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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NHLH1

Z-value: 0.85

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Transcription factors associated with NHLH1

Gene Symbol Gene ID Gene Info
NHLH1
ENSG00000171786.6 nescient helix-loop-helix 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NHLH1hg38_v1_chr1_+_160367061_1603670780.147.4e-01Click!

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_41124178 1.65 ENST00000394014.2
KRTAP4-12
keratin associated protein 4-12
chr12_-_52493250 1.17 ENST00000330722.7
KRT6A
keratin 6A
chr7_-_140062841 1.10 ENST00000263549.8
PARP12
poly(ADP-ribose) polymerase family member 12
chr17_-_41118369 0.82 ENST00000391413.4
KRTAP4-11
keratin associated protein 4-11
chr12_-_52473798 0.81 ENST00000252250.7
KRT6C
keratin 6C
chr16_+_22814154 0.79 ENST00000261374.4
HS3ST2
heparan sulfate-glucosamine 3-sulfotransferase 2
chr17_-_41140487 0.75 ENST00000345847.4
KRTAP4-6
keratin associated protein 4-6
chr20_+_59604527 0.68 ENST00000371015.6
PHACTR3
phosphatase and actin regulator 3
chr5_+_53480619 0.66 ENST00000396947.7
ENST00000256759.8
FST
follistatin
chr6_+_30880780 0.65 ENST00000460944.6
ENST00000324771.12
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_+_81800906 0.64 ENST00000674393.1
ENST00000674208.1
ADGRL2
adhesion G protein-coupled receptor L2
chr6_+_150143018 0.59 ENST00000361131.5
PPP1R14C
protein phosphatase 1 regulatory inhibitor subunit 14C
chr5_+_167754918 0.57 ENST00000519204.5
TENM2
teneurin transmembrane protein 2
chr9_-_23821275 0.56 ENST00000380110.8
ELAVL2
ELAV like RNA binding protein 2
chr11_+_394196 0.53 ENST00000331563.7
ENST00000531857.1
PKP3
plakophilin 3
chr9_-_27529705 0.52 ENST00000262244.6
MOB3B
MOB kinase activator 3B
chr8_-_124728273 0.49 ENST00000325064.9
ENST00000518547.6
MTSS1
MTSS I-BAR domain containing 1
chr9_-_23826231 0.46 ENST00000397312.7
ELAVL2
ELAV like RNA binding protein 2
chr8_+_85463997 0.42 ENST00000285379.10
CA2
carbonic anhydrase 2
chr18_+_11689210 0.41 ENST00000334049.11
GNAL
G protein subunit alpha L
chr6_+_125153649 0.41 ENST00000304877.17
ENST00000368402.9
ENST00000368388.6
ENST00000534000.6
TPD52L1
TPD52 like 1
chr22_+_44702186 0.40 ENST00000336985.11
ENST00000403696.5
ENST00000457960.5
ENST00000361473.9
PRR5
PRR5-ARHGAP8
proline rich 5
PRR5-ARHGAP8 readthrough
chr20_+_46008900 0.39 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr4_-_36244438 0.38 ENST00000303965.9
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_1882902 0.37 ENST00000231357.7
IRX4
iroquois homeobox 4
chr17_+_41105332 0.36 ENST00000391415.1
ENST00000617453.1
KRTAP4-9
keratin associated protein 4-9
chr6_+_125153793 0.35 ENST00000527711.5
TPD52L1
TPD52 like 1
chr6_+_125154189 0.35 ENST00000532429.5
ENST00000534199.5
TPD52L1
TPD52 like 1
chr17_+_41226648 0.34 ENST00000377721.3
KRTAP9-2
keratin associated protein 9-2
chr8_+_24914942 0.34 ENST00000433454.3
NEFM
neurofilament medium
chr12_-_66678934 0.33 ENST00000545666.5
ENST00000398016.7
ENST00000359742.9
ENST00000538211.5
GRIP1
glutamate receptor interacting protein 1
chr22_+_39994926 0.32 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr1_-_37808168 0.31 ENST00000373044.3
YRDC
yrdC N6-threonylcarbamoyltransferase domain containing
chr19_+_45340760 0.31 ENST00000585434.5
KLC3
kinesin light chain 3
chr2_+_68774782 0.31 ENST00000409030.7
ENST00000409220.5
ARHGAP25
Rho GTPase activating protein 25
chr1_+_13583762 0.31 ENST00000376057.8
ENST00000621990.5
ENST00000510906.5
PDPN
podoplanin
chr19_+_45340736 0.30 ENST00000391946.7
KLC3
kinesin light chain 3
chr19_+_44777860 0.30 ENST00000341505.4
ENST00000647358.2
CBLC
Cbl proto-oncogene C
chr1_-_209806124 0.30 ENST00000367021.8
ENST00000542854.5
IRF6
interferon regulatory factor 6
chr9_-_137054016 0.29 ENST00000312665.7
ENST00000355097.7
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
chr15_+_40252888 0.28 ENST00000559139.5
ENST00000560669.5
ENST00000542403.3
PAK6
p21 (RAC1) activated kinase 6
chr4_+_88378733 0.27 ENST00000273960.7
ENST00000380265.9
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr16_+_57639518 0.26 ENST00000540164.6
ENST00000568531.5
ADGRG1
adhesion G protein-coupled receptor G1
chr17_+_82735551 0.26 ENST00000300784.8
FN3K
fructosamine 3 kinase
chr17_-_41184895 0.26 ENST00000620667.1
ENST00000398472.2
KRTAP4-1
keratin associated protein 4-1
chr14_-_53956811 0.26 ENST00000559087.5
ENST00000245451.9
BMP4
bone morphogenetic protein 4
chr4_+_88378842 0.26 ENST00000264346.12
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr2_+_197705353 0.25 ENST00000282276.8
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr9_-_23826299 0.25 ENST00000380117.5
ELAVL2
ELAV like RNA binding protein 2
chr7_+_20330678 0.25 ENST00000537992.5
ITGB8
integrin subunit beta 8
chr16_+_67431112 0.24 ENST00000326152.6
HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
chr5_+_56815534 0.24 ENST00000399503.4
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr1_-_6602885 0.24 ENST00000377663.3
KLHL21
kelch like family member 21
chr1_+_156284299 0.23 ENST00000456810.1
ENST00000405535.3
TMEM79
transmembrane protein 79
chr4_-_138242325 0.23 ENST00000280612.9
SLC7A11
solute carrier family 7 member 11
chr19_+_45340774 0.23 ENST00000589837.5
KLC3
kinesin light chain 3
chr2_-_234497035 0.23 ENST00000390645.2
ENST00000339728.6
ARL4C
ADP ribosylation factor like GTPase 4C
chr1_-_6602859 0.23 ENST00000377658.8
KLHL21
kelch like family member 21
chr17_-_41168219 0.23 ENST00000391356.4
KRTAP4-3
keratin associated protein 4-3
chr8_+_144148027 0.23 ENST00000423230.6
MROH1
maestro heat like repeat family member 1
chr17_-_35795592 0.23 ENST00000615136.4
ENST00000605424.6
ENST00000612672.1
MMP28
matrix metallopeptidase 28
chr15_+_40358207 0.23 ENST00000267889.5
DISP2
dispatched RND transporter family member 2
chr22_-_37486357 0.22 ENST00000356998.8
ENST00000416983.7
ENST00000424765.2
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr18_+_58255433 0.22 ENST00000635997.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr20_-_14337602 0.22 ENST00000378053.3
ENST00000341420.5
FLRT3
fibronectin leucine rich transmembrane protein 3
chr4_-_80073057 0.21 ENST00000681710.1
ANTXR2
ANTXR cell adhesion molecule 2
chr20_+_63861498 0.21 ENST00000369916.5
ABHD16B
abhydrolase domain containing 16B
chr2_+_195657179 0.21 ENST00000359634.10
SLC39A10
solute carrier family 39 member 10
chr4_+_74445126 0.21 ENST00000395748.8
AREG
amphiregulin
chr7_+_129144691 0.20 ENST00000486685.3
TSPAN33
tetraspanin 33
chr2_-_96145431 0.20 ENST00000288943.5
DUSP2
dual specificity phosphatase 2
chr6_-_81752671 0.20 ENST00000320172.11
ENST00000369754.7
ENST00000369756.3
TENT5A
terminal nucleotidyltransferase 5A
chr22_+_44677044 0.20 ENST00000006251.11
PRR5
proline rich 5
chr4_+_74445302 0.20 ENST00000502307.1
AREG
amphiregulin
chr7_-_727611 0.19 ENST00000403562.5
PRKAR1B
protein kinase cAMP-dependent type I regulatory subunit beta
chr17_+_57085092 0.19 ENST00000575322.1
ENST00000337714.8
AKAP1
A-kinase anchoring protein 1
chr4_-_80073170 0.19 ENST00000403729.7
ANTXR2
ANTXR cell adhesion molecule 2
chr8_+_24913752 0.19 ENST00000518131.5
ENST00000221166.10
ENST00000437366.2
NEFM
neurofilament medium
chr5_+_69492767 0.18 ENST00000681041.1
ENST00000680098.1
ENST00000680784.1
ENST00000396442.7
ENST00000681895.1
OCLN
occludin
chr17_+_75516514 0.18 ENST00000333213.11
ENST00000545228.3
ENST00000680999.1
TSEN54
tRNA splicing endonuclease subunit 54
chr12_+_41188301 0.18 ENST00000402685.7
PDZRN4
PDZ domain containing ring finger 4
chr1_+_32741779 0.18 ENST00000401073.7
KIAA1522
KIAA1522
chr8_-_130016395 0.18 ENST00000523509.5
CYRIB
CYFIP related Rac1 interactor B
chr8_-_130016414 0.18 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYRIB
CYFIP related Rac1 interactor B
chr22_-_24593038 0.18 ENST00000318753.13
LRRC75B
leucine rich repeat containing 75B
chrX_-_85379659 0.17 ENST00000262753.9
POF1B
POF1B actin binding protein
chr17_+_41237998 0.17 ENST00000254072.7
KRTAP9-8
keratin associated protein 9-8
chr9_+_98807619 0.17 ENST00000375011.4
GALNT12
polypeptide N-acetylgalactosaminyltransferase 12
chr6_-_30744537 0.17 ENST00000259874.6
ENST00000376377.2
IER3
immediate early response 3
chr12_+_49623543 0.17 ENST00000548825.7
ENST00000261897.5
PRPF40B
pre-mRNA processing factor 40 homolog B
chr9_-_123268538 0.16 ENST00000360998.3
ENST00000348403.10
STRBP
spermatid perinuclear RNA binding protein
chr19_-_2051224 0.16 ENST00000309340.11
ENST00000589534.2
ENST00000250896.9
ENST00000589509.5
MKNK2
MAPK interacting serine/threonine kinase 2
chr17_-_17206264 0.16 ENST00000321560.4
PLD6
phospholipase D family member 6
chr16_+_2964216 0.16 ENST00000572045.5
ENST00000571007.5
ENST00000575885.5
ENST00000303746.10
ENST00000319500.10
KREMEN2
kringle containing transmembrane protein 2
chr1_+_156154371 0.16 ENST00000368282.1
SEMA4A
semaphorin 4A
chr14_+_23372809 0.16 ENST00000397242.2
ENST00000329715.2
IL25
interleukin 25
chr8_+_97775775 0.16 ENST00000521545.7
LAPTM4B
lysosomal protein transmembrane 4 beta
chr6_+_18155399 0.16 ENST00000650836.2
ENST00000449850.2
ENST00000297792.9
KDM1B
lysine demethylase 1B
chr16_+_1706163 0.16 ENST00000250894.8
ENST00000673691.1
ENST00000356010.9
ENST00000610761.2
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
chr5_-_95284535 0.16 ENST00000515393.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr8_-_38150943 0.16 ENST00000276449.9
STAR
steroidogenic acute regulatory protein
chr8_+_144509049 0.16 ENST00000301327.5
MFSD3
major facilitator superfamily domain containing 3
chr15_-_52295792 0.15 ENST00000261839.12
MYO5C
myosin VC
chr14_+_69879408 0.15 ENST00000361956.8
ENST00000381280.4
SMOC1
SPARC related modular calcium binding 1
chr1_+_31413187 0.15 ENST00000373709.8
SERINC2
serine incorporator 2
chr8_+_141128612 0.15 ENST00000518347.5
ENST00000262585.6
ENST00000520986.5
ENST00000523058.5
ENST00000518668.5
DENND3
DENN domain containing 3
chr16_+_23835946 0.15 ENST00000321728.12
ENST00000643927.1
PRKCB
protein kinase C beta
chr14_+_63204859 0.15 ENST00000555125.1
RHOJ
ras homolog family member J
chr8_+_141128581 0.15 ENST00000519811.6
DENND3
DENN domain containing 3
chr16_+_2817230 0.15 ENST00000005995.8
ENST00000574813.5
PRSS21
serine protease 21
chr1_+_14945775 0.15 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr18_+_46334197 0.15 ENST00000588679.1
ENST00000543885.2
RNF165
ring finger protein 165
chr12_+_122021850 0.14 ENST00000261822.5
BCL7A
BAF chromatin remodeling complex subunit BCL7A
chr19_-_38253238 0.14 ENST00000587515.5
PPP1R14A
protein phosphatase 1 regulatory inhibitor subunit 14A
chr8_+_97775829 0.14 ENST00000517924.5
LAPTM4B
lysosomal protein transmembrane 4 beta
chr19_-_17448664 0.14 ENST00000341130.6
TMEM221
transmembrane protein 221
chr1_+_202348727 0.14 ENST00000356764.6
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr17_-_32877106 0.14 ENST00000318217.10
ENST00000579584.5
ENST00000583621.1
MYO1D
myosin ID
chr12_+_7155867 0.14 ENST00000535313.2
ENST00000331148.5
CLSTN3
calsyntenin 3
chr10_-_101588126 0.14 ENST00000339310.7
ENST00000299206.8
ENST00000413344.5
ENST00000429502.1
ENST00000430045.1
ENST00000370172.5
ENST00000370162.8
ENST00000628479.2
POLL
DNA polymerase lambda
chr12_+_6946468 0.14 ENST00000543115.5
ENST00000399448.5
PTPN6
protein tyrosine phosphatase non-receptor type 6
chr3_-_45146351 0.14 ENST00000296129.6
ENST00000425231.2
CDCP1
CUB domain containing protein 1
chr2_+_232697362 0.13 ENST00000482666.5
ENST00000483164.5
ENST00000490229.5
ENST00000464805.5
ENST00000489328.1
GIGYF2
GRB10 interacting GYF protein 2
chr17_+_49575828 0.13 ENST00000328741.6
NXPH3
neurexophilin 3
chr2_+_127645864 0.13 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr4_-_80073465 0.13 ENST00000404191.5
ANTXR2
ANTXR cell adhesion molecule 2
chr6_+_14117764 0.13 ENST00000379153.4
CD83
CD83 molecule
chr14_+_32934383 0.13 ENST00000551634.6
NPAS3
neuronal PAS domain protein 3
chr11_-_64166102 0.13 ENST00000255681.7
ENST00000675777.1
MACROD1
mono-ADP ribosylhydrolase 1
chr16_+_11345429 0.13 ENST00000576027.1
ENST00000312499.6
ENST00000648619.1
RMI2
RecQ mediated genome instability 2
chr16_+_74999312 0.13 ENST00000566250.5
ENST00000567962.5
ZNRF1
zinc and ring finger 1
chr8_-_143815649 0.13 ENST00000356994.7
SCRIB
scribble planar cell polarity protein
chr12_+_109713817 0.12 ENST00000538780.2
FAM222A
family with sequence similarity 222 member A
chr2_+_48314637 0.12 ENST00000413569.5
ENST00000340553.8
FOXN2
forkhead box N2
chr2_-_73284431 0.12 ENST00000521871.5
ENST00000520530.3
FBXO41
F-box protein 41
chr8_+_127735597 0.12 ENST00000651626.1
MYC
MYC proto-oncogene, bHLH transcription factor
chr16_-_29926155 0.12 ENST00000567795.3
ENST00000568000.6
ENST00000561540.2
KCTD13
potassium channel tetramerization domain containing 13
chr14_+_70907661 0.12 ENST00000439984.7
PCNX1
pecanex 1
chr18_-_55586092 0.12 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
TCF4
transcription factor 4
chr3_-_165837412 0.12 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr11_+_44726811 0.12 ENST00000533202.5
ENST00000520358.7
ENST00000533080.5
ENST00000520999.6
TSPAN18
tetraspanin 18
chr3_-_195909711 0.12 ENST00000333602.14
TNK2
tyrosine kinase non receptor 2
chr15_+_50182215 0.12 ENST00000380902.8
SLC27A2
solute carrier family 27 member 2
chr16_+_27402167 0.12 ENST00000564089.5
ENST00000337929.8
IL21R
interleukin 21 receptor
chr11_-_66958366 0.12 ENST00000651036.1
ENST00000652125.1
ENST00000531614.6
ENST00000524491.6
ENST00000529047.6
ENST00000393960.7
ENST00000393958.7
ENST00000528403.6
ENST00000651854.1
PC
pyruvate carboxylase
chr2_-_72147819 0.12 ENST00000001146.7
ENST00000546307.5
ENST00000474509.1
CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr15_-_83284645 0.12 ENST00000345382.7
BNC1
basonuclin 1
chr11_-_65606959 0.11 ENST00000532507.5
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr3_-_133895753 0.11 ENST00000460865.3
RAB6B
RAB6B, member RAS oncogene family
chr6_+_142301926 0.11 ENST00000296932.13
ENST00000367609.8
ADGRG6
adhesion G protein-coupled receptor G6
chr17_-_28951443 0.11 ENST00000268756.7
ENST00000332830.9
ENST00000584685.1
PHF12
PHD finger protein 12
chr11_+_67303476 0.11 ENST00000376757.9
ENST00000308298.11
SSH3
slingshot protein phosphatase 3
chr10_+_122163426 0.11 ENST00000360561.7
TACC2
transforming acidic coiled-coil containing protein 2
chr18_+_46334007 0.11 ENST00000269439.12
ENST00000590330.1
RNF165
ring finger protein 165
chr9_-_115118145 0.11 ENST00000350763.9
TNC
tenascin C
chr9_-_115118198 0.11 ENST00000534839.1
ENST00000535648.5
TNC
tenascin C
chr2_+_195656734 0.11 ENST00000409086.7
SLC39A10
solute carrier family 39 member 10
chr10_+_122163590 0.11 ENST00000368999.5
TACC2
transforming acidic coiled-coil containing protein 2
chr7_-_77416300 0.11 ENST00000257626.12
GSAP
gamma-secretase activating protein
chr12_+_119989869 0.11 ENST00000397558.6
BICDL1
BICD family like cargo adaptor 1
chr2_+_232870284 0.11 ENST00000331342.4
SNORC
secondary ossification center associated regulator of chondrocyte maturation
chr8_-_97277890 0.11 ENST00000322128.5
TSPYL5
TSPY like 5
chr16_-_90019414 0.11 ENST00000002501.11
DBNDD1
dysbindin domain containing 1
chr19_+_39196956 0.11 ENST00000339852.5
NCCRP1
NCCRP1, F-box associated domain containing
chr22_+_25742141 0.11 ENST00000536101.5
ENST00000335473.12
ENST00000407587.6
MYO18B
myosin XVIIIB
chr1_+_178513103 0.11 ENST00000319416.7
ENST00000367643.7
ENST00000367642.3
ENST00000367641.7
ENST00000367639.1
TEX35
testis expressed 35
chr20_+_50731571 0.11 ENST00000371610.7
PARD6B
par-6 family cell polarity regulator beta
chr7_+_151114597 0.11 ENST00000335367.7
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_2530256 0.10 ENST00000378453.4
HES5
hes family bHLH transcription factor 5
chr10_+_122163672 0.10 ENST00000369004.7
ENST00000260733.7
TACC2
transforming acidic coiled-coil containing protein 2
chrX_+_85244075 0.10 ENST00000276123.7
ZNF711
zinc finger protein 711
chr10_+_69451456 0.10 ENST00000373290.7
TSPAN15
tetraspanin 15
chr1_-_21622509 0.10 ENST00000374761.6
RAP1GAP
RAP1 GTPase activating protein
chr1_+_20589044 0.10 ENST00000375071.4
CDA
cytidine deaminase
chr7_+_20330893 0.10 ENST00000222573.5
ITGB8
integrin subunit beta 8
chr8_+_103298836 0.10 ENST00000523739.5
ENST00000358755.5
FZD6
frizzled class receptor 6
chr16_-_90019821 0.10 ENST00000568838.2
DBNDD1
dysbindin domain containing 1
chr5_-_16936231 0.10 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
MYO10
myosin X
chr17_-_7393404 0.10 ENST00000575434.4
PLSCR3
phospholipid scramblase 3
chr18_+_10454584 0.10 ENST00000355285.10
APCDD1
APC down-regulated 1
chr19_+_7595830 0.10 ENST00000160298.9
ENST00000446248.4
CAMSAP3
calmodulin regulated spectrin associated protein family member 3
chr14_-_24263162 0.10 ENST00000206765.11
ENST00000544573.5
TGM1
transglutaminase 1
chr3_-_33659441 0.10 ENST00000650653.1
ENST00000480013.6
CLASP2
cytoplasmic linker associated protein 2
chr21_+_33070133 0.10 ENST00000382348.2
OLIG1
oligodendrocyte transcription factor 1
chr13_-_36131286 0.10 ENST00000255448.8
ENST00000379892.4
DCLK1
doublecortin like kinase 1
chr5_+_127290785 0.10 ENST00000503335.7
MEGF10
multiple EGF like domains 10
chr1_-_3796478 0.10 ENST00000378251.3
LRRC47
leucine rich repeat containing 47
chr17_+_7435416 0.09 ENST00000323206.2
ENST00000396568.1
TMEM102
transmembrane protein 102
chr3_-_197183806 0.09 ENST00000671246.1
ENST00000660553.1
DLG1
discs large MAGUK scaffold protein 1
chr11_+_7576975 0.09 ENST00000684215.1
ENST00000650027.1
PPFIBP2
PPFIA binding protein 2
chr3_+_5187697 0.09 ENST00000256497.9
EDEM1
ER degradation enhancing alpha-mannosidase like protein 1
chr14_+_30874497 0.09 ENST00000216361.9
COCH
cochlin
chr8_+_135457442 0.09 ENST00000355849.10
KHDRBS3
KH RNA binding domain containing, signal transduction associated 3
chr7_-_139036017 0.09 ENST00000275766.2
ZC3HAV1L
zinc finger CCCH-type containing, antiviral 1 like
chr5_+_76819022 0.09 ENST00000296677.5
F2RL1
F2R like trypsin receptor 1
chr3_-_197183963 0.09 ENST00000653795.1
DLG1
discs large MAGUK scaffold protein 1
chr19_-_17334844 0.09 ENST00000159087.7
ANO8
anoctamin 8
chr15_+_50182188 0.09 ENST00000267842.10
SLC27A2
solute carrier family 27 member 2
chr1_-_156677400 0.09 ENST00000368223.4
NES
nestin
chr10_-_124744280 0.09 ENST00000337318.8
FAM53B
family with sequence similarity 53 member B

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0051710 cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
0.1 0.4 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.5 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.5 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.4 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.3 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.1 0.3 GO:2000007 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.2 GO:0060739 mesenchymal-epithelial cell signaling involved in prostate gland development(GO:0060739)
0.1 0.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.3 GO:0009137 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 0.2 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.1 0.2 GO:0042335 cuticle development(GO:0042335)
0.1 0.2 GO:0007308 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.1 0.2 GO:0070859 phthalate metabolic process(GO:0018963) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 0.2 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.4 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.1 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 0.5 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.4 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.7 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.2 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.1 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.1 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.0 0.6 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.2 GO:0009624 response to nematode(GO:0009624)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.0 0.1 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.2 GO:0043652 skeletal muscle satellite cell activation(GO:0014719) engulfment of apoptotic cell(GO:0043652)
0.0 0.4 GO:0060022 hard palate development(GO:0060022)
0.0 0.1 GO:0035625 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0 0.1 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 3.3 GO:0031424 keratinization(GO:0031424)
0.0 0.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.1 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.0 GO:0034034 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.0 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.1 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.0 0.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.0 GO:0048865 stem cell fate commitment(GO:0048865)
0.0 0.0 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339) negative regulation of type B pancreatic cell development(GO:2000077)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.0 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.0 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 5.7 GO:0045095 keratin filament(GO:0045095)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.3 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0042565 RNA nuclear export complex(GO:0042565)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.1 0.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0097604 temperature-gated cation channel activity(GO:0097604)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 1.0 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol