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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HDX

Z-value: 0.36

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.14 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg38_v1_chrX_-_84502442_84502501-0.772.7e-02Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_31447732 0.70 ENST00000257189.5
DSG3
desmoglein 3
chr2_-_112836702 0.69 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
IL1B
interleukin 1 beta
chr1_-_153390976 0.58 ENST00000368732.5
ENST00000368733.4
S100A8
S100 calcium binding protein A8
chr1_-_209652329 0.37 ENST00000367030.7
ENST00000356082.9
LAMB3
laminin subunit beta 3
chr5_+_140786291 0.27 ENST00000394633.7
PCDHA1
protocadherin alpha 1
chr5_-_35230332 0.19 ENST00000504500.5
PRLR
prolactin receptor
chr2_+_112977998 0.16 ENST00000259205.5
ENST00000376489.6
IL36G
interleukin 36 gamma
chr18_+_58362467 0.15 ENST00000675101.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_+_84164684 0.15 ENST00000370680.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr1_-_10964201 0.13 ENST00000418570.6
C1orf127
chromosome 1 open reading frame 127
chr1_+_117060309 0.12 ENST00000369466.9
TTF2
transcription termination factor 2
chr12_-_39340963 0.11 ENST00000552961.5
KIF21A
kinesin family member 21A
chr4_+_70334963 0.09 ENST00000273936.6
CABS1
calcium binding protein, spermatid associated 1
chr2_+_127645864 0.08 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr19_-_41428730 0.08 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_-_205422050 0.07 ENST00000367153.9
LEMD1
LEM domain containing 1
chr2_+_127646145 0.07 ENST00000486700.2
ENST00000272644.7
GPR17
G protein-coupled receptor 17
chr7_-_135728177 0.07 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr7_+_80135694 0.06 ENST00000457358.7
GNAI1
G protein subunit alpha i1
chr15_-_53733103 0.06 ENST00000559418.5
WDR72
WD repeat domain 72
chr12_+_56763316 0.06 ENST00000322165.1
HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
chr1_+_62597510 0.05 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr3_-_51499950 0.04 ENST00000423656.5
ENST00000504652.5
ENST00000684031.1
DCAF1
DDB1 and CUL4 associated factor 1
chr1_-_169711603 0.04 ENST00000236147.6
ENST00000650983.1
SELL
selectin L
chrX_+_55623400 0.03 ENST00000339140.5
FOXR2
forkhead box R2
chr7_+_129368123 0.03 ENST00000460109.5
ENST00000474594.5
AHCYL2
adenosylhomocysteinase like 2
chr5_-_135954962 0.03 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr1_-_110519175 0.03 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr12_-_118359639 0.02 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr19_-_57974527 0.02 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr10_+_18400562 0.01 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr20_-_37158904 0.01 ENST00000417458.5
MROH8
maestro heat like repeat family member 8
chr3_+_107523026 0.01 ENST00000416476.6
BBX
BBX high mobility group box domain containing
chr5_-_35230467 0.01 ENST00000515839.1
ENST00000618457.5
PRLR
prolactin receptor
chr3_+_107522936 0.00 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX
BBX high mobility group box domain containing
chr8_+_109086585 0.00 ENST00000518632.2
TRHR
thyrotropin releasing hormone receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.6 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.7 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling