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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HOXB13

Z-value: 0.45

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.8 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_487287560.265.3e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_78303865 0.84 ENST00000370758.5
PTGFR
prostaglandin F receptor
chr2_-_189179754 0.82 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr8_+_96584920 0.79 ENST00000521590.5
SDC2
syndecan 2
chr3_-_195583931 0.33 ENST00000343267.8
ENST00000421243.5
ENST00000453131.1
APOD
apolipoprotein D
chr11_-_102955705 0.32 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
MMP13
matrix metallopeptidase 13
chr8_+_76681208 0.28 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr3_-_115071333 0.27 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_50561119 0.24 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_244352627 0.21 ENST00000366537.5
ENST00000308105.5
C1orf100
chromosome 1 open reading frame 100
chr17_+_18183052 0.18 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr3_-_15797930 0.18 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr5_+_136160986 0.17 ENST00000507637.1
SMAD5
SMAD family member 5
chr7_-_75772172 0.17 ENST00000005180.9
CCL26
C-C motif chemokine ligand 26
chr9_+_122371014 0.15 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr16_+_30378312 0.13 ENST00000528032.5
ENST00000622647.3
ZNF48
zinc finger protein 48
chr2_+_74458400 0.13 ENST00000393972.7
ENST00000233615.7
ENST00000409737.5
ENST00000428943.1
WBP1
WW domain binding protein 1
chr21_-_34526850 0.12 ENST00000481448.5
ENST00000381132.6
RCAN1
regulator of calcineurin 1
chr9_-_128067310 0.12 ENST00000373078.5
NAIF1
nuclear apoptosis inducing factor 1
chr20_+_58907981 0.12 ENST00000656419.1
GNAS
GNAS complex locus
chr3_-_15798184 0.11 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr12_+_8157034 0.10 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr16_-_24930952 0.09 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr1_-_155910881 0.09 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr16_-_24931090 0.09 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr6_+_122471913 0.09 ENST00000615438.4
ENST00000392491.6
PKIB
cAMP-dependent protein kinase inhibitor beta
chr19_-_5903703 0.08 ENST00000586349.5
ENST00000585661.1
ENST00000592634.5
ENST00000418389.6
ENST00000308961.5
ENSG00000267740.5
NDUFA11
novel protein
NADH:ubiquinone oxidoreductase subunit A11
chr2_-_174764407 0.08 ENST00000409219.5
ENST00000409542.5
CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
chr1_+_84164962 0.08 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr3_-_123991352 0.08 ENST00000184183.8
ROPN1
rhophilin associated tail protein 1
chr1_+_210328244 0.07 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr2_-_135530561 0.07 ENST00000536680.5
ENST00000401392.5
ZRANB3
zinc finger RANBP2-type containing 3
chr6_-_43053832 0.07 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr14_-_77423517 0.06 ENST00000555603.1
NOXRED1
NADP dependent oxidoreductase domain containing 1
chr1_-_36397880 0.06 ENST00000315732.3
LSM10
LSM10, U7 small nuclear RNA associated
chr17_+_18183803 0.05 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr1_-_45491150 0.05 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr5_-_145835330 0.05 ENST00000394450.6
ENST00000683046.1
PRELID2
PRELI domain containing 2
chrM_-_14669 0.05 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr7_+_133253064 0.05 ENST00000393161.6
ENST00000253861.5
EXOC4
exocyst complex component 4
chr22_+_35066136 0.04 ENST00000308700.6
ENST00000404699.7
ISX
intestine specific homeobox
chr11_-_102843597 0.04 ENST00000299855.10
MMP3
matrix metallopeptidase 3
chr9_-_14180779 0.04 ENST00000380924.1
ENST00000543693.5
NFIB
nuclear factor I B
chr1_+_84164370 0.04 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr5_+_102808057 0.04 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr6_-_27814757 0.04 ENST00000333151.5
H2AC14
H2A clustered histone 14
chr19_+_47994696 0.03 ENST00000596043.5
ENST00000597519.5
ELSPBP1
epididymal sperm binding protein 1
chr9_+_122370523 0.03 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr17_-_48728705 0.03 ENST00000290295.8
HOXB13
homeobox B13
chr19_+_47994625 0.03 ENST00000339841.7
ELSPBP1
epididymal sperm binding protein 1
chr18_+_3252267 0.03 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr16_-_71577082 0.03 ENST00000355962.5
TAT
tyrosine aminotransferase
chr2_-_174764436 0.03 ENST00000409323.1
ENST00000261007.9
ENST00000348749.9
ENST00000672640.1
CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
chr4_+_67558719 0.03 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr9_+_101185029 0.03 ENST00000395056.2
PLPPR1
phospholipid phosphatase related 1
chr20_-_10420737 0.03 ENST00000649912.1
ENSG00000285723.1
novel protein
chr5_-_145835285 0.02 ENST00000505416.5
ENST00000334744.8
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr1_+_44405164 0.02 ENST00000355387.6
RNF220
ring finger protein 220
chr5_-_127073467 0.02 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
C5orf63
chromosome 5 open reading frame 63
chr5_-_140673568 0.02 ENST00000542735.2
DND1
DND microRNA-mediated repression inhibitor 1
chr14_-_67533720 0.02 ENST00000554278.6
TMEM229B
transmembrane protein 229B
chr19_+_55643592 0.02 ENST00000270451.6
ENST00000588537.1
ZNF581
zinc finger protein 581
chr1_-_149812359 0.02 ENST00000369167.2
ENST00000545683.1
H2BC18
H2B clustered histone 18
chr9_+_122371036 0.02 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_73151833 0.01 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr7_-_11832190 0.01 ENST00000423059.9
ENST00000617773.1
THSD7A
thrombospondin type 1 domain containing 7A
chr6_+_27815010 0.01 ENST00000621112.2
H2BC14
H2B clustered histone 14
chr15_-_55249029 0.01 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr4_+_109827963 0.01 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr12_-_81598332 0.01 ENST00000443686.7
PPFIA2
PTPRF interacting protein alpha 2
chr2_-_175181663 0.01 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr1_+_50105666 0.00 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr12_-_52321395 0.00 ENST00000293670.3
KRT83
keratin 83
chr18_+_3252208 0.00 ENST00000578562.6
MYL12A
myosin light chain 12A
chr22_-_37844308 0.00 ENST00000411961.6
ENST00000434930.1
ENST00000215941.9
ANKRD54
ankyrin repeat domain 54

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.8 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.2 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.0 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:1990393 3M complex(GO:1990393)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions