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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NKX2-6

Z-value: 0.79

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
ENSG00000180053.8 NK2 homeobox 6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_55681711 1.45 ENST00000394252.4
methyltransferase like 7B
chr12_+_55681647 1.41 ENST00000614691.1
methyltransferase like 7B
chr14_-_59870752 1.30 ENST00000611068.1
ENST00000267484.10
reticulon 1
chr7_+_100602344 1.24 ENST00000223061.6
procollagen C-endopeptidase enhancer
chr14_-_105940235 0.87 ENST00000390593.2
immunoglobulin heavy variable 6-1
chr8_-_119638780 0.81 ENST00000522826.5
ENST00000520066.5
ENST00000259486.10
ENST00000075322.11
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_174597795 0.77 ENST00000679041.1
WAS/WASL interacting protein family member 1
chr6_-_131951364 0.72 ENST00000367976.4
cellular communication network factor 2
chr4_-_137532452 0.70 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr22_+_30764252 0.56 ENST00000445781.5
ENST00000401475.5
oxysterol binding protein 2
chr5_-_111756245 0.54 ENST00000447165.6
neuronal regeneration related protein
chr1_+_50970234 0.51 ENST00000371761.4
cyclin dependent kinase inhibitor 2C
chr12_-_55842927 0.49 ENST00000322569.9
ENST00000409200.7
matrix metallopeptidase 19
chr2_-_174598206 0.39 ENST00000392546.6
ENST00000436221.1
WAS/WASL interacting protein family member 1
chr3_-_115071333 0.35 ENST00000462705.5
zinc finger and BTB domain containing 20
chr2_-_162243375 0.35 ENST00000188790.9
ENST00000443424.5
fibroblast activation protein alpha
chr9_+_94084458 0.34 ENST00000620992.5
ENST00000288976.3
protein tyrosine phosphatase domain containing 1
chr12_-_38906269 0.33 ENST00000550863.1
copine 8
chr6_+_28267355 0.33 ENST00000614088.1
ENST00000619937.4
zinc finger and SCAN domain containing 26
chr18_+_7754959 0.33 ENST00000400053.8
protein tyrosine phosphatase receptor type M
chr8_+_27771942 0.32 ENST00000523566.5
establishment of sister chromatid cohesion N-acetyltransferase 2
chr10_-_27240505 0.32 ENST00000375888.5
ENST00000676732.1
acyl-CoA binding domain containing 5
chrX_+_10156960 0.30 ENST00000380833.9
chloride voltage-gated channel 4
chr8_-_92095627 0.29 ENST00000517919.5
ENST00000617740.4
ENST00000613302.4
ENST00000436581.6
ENST00000614812.4
ENST00000519847.5
RUNX1 partner transcriptional co-repressor 1
chr4_+_112818088 0.29 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ankyrin 2
chr15_-_56465130 0.29 ENST00000260453.4
meiosis specific nuclear structural 1
chr4_+_112818032 0.28 ENST00000672356.1
ENST00000672955.1
ankyrin 2
chr5_-_140557414 0.28 ENST00000336283.9
steroid receptor RNA activator 1
chr12_-_89526253 0.27 ENST00000547474.1
POC1B-GALNT4 readthrough
chr4_-_155953851 0.25 ENST00000679136.1
ENST00000433477.4
ENST00000679996.1
ENST00000680741.1
ENST00000680553.1
ENST00000679942.1
cathepsin O
chr6_+_28267044 0.25 ENST00000316606.10
zinc finger and SCAN domain containing 26
chr6_+_28267107 0.24 ENST00000621053.1
ENST00000617168.4
ENST00000421553.7
ENST00000611552.2
ENST00000623276.3
novel protein
zinc finger and SCAN domain containing 26
chr11_-_119030848 0.24 ENST00000330775.9
ENST00000357590.9
ENST00000538950.5
ENST00000545985.5
solute carrier family 37 member 4
chr12_+_43758936 0.23 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
interleukin 1 receptor associated kinase 4
chr7_+_142800957 0.23 ENST00000466254.1
T cell receptor beta constant 2
chr12_+_59689337 0.23 ENST00000261187.8
solute carrier family 16 member 7
chr10_-_100081854 0.23 ENST00000370418.8
carboxypeptidase N subunit 1
chr2_-_174597728 0.22 ENST00000409891.5
ENST00000410117.5
WAS/WASL interacting protein family member 1
chr11_-_62754141 0.22 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
zinc finger and BTB domain containing 3
chr17_+_35587239 0.22 ENST00000621914.4
ENST00000621668.4
ENST00000616681.4
ENST00000612035.4
ENST00000610402.5
ENST00000614600.4
ENST00000590432.5
ENST00000612116.5
adaptor related protein complex 2 subunit beta 1
chr11_-_64759967 0.21 ENST00000377432.7
ENST00000164139.4
glycogen phosphorylase, muscle associated
chr17_+_35587478 0.21 ENST00000618940.4
adaptor related protein complex 2 subunit beta 1
chr4_+_165378998 0.21 ENST00000402744.9
carboxypeptidase E
chr7_-_138627444 0.21 ENST00000463557.1
SVOP like
chr11_+_111255982 0.21 ENST00000637637.1
chromosome 11 open reading frame 53
chr13_+_114235044 0.20 ENST00000252457.9
ENST00000375308.5
cell division cycle 16
chr17_+_60677822 0.20 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3 microtubule associated cell migration factor
chr13_+_114235066 0.20 ENST00000252458.6
cell division cycle 16
chr20_-_290364 0.20 ENST00000382369.9
chromosome 20 open reading frame 96
chr9_-_83063159 0.20 ENST00000340717.4
RAS and EF-hand domain containing
chr9_-_131531178 0.19 ENST00000372210.7
ENST00000372211.7
uridine-cytidine kinase 1
chr4_+_17577487 0.19 ENST00000606142.5
leucine aminopeptidase 3
chr2_-_27323072 0.19 ENST00000428910.5
ENST00000402722.5
ENST00000380044.6
ENST00000399052.8
ENST00000405076.5
mitochondrial inner membrane protein MPV17
chr22_-_38084093 0.19 ENST00000681075.1
solute carrier family 16 member 8
chr11_-_65862026 0.19 ENST00000532134.5
cofilin 1
chr5_+_75611182 0.18 ENST00000672850.1
ENST00000672844.1
ankyrin repeat and death domain containing 1B
chr6_+_31571957 0.18 ENST00000454783.5
lymphotoxin alpha
chr11_-_106022209 0.18 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr20_-_290717 0.18 ENST00000360321.7
ENST00000400269.4
chromosome 20 open reading frame 96
chr11_-_122116215 0.17 ENST00000560104.2
BH3-like motif containing, cell death inducer
chr8_-_92095598 0.17 ENST00000520724.5
ENST00000518844.5
RUNX1 partner transcriptional co-repressor 1
chr7_-_139716980 0.17 ENST00000342645.7
homeodomain interacting protein kinase 2
chr9_-_131531224 0.17 ENST00000372208.7
ENST00000372215.5
uridine-cytidine kinase 1
chr16_-_69339493 0.17 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
component of oligomeric golgi complex 8
chrX_-_154409246 0.16 ENST00000369807.6
deoxyribonuclease 1 like 1
chrX_-_47659128 0.16 ENST00000333119.7
ENST00000335890.3
ubiquitously expressed prefoldin like chaperone
chr5_+_108747879 0.16 ENST00000281092.9
FER tyrosine kinase
chr3_-_177197429 0.16 ENST00000457928.7
TBL1X receptor 1
chr3_+_114294020 0.16 ENST00000383671.8
T cell immunoreceptor with Ig and ITIM domains
chr17_+_68525795 0.16 ENST00000592800.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr5_-_134174765 0.15 ENST00000520417.1
S-phase kinase associated protein 1
chr13_+_43879895 0.15 ENST00000325686.7
laccase domain containing 1
chr3_-_41961989 0.15 ENST00000420927.5
ENST00000301831.9
ENST00000414606.1
unc-51 like kinase 4
chr17_-_42964437 0.15 ENST00000427569.7
ENST00000430739.5
alanyl-tRNA synthetase domain containing 1
chr6_+_125781108 0.15 ENST00000368357.7
nuclear receptor coactivator 7
chr22_-_23754376 0.15 ENST00000398465.3
ENST00000248948.4
V-set pre-B cell surrogate light chain 3
chr19_+_39412650 0.15 ENST00000425673.6
pleckstrin homology and RhoGEF domain containing G2
chr3_-_48595267 0.14 ENST00000328333.12
ENST00000681320.1
collagen type VII alpha 1 chain
chr9_+_122371014 0.14 ENST00000362012.7
prostaglandin-endoperoxide synthase 1
chr3_-_39192584 0.14 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
xin actin binding repeat containing 1
chr10_-_72626111 0.14 ENST00000604238.2
ENST00000642044.1
ENST00000635239.1
ENST00000398761.8
mitochondrial calcium uptake 1
chr12_-_75209701 0.14 ENST00000350228.6
ENST00000298972.5
potassium voltage-gated channel subfamily C member 2
chr12_+_32106762 0.14 ENST00000551848.1
ENST00000652176.1
BICD cargo adaptor 1
chr14_+_31025634 0.14 ENST00000673317.1
ENST00000556232.6
ENST00000542754.7
ENST00000554345.6
ENST00000334725.8
ENST00000554609.6
ENST00000313566.11
adaptor related protein complex 4 subunit sigma 1
chr11_+_65860394 0.13 ENST00000308110.9
MUS81 structure-specific endonuclease subunit
chrX_-_154409278 0.13 ENST00000369808.7
deoxyribonuclease 1 like 1
chr1_+_158999963 0.13 ENST00000566111.5
interferon gamma inducible protein 16
chr12_-_75209422 0.13 ENST00000393288.2
ENST00000540018.5
potassium voltage-gated channel subfamily C member 2
chr9_+_35906179 0.13 ENST00000354323.3
histidine rich carboxyl terminus 1
chr4_-_95548956 0.13 ENST00000513796.5
ENST00000453304.6
unc-5 netrin receptor C
chr11_+_59436469 0.12 ENST00000641045.1
olfactory receptor family 5 subfamily A member 1
chr19_+_496454 0.12 ENST00000346144.8
ENST00000215637.8
ENST00000382683.8
mucosal vascular addressin cell adhesion molecule 1
chr22_+_44181844 0.11 ENST00000466375.2
parvin gamma
chr20_-_33674359 0.11 ENST00000606690.5
ENST00000439478.5
ENST00000246190.11
ENST00000375238.8
N-terminal EF-hand calcium binding protein 3
chr1_-_173824856 0.11 ENST00000682279.1
centromere protein L
chr5_-_177462379 0.11 ENST00000512501.1
drebrin 1
chr1_-_160282458 0.11 ENST00000485079.1
novel protein
chrX_-_53281524 0.11 ENST00000498281.2
IQ motif and Sec7 domain ArfGEF 2
chr12_-_89526164 0.11 ENST00000548729.5
POC1B-GALNT4 readthrough
chr12_-_43758748 0.10 ENST00000416848.6
ENST00000550784.5
ENST00000547156.1
ENST00000549868.1
ENST00000551923.5
ENST00000344862.10
ENST00000431332.7
pseudouridine synthase 7 like
chr19_+_49930219 0.10 ENST00000596658.1
activating transcription factor 5
chr19_+_10452891 0.10 ENST00000344979.7
phosphodiesterase 4A
chr2_+_112911159 0.10 ENST00000263326.8
interleukin 37
chr12_-_109093458 0.10 ENST00000536242.1
ENST00000343075.7
ENST00000429722.3
ENST00000536358.1
ENST00000619381.4
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
chr4_-_185395882 0.10 ENST00000505916.6
LRP2 binding protein
chr3_-_48089203 0.10 ENST00000468075.2
ENST00000360240.10
microtubule associated protein 4
chr6_+_10528326 0.10 ENST00000379597.7
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr8_-_61689768 0.10 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
aspartate beta-hydroxylase
chr5_-_140691312 0.09 ENST00000438307.6
ENST00000415192.6
ENST00000509087.2
ENST00000675698.1
ENST00000504156.7
ENST00000457527.6
ENST00000307633.7
ENST00000676327.1
ENST00000675851.1
ENST00000675366.1
ENST00000675204.1
ENST00000507746.7
ENST00000431330.7
histidyl-tRNA synthetase 1
chr1_-_120051714 0.09 ENST00000579475.7
notch receptor 2
chr19_-_39391029 0.09 ENST00000221265.8
PAF1 homolog, Paf1/RNA polymerase II complex component
chr16_+_8712943 0.09 ENST00000561870.5
ENST00000396600.6
4-aminobutyrate aminotransferase
chr15_+_75347431 0.09 ENST00000567657.5
nei like DNA glycosylase 1
chr8_+_42541569 0.09 ENST00000417410.7
ENST00000518574.1
ENST00000414154.6
small integral membrane protein 19
chr5_+_140691427 0.09 ENST00000643996.1
ENST00000509299.6
ENST00000645065.1
ENST00000642752.1
ENST00000503873.6
ENST00000642970.1
ENST00000230771.9
ENST00000646468.1
ENST00000645749.1
histidyl-tRNA synthetase 2, mitochondrial
chr1_-_203175783 0.09 ENST00000621380.1
ENST00000255416.9
myosin binding protein H
chr6_-_30113086 0.08 ENST00000376734.4
tripartite motif containing 31
chr22_+_22887780 0.08 ENST00000532223.2
ENST00000526893.6
ENST00000531372.1
immunoglobulin lambda like polypeptide 5
chr1_+_171512032 0.08 ENST00000426496.6
proline rich coiled-coil 2C
chr6_-_159045010 0.08 ENST00000338313.5
T cell activation RhoGTPase activating protein
chr1_-_20786610 0.08 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
heterochromatin protein 1 binding protein 3
chr1_-_70354673 0.08 ENST00000370944.9
ENST00000262346.6
ankyrin repeat domain 13C
chr7_+_142791635 0.08 ENST00000633705.1
T cell receptor beta constant 1
chr2_-_69643152 0.08 ENST00000606389.7
AP2 associated kinase 1
chr5_+_140691591 0.08 ENST00000508522.5
ENST00000448069.2
histidyl-tRNA synthetase 2, mitochondrial
chrX_-_53281566 0.08 ENST00000638583.1
ENST00000639161.2
ENST00000485377.5
IQ motif and Sec7 domain ArfGEF 2
chr2_+_202912214 0.07 ENST00000402905.7
ENST00000320443.12
ENST00000414490.5
ENST00000431787.5
ENST00000444724.5
ENST00000414857.5
ENST00000438828.4
ENST00000430899.5
ENST00000445120.5
ENST00000441569.5
ENST00000432024.5
ENST00000443740.5
ENST00000414439.5
ENST00000428585.5
ENST00000447539.5
ENST00000434998.5
calcium responsive transcription factor
chr3_+_186640355 0.07 ENST00000382134.7
ENST00000265029.8
fetuin B
chr5_+_141208697 0.07 ENST00000624949.1
ENST00000622978.1
ENST00000239450.4
protocadherin beta 12
chr6_-_89315291 0.07 ENST00000402938.4
gamma-aminobutyric acid type A receptor subunit rho2
chr3_+_36993798 0.07 ENST00000455445.6
ENST00000539477.6
ENST00000435176.5
ENST00000429117.5
ENST00000441265.6
mutL homolog 1
chr1_-_169367746 0.07 ENST00000367811.8
ENST00000472647.5
NME/NM23 family member 7
chr18_+_41955186 0.07 ENST00000639914.1
ENST00000262039.9
ENST00000398870.7
ENST00000586545.5
ENST00000585528.5
phosphatidylinositol 3-kinase catalytic subunit type 3
chr22_+_29205877 0.07 ENST00000334018.11
ENST00000429226.5
ENST00000404755.7
ENST00000404820.7
ENST00000430127.1
EMI domain containing 1
chr13_+_24309565 0.07 ENST00000332018.4
C1q and TNF related 9
chr16_-_23713197 0.07 ENST00000256797.9
ENST00000457008.6
endoplasmic reticulum to nucleus signaling 2
chr16_-_1230089 0.07 ENST00000612142.1
ENST00000606293.5
tryptase beta 2
chr6_+_63563448 0.07 ENST00000673199.1
protein tyrosine phosphatase 4A1
chr6_-_166587594 0.07 ENST00000444122.2
RNA guanine-7 methyltransferase activating subunit like (pseudogene)
chr12_-_49900250 0.07 ENST00000552669.5
Fas apoptotic inhibitory molecule 2
chr9_-_33402551 0.06 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
aquaporin 7
chr13_+_111114550 0.06 ENST00000317133.9
Rho guanine nucleotide exchange factor 7
chr7_-_56034133 0.06 ENST00000421626.5
phosphoserine phosphatase
chr15_+_65550819 0.06 ENST00000569894.5
3-hydroxyacyl-CoA dehydratase 3
chr5_+_52787899 0.06 ENST00000274311.3
ENST00000282588.7
pelota mRNA surveillance and ribosome rescue factor
integrin subunit alpha 1
chr17_-_3063607 0.06 ENST00000575751.1
olfactory receptor family 1 subfamily D member 5
chr9_+_122371036 0.06 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr13_-_43879696 0.06 ENST00000444614.8
coiled-coil domain containing 122
chr19_-_49036885 0.06 ENST00000604577.1
ENST00000591656.1
ENST00000301407.8
ENST00000601167.1
novel protein
chorionic gonadotropin subunit beta 1
chr7_+_23680130 0.06 ENST00000409192.7
ENST00000409653.5
ENST00000409994.3
ENST00000344962.9
family with sequence similarity 221 member A
chr11_+_99021066 0.06 ENST00000527185.5
ENST00000528682.5
contactin 5
chr8_+_42541775 0.06 ENST00000416469.6
small integral membrane protein 19
chr12_-_49897056 0.06 ENST00000552863.5
Fas apoptotic inhibitory molecule 2
chr2_+_70978380 0.06 ENST00000272421.10
ENST00000441349.5
ENST00000457410.5
ankyrin repeat domain 53
chr7_-_151080787 0.05 ENST00000540185.5
ENST00000297532.11
Fas activated serine/threonine kinase
chrX_-_47482529 0.05 ENST00000313116.11
zinc finger protein 41
chr1_-_173824322 0.05 ENST00000356198.6
centromere protein L
chr6_+_122471913 0.05 ENST00000615438.4
ENST00000392491.6
cAMP-dependent protein kinase inhibitor beta
chr17_+_62423891 0.05 ENST00000616852.1
ENST00000311506.10
methyltransferase like 2A
chr1_-_173824107 0.05 ENST00000345664.10
ENST00000367710.7
centromere protein L
chr14_+_21797272 0.05 ENST00000390430.2
T cell receptor alpha variable 8-1
chr9_+_131190119 0.05 ENST00000483497.6
nucleoporin 214
chr2_-_24123251 0.05 ENST00000313213.5
ENST00000436622.1
profilin family member 4
chr11_+_119087979 0.05 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
hydroxymethylbilane synthase
chr4_+_168497066 0.05 ENST00000261509.10
palladin, cytoskeletal associated protein
chr7_+_128476748 0.05 ENST00000262432.13
ENST00000480046.5
methyltransferase like 2B
chr3_-_39154558 0.05 ENST00000514182.1
cysteine and serine rich nuclear protein 1
chrX_+_24693879 0.05 ENST00000379068.8
ENST00000677890.1
ENST00000379059.7
DNA polymerase alpha 1, catalytic subunit
chr7_-_38368169 0.05 ENST00000390348.2
T cell receptor gamma variable 1 (non-functional)
chr11_-_66593031 0.04 ENST00000333861.5
coiled-coil domain containing 87
chr21_-_29019314 0.04 ENST00000493196.2
RWD domain containing 2B
chr17_-_49646581 0.04 ENST00000510476.5
ENST00000503676.5
speckle type BTB/POZ protein
chr10_+_18340699 0.04 ENST00000377329.10
calcium voltage-gated channel auxiliary subunit beta 2
chr9_+_122370523 0.04 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr1_-_198540674 0.04 ENST00000489986.1
ENST00000367382.6
ATPase H+ transporting V1 subunit G3
chr22_+_41621977 0.04 ENST00000405506.2
X-ray repair cross complementing 6
chr8_-_132625378 0.04 ENST00000522789.5
leucine rich repeat containing 6
chr11_+_27040725 0.04 ENST00000529202.5
ENST00000263182.8
gamma-butyrobetaine hydroxylase 1
chrX_+_47193796 0.04 ENST00000442035.5
ENST00000335972.11
ENST00000457753.5
ubiquitin like modifier activating enzyme 1
chr11_+_1870252 0.04 ENST00000612798.4
lymphocyte specific protein 1
chr3_+_36993764 0.04 ENST00000674019.1
ENST00000458205.6
mutL homolog 1
chr8_+_84184875 0.04 ENST00000517638.5
ENST00000522647.1
RALY RNA binding protein like
chr11_-_790062 0.04 ENST00000330106.5
cell cycle exit and neuronal differentiation 1
chr11_+_93330712 0.04 ENST00000298050.9
deuterosome assembly protein 1
chr1_-_19251509 0.04 ENST00000375199.7
ENST00000375208.7
ENST00000477853.6
ER membrane protein complex subunit 1
chr8_-_70071226 0.04 ENST00000276594.3
PR/SET domain 14
chr1_-_77979054 0.04 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
far upstream element binding protein 1
chr8_-_6877928 0.04 ENST00000297439.4
defensin beta 1
chr11_+_66593194 0.03 ENST00000310190.8
copper chaperone for superoxide dismutase
chr4_+_168497044 0.03 ENST00000505667.6
palladin, cytoskeletal associated protein
chr3_+_186717348 0.03 ENST00000447445.1
ENST00000287611.8
ENST00000644859.2
kininogen 1
chr11_+_122838492 0.03 ENST00000227348.9
cytotoxic and regulatory T cell molecule
chr8_-_120445092 0.03 ENST00000518918.1
mitochondrial ribosomal protein L13
chr19_+_55600277 0.03 ENST00000301073.4
zinc finger protein 524
chr13_-_48095096 0.03 ENST00000258648.7
ENST00000378586.5
mediator complex subunit 4
chr16_-_47459130 0.03 ENST00000565940.6
integrin alpha FG-GAP repeat containing 1
chr3_+_100709424 0.03 ENST00000675246.1
ENST00000675692.1
ENST00000675890.1
ENST00000675586.1
ENST00000674645.1
ENST00000675958.1
ENST00000479672.6
ENST00000675420.1
ENST00000674615.1
ENST00000676431.1
ENST00000674758.1
trafficking from ER to golgi regulator
chr3_+_100709290 0.03 ENST00000675047.1
ENST00000490574.6
ENST00000675543.1
ENST00000676308.1
ENST00000675499.1
trafficking from ER to golgi regulator
chr14_+_64214136 0.03 ENST00000557084.1
ENST00000458046.6
spectrin repeat containing nuclear envelope protein 2
chr9_-_109119915 0.03 ENST00000374586.8
transmembrane protein 245

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030070 insulin processing(GO:0030070)
0.1 0.3 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.2 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.1 0.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.8 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.5 GO:0001554 luteolysis(GO:0001554)
0.0 0.4 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.0 0.1 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.1 GO:1900276 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.2 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.0 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882) lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 1.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.0 GO:0001827 inner cell mass cell fate commitment(GO:0001827) germ-line stem cell population maintenance(GO:0030718)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.0 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.3 GO:0010842 retina layer formation(GO:0010842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.1 GO:0039713 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 1.5 GO:0005522 profilin binding(GO:0005522)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 1.2 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase