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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for PLAGL1
Z-value: 1.53
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg38_v1_chr6_-_144008396_144008430 | -0.78 | 2.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_3028356 Show fit | 1.13 |
ENST00000586422.5
|
TLE family member 2, transcriptional corepressor |
|
| chr21_+_46098102 Show fit | 1.08 |
ENST00000300527.9
ENST00000310645.9 |
collagen type VI alpha 2 chain |
|
| chr5_-_169300782 Show fit | 0.98 |
ENST00000332966.8
|
slit guidance ligand 3 |
|
| chr9_-_93134234 Show fit | 0.95 |
ENST00000375446.5
|
ninjurin 1 |
|
| chr20_+_64063481 Show fit | 0.92 |
ENST00000415602.5
|
transcription elongation factor A2 |
|
| chr20_+_64063105 Show fit | 0.92 |
ENST00000395053.7
ENST00000343484.10 ENST00000339217.8 |
transcription elongation factor A2 |
|
| chr14_-_91947383 Show fit | 0.88 |
ENST00000267620.14
|
fibulin 5 |
|
| chr6_-_73452124 Show fit | 0.88 |
ENST00000680833.1
|
cyclic GMP-AMP synthase |
|
| chr16_+_2830155 Show fit | 0.87 |
ENST00000382280.7
|
zymogen granule protein 16B |
|
| chr4_-_56656448 Show fit | 0.86 |
ENST00000553379.6
|
HOP homeobox |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | GO:1902807 | negative regulation of cell cycle G1/S phase transition(GO:1902807) |
| 0.2 | 2.9 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 2.8 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 2.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 2.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 2.7 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.1 | 2.6 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 2.4 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.1 | 2.2 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.1 | 2.1 | GO:0060180 | female mating behavior(GO:0060180) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 3.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.4 | 3.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 3.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 2.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 5.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 4.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 3.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 2.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 2.7 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 2.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 2.2 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 2.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 2.1 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.9 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 2.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 2.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 5.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 4.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 3.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 3.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 3.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |