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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.22

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.8 orthopedia homeobox
PHOX2B
ENSG00000109132.7 paired like homeobox 2B
LHX1
ENSG00000273706.5 LIM homeobox 1
LMX1A
ENSG00000162761.14 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.4 LIM homeobox 5
HOXC4
ENSG00000198353.8 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OTPhg38_v1_chr5_-_77638713_77638713-0.866.4e-03Click!
LMX1Ahg38_v1_chr1_-_165355746_165355779-0.667.4e-02Click!
HOXC4hg38_v1_chr12_+_54053815_54053875-0.472.4e-01Click!
LHX5hg38_v1_chr12_-_113471851_113471876-0.294.8e-01Click!
PHOX2Bhg38_v1_chr4_-_41748713_41748731-0.245.7e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_49513353 2.83 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr11_-_63608542 2.67 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr5_-_20575850 2.42 ENST00000507958.5
CDH18
cadherin 18
chr17_+_1771688 2.08 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chr19_+_49513154 2.05 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr2_+_151357583 1.80 ENST00000243347.5
TNFAIP6
TNF alpha induced protein 6
chr5_+_95731300 1.69 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chr6_+_113857333 1.48 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr20_-_35147285 1.41 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr3_+_45886501 1.28 ENST00000395963.2
CCR9
C-C motif chemokine receptor 9
chr3_+_157436842 1.23 ENST00000295927.4
PTX3
pentraxin 3
chr9_-_96778053 1.07 ENST00000375231.5
ENST00000223428.9
ZNF510
zinc finger protein 510
chr16_-_66549839 1.01 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
TK2
thymidine kinase 2
chrX_+_10158448 1.00 ENST00000380829.5
ENST00000421085.7
ENST00000674669.1
ENST00000454850.1
CLCN4
chloride voltage-gated channel 4
chr1_-_91906280 0.99 ENST00000370399.6
TGFBR3
transforming growth factor beta receptor 3
chr7_+_134843884 0.97 ENST00000445569.6
CALD1
caldesmon 1
chr16_-_66550091 0.96 ENST00000564917.5
ENST00000677420.1
TK2
thymidine kinase 2
chr3_-_165078480 0.94 ENST00000264382.8
SI
sucrase-isomaltase
chr16_-_66550005 0.90 ENST00000527284.6
TK2
thymidine kinase 2
chr3_+_12287899 0.86 ENST00000643888.2
PPARG
peroxisome proliferator activated receptor gamma
chr3_+_12287859 0.84 ENST00000309576.11
ENST00000397015.7
PPARG
peroxisome proliferator activated receptor gamma
chr2_-_40453438 0.79 ENST00000455476.5
SLC8A1
solute carrier family 8 member A1
chr4_+_168497066 0.78 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr19_-_13953302 0.78 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr11_-_122116215 0.77 ENST00000560104.2
BLID
BH3-like motif containing, cell death inducer
chr1_+_78303865 0.76 ENST00000370758.5
PTGFR
prostaglandin F receptor
chrX_+_22032301 0.76 ENST00000379374.5
PHEX
phosphate regulating endopeptidase homolog X-linked
chr14_-_50561119 0.73 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr17_-_55722857 0.73 ENST00000424486.3
TMEM100
transmembrane protein 100
chr1_-_56579555 0.72 ENST00000371250.4
PLPP3
phospholipid phosphatase 3
chr7_+_138460238 0.69 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr20_+_45416551 0.68 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr14_+_34993240 0.68 ENST00000677647.1
SRP54
signal recognition particle 54
chr5_-_88823763 0.65 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr16_-_66550142 0.64 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
TK2
thymidine kinase 2
chr12_+_8157034 0.62 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr5_+_141382702 0.60 ENST00000617050.1
ENST00000518325.2
PCDHGA7
protocadherin gamma subfamily A, 7
chr13_-_37598750 0.57 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
POSTN
periostin
chr4_+_168497044 0.56 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr10_-_28282086 0.54 ENST00000375719.7
ENST00000375732.5
MPP7
membrane palmitoylated protein 7
chrX_+_43656289 0.54 ENST00000338702.4
MAOA
monoamine oxidase A
chr8_-_42768602 0.51 ENST00000534622.5
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chr3_-_142000353 0.51 ENST00000499676.5
TFDP2
transcription factor Dp-2
chr12_+_26011713 0.50 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr20_-_18497218 0.49 ENST00000337227.9
RBBP9
RB binding protein 9, serine hydrolase
chr5_-_111758061 0.47 ENST00000509979.5
ENST00000513100.5
ENST00000508161.5
ENST00000455559.6
NREP
neuronal regeneration related protein
chr1_-_113871665 0.44 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr12_-_54259531 0.43 ENST00000550411.5
ENST00000439541.6
CBX5
chromobox 5
chr19_-_43883964 0.43 ENST00000587539.2
ZNF404
zinc finger protein 404
chr17_+_7407838 0.41 ENST00000302926.7
NLGN2
neuroligin 2
chr3_-_9952337 0.41 ENST00000411976.2
ENST00000412055.6
PRRT3
proline rich transmembrane protein 3
chr11_+_92969651 0.41 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr15_+_92900338 0.41 ENST00000625990.3
CHD2
chromodomain helicase DNA binding protein 2
chrX_+_51743395 0.40 ENST00000340438.6
GSPT2
G1 to S phase transition 2
chr10_+_92691897 0.39 ENST00000492654.3
HHEX
hematopoietically expressed homeobox
chr3_-_157503574 0.39 ENST00000494677.5
ENST00000468233.5
VEPH1
ventricular zone expressed PH domain containing 1
chr20_+_15196834 0.38 ENST00000402914.5
MACROD2
mono-ADP ribosylhydrolase 2
chr9_+_72577788 0.38 ENST00000645208.2
TMC1
transmembrane channel like 1
chr9_+_122371014 0.38 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr15_-_19988117 0.38 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr4_+_70242583 0.37 ENST00000304954.3
CSN3
casein kappa
chr9_+_72577369 0.37 ENST00000651183.1
TMC1
transmembrane channel like 1
chr5_-_126595237 0.37 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr6_+_136038195 0.36 ENST00000615259.4
PDE7B
phosphodiesterase 7B
chr17_+_41966814 0.35 ENST00000393888.1
ENST00000441615.2
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr4_+_112647059 0.34 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr10_-_27240505 0.33 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr3_+_138621225 0.33 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr12_+_64404338 0.33 ENST00000332707.10
XPOT
exportin for tRNA
chr3_+_69763549 0.32 ENST00000472437.5
MITF
melanocyte inducing transcription factor
chr13_-_109786567 0.32 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr5_-_127073467 0.31 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
C5orf63
chromosome 5 open reading frame 63
chr1_+_177170916 0.31 ENST00000361539.5
BRINP2
BMP/retinoic acid inducible neural specific 2
chr5_+_154941063 0.30 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
MRPL22
mitochondrial ribosomal protein L22
chr21_+_32298849 0.30 ENST00000303645.10
MRAP
melanocortin 2 receptor accessory protein
chr8_+_103372388 0.30 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr1_+_158461574 0.29 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
OR10K1
olfactory receptor family 10 subfamily K member 1
chr1_+_77918128 0.29 ENST00000342754.5
NEXN
nexilin F-actin binding protein
chr10_+_92691813 0.28 ENST00000472590.6
HHEX
hematopoietically expressed homeobox
chr20_+_58907981 0.27 ENST00000656419.1
GNAS
GNAS complex locus
chr17_-_445939 0.27 ENST00000329099.4
RFLNB
refilin B
chr7_-_22822829 0.26 ENST00000358435.9
ENST00000621567.1
TOMM7
translocase of outer mitochondrial membrane 7
chrX_+_85003863 0.26 ENST00000373173.7
APOOL
apolipoprotein O like
chr7_-_22822779 0.25 ENST00000372879.8
TOMM7
translocase of outer mitochondrial membrane 7
chr9_-_26947222 0.24 ENST00000520884.5
ENST00000397292.8
PLAA
phospholipase A2 activating protein
chrX_-_101617921 0.24 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr1_+_201648136 0.24 ENST00000367296.8
NAV1
neuron navigator 1
chr3_+_69763726 0.24 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr3_+_138621207 0.22 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr4_-_69860138 0.22 ENST00000226444.4
SULT1E1
sulfotransferase family 1E member 1
chr12_+_130953898 0.21 ENST00000261654.10
ADGRD1
adhesion G protein-coupled receptor D1
chr10_+_18260715 0.21 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr2_+_108621260 0.20 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr19_-_51417791 0.20 ENST00000353836.9
SIGLEC10
sialic acid binding Ig like lectin 10
chr20_-_57690624 0.20 ENST00000414037.5
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_-_64225436 0.20 ENST00000638394.2
PRICKLE2
prickle planar cell polarity protein 2
chr2_-_74391837 0.20 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
DCTN1
dynactin subunit 1
chr8_+_23288081 0.19 ENST00000265806.12
ENST00000519952.6
ENST00000518840.6
R3HCC1
R3H domain and coiled-coil containing 1
chr3_-_149576203 0.19 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr7_+_130293134 0.19 ENST00000445470.6
ENST00000492072.5
ENST00000222482.10
ENST00000473956.5
ENST00000493259.5
ENST00000486598.1
CPA4
carboxypeptidase A4
chr1_+_212791828 0.19 ENST00000532324.5
ENST00000530441.5
ENST00000526641.5
ENST00000531963.5
ENST00000366973.8
ENST00000366974.9
ENST00000526997.5
ENST00000488246.6
TATDN3
TatD DNase domain containing 3
chr15_+_41286011 0.19 ENST00000661438.1
ENSG00000285920.2
novel protein
chr3_-_157503375 0.19 ENST00000362010.7
VEPH1
ventricular zone expressed PH domain containing 1
chr14_+_55027200 0.19 ENST00000395472.2
ENST00000555846.2
SOCS4
suppressor of cytokine signaling 4
chr18_-_35290184 0.18 ENST00000589178.5
ENST00000592278.1
ENST00000333206.10
ENST00000592211.1
ENST00000420878.7
ENST00000610712.1
ENST00000586922.2
ZSCAN30
ENSG00000268573.1
zinc finger and SCAN domain containing 30
novel transcript
chr16_-_66550112 0.18 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
TK2
thymidine kinase 2
chr9_-_111036207 0.18 ENST00000541779.5
LPAR1
lysophosphatidic acid receptor 1
chr17_-_8295342 0.17 ENST00000579192.5
ENST00000577745.2
SLC25A35
solute carrier family 25 member 35
chr17_+_18183052 0.17 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr17_+_41966787 0.17 ENST00000393892.8
ENST00000587679.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr13_+_45702306 0.17 ENST00000533564.1
ENST00000310521.6
CBY2
chibby family member 2
chr20_+_33283205 0.17 ENST00000253354.2
BPIFB1
BPI fold containing family B member 1
chr14_+_24120956 0.16 ENST00000558325.2
ENSG00000259371.2
novel protein
chr19_-_14835252 0.16 ENST00000641666.1
ENST00000642030.1
ENST00000642000.1
OR7C1
olfactory receptor family 7 subfamily C member 1
chr6_+_26402289 0.16 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr15_+_92900189 0.16 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr14_+_55027576 0.16 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr6_+_47781982 0.16 ENST00000489301.6
ENST00000638973.1
ENST00000371211.6
ENST00000393699.2
OPN5
opsin 5
chr3_-_157503339 0.16 ENST00000392833.6
VEPH1
ventricular zone expressed PH domain containing 1
chr13_+_45702411 0.15 ENST00000610924.1
CBY2
chibby family member 2
chr19_+_52297157 0.15 ENST00000595962.6
ENST00000598016.5
ENST00000334564.11
ENST00000490272.1
ZNF480
zinc finger protein 480
chr17_+_76467597 0.15 ENST00000392492.8
AANAT
aralkylamine N-acetyltransferase
chr6_+_26440472 0.14 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr19_-_14835162 0.14 ENST00000322301.5
OR7A5
olfactory receptor family 7 subfamily A member 5
chr7_-_143902114 0.14 ENST00000355951.2
ENST00000479870.6
ENST00000478172.1
TCAF1
TRPM8 channel associated factor 1
chr13_+_53028806 0.14 ENST00000219022.3
OLFM4
olfactomedin 4
chrX_+_55717733 0.13 ENST00000414239.5
ENST00000374941.9
RRAGB
Ras related GTP binding B
chr7_+_8433602 0.13 ENST00000405863.6
NXPH1
neurexophilin 1
chr11_-_117316230 0.13 ENST00000313005.11
ENST00000528053.5
BACE1
beta-secretase 1
chr2_+_102473219 0.13 ENST00000295269.5
SLC9A4
solute carrier family 9 member A4
chr6_-_41071825 0.13 ENST00000468811.5
OARD1
O-acyl-ADP-ribose deacylase 1
chr11_-_18046262 0.13 ENST00000682019.1
TPH1
tryptophan hydroxylase 1
chr12_+_26195647 0.13 ENST00000535504.1
SSPN
sarcospan
chr13_-_61415508 0.13 ENST00000409204.4
PCDH20
protocadherin 20
chrX_+_55717796 0.12 ENST00000262850.7
RRAGB
Ras related GTP binding B
chr2_-_20823048 0.12 ENST00000402479.6
ENST00000237822.8
ENST00000626491.2
ENST00000432947.1
ENST00000403006.6
ENST00000419825.2
ENST00000381090.7
ENST00000412261.5
ENST00000619656.4
ENST00000541941.5
ENST00000440866.6
ENST00000435420.6
LDAH
lipid droplet associated hydrolase
chr1_-_109075944 0.12 ENST00000338366.6
TAF13
TATA-box binding protein associated factor 13
chr17_+_68515399 0.12 ENST00000588188.6
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr1_+_117001744 0.12 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr12_+_8509460 0.12 ENST00000382064.6
CLEC4D
C-type lectin domain family 4 member D
chrX_+_109535775 0.12 ENST00000218004.5
NXT2
nuclear transport factor 2 like export factor 2
chr7_+_150323239 0.12 ENST00000323078.7
ENST00000493307.1
ENST00000359623.9
LRRC61
leucine rich repeat containing 61
chr19_+_21142024 0.12 ENST00000600692.5
ENST00000599296.5
ENST00000594425.5
ENST00000311048.11
ZNF431
zinc finger protein 431
chr1_+_248508073 0.11 ENST00000641804.1
OR2G6
olfactory receptor family 2 subfamily G member 6
chr2_-_74392025 0.11 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr9_+_93234923 0.11 ENST00000411624.5
WNK2
WNK lysine deficient protein kinase 2
chr15_+_64387828 0.11 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr18_+_34976928 0.10 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr20_-_31390483 0.10 ENST00000376315.2
DEFB119
defensin beta 119
chr14_-_106470788 0.10 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr8_-_89984231 0.10 ENST00000517337.1
ENST00000409330.5
NBN
nibrin
chr11_-_102705737 0.10 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chr15_+_21579912 0.10 ENST00000628444.1
LINC02203
long intergenic non-protein coding RNA 2203
chr8_-_115492221 0.10 ENST00000518018.1
TRPS1
transcriptional repressor GATA binding 1
chr16_+_28553908 0.10 ENST00000317058.8
SGF29
SAGA complex associated factor 29
chr6_-_111793871 0.09 ENST00000368667.6
FYN
FYN proto-oncogene, Src family tyrosine kinase
chr3_-_99850976 0.09 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr14_-_106658251 0.09 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr3_-_157499538 0.09 ENST00000392832.6
VEPH1
ventricular zone expressed PH domain containing 1
chr9_-_28670285 0.09 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
LINGO2
leucine rich repeat and Ig domain containing 2
chr6_+_122471913 0.09 ENST00000615438.4
ENST00000392491.6
PKIB
cAMP-dependent protein kinase inhibitor beta
chr14_+_21997531 0.09 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr12_+_8513499 0.09 ENST00000299665.3
CLEC4D
C-type lectin domain family 4 member D
chr3_+_141387801 0.08 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr3_-_191282383 0.08 ENST00000427544.6
UTS2B
urotensin 2B
chr2_-_190250503 0.08 ENST00000409820.2
ENST00000410045.5
HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr7_+_134127299 0.08 ENST00000645682.1
ENST00000285928.2
LRGUK
leucine rich repeats and guanylate kinase domain containing
chr16_-_71809049 0.08 ENST00000569748.5
ENST00000570017.1
ENST00000393512.7
AP1G1
adaptor related protein complex 1 subunit gamma 1
chr1_-_212791762 0.08 ENST00000626725.1
ENST00000366977.8
ENST00000366976.3
NSL1
NSL1 component of MIS12 kinetochore complex
chr7_-_122098831 0.08 ENST00000681213.1
ENST00000679419.1
AASS
aminoadipate-semialdehyde synthase
chr3_-_146528750 0.08 ENST00000483300.5
PLSCR1
phospholipid scramblase 1
chr3_+_44799187 0.07 ENST00000425755.5
KIF15
kinesin family member 15
chr3_-_186544377 0.07 ENST00000307944.6
CRYGS
crystallin gamma S
chr4_+_186069144 0.07 ENST00000513189.1
ENST00000296795.8
TLR3
toll like receptor 3
chr20_-_35529618 0.07 ENST00000246199.5
ENST00000424444.1
ENST00000374345.8
ENST00000444723.3
C20orf173
chromosome 20 open reading frame 173
chr3_+_140678041 0.07 ENST00000286349.4
TRIM42
tripartite motif containing 42
chr1_-_158426237 0.07 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr1_-_100894818 0.07 ENST00000370114.8
EXTL2
exostosin like glycosyltransferase 2
chr1_-_100894775 0.07 ENST00000416479.1
ENST00000370113.7
EXTL2
exostosin like glycosyltransferase 2
chr9_+_34652167 0.07 ENST00000441545.7
ENST00000553620.5
IL11RA
interleukin 11 receptor subunit alpha
chr12_+_9971402 0.07 ENST00000304361.9
ENST00000396507.7
ENST00000434319.6
CLEC12A
C-type lectin domain family 12 member A
chr4_+_26343156 0.07 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_70226116 0.07 ENST00000317987.6
FDCSP
follicular dendritic cell secreted protein
chr3_+_141738263 0.07 ENST00000480908.1
ENST00000393000.3
ENST00000273480.4
RNF7
ring finger protein 7
chr1_-_157700738 0.07 ENST00000368186.9
ENST00000496769.1
ENST00000368184.8
FCRL3
Fc receptor like 3
chr4_-_151227881 0.07 ENST00000652233.1
ENST00000514152.5
SH3D19
SH3 domain containing 19
chr2_+_30447211 0.06 ENST00000466477.5
ENST00000465200.5
ENST00000319406.8
ENST00000379509.8
ENST00000488144.5
ENST00000465538.5
ENST00000309052.8
LCLAT1
lysocardiolipin acyltransferase 1
chr5_-_131165231 0.06 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
HINT1
histidine triad nucleotide binding protein 1
chr5_-_131165272 0.06 ENST00000675491.1
ENST00000506908.2
HINT1
histidine triad nucleotide binding protein 1
chr5_-_177462379 0.06 ENST00000512501.1
DBN1
drebrin 1
chr9_-_74952904 0.06 ENST00000376854.6
C9orf40
chromosome 9 open reading frame 40
chr9_+_108862255 0.06 ENST00000333999.5
ACTL7A
actin like 7A
chr18_-_36798482 0.06 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr8_-_92966129 0.06 ENST00000522925.5
ENST00000522903.5
ENST00000537541.1
ENST00000521988.6
ENST00000518748.5
ENST00000519069.5
TRIQK
triple QxxK/R motif containing
chr12_-_118359105 0.06 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr6_-_169250825 0.06 ENST00000676869.1
ENST00000676760.1
THBS2
thrombospondin 2
chr7_-_87475839 0.06 ENST00000359206.8
ABCB4
ATP binding cassette subfamily B member 4
chr15_-_75455767 0.05 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chrX_+_77910656 0.05 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATP7A
PGK1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr19_-_44401575 0.05 ENST00000591679.5
ENST00000544719.6
ENST00000614994.5
ENST00000585868.1
ENST00000588212.1
ZNF285
ENSG00000267173.1
zinc finger protein 285
novel protein

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.6 3.7 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.5 1.4 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.4 1.3 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.4 1.2 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.3 2.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.2 1.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699)
0.2 1.7 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.2 0.7 GO:0061011 hepatic duct development(GO:0061011)
0.2 0.8 GO:1904383 response to sodium phosphate(GO:1904383)
0.2 0.7 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.6 GO:1990523 bone regeneration(GO:1990523)
0.1 0.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.5 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.3 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.4 GO:1902523 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.4 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.1 0.6 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.5 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.8 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 0.2 GO:0006711 estrogen catabolic process(GO:0006711)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.8 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 0.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.3 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 1.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.7 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 1.6 GO:0030728 ovulation(GO:0030728)
0.0 0.3 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.2 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0042435 serotonin biosynthetic process(GO:0042427) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.1 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0072573 tolerance induction to lipopolysaccharide(GO:0072573)
0.0 0.1 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0031860 regulation of DNA-dependent DNA replication initiation(GO:0030174) telomeric 3' overhang formation(GO:0031860)
0.0 1.1 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:1905237 response to cyclosporin A(GO:1905237) positive regulation of response to drug(GO:2001025)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0034344 microglial cell activation involved in immune response(GO:0002282) regulation of dendritic cell cytokine production(GO:0002730) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.8 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.0 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390) metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 2.3 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.5 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.6 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0033306 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 2.1 GO:0043203 axon hillock(GO:0043203)
0.2 1.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.4 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 0.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0019770 IgG receptor activity(GO:0019770)
0.5 3.7 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.3 0.8 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 0.9 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 1.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.2 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.7 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.3 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.8 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.7 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.7 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.5 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.0 GO:0019166 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 2.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME OPSINS Genes involved in Opsins