Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Gene Symbol | Gene ID | Gene Info |
---|---|---|
ENSG00000172201.12 | inhibitor of DNA binding 4, HLH protein | |
ENSG00000196628.20 | transcription factor 4 | |
ENSG00000019549.13 | snail family transcriptional repressor 2 |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
TCF4 | hg38_v1_chr18_-_55403682_55403764 | 0.83 | 1.0e-02 | Click! |
SNAI2 | hg38_v1_chr8_-_48921419_48921437 | 0.51 | 2.0e-01 | Click! |
ID4 | hg38_v1_chr6_+_19837362_19837381 | 0.35 | 3.9e-01 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.1 | 30.5 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
0.3 | 25.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
0.8 | 22.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 21.4 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
4.7 | 18.7 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
0.3 | 15.2 | GO:0051602 | response to electrical stimulus(GO:0051602) |
0.1 | 13.5 | GO:0070268 | cornification(GO:0070268) |
1.6 | 12.8 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
0.6 | 12.3 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
2.0 | 12.2 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.3 | 32.5 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.8 | 26.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 23.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.8 | 21.3 | GO:0005922 | connexon complex(GO:0005922) |
0.7 | 20.9 | GO:0030057 | desmosome(GO:0030057) |
1.5 | 19.8 | GO:0045179 | apical cortex(GO:0045179) |
0.2 | 16.6 | GO:0045095 | keratin filament(GO:0045095) |
0.2 | 15.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.1 | 14.6 | GO:0070160 | occluding junction(GO:0070160) |
0.2 | 14.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 26.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.1 | 19.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 18.0 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
0.5 | 14.9 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
1.1 | 13.5 | GO:0038132 | neuregulin binding(GO:0038132) |
1.6 | 12.8 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
0.4 | 11.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 11.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.8 | 10.6 | GO:0031014 | troponin T binding(GO:0031014) |
0.1 | 10.2 | GO:0019894 | kinesin binding(GO:0019894) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 23.8 | PID RAS PATHWAY | Regulation of Ras family activation |
0.6 | 22.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
0.4 | 19.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
0.9 | 17.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.1 | 10.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 9.1 | PID P73PATHWAY | p73 transcription factor network |
0.1 | 8.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
0.4 | 7.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.2 | 6.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
0.0 | 5.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 27.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.9 | 21.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
0.5 | 20.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
0.2 | 18.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
0.8 | 17.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.4 | 15.4 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.4 | 14.2 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
0.1 | 12.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
0.1 | 7.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
0.2 | 7.4 | REACTOME KINESINS | Genes involved in Kinesins |