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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for MEF2D_MEF2A

Z-value: 0.75

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol Gene ID Gene Info
MEF2D
ENSG00000116604.18 myocyte enhancer factor 2D
MEF2A
ENSG00000068305.17 myocyte enhancer factor 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Dhg38_v1_chr1_-_156500723_156500753-0.695.8e-02Click!
MEF2Ahg38_v1_chr15_+_99565921_995659290.541.7e-01Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_111756245 2.33 ENST00000447165.6
NREP
neuronal regeneration related protein
chr3_+_99638475 1.33 ENST00000452013.5
ENST00000261037.7
ENST00000652472.1
ENST00000273342.8
ENST00000621757.1
COL8A1
collagen type VIII alpha 1 chain
chr1_+_183636065 1.12 ENST00000304685.8
RGL1
ral guanine nucleotide dissociation stimulator like 1
chr5_-_151141631 1.06 ENST00000523714.5
ENST00000521749.5
ANXA6
annexin A6
chrX_-_143635081 0.99 ENST00000338017.8
SLITRK4
SLIT and NTRK like family member 4
chr2_-_144431001 0.99 ENST00000636413.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_144430934 0.97 ENST00000638087.1
ENST00000638007.1
ZEB2
zinc finger E-box binding homeobox 2
chr12_-_91146195 0.96 ENST00000548218.1
DCN
decorin
chr1_+_170664121 0.94 ENST00000239461.11
PRRX1
paired related homeobox 1
chr2_-_189179754 0.86 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr1_+_170663917 0.73 ENST00000497230.2
PRRX1
paired related homeobox 1
chr2_+_232633551 0.69 ENST00000264059.8
EFHD1
EF-hand domain family member D1
chr6_-_154430495 0.67 ENST00000424998.3
CNKSR3
CNKSR family member 3
chr1_+_113979391 0.62 ENST00000393300.6
ENST00000369551.5
OLFML3
olfactomedin like 3
chr1_+_113979460 0.62 ENST00000320334.5
OLFML3
olfactomedin like 3
chr6_+_135851681 0.55 ENST00000308191.11
PDE7B
phosphodiesterase 7B
chr2_+_148021404 0.54 ENST00000638043.2
MBD5
methyl-CpG binding domain protein 5
chr3_-_112641128 0.52 ENST00000206423.8
CCDC80
coiled-coil domain containing 80
chr6_+_131808011 0.50 ENST00000647893.1
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_-_145910031 0.47 ENST00000369304.8
ITGA10
integrin subunit alpha 10
chr13_+_75804169 0.46 ENST00000526371.1
ENST00000526528.1
LMO7
LIM domain 7
chr1_-_145910066 0.45 ENST00000539363.2
ITGA10
integrin subunit alpha 10
chr3_-_112641292 0.45 ENST00000439685.6
CCDC80
coiled-coil domain containing 80
chr9_+_121286115 0.45 ENST00000477104.2
ENST00000394353.7
GSN
gelsolin
chr5_+_93583212 0.44 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr5_+_68288346 0.43 ENST00000320694.12
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr4_+_54229261 0.43 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
PDGFRA
platelet derived growth factor receptor alpha
chr5_+_173889337 0.42 ENST00000520867.5
ENST00000334035.9
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr4_-_39638893 0.42 ENST00000511809.5
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr3_+_138348570 0.41 ENST00000423968.7
MRAS
muscle RAS oncogene homolog
chr13_+_75804221 0.41 ENST00000489941.6
ENST00000525373.5
LMO7
LIM domain 7
chr13_+_75760362 0.40 ENST00000534657.5
LMO7
LIM domain 7
chr10_-_60944132 0.39 ENST00000337910.10
RHOBTB1
Rho related BTB domain containing 1
chr3_+_138348592 0.37 ENST00000621127.4
ENST00000494949.5
MRAS
muscle RAS oncogene homolog
chr4_-_39638846 0.36 ENST00000295958.10
SMIM14
small integral membrane protein 14
chr20_+_58907981 0.34 ENST00000656419.1
GNAS
GNAS complex locus
chrX_-_21758097 0.33 ENST00000379494.4
SMPX
small muscle protein X-linked
chr19_+_36605292 0.33 ENST00000460670.5
ENST00000292928.7
ENST00000439428.5
ZNF382
zinc finger protein 382
chr3_+_69763726 0.33 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr16_+_88382950 0.32 ENST00000565624.3
ZNF469
zinc finger protein 469
chr8_+_27325516 0.32 ENST00000346049.10
ENST00000420218.3
PTK2B
protein tyrosine kinase 2 beta
chr1_+_156126160 0.32 ENST00000448611.6
ENST00000368297.5
LMNA
lamin A/C
chr1_-_153545793 0.30 ENST00000354332.8
ENST00000368716.9
S100A4
S100 calcium binding protein A4
chr8_-_27614681 0.29 ENST00000519472.5
ENST00000523589.5
ENST00000522413.5
ENST00000523396.1
ENST00000316403.15
CLU
clusterin
chr6_+_108656346 0.29 ENST00000540898.1
FOXO3
forkhead box O3
chr21_-_26843063 0.29 ENST00000678221.1
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr1_-_31373067 0.28 ENST00000373713.7
FABP3
fatty acid binding protein 3
chr21_-_26843012 0.28 ENST00000517777.6
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr17_+_70169516 0.28 ENST00000243457.4
KCNJ2
potassium inwardly rectifying channel subfamily J member 2
chr17_+_44170695 0.28 ENST00000293414.6
ASB16
ankyrin repeat and SOCS box containing 16
chr12_+_78864768 0.27 ENST00000261205.9
ENST00000457153.6
SYT1
synaptotagmin 1
chr13_+_75760659 0.26 ENST00000526202.5
ENST00000465261.6
LMO7
LIM domain 7
chr10_+_102419189 0.26 ENST00000432590.5
FBXL15
F-box and leucine rich repeat protein 15
chr17_-_1485733 0.26 ENST00000648446.1
MYO1C
myosin IC
chr2_+_148021083 0.25 ENST00000642680.2
MBD5
methyl-CpG binding domain protein 5
chr17_-_1486124 0.25 ENST00000575158.5
MYO1C
myosin IC
chr3_-_146161167 0.25 ENST00000360060.7
ENST00000282903.10
PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
chr8_-_13514821 0.25 ENST00000276297.9
DLC1
DLC1 Rho GTPase activating protein
chr7_-_134459089 0.25 ENST00000285930.9
AKR1B1
aldo-keto reductase family 1 member B
chr2_-_210303608 0.25 ENST00000341685.8
MYL1
myosin light chain 1
chr9_+_136977496 0.25 ENST00000371625.8
ENST00000457950.5
PTGDS
prostaglandin D2 synthase
chr10_-_48652493 0.25 ENST00000435790.6
ARHGAP22
Rho GTPase activating protein 22
chr2_+_148021001 0.25 ENST00000407073.5
MBD5
methyl-CpG binding domain protein 5
chr19_+_35139440 0.24 ENST00000455515.6
FXYD1
FXYD domain containing ion transport regulator 1
chr3_+_8501846 0.24 ENST00000454244.4
LMCD1
LIM and cysteine rich domains 1
chr19_+_1266653 0.23 ENST00000586472.5
ENST00000589266.5
CIRBP
cold inducible RNA binding protein
chr4_+_128809684 0.23 ENST00000226319.11
ENST00000511647.5
JADE1
jade family PHD finger 1
chr13_+_75636311 0.23 ENST00000377499.9
ENST00000377534.8
LMO7
LIM domain 7
chr3_+_141387801 0.22 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr13_+_75760431 0.22 ENST00000321797.12
LMO7
LIM domain 7
chr3_+_141387616 0.21 ENST00000509883.5
ZBTB38
zinc finger and BTB domain containing 38
chr1_+_201648136 0.21 ENST00000367296.8
NAV1
neuron navigator 1
chr2_+_219279330 0.21 ENST00000425450.5
ENST00000392086.8
ENST00000421532.5
ENST00000336576.10
DNAJB2
DnaJ heat shock protein family (Hsp40) member B2
chr3_-_39192584 0.20 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin binding repeat containing 1
chr10_-_3785179 0.20 ENST00000469435.1
KLF6
Kruppel like factor 6
chr4_-_185775271 0.20 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr2_-_105438503 0.20 ENST00000393352.7
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr19_-_49423441 0.18 ENST00000270631.2
PTH2
parathyroid hormone 2
chr8_-_13514744 0.18 ENST00000316609.9
DLC1
DLC1 Rho GTPase activating protein
chr3_+_8501807 0.18 ENST00000426878.2
ENST00000397386.7
ENST00000415597.5
ENST00000157600.8
LMCD1
LIM and cysteine rich domains 1
chr22_+_19723525 0.18 ENST00000366425.4
GP1BB
glycoprotein Ib platelet subunit beta
chr1_+_156126525 0.17 ENST00000504687.6
ENST00000473598.6
LMNA
lamin A/C
chr3_-_138115594 0.17 ENST00000327532.7
ENST00000467030.5
DZIP1L
DAZ interacting zinc finger protein 1 like
chr17_-_36090133 0.16 ENST00000613922.2
CCL3
C-C motif chemokine ligand 3
chr4_+_159241016 0.16 ENST00000644902.1
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr10_-_3785197 0.16 ENST00000497571.6
KLF6
Kruppel like factor 6
chr3_+_138348823 0.16 ENST00000475711.5
ENST00000464896.5
MRAS
muscle RAS oncogene homolog
chr3_-_114624193 0.16 ENST00000481632.5
ZBTB20
zinc finger and BTB domain containing 20
chr15_-_52652031 0.15 ENST00000546305.6
FAM214A
family with sequence similarity 214 member A
chr11_-_19201976 0.15 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr15_-_82806054 0.15 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr5_-_67196791 0.15 ENST00000256447.5
CD180
CD180 molecule
chr1_-_46176482 0.15 ENST00000540385.2
ENST00000506599.2
P3R3URF-PIK3R3
P3R3URF
P3R3URF-PIK3R3 readthrough
PIK3R3 upstream reading frame
chr2_-_210315160 0.15 ENST00000352451.4
MYL1
myosin light chain 1
chr15_+_99565950 0.15 ENST00000557785.5
ENST00000558049.5
ENST00000449277.6
MEF2A
myocyte enhancer factor 2A
chr1_+_160081529 0.15 ENST00000368088.4
KCNJ9
potassium inwardly rectifying channel subfamily J member 9
chr1_-_206772484 0.15 ENST00000423557.1
IL10
interleukin 10
chr15_+_99565921 0.15 ENST00000558812.5
ENST00000338042.10
MEF2A
myocyte enhancer factor 2A
chr10_-_3785225 0.15 ENST00000542957.1
KLF6
Kruppel like factor 6
chr2_+_44275457 0.15 ENST00000611973.4
ENST00000409387.5
SLC3A1
solute carrier family 3 member 1
chr13_-_102759059 0.15 ENST00000322527.4
CCDC168
coiled-coil domain containing 168
chr6_+_25726767 0.14 ENST00000274764.5
H2BC1
H2B clustered histone 1
chr1_+_150272772 0.14 ENST00000369098.3
ENST00000369099.8
C1orf54
chromosome 1 open reading frame 54
chr9_-_83267230 0.14 ENST00000328788.5
FRMD3
FERM domain containing 3
chrX_-_47574738 0.14 ENST00000640721.1
SYN1
synapsin I
chr15_+_92900338 0.14 ENST00000625990.3
CHD2
chromodomain helicase DNA binding protein 2
chr9_+_124291935 0.14 ENST00000546191.5
NEK6
NIMA related kinase 6
chr8_-_69833338 0.14 ENST00000524945.5
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr1_-_58784035 0.14 ENST00000371222.4
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
chr3_+_179653032 0.14 ENST00000680587.1
ENST00000681064.1
ENST00000263966.8
ENST00000681358.1
ENST00000679749.1
USP13
ubiquitin specific peptidase 13
chr12_+_12785652 0.14 ENST00000356591.5
APOLD1
apolipoprotein L domain containing 1
chr4_+_37891060 0.14 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1D1
TBC1 domain family member 1
chr4_+_113049616 0.14 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ANK2
ankyrin 2
chr6_+_113857333 0.14 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr2_+_44275473 0.14 ENST00000260649.11
SLC3A1
solute carrier family 3 member 1
chr15_+_99566066 0.14 ENST00000557942.5
MEF2A
myocyte enhancer factor 2A
chr8_-_27992624 0.13 ENST00000524352.5
SCARA5
scavenger receptor class A member 5
chr4_-_113761068 0.13 ENST00000342666.9
ENST00000514328.5
ENST00000515496.5
ENST00000508738.5
ENST00000379773.6
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr3_-_177196451 0.13 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr11_-_64759967 0.13 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chr1_+_89633086 0.13 ENST00000370454.9
LRRC8C
leucine rich repeat containing 8 VRAC subunit C
chr12_-_114683590 0.13 ENST00000257566.7
TBX3
T-box transcription factor 3
chr7_-_151248668 0.13 ENST00000262188.13
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr12_+_15546344 0.12 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr2_-_165203870 0.12 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr11_+_45896541 0.12 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_+_50279080 0.12 ENST00000316436.4
LSMEM2
leucine rich single-pass membrane protein 2
chr3_+_179653129 0.12 ENST00000680008.1
USP13
ubiquitin specific peptidase 13
chr9_+_35341830 0.12 ENST00000636694.1
UNC13B
unc-13 homolog B
chr14_-_88554898 0.12 ENST00000556564.6
PTPN21
protein tyrosine phosphatase non-receptor type 21
chr15_+_90903288 0.12 ENST00000559717.6
MAN2A2
mannosidase alpha class 2A member 2
chr16_-_15643024 0.12 ENST00000540441.6
MARF1
meiosis regulator and mRNA stability factor 1
chr16_-_15643105 0.12 ENST00000548025.5
ENST00000551742.5
ENST00000396368.8
MARF1
meiosis regulator and mRNA stability factor 1
chr4_-_185775890 0.12 ENST00000437304.6
SORBS2
sorbin and SH3 domain containing 2
chr3_+_54123452 0.11 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr2_+_161136901 0.11 ENST00000259075.6
ENST00000432002.5
TANK
TRAF family member associated NFKB activator
chr2_+_42494547 0.11 ENST00000405592.5
MTA3
metastasis associated 1 family member 3
chr17_+_7558296 0.11 ENST00000438470.5
ENST00000436057.5
TNFSF13
TNF superfamily member 13
chr15_+_84817346 0.11 ENST00000258888.6
ALPK3
alpha kinase 3
chr8_-_61689768 0.11 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
ASPH
aspartate beta-hydroxylase
chr17_+_82229034 0.11 ENST00000582743.6
ENST00000578684.6
ENST00000577650.6
ENST00000582715.1
SLC16A3
solute carrier family 16 member 3
chr22_-_31346143 0.11 ENST00000405309.7
ENST00000351933.8
PATZ1
POZ/BTB and AT hook containing zinc finger 1
chr1_+_84164962 0.11 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_-_165204042 0.10 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr21_-_33643926 0.10 ENST00000438788.1
CRYZL1
crystallin zeta like 1
chr22_+_25199856 0.10 ENST00000215855.7
ENST00000404334.1
CRYBB3
crystallin beta B3
chr1_-_1000139 0.10 ENST00000428771.6
HES4
hes family bHLH transcription factor 4
chr15_-_37099306 0.10 ENST00000557796.6
ENST00000397620.6
MEIS2
Meis homeobox 2
chr1_+_151156659 0.10 ENST00000602841.5
SCNM1
sodium channel modifier 1
chr2_+_161231078 0.10 ENST00000439442.1
TANK
TRAF family member associated NFKB activator
chr17_-_44123628 0.10 ENST00000587135.1
ENST00000225983.10
ENST00000682912.1
ENST00000588703.5
HDAC5
histone deacetylase 5
chr6_+_122717544 0.09 ENST00000354275.2
ENST00000368446.1
PKIB
cAMP-dependent protein kinase inhibitor beta
chr19_+_35138993 0.09 ENST00000612146.4
ENST00000589209.5
FXYD1
FXYD domain containing ion transport regulator 1
chr17_+_39665340 0.09 ENST00000578283.1
ENST00000309889.3
TCAP
titin-cap
chr12_+_53461015 0.09 ENST00000553064.6
ENST00000547859.2
PCBP2
poly(rC) binding protein 2
chr14_-_70080180 0.09 ENST00000394330.6
ENST00000533541.1
ENST00000216568.11
SLC8A3
solute carrier family 8 member A3
chr3_-_158106408 0.09 ENST00000483851.7
SHOX2
short stature homeobox 2
chr7_+_30911845 0.09 ENST00000652696.1
ENST00000311813.11
AQP1
aquaporin 1 (Colton blood group)
chrX_-_132219439 0.09 ENST00000370874.2
RAP2C
RAP2C, member of RAS oncogene family
chr8_-_71356653 0.09 ENST00000388742.8
ENST00000388740.4
EYA1
EYA transcriptional coactivator and phosphatase 1
chr10_-_102419934 0.09 ENST00000406432.5
PSD
pleckstrin and Sec7 domain containing
chrX_-_132219473 0.09 ENST00000620646.4
RAP2C
RAP2C, member of RAS oncogene family
chr4_+_119135825 0.09 ENST00000307128.6
MYOZ2
myozenin 2
chr17_-_44123590 0.09 ENST00000336057.9
HDAC5
histone deacetylase 5
chr2_+_167187283 0.09 ENST00000409605.1
ENST00000409273.6
XIRP2
xin actin binding repeat containing 2
chr3_-_158106050 0.09 ENST00000441443.6
ENST00000389589.8
SHOX2
short stature homeobox 2
chrX_-_15314543 0.09 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr6_-_2744126 0.08 ENST00000647417.1
MYLK4
myosin light chain kinase family member 4
chr8_-_71356511 0.08 ENST00000419131.6
ENST00000388743.6
EYA1
EYA transcriptional coactivator and phosphatase 1
chr12_+_40224956 0.08 ENST00000298910.12
ENST00000343742.6
LRRK2
leucine rich repeat kinase 2
chr12_+_68808143 0.08 ENST00000258149.11
ENST00000428863.6
ENST00000393412.7
MDM2
MDM2 proto-oncogene
chr9_+_126914760 0.08 ENST00000424082.6
ENST00000259351.10
ENST00000394022.7
ENST00000394011.7
ENST00000319107.8
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr12_-_49187369 0.08 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr12_-_48999363 0.08 ENST00000421952.3
DDN
dendrin
chr19_+_10013468 0.08 ENST00000591589.3
RDH8
retinol dehydrogenase 8
chr4_-_139177185 0.08 ENST00000394235.6
ELF2
E74 like ETS transcription factor 2
chr9_-_33402551 0.08 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr2_-_230960954 0.08 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr5_-_42811884 0.08 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
SELENOP
selenoprotein P
chr5_-_138139382 0.08 ENST00000265191.4
NME5
NME/NM23 family member 5
chr9_-_127877665 0.08 ENST00000644144.2
AK1
adenylate kinase 1
chr1_+_156242177 0.08 ENST00000368272.5
BGLAP
bone gamma-carboxyglutamate protein
chr16_+_8674605 0.08 ENST00000268251.13
ABAT
4-aminobutyrate aminotransferase
chr22_-_35617321 0.08 ENST00000397326.7
ENST00000442617.1
MB
myoglobin
chr5_+_161848112 0.08 ENST00000393943.10
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr5_-_141651376 0.08 ENST00000522783.5
ENST00000519800.1
ENST00000435817.7
FCHSD1
FCH and double SH3 domains 1
chrX_-_72714181 0.08 ENST00000339490.7
ENST00000541944.5
ENST00000373539.3
PHKA1
phosphorylase kinase regulatory subunit alpha 1
chr1_-_150720842 0.08 ENST00000442853.5
ENST00000368995.8
ENST00000322343.11
ENST00000361824.7
HORMAD1
HORMA domain containing 1
chr6_-_43016856 0.08 ENST00000645375.1
ENST00000645410.1
MEA1
male-enhanced antigen 1
chrX_-_72714278 0.08 ENST00000373542.9
ENST00000373545.7
PHKA1
phosphorylase kinase regulatory subunit alpha 1
chr5_-_36151853 0.08 ENST00000296603.5
LMBRD2
LMBR1 domain containing 2
chr2_+_167187364 0.08 ENST00000672671.1
XIRP2
xin actin binding repeat containing 2
chr10_+_86668501 0.08 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LDB3
LIM domain binding 3
chr1_-_117210918 0.07 ENST00000369458.8
ENST00000430871.3
ENST00000328189.7
VTCN1
V-set domain containing T cell activation inhibitor 1
chr11_-_18012883 0.07 ENST00000530613.5
ENST00000532389.5
ENST00000529728.5
ENST00000532265.5
SERGEF
secretion regulating guanine nucleotide exchange factor
chr1_-_203175783 0.07 ENST00000621380.1
ENST00000255416.9
MYBPH
myosin binding protein H
chr10_-_102419693 0.07 ENST00000611678.4
PSD
pleckstrin and Sec7 domain containing
chr19_+_35138778 0.07 ENST00000351325.9
ENST00000586871.5
ENST00000592174.1
FXYD1
ENSG00000221857.7
FXYD domain containing ion transport regulator 1
novel transcript
chr4_-_82844418 0.07 ENST00000503937.5
SEC31A
SEC31 homolog A, COPII coat complex component
chrX_+_16650155 0.07 ENST00000380200.3
S100G
S100 calcium binding protein G

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 2.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.0 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 0.5 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.4 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.3 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.3 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.4 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 0.3 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 0.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.4 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.2 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1 0.1 GO:0060932 His-Purkinje system cell differentiation(GO:0060932)
0.1 0.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.3 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.1 GO:0035026 leading edge cell differentiation(GO:0035026) cellular response to potassium ion starvation(GO:0051365)
0.0 0.3 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.3 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 1.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0072019 nitric oxide transport(GO:0030185) cerebrospinal fluid secretion(GO:0033326) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.0 0.1 GO:1903217 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.1 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.7 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:1904450 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 0.1 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.2 GO:0036309 protein localization to M-band(GO:0036309)
0.0 0.1 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0033058 directional locomotion(GO:0033058)
0.0 0.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.0 GO:1905006 negative regulation of alkaline phosphatase activity(GO:0010693) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
0.0 0.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.2 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.0 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.0 GO:0009305 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.0 0.8 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.0 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.9 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.3 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.5 GO:0045160 myosin I complex(GO:0045160)
0.1 1.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.3 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 1.0 GO:0010369 chromocenter(GO:0010369)
0.0 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.3 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 1.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.5 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 1.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.0 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.0 0.1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)