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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for IKZF2

Z-value: 0.98

Motif logo

Transcription factors associated with IKZF2

Gene Symbol Gene ID Gene Info
ENSG00000030419.17 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IKZF2hg38_v1_chr2_-_213151590_2131516190.821.3e-02Click!

Activity profile of IKZF2 motif

Sorted Z-values of IKZF2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_188974364 2.68 ENST00000304636.9
ENST00000317840.9
collagen type III alpha 1 chain
chr1_-_56579555 2.26 ENST00000371250.4
phospholipid phosphatase 3
chr12_-_91179472 2.15 ENST00000550099.5
ENST00000546391.5
decorin
chr12_-_91179355 1.83 ENST00000550563.5
ENST00000546370.5
decorin
chr8_+_96584920 1.74 ENST00000521590.5
syndecan 2
chr7_+_94394886 1.57 ENST00000297268.11
ENST00000620463.1
collagen type I alpha 2 chain
chr3_+_12351493 1.30 ENST00000683699.1
peroxisome proliferator activated receptor gamma
chr4_+_123399488 1.30 ENST00000394339.2
sprouty RTK signaling antagonist 1
chr17_-_69141878 1.20 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr13_-_37598750 1.20 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
periostin
chr3_+_12351470 1.16 ENST00000287820.10
peroxisome proliferator activated receptor gamma
chr12_-_55688891 1.12 ENST00000557555.2
integrin subunit alpha 7
chr5_+_32711313 1.02 ENST00000265074.13
natriuretic peptide receptor 3
chr5_+_32710630 0.99 ENST00000326958.5
natriuretic peptide receptor 3
chr7_+_93921720 0.91 ENST00000248564.6
G protein subunit gamma 11
chr2_+_209580024 0.90 ENST00000392194.5
microtubule associated protein 2
chr8_-_107498041 0.78 ENST00000297450.7
angiopoietin 1
chr14_+_51860391 0.72 ENST00000335281.8
G protein subunit gamma 2
chr2_+_209579399 0.71 ENST00000360351.8
microtubule associated protein 2
chr2_+_209579598 0.70 ENST00000445941.5
ENST00000673860.1
microtubule associated protein 2
chr2_-_189179754 0.67 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chrX_+_81202066 0.65 ENST00000373212.6
SH3 domain binding glutamate rich protein like
chr11_-_1757452 0.64 ENST00000427721.3
novel protein
chr3_-_112610262 0.62 ENST00000479368.1
coiled-coil domain containing 80
chr9_-_70869076 0.61 ENST00000677594.1
transient receptor potential cation channel subfamily M member 3
chr1_+_78649818 0.61 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr15_-_82045998 0.57 ENST00000329713.5
mex-3 RNA binding family member B
chr5_-_111756245 0.57 ENST00000447165.6
neuronal regeneration related protein
chr6_+_31655888 0.56 ENST00000375916.4
apolipoprotein M
chr15_-_82046119 0.55 ENST00000558133.1
mex-3 RNA binding family member B
chr3_-_18424533 0.55 ENST00000417717.6
SATB homeobox 1
chr3_+_69763726 0.52 ENST00000448226.9
melanocyte inducing transcription factor
chr4_-_185775271 0.52 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chrX_-_136780925 0.52 ENST00000250617.7
Rac/Cdc42 guanine nucleotide exchange factor 6
chr2_-_101151253 0.51 ENST00000376840.8
ENST00000409318.2
TBC1 domain family member 8
chrX_+_103776493 0.49 ENST00000433491.5
ENST00000612423.4
ENST00000443502.5
proteolipid protein 1
chr4_+_73481737 0.48 ENST00000226355.5
afamin
chrX_+_103776831 0.48 ENST00000621218.5
ENST00000619236.1
proteolipid protein 1
chr4_-_156970903 0.48 ENST00000422544.2
platelet derived growth factor C
chr3_-_18438767 0.46 ENST00000454909.6
SATB homeobox 1
chr3_+_46577778 0.46 ENST00000296145.6
teratocarcinoma-derived growth factor 1
chr11_+_126283059 0.46 ENST00000392679.6
ENST00000392678.7
ENST00000392680.6
TIR domain containing adaptor protein
chr2_+_157257687 0.46 ENST00000259056.5
polypeptide N-acetylgalactosaminyltransferase 5
chr2_-_118847638 0.46 ENST00000295206.7
engrailed homeobox 1
chr2_+_209579429 0.45 ENST00000361559.8
microtubule associated protein 2
chr12_+_65279445 0.44 ENST00000642404.1
methionine sulfoxide reductase B3
chrX_+_55452119 0.44 ENST00000342972.3
MAGE family member H1
chr1_+_60865259 0.44 ENST00000371191.5
nuclear factor I A
chr8_-_71356653 0.43 ENST00000388742.8
ENST00000388740.4
EYA transcriptional coactivator and phosphatase 1
chr2_-_175005357 0.42 ENST00000409156.7
ENST00000444573.2
ENST00000409900.9
chimerin 1
chr8_-_71356511 0.42 ENST00000419131.6
ENST00000388743.6
EYA transcriptional coactivator and phosphatase 1
chr2_+_27078598 0.42 ENST00000380320.9
elastin microfibril interfacer 1
chr12_+_8157034 0.42 ENST00000396570.7
zinc finger protein 705A
chr15_+_76336755 0.41 ENST00000290759.9
ISL LIM homeobox 2
chr12_-_10453330 0.41 ENST00000347831.9
ENST00000359151.8
killer cell lectin like receptor C1
chr4_-_185812209 0.39 ENST00000393523.6
ENST00000393528.7
ENST00000449407.6
sorbin and SH3 domain containing 2
chr5_+_173889337 0.39 ENST00000520867.5
ENST00000334035.9
cytoplasmic polyadenylation element binding protein 4
chr19_+_49930219 0.39 ENST00000596658.1
activating transcription factor 5
chr6_-_15586006 0.39 ENST00000462989.6
dystrobrevin binding protein 1
chr9_-_70869029 0.39 ENST00000361823.9
ENST00000377101.5
ENST00000360823.6
ENST00000377105.5
transient receptor potential cation channel subfamily M member 3
chr1_-_153985366 0.38 ENST00000614713.4
RAB13, member RAS oncogene family
chr10_+_97319250 0.36 ENST00000371021.5
FRAT regulator of WNT signaling pathway 1
chr2_+_102070360 0.35 ENST00000409929.5
ENST00000424272.5
interleukin 1 receptor type 1
chr8_+_76681208 0.35 ENST00000651372.2
zinc finger homeobox 4
chr19_-_43205551 0.35 ENST00000599391.1
ENST00000244295.13
ENST00000596907.5
ENST00000405312.8
ENST00000451895.1
ENST00000433626.6
pregnancy specific beta-1-glycoprotein 4
chr10_-_30999469 0.34 ENST00000538351.6
zinc finger protein 438
chr16_-_20900319 0.33 ENST00000564349.5
ENST00000324344.9
ERI1 exoribonuclease family member 2
defective in cullin neddylation 1 domain containing 3
chr5_-_151686908 0.33 ENST00000231061.9
secreted protein acidic and cysteine rich
chr17_+_41226648 0.33 ENST00000377721.3
keratin associated protein 9-2
chr1_+_103571077 0.33 ENST00000610648.1
amylase alpha 2B
chr10_+_80132591 0.32 ENST00000372267.6
placenta associated 9
chrX_+_9543103 0.31 ENST00000683056.1
transducin beta like 1 X-linked
chr1_+_103655760 0.30 ENST00000370083.9
amylase alpha 1A
chr1_+_103745323 0.29 ENST00000684141.1
amylase alpha 1C
chr12_+_26195543 0.29 ENST00000242729.7
sarcospan
chr9_+_89605004 0.29 ENST00000252506.11
ENST00000375769.1
growth arrest and DNA damage inducible gamma
chr22_+_23856962 0.28 ENST00000611880.4
solute carrier family 2 member 11
chr1_-_48400826 0.28 ENST00000371841.1
spermatogenesis associated 6
chr22_+_23856857 0.27 ENST00000403208.7
ENST00000398356.6
solute carrier family 2 member 11
chr7_+_74028066 0.27 ENST00000431562.5
ENST00000320492.11
ENST00000438906.5
elastin
chr11_+_20022550 0.27 ENST00000533917.5
neuron navigator 2
chr10_-_37858037 0.26 ENST00000395873.7
ENST00000357328.8
ENST00000395874.2
zinc finger protein 248
chr2_-_85410336 0.26 ENST00000263867.9
ENST00000409921.5
capping actin protein, gelsolin like
chr10_+_88880236 0.26 ENST00000371926.8
STAM binding protein like 1
chr19_+_18386150 0.26 ENST00000252809.3
growth differentiation factor 15
chr11_-_96343170 0.26 ENST00000524717.6
mastermind like transcriptional coactivator 2
chr7_-_23470469 0.26 ENST00000258729.8
insulin like growth factor 2 mRNA binding protein 3
chr12_+_26195313 0.26 ENST00000422622.3
sarcospan
chr19_-_31349408 0.26 ENST00000240587.5
teashirt zinc finger homeobox 3
chr10_+_113709261 0.25 ENST00000672138.1
ENST00000452490.3
caspase 7
chr9_+_2159672 0.25 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_+_120988683 0.25 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr21_-_26967057 0.25 ENST00000284987.6
ADAM metallopeptidase with thrombospondin type 1 motif 5
chr7_+_74028127 0.25 ENST00000438880.5
ENST00000414324.5
ENST00000380562.8
ENST00000380575.8
ENST00000380584.8
ENST00000458204.5
ENST00000357036.9
ENST00000417091.5
ENST00000429192.5
ENST00000252034.12
ENST00000442310.5
ENST00000380553.8
ENST00000380576.9
ENST00000428787.5
ENST00000320399.10
elastin
chr12_-_71157992 0.25 ENST00000247829.8
tetraspanin 8
chr12_-_71157872 0.24 ENST00000546561.2
tetraspanin 8
chr10_+_103277129 0.24 ENST00000369849.9
internexin neuronal intermediate filament protein alpha
chrX_+_136169891 0.24 ENST00000449474.5
four and a half LIM domains 1
chr22_+_23856703 0.24 ENST00000345044.10
solute carrier family 2 member 11
chr4_-_82844418 0.24 ENST00000503937.5
SEC31 homolog A, COPII coat complex component
chr14_-_106658251 0.24 ENST00000454421.2
immunoglobulin heavy variable 3-64
chr10_+_89327989 0.23 ENST00000679923.1
ENST00000680085.1
ENST00000371818.9
ENST00000680779.1
interferon induced protein with tetratricopeptide repeats 3
chr9_+_2159850 0.23 ENST00000416751.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_+_89327977 0.23 ENST00000681277.1
interferon induced protein with tetratricopeptide repeats 3
chrX_-_63785510 0.23 ENST00000437457.6
ENST00000374878.5
ENST00000623517.3
Cdc42 guanine nucleotide exchange factor 9
chrX_+_56729231 0.23 ENST00000637096.1
ENST00000374922.9
ENST00000423617.2
negative regulator of P-body association
chr3_-_71583683 0.23 ENST00000649631.1
ENST00000648718.1
forkhead box P1
chr3_+_46354072 0.23 ENST00000445132.3
ENST00000421659.1
C-C motif chemokine receptor 2
chr9_+_121299793 0.22 ENST00000373818.8
gelsolin
chrX_+_136169833 0.22 ENST00000628032.2
four and a half LIM domains 1
chr15_-_89815332 0.21 ENST00000559874.2
alanyl aminopeptidase, membrane
chrX_+_136148440 0.21 ENST00000627383.2
ENST00000630084.2
four and a half LIM domains 1
chr10_-_125816596 0.20 ENST00000368786.5
uroporphyrinogen III synthase
chr14_+_23377136 0.20 ENST00000382809.2
CKLF like MARVEL transmembrane domain containing 5
chr7_-_138798188 0.20 ENST00000310018.7
ATPase H+ transporting V0 subunit a4
chr7_-_138798104 0.20 ENST00000353492.4
ATPase H+ transporting V0 subunit a4
chr12_+_26195647 0.20 ENST00000535504.1
sarcospan
chr20_+_15196834 0.20 ENST00000402914.5
mono-ADP ribosylhydrolase 2
chr7_+_74027770 0.20 ENST00000445912.5
ENST00000621115.4
elastin
chr1_+_100719734 0.20 ENST00000370119.8
ENST00000294728.7
ENST00000347652.6
ENST00000370115.1
vascular cell adhesion molecule 1
chr9_-_127905313 0.19 ENST00000622357.5
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_+_136169664 0.19 ENST00000456445.5
four and a half LIM domains 1
chr3_-_122022122 0.19 ENST00000393631.5
ENST00000273691.7
ENST00000344209.10
immunoglobulin like domain containing receptor 1
chr1_+_10430384 0.19 ENST00000470413.6
ENST00000602787.6
ENST00000309048.8
CENPS-CORT readthrough
centromere protein S
chr6_+_36871841 0.19 ENST00000359359.6
chromosome 6 open reading frame 89
chr8_-_132625378 0.19 ENST00000522789.5
leucine rich repeat containing 6
chr2_-_127675459 0.19 ENST00000355119.9
LIM zinc finger domain containing 2
chr3_-_71583592 0.19 ENST00000650156.1
ENST00000649596.1
forkhead box P1
chr12_-_104050112 0.18 ENST00000547583.1
ENST00000546851.1
ENST00000360814.9
glycosyltransferase 8 domain containing 2
chr10_+_61662921 0.18 ENST00000648843.3
ENST00000330194.2
ENST00000389639.3
ciliary associated calcium binding coiled-coil 1
chr12_-_91179517 0.18 ENST00000551354.1
decorin
chr5_-_134371004 0.17 ENST00000521755.1
ENST00000523054.5
ENST00000518409.1
cyclin dependent kinase like 3
novel transcript
chr9_+_72628020 0.17 ENST00000646619.1
transmembrane channel like 1
chr10_-_7410973 0.17 ENST00000684547.1
ENST00000673876.1
ENST00000397167.6
Scm like with four mbt domains 2
chr21_-_10649835 0.17 ENST00000622028.1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr18_-_49813869 0.16 ENST00000586485.5
ENST00000587994.5
ENST00000586100.1
acetyl-CoA acyltransferase 2
chr14_-_106235582 0.16 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr2_-_127675065 0.16 ENST00000545738.6
ENST00000409808.6
LIM zinc finger domain containing 2
chr13_+_48976597 0.16 ENST00000541916.5
fibronectin type III domain containing 3A
chr19_+_30372364 0.16 ENST00000355537.4
zinc finger protein 536
chr12_+_103587266 0.16 ENST00000388887.7
stabilin 2
chr19_-_57559833 0.16 ENST00000457177.5
zinc finger protein 550
chr1_+_171248471 0.16 ENST00000402921.6
ENST00000617670.6
ENST00000367750.7
flavin containing dimethylaniline monoxygenase 1
chr1_-_68232539 0.16 ENST00000370976.7
ENST00000354777.6
Wnt ligand secretion mediator
chr10_-_102432565 0.16 ENST00000369937.5
CUE domain containing 2
chr7_-_139716980 0.16 ENST00000342645.7
homeodomain interacting protein kinase 2
chr1_-_15524183 0.16 ENST00000333868.10
ENST00000440484.1
caspase 9
chr5_+_141245384 0.16 ENST00000623671.1
ENST00000231173.6
protocadherin beta 15
chrX_+_136169624 0.15 ENST00000394153.6
four and a half LIM domains 1
chr20_-_58515382 0.15 ENST00000371149.8
APC down-regulated 1 like
chr4_-_87391149 0.15 ENST00000507286.1
ENST00000358290.9
hydroxysteroid 17-beta dehydrogenase 11
chr3_-_71583713 0.15 ENST00000649528.3
ENST00000471386.3
ENST00000493089.7
forkhead box P1
chr19_+_18340581 0.15 ENST00000604499.6
ENST00000269919.11
ENST00000595066.5
ENST00000252813.5
pyroglutamyl-peptidase I
chr4_+_147732070 0.15 ENST00000336498.8
Rho GTPase activating protein 10
chr15_+_84603896 0.15 ENST00000541040.5
ENST00000538076.5
ENST00000485222.2
zinc finger and SCAN domain containing 2
chr4_+_26320975 0.15 ENST00000509158.6
ENST00000681856.1
ENST00000680140.1
ENST00000355476.8
ENST00000680511.1
recombination signal binding protein for immunoglobulin kappa J region
chr16_-_21278282 0.15 ENST00000572914.2
crystallin mu
chr9_-_90642855 0.15 ENST00000637905.1
DIRAS family GTPase 2
chr6_+_52423680 0.14 ENST00000538167.2
EF-hand domain containing 1
chr15_-_19988117 0.14 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr14_+_57268963 0.14 ENST00000261558.8
adaptor related protein complex 5 subunit mu 1
chr1_+_152878312 0.14 ENST00000368765.4
sperm mitochondria associated cysteine rich protein
chr12_+_59664677 0.14 ENST00000548610.5
solute carrier family 16 member 7
chr11_+_72192126 0.14 ENST00000393676.5
folate receptor alpha
chr1_+_53014926 0.14 ENST00000430330.6
ENST00000408941.7
ENST00000478274.6
ENST00000484100.5
ENST00000435345.6
ENST00000488965.1
sterol carrier protein 2
chr7_-_29195186 0.14 ENST00000449801.5
ENST00000409850.5
carboxypeptidase vitellogenic like
chr22_-_35824373 0.14 ENST00000473487.6
RNA binding fox-1 homolog 2
chr20_+_58891302 0.14 ENST00000371095.7
ENST00000265620.11
ENST00000354359.12
ENST00000371085.8
GNAS complex locus
chr5_+_176388731 0.14 ENST00000274787.3
HIG1 hypoxia inducible domain family member 2A
chr3_+_160842143 0.14 ENST00000464260.5
ENST00000295839.9
protein phosphatase, Mg2+/Mn2+ dependent 1L
chr14_-_35121950 0.14 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr14_+_44962177 0.13 ENST00000361462.7
ENST00000361577.7
TOG array regulator of axonemal microtubules 1
chr10_-_110918934 0.13 ENST00000605742.5
BBSome interacting protein 1
chr9_-_91423819 0.13 ENST00000297689.4
nuclear factor, interleukin 3 regulated
chr10_-_110919146 0.13 ENST00000652396.1
ENST00000423273.5
ENST00000436562.1
ENST00000651952.1
ENST00000448814.7
ENST00000652400.1
ENST00000447005.5
ENST00000454061.5
BBSome interacting protein 1
chr10_+_110919595 0.13 ENST00000369452.9
SHOC2 leucine rich repeat scaffold protein
chr12_-_49187369 0.13 ENST00000547939.6
tubulin alpha 1a
chr17_-_38748184 0.13 ENST00000618941.4
ENST00000620225.5
ENST00000618506.1
ENST00000616129.4
polycomb group ring finger 2
chr4_+_26320782 0.12 ENST00000514807.5
ENST00000348160.9
recombination signal binding protein for immunoglobulin kappa J region
chr1_+_61081728 0.12 ENST00000371189.8
nuclear factor I A
chr16_-_29899245 0.12 ENST00000537485.5
seizure related 6 homolog like 2
chr1_-_15524344 0.12 ENST00000348549.9
ENST00000546424.5
caspase 9
chr10_+_80132722 0.12 ENST00000372263.4
placenta associated 9
chr14_-_106117159 0.12 ENST00000390601.3
immunoglobulin heavy variable 3-11
chr12_-_123436664 0.12 ENST00000280571.10
Rab interacting lysosomal protein like 2
chr10_+_117543567 0.12 ENST00000616794.1
empty spiracles homeobox 2
chr4_+_133149307 0.12 ENST00000618019.1
protocadherin 10
chr3_-_183099508 0.12 ENST00000476176.5
methylcrotonoyl-CoA carboxylase 1
chr11_+_61755372 0.12 ENST00000265460.9
myelin regulatory factor
chr16_-_29899043 0.12 ENST00000346932.9
ENST00000350527.7
ENST00000568380.1
seizure related 6 homolog like 2
chr3_-_158105718 0.12 ENST00000554685.2
short stature homeobox 2
chrX_-_15601077 0.12 ENST00000680121.1
angiotensin I converting enzyme 2
chr6_+_68635273 0.12 ENST00000370598.6
adhesion G protein-coupled receptor B3
chr11_-_102724945 0.12 ENST00000236826.8
matrix metallopeptidase 8
chr1_-_47190013 0.11 ENST00000294338.7
PDZK1 interacting protein 1
chr2_+_63842325 0.11 ENST00000445915.6
ENST00000475462.5
UDP-glucose pyrophosphorylase 2
chr4_+_26320563 0.11 ENST00000361572.10
recombination signal binding protein for immunoglobulin kappa J region
chr14_+_64503943 0.11 ENST00000556965.1
ENST00000554015.5
zinc finger and BTB domain containing 1
chr1_-_159714581 0.11 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
C-reactive protein
chr5_+_43602648 0.11 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
nicotinamide nucleotide transhydrogenase

Network of associatons between targets according to the STRING database.

First level regulatory network of IKZF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 2.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.3 1.3 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.3 1.2 GO:1990523 bone regeneration(GO:1990523)
0.3 1.7 GO:0008218 bioluminescence(GO:0008218)
0.3 0.8 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.2 4.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 0.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 2.3 GO:0008354 germ cell migration(GO:0008354)
0.1 0.6 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.1 0.4 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.3 GO:0044691 tooth eruption(GO:0044691)
0.1 2.0 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.4 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 1.6 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.6 GO:0061743 motor learning(GO:0061743)
0.1 0.4 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.1 0.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.2 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.1 0.2 GO:1903977 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) negative regulation of eosinophil activation(GO:1902567) positive regulation of glial cell migration(GO:1903977) positive regulation of monocyte extravasation(GO:2000439)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.5 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000343)
0.1 0.3 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.4 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.2 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.1 0.2 GO:1903259 exon-exon junction complex disassembly(GO:1903259)
0.0 0.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.0 0.3 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 1.0 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.2 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.5 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.1 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.4 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.0 0.1 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.6 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 1.1 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.8 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.1 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.4 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 3.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.5 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.2 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0019255 UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.5 GO:0072189 ureter development(GO:0072189)
0.0 0.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.2 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.9 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.0 GO:2000724 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0051597 response to methylmercury(GO:0051597)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.2 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.3 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0043366 beta selection(GO:0043366)
0.0 0.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.3 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 1.0 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.0 GO:0048880 thiamine pyrophosphate transport(GO:0030974) sensory system development(GO:0048880)
0.0 0.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) kinetochore assembly(GO:0051382)
0.0 0.1 GO:0042262 DNA protection(GO:0042262)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 4.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 4.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.3 GO:0043293 apoptosome(GO:0043293)
0.1 0.3 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.7 GO:0071953 elastic fiber(GO:0071953)
0.1 0.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.4 GO:0008305 integrin complex(GO:0008305)
0.0 1.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 2.3 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.3 4.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 2.5 GO:0050692 DBD domain binding(GO:0050692)
0.2 0.6 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 0.5 GO:0008431 vitamin E binding(GO:0008431)
0.2 0.5 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.4 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.4 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 0.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 4.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.2 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.0 GO:0030305 heparanase activity(GO:0030305)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.8 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 0.0 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.0 GO:0090422 thiamine pyrophosphate transporter activity(GO:0090422)
0.0 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0046790 virion binding(GO:0046790)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 1.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins