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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HOXB13

Z-value: 0.45

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
ENSG00000159184.8 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_487287560.265.3e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_78303865 0.84 ENST00000370758.5
prostaglandin F receptor
chr2_-_189179754 0.82 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr8_+_96584920 0.79 ENST00000521590.5
syndecan 2
chr3_-_195583931 0.33 ENST00000343267.8
ENST00000421243.5
ENST00000453131.1
apolipoprotein D
chr11_-_102955705 0.32 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
matrix metallopeptidase 13
chr8_+_76681208 0.28 ENST00000651372.2
zinc finger homeobox 4
chr3_-_115071333 0.27 ENST00000462705.5
zinc finger and BTB domain containing 20
chr14_-_50561119 0.24 ENST00000555216.5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_244352627 0.21 ENST00000366537.5
ENST00000308105.5
chromosome 1 open reading frame 100
chr17_+_18183052 0.18 ENST00000541285.1
alkB homolog 5, RNA demethylase
chr3_-_15797930 0.18 ENST00000683139.1
ankyrin repeat domain 28
chr5_+_136160986 0.17 ENST00000507637.1
SMAD family member 5
chr7_-_75772172 0.17 ENST00000005180.9
C-C motif chemokine ligand 26
chr9_+_122371014 0.15 ENST00000362012.7
prostaglandin-endoperoxide synthase 1
chr16_+_30378312 0.13 ENST00000528032.5
ENST00000622647.3
zinc finger protein 48
chr2_+_74458400 0.13 ENST00000393972.7
ENST00000233615.7
ENST00000409737.5
ENST00000428943.1
WW domain binding protein 1
chr21_-_34526850 0.12 ENST00000481448.5
ENST00000381132.6
regulator of calcineurin 1
chr9_-_128067310 0.12 ENST00000373078.5
nuclear apoptosis inducing factor 1
chr20_+_58907981 0.12 ENST00000656419.1
GNAS complex locus
chr3_-_15798184 0.11 ENST00000624145.3
ankyrin repeat domain 28
chr12_+_8157034 0.10 ENST00000396570.7
zinc finger protein 705A
chr16_-_24930952 0.09 ENST00000571406.1
Rho GTPase activating protein 17
chr1_-_155910881 0.09 ENST00000609492.1
ENST00000368322.7
Ras like without CAAX 1
chr16_-_24931090 0.09 ENST00000571843.1
Rho GTPase activating protein 17
chr6_+_122471913 0.09 ENST00000615438.4
ENST00000392491.6
cAMP-dependent protein kinase inhibitor beta
chr19_-_5903703 0.08 ENST00000586349.5
ENST00000585661.1
ENST00000592634.5
ENST00000418389.6
ENST00000308961.5
novel protein
NADH:ubiquinone oxidoreductase subunit A11
chr2_-_174764407 0.08 ENST00000409219.5
ENST00000409542.5
cholinergic receptor nicotinic alpha 1 subunit
chr1_+_84164962 0.08 ENST00000614872.4
ENST00000394839.6
protein kinase cAMP-activated catalytic subunit beta
chr3_-_123991352 0.08 ENST00000184183.8
rhophilin associated tail protein 1
chr1_+_210328244 0.07 ENST00000541565.5
ENST00000413764.6
hedgehog acyltransferase
chr2_-_135530561 0.07 ENST00000536680.5
ENST00000401392.5
zinc finger RANBP2-type containing 3
chr6_-_43053832 0.07 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
cullin 7
chr14_-_77423517 0.06 ENST00000555603.1
NADP dependent oxidoreductase domain containing 1
chr1_-_36397880 0.06 ENST00000315732.3
LSM10, U7 small nuclear RNA associated
chr17_+_18183803 0.05 ENST00000399138.5
alkB homolog 5, RNA demethylase
chr1_-_45491150 0.05 ENST00000372086.4
testis associated actin remodelling kinase 2
chr5_-_145835330 0.05 ENST00000394450.6
ENST00000683046.1
PRELI domain containing 2
chrM_-_14669 0.05 ENST00000361681.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr7_+_133253064 0.05 ENST00000393161.6
ENST00000253861.5
exocyst complex component 4
chr22_+_35066136 0.04 ENST00000308700.6
ENST00000404699.7
intestine specific homeobox
chr11_-_102843597 0.04 ENST00000299855.10
matrix metallopeptidase 3
chr9_-_14180779 0.04 ENST00000380924.1
ENST00000543693.5
nuclear factor I B
chr1_+_84164370 0.04 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
protein kinase cAMP-activated catalytic subunit beta
chr5_+_102808057 0.04 ENST00000684043.1
ENST00000682407.1
peptidylglycine alpha-amidating monooxygenase
chr6_-_27814757 0.04 ENST00000333151.5
H2A clustered histone 14
chr19_+_47994696 0.03 ENST00000596043.5
ENST00000597519.5
epididymal sperm binding protein 1
chr9_+_122370523 0.03 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr17_-_48728705 0.03 ENST00000290295.8
homeobox B13
chr19_+_47994625 0.03 ENST00000339841.7
epididymal sperm binding protein 1
chr18_+_3252267 0.03 ENST00000536605.1
ENST00000580887.5
myosin light chain 12A
chr16_-_71577082 0.03 ENST00000355962.5
tyrosine aminotransferase
chr2_-_174764436 0.03 ENST00000409323.1
ENST00000261007.9
ENST00000348749.9
ENST00000672640.1
cholinergic receptor nicotinic alpha 1 subunit
chr4_+_67558719 0.03 ENST00000265404.7
ENST00000396225.1
signal transducing adaptor family member 1
chr9_+_101185029 0.03 ENST00000395056.2
phospholipid phosphatase related 1
chr20_-_10420737 0.03 ENST00000649912.1
novel protein
chr5_-_145835285 0.02 ENST00000505416.5
ENST00000334744.8
ENST00000511435.1
PRELI domain containing 2
chr1_+_44405164 0.02 ENST00000355387.6
ring finger protein 220
chr5_-_127073467 0.02 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
chromosome 5 open reading frame 63
chr5_-_140673568 0.02 ENST00000542735.2
DND microRNA-mediated repression inhibitor 1
chr14_-_67533720 0.02 ENST00000554278.6
transmembrane protein 229B
chr19_+_55643592 0.02 ENST00000270451.6
ENST00000588537.1
zinc finger protein 581
chr1_-_149812359 0.02 ENST00000369167.2
ENST00000545683.1
H2B clustered histone 18
chr9_+_122371036 0.02 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr9_+_73151833 0.01 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
annexin A1
chr7_-_11832190 0.01 ENST00000423059.9
ENST00000617773.1
thrombospondin type 1 domain containing 7A
chr6_+_27815010 0.01 ENST00000621112.2
H2B clustered histone 14
chr15_-_55249029 0.01 ENST00000566877.5
RAB27A, member RAS oncogene family
chr4_+_109827963 0.01 ENST00000317735.7
retinal pigment epithelium-derived rhodopsin homolog
chr12_-_81598332 0.01 ENST00000443686.7
PTPRF interacting protein alpha 2
chr2_-_175181663 0.01 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP synthase membrane subunit c locus 3
chr1_+_50105666 0.00 ENST00000651347.1
ELAV like RNA binding protein 4
chr12_-_52321395 0.00 ENST00000293670.3
keratin 83
chr18_+_3252208 0.00 ENST00000578562.6
myosin light chain 12A
chr22_-_37844308 0.00 ENST00000411961.6
ENST00000434930.1
ENST00000215941.9
ankyrin repeat domain 54

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.8 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.2 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.0 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:1990393 3M complex(GO:1990393)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions