666718 0.12 ENST00000621234.4
ENST00000511108.5
guanylate cyclase 1 soluble subunit alpha 1
chr9_+_69123009 0.11 ENST00000647986.1
tight junction protein 2
chr11_+_119168188 0.11 ENST00000454811.5
ENST00000409265.8
ENST00000449394.5
NLR family member X1
chr14_+_23469681 0.10 ENST00000408901.8
ENST00000397154.7
ENST00000555128.5
neuroguidin
chr4_+_155666827 0.10 ENST00000511507.5
ENST00000506455.6
guanylate cyclase 1 soluble subunit alpha 1
chr18_+_9474994 0.10 ENST00000019317.8
ralA binding protein 1
chr1_+_244352627 0.10 ENST00000366537.5
ENST00000308105.5
chromosome 1 open reading frame 100
chr10_-_50885619 0.09 ENST00000373997.8
APOBEC1 complementation factor
chr16_+_2514253 0.09 ENST00000565223.1
ATPase H+ transporting V0 subunit c
chr17_-_62806632 0.09 ENST00000583803.1
ENST00000456609.6
membrane associated ring-CH-type finger 10
chr2_+_167248638 0.09 ENST00000295237.10
xin actin binding repeat containing 2
chrX_+_147912039 0.08 ENST00000334557.10
ENST00000439526.6
FMRP translational regulator 1
chr17_+_7572818 0.07 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
eukaryotic translation initiation factor 4A1
novel transcript
chr11_-_11353241 0.07 ENST00000528848.3
casein kinase 2 alpha 3
chr3_-_113696624 0.07 ENST00000316407.9
ENST00000491165.5
upstream transcription factor family member 3
chr20_-_62427528 0.07 ENST00000252998.2
RBBP8 N-terminal like
chr10_-_50885656 0.06 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
APOBEC1 complementation factor
chr19_+_10625507 0.06 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
solute carrier family 44 member 2
chr1_-_52055156 0.06 ENST00000371626.9
ENST00000610127.2
thioredoxin domain containing 12
chr4_+_109815734 0.06 ENST00000226796.7
GAR1 ribonucleoprotein
chr6_-_46921926 0.05 ENST00000283296.12
adhesion G protein-coupled receptor F5
chr4_+_155667198 0.05 ENST00000296518.11
guanylate cyclase 1 soluble subunit alpha 1
chr11_-_64166102 0.05 ENST00000255681.7
ENST00000675777.1
mono-ADP ribosylhydrolase 1
chr12_-_3753091 0.05 ENST00000252322.1
ENST00000440314.7
calcium release activated channel regulator 2A
chr4_+_155666963 0.05 ENST00000455639.6
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155667096 0.04 ENST00000393832.7
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_109815503 0.04 ENST00000394631.7
GAR1 ribonucleoprotein
chr10_-_92243246 0.04 ENST00000412050.8
ENST00000614585.4
cytoplasmic polyadenylation element binding protein 3
chr5_+_126423176 0.03 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr1_+_40258202 0.03 ENST00000372759.4
zinc metallopeptidase STE24
chr21_+_32298945 0.03 ENST00000339944.4
melanocortin 2 receptor accessory protein
chr5_+_126423122 0.02 ENST00000515200.5
GRAM domain containing 2B
chr5_+_126423363 0.00 ENST00000285689.8
GRAM domain containing 2B
chr2_+_190408324 0.00 ENST00000417958.5
ENST00000432036.5
ENST00000392328.6
major facilitator superfamily domain containing 6
chr15_+_41559189 0.00 ENST00000263798.8
TYRO3 protein tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.2 0.7 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 1.3 GO:0060214 endocardium formation(GO:0060214)
0.1 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.4 GO:0032827 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 2.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.6 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0031268 pseudopodium organization(GO:0031268)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.3 GO:0019732 antifungal humoral response(GO:0019732)
0.0 1.8 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.3 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0044393 microspike(GO:0044393)
0.1 0.2 GO:1902737 dendritic filopodium(GO:1902737)
0.1 1.9 GO:0005922 connexon complex(GO:0005922)
0.0 1.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0005055 laminin receptor activity(GO:0005055)
0.3 1.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.6 GO:0042835 BRE binding(GO:0042835)
0.1 0.4 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.3 GO:0036505 prosaposin receptor activity(GO:0036505)
0.1 1.9 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 2.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0004030 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling