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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for MSX1

Z-value: 0.72

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Transcription factors associated with MSX1

Gene Symbol Gene ID Gene Info
ENSG00000163132.8 msh homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX1hg38_v1_chr4_+_4859658_48596720.658.1e-02Click!

Activity profile of MSX1 motif

Sorted Z-values of MSX1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_37598750 3.54 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
periostin
chr5_-_76623391 0.92 ENST00000296641.5
ENST00000504899.1
coagulation factor II thrombin receptor like 2
chr9_+_76459152 0.85 ENST00000444201.6
ENST00000376730.5
glucosaminyl (N-acetyl) transferase 1
chr1_-_72100930 0.80 ENST00000306821.3
neuronal growth regulator 1
chr6_+_28281555 0.68 ENST00000259883.3
ENST00000682144.1
piggyBac transposable element derived 1
chr9_+_87497222 0.65 ENST00000358077.9
death associated protein kinase 1
chr5_+_83471764 0.63 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
versican
chr5_+_83471668 0.60 ENST00000342785.8
ENST00000343200.9
versican
chr5_+_83471736 0.57 ENST00000265077.8
versican
chr19_-_53159004 0.52 ENST00000599096.1
ENST00000597183.5
ENST00000601804.5
ENST00000334197.12
ENST00000601469.2
ENST00000452676.6
zinc finger protein 347
chr2_+_209579598 0.50 ENST00000445941.5
ENST00000673860.1
microtubule associated protein 2
chr2_+_209579399 0.50 ENST00000360351.8
microtubule associated protein 2
chr2_+_157257687 0.37 ENST00000259056.5
polypeptide N-acetylgalactosaminyltransferase 5
chr9_-_92482350 0.36 ENST00000375543.2
asporin
chr1_-_12831410 0.33 ENST00000619922.1
PRAME family member 11
chr13_+_48976597 0.33 ENST00000541916.5
fibronectin type III domain containing 3A
chr16_-_66549839 0.29 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
thymidine kinase 2
chr16_-_66550091 0.28 ENST00000564917.5
ENST00000677420.1
thymidine kinase 2
chr7_+_148590760 0.26 ENST00000307003.3
chromosome 7 open reading frame 33
chr2_+_209579429 0.26 ENST00000361559.8
microtubule associated protein 2
chr6_+_28124596 0.26 ENST00000340487.5
zinc finger and SCAN domain containing 16
chr19_-_53254841 0.26 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
zinc finger protein 677
chr1_+_210328244 0.26 ENST00000541565.5
ENST00000413764.6
hedgehog acyltransferase
chr11_+_101914997 0.26 ENST00000263468.13
centrosomal protein 126
chr6_+_135851681 0.26 ENST00000308191.11
phosphodiesterase 7B
chr5_+_173889337 0.25 ENST00000520867.5
ENST00000334035.9
cytoplasmic polyadenylation element binding protein 4
chr19_-_53254688 0.25 ENST00000594517.5
ENST00000601413.5
ENST00000594681.5
zinc finger protein 677
chr16_-_66550005 0.24 ENST00000527284.6
thymidine kinase 2
chr11_-_102530738 0.24 ENST00000260227.5
matrix metallopeptidase 7
chr1_+_224183197 0.24 ENST00000323699.9
delta 4-desaturase, sphingolipid 1
chr15_+_76336755 0.23 ENST00000290759.9
ISL LIM homeobox 2
chr18_-_5396265 0.22 ENST00000579951.2
erythrocyte membrane protein band 4.1 like 3
chr16_-_66550142 0.21 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
thymidine kinase 2
chr16_+_21678514 0.21 ENST00000286149.8
ENST00000388958.8
otoancorin
chr4_-_185775271 0.20 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chr6_+_6588082 0.17 ENST00000379953.6
lymphocyte antigen 86
chr10_+_17228215 0.17 ENST00000544301.7
vimentin
chr17_-_8210203 0.17 ENST00000578549.5
ENST00000582368.5
aurora kinase B
chr16_-_71484543 0.17 ENST00000565100.6
zinc finger protein 19
chr20_+_58389197 0.16 ENST00000475243.6
ENST00000395802.7
VAMP associated protein B and C
chr16_-_66550112 0.16 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
thymidine kinase 2
chr8_-_7385558 0.16 ENST00000400156.4
zinc finger protein 705G
chr6_+_26240385 0.16 ENST00000244537.6
H4 clustered histone 6
chr1_-_53940100 0.15 ENST00000371376.1
heat shock protein family B (small) member 11
chr6_+_131573219 0.15 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
arginase 1
chr2_-_168890368 0.13 ENST00000282074.7
SPC25 component of NDC80 kinetochore complex
chr4_+_112647059 0.13 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr1_-_158426237 0.12 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr3_-_21751189 0.12 ENST00000281523.8
zinc finger protein 385D
chr4_+_70242583 0.12 ENST00000304954.3
casein kappa
chr1_+_244835616 0.12 ENST00000366528.3
ENST00000411948.7
cytochrome c oxidase assembly factor COX20
chr8_-_25424260 0.11 ENST00000421054.7
gonadotropin releasing hormone 1
chr14_+_51860632 0.11 ENST00000555472.5
ENST00000556766.5
G protein subunit gamma 2
chr11_+_61430100 0.11 ENST00000542074.1
ENST00000534878.5
ENST00000301761.7
ENST00000537782.5
ENST00000543265.1
succinate dehydrogenase complex assembly factor 2
chr10_-_32378720 0.11 ENST00000375110.6
enhancer of polycomb homolog 1
chr21_+_32298849 0.11 ENST00000303645.10
melanocortin 2 receptor accessory protein
chrX_-_104254921 0.11 ENST00000372588.4
ESX homeobox 1
chr9_-_128656649 0.10 ENST00000372715.7
dynein 2 intermediate chain 2
chr10_-_29634964 0.10 ENST00000375398.6
ENST00000355867.8
supervillin
chr17_+_32350132 0.10 ENST00000321233.10
ENST00000394673.6
ENST00000394670.9
ENST00000579634.5
ENST00000580759.5
ENST00000342555.10
ENST00000577908.5
ENST00000394679.9
ENST00000582165.1
zinc finger protein 207
chr15_-_77420087 0.10 ENST00000564328.5
ENST00000682557.1
ENST00000558305.5
pseudopodium enriched atypical kinase 1
chr15_-_77420135 0.09 ENST00000560626.6
pseudopodium enriched atypical kinase 1
chr1_+_159015665 0.09 ENST00000567661.5
ENST00000474473.1
interferon gamma inducible protein 16
chr15_+_51377247 0.09 ENST00000396399.6
gliomedin
chr9_-_15510289 0.09 ENST00000397519.6
PC4 and SFRS1 interacting protein 1
chr3_+_108589667 0.09 ENST00000361582.8
ENST00000486815.5
DAZ interacting zinc finger protein 3
chr3_+_114294020 0.09 ENST00000383671.8
T cell immunoreceptor with Ig and ITIM domains
chr2_+_188292814 0.08 ENST00000409580.5
ENST00000409637.7
GULP PTB domain containing engulfment adaptor 1
chr2_-_135530561 0.08 ENST00000536680.5
ENST00000401392.5
zinc finger RANBP2-type containing 3
chr3_-_47513677 0.08 ENST00000296149.9
elongator acetyltransferase complex subunit 6
chr14_+_55129242 0.08 ENST00000254301.14
ENST00000554715.1
galectin 3
chr9_+_130664594 0.08 ENST00000253008.3
ENST00000676323.1
PR/SET domain 12
chr11_+_62270150 0.08 ENST00000525380.1
ENST00000227918.3
secretoglobin family 2A member 2
chr20_+_6007245 0.08 ENST00000378868.4
cardiolipin synthase 1
chr2_+_95165784 0.08 ENST00000622059.4
ENST00000614034.5
ENST00000611147.1
zinc finger protein 2
chr1_-_167518583 0.08 ENST00000392122.3
CD247 molecule
chr5_-_11588842 0.08 ENST00000503622.5
catenin delta 2
chr15_+_78873723 0.08 ENST00000559690.5
ENST00000559158.5
mortality factor 4 like 1
chr5_-_147782518 0.07 ENST00000507386.5
janus kinase and microtubule interacting protein 2
chr3_+_190388120 0.07 ENST00000456423.2
ENST00000264734.3
claudin 16
chr6_+_96563117 0.07 ENST00000450218.6
four and a half LIM domains 5
chr15_-_42208153 0.07 ENST00000348544.4
ENST00000318006.10
VPS39 subunit of HOPS complex
chr8_+_28891304 0.07 ENST00000355231.9
homeobox containing 1
chr14_+_55027576 0.07 ENST00000339298.2
suppressor of cytokine signaling 4
chr22_+_41301514 0.07 ENST00000352645.5
zinc finger CCCH-type containing 7B
chr11_+_94512452 0.07 ENST00000542198.3
chromosome 11 open reading frame 97
chr18_+_63970029 0.07 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
serpin family B member 8
chr20_+_35542038 0.07 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC and golgi 3
chr11_-_114559866 0.06 ENST00000534921.2
neurexophilin and PC-esterase domain family member 1
chr1_-_167518521 0.06 ENST00000362089.10
CD247 molecule
chr14_+_55027200 0.06 ENST00000395472.2
ENST00000555846.2
suppressor of cytokine signaling 4
chr3_-_15440560 0.06 ENST00000595627.5
ENST00000597949.1
ENST00000494875.3
ENST00000595975.1
ENST00000598878.1
EAF1 antisense RNA 1
methyltransferase like 6
chr14_-_73558945 0.06 ENST00000563329.1
ENST00000553558.6
ENST00000334988.2
HEAT repeat containing 4
chr19_-_49036885 0.06 ENST00000604577.1
ENST00000591656.1
ENST00000301407.8
ENST00000601167.1
novel protein
chorionic gonadotropin subunit beta 1
chr12_-_10826358 0.06 ENST00000240619.2
taste 2 receptor member 10
chr14_+_22495890 0.05 ENST00000390494.1
T cell receptor alpha joining 43
chr7_-_29990113 0.05 ENST00000426154.5
ENST00000421434.5
ENST00000434476.6
secernin 1
chr1_-_149936324 0.05 ENST00000369140.7
myotubularin related protein 11
chr11_-_114559847 0.05 ENST00000251921.6
neurexophilin and PC-esterase domain family member 1
chr1_+_202122881 0.05 ENST00000683302.1
ENST00000683557.1
G protein-coupled receptor 37 like 1
chr8_+_24384275 0.05 ENST00000256412.8
ADAM like decysin 1
chr1_+_202122910 0.05 ENST00000682545.1
ENST00000367282.6
ENST00000682887.1
G protein-coupled receptor 37 like 1
chr6_-_31862809 0.04 ENST00000375631.5
neuraminidase 1
chr6_-_75363003 0.04 ENST00000370020.1
filamin A interacting protein 1
chr8_+_24384455 0.04 ENST00000522298.1
ADAM like decysin 1
chr7_+_139133744 0.04 ENST00000430935.5
ENST00000495038.5
ENST00000474035.6
ENST00000478836.6
ENST00000464848.5
ENST00000343187.8
tetratricopeptide repeat domain 26
chr17_-_39778213 0.04 ENST00000583368.1
IKAROS family zinc finger 3
chr1_+_7961894 0.04 ENST00000377491.5
ENST00000377488.5
Parkinsonism associated deglycase
chr8_-_71361860 0.04 ENST00000303824.11
ENST00000645451.1
EYA transcriptional coactivator and phosphatase 1
chr4_-_99219230 0.04 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
alcohol dehydrogenase 6 (class V)
chr12_-_42144823 0.04 ENST00000398675.8
glucoside xylosyltransferase 1
chrY_-_6872608 0.04 ENST00000383036.1
amelogenin Y-linked
chr14_+_93185304 0.03 ENST00000415050.3
transmembrane protein 251
chr16_+_69311339 0.03 ENST00000254950.13
vacuolar protein sorting 4 homolog A
chr14_+_77116562 0.03 ENST00000557408.5
transmembrane protein 63C
chr3_-_94062906 0.03 ENST00000314636.3
ENST00000394221.3
dihydrofolate reductase 2
chr11_-_55936400 0.03 ENST00000301532.3
olfactory receptor family 5 subfamily I member 1
chr19_-_20039205 0.03 ENST00000358523.9
ENST00000397162.5
ENST00000601100.5
zinc finger protein 682
chrX_+_11293411 0.03 ENST00000348912.4
ENST00000380714.7
ENST00000380712.7
amelogenin X-linked
chr3_-_180679468 0.02 ENST00000651046.1
ENST00000476379.6
coiled-coil domain containing 39
chr9_+_65700287 0.02 ENST00000489273.1
COBW domain containing 5
chr3_-_167407837 0.02 ENST00000455345.7
zinc finger B-box domain containing
chr11_-_93197932 0.02 ENST00000326402.9
solute carrier family 36 member 4
chr13_-_52159844 0.02 ENST00000611833.4
NIMA related kinase 3
chr19_-_7747511 0.02 ENST00000593660.5
ENST00000204801.12
ENST00000315591.12
ENST00000354397.10
ENST00000394161.9
ENST00000593821.5
ENST00000602261.5
ENST00000601256.1
ENST00000601951.5
ENST00000315599.12
CD209 molecule
chr21_+_32298945 0.01 ENST00000339944.4
melanocortin 2 receptor accessory protein
chr3_-_94062881 0.01 ENST00000619045.1
dihydrofolate reductase 2
chr13_-_52159559 0.01 ENST00000620675.4
ENST00000610828.5
NIMA related kinase 3
chr6_-_109483208 0.01 ENST00000230122.4
zinc finger and BTB domain containing 24
chr4_+_158521714 0.01 ENST00000613319.4
ENST00000423548.5
ENST00000448688.6
relaxin family peptide receptor 1
chr15_+_36579782 0.01 ENST00000437989.6
CDAN1 interacting nuclease 1
chr4_-_163613505 0.01 ENST00000339875.9
membrane associated ring-CH-type finger 1
chr18_-_72865680 0.01 ENST00000397929.5
neuropilin and tolloid like 1
chrX_-_123622809 0.01 ENST00000441692.5
THO complex 2
chr19_-_9107475 0.01 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr9_-_83978429 0.00 ENST00000351839.7
heterogeneous nuclear ribonucleoprotein K
chr9_-_21240002 0.00 ENST00000380222.4
interferon alpha 14

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:1990523 bone regeneration(GO:1990523)
0.2 1.2 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.8 GO:0060352 cell adhesion molecule production(GO:0060352)
0.1 1.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.9 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121) respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.1 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.7 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.1 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.0 GO:1903181 enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.0 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 3.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.2 1.2 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.1 0.9 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.2 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.1 GO:0036505 prosaposin receptor activity(GO:0036505)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 3.9 GO:0008201 heparin binding(GO:0008201)
0.0 0.0 GO:0004146 dihydrofolate reductase activity(GO:0004146)
0.0 0.0 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins