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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for POU4F2

Z-value: 0.39

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_114684612 0.40 ENST00000533213.6
ENST00000369252.8
ABLIM1
actin binding LIM protein 1
chr10_-_114684457 0.39 ENST00000392955.7
ABLIM1
actin binding LIM protein 1
chr1_+_160400543 0.36 ENST00000368061.3
VANGL2
VANGL planar cell polarity protein 2
chr2_-_70553440 0.26 ENST00000450929.5
TGFA
transforming growth factor alpha
chr5_-_135578983 0.22 ENST00000512158.6
CXCL14
C-X-C motif chemokine ligand 14
chr6_-_25874212 0.16 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr12_-_89352487 0.15 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr8_+_49911801 0.15 ENST00000643809.1
SNTG1
syntrophin gamma 1
chr12_-_89352395 0.14 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr6_+_130018565 0.13 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr5_+_67004618 0.13 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr7_-_25228485 0.13 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr4_+_75556048 0.12 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr3_+_63443076 0.11 ENST00000295894.9
SYNPR
synaptoporin
chr21_-_30813270 0.10 ENST00000329621.6
KRTAP8-1
keratin associated protein 8-1
chr11_+_31650024 0.10 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr7_-_81770122 0.10 ENST00000423064.7
HGF
hepatocyte growth factor
chr12_+_53954870 0.10 ENST00000243103.4
HOXC12
homeobox C12
chr6_+_157036315 0.08 ENST00000637904.1
ARID1B
AT-rich interaction domain 1B
chr4_-_122621011 0.08 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr17_-_41424583 0.08 ENST00000225550.4
KRT37
keratin 37
chr17_+_50165990 0.08 ENST00000262018.8
ENST00000344627.10
ENST00000682109.1
ENST00000504073.2
SGCA
sarcoglycan alpha
chr7_+_143284930 0.07 ENST00000409244.5
ENST00000409541.5
ENST00000410004.1
ENST00000359333.8
TMEM139
transmembrane protein 139
chr4_+_143433491 0.07 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr11_+_72114840 0.07 ENST00000622388.4
FOLR3
folate receptor gamma
chr5_+_159916475 0.07 ENST00000306675.5
ADRA1B
adrenoceptor alpha 1B
chr10_+_97584314 0.06 ENST00000370647.8
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr18_+_31318144 0.06 ENST00000257192.5
DSG1
desmoglein 1
chr9_+_122370523 0.06 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr17_+_58169401 0.06 ENST00000641866.1
OR4D2
olfactory receptor family 4 subfamily D member 2
chr8_+_22999535 0.06 ENST00000251822.7
RHOBTB2
Rho related BTB domain containing 2
chr8_-_18684093 0.06 ENST00000428502.6
PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_51875597 0.06 ENST00000446461.2
IQCF5
IQ motif containing F5
chr5_-_141619049 0.05 ENST00000647433.1
ENST00000253811.10
ENST00000389057.9
ENST00000398557.8
DIAPH1
diaphanous related formin 1
chr3_+_122055355 0.05 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr17_+_18183052 0.05 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr3_-_79767987 0.05 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr16_+_28494634 0.05 ENST00000564831.6
ENST00000431282.2
APOBR
apolipoprotein B receptor
chr17_+_18183803 0.05 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr16_-_20404731 0.05 ENST00000302451.9
PDILT
protein disulfide isomerase like, testis expressed
chr13_+_45464901 0.05 ENST00000349995.10
COG3
component of oligomeric golgi complex 3
chr5_-_141618957 0.05 ENST00000389054.8
DIAPH1
diaphanous related formin 1
chr5_-_141618914 0.04 ENST00000518047.5
DIAPH1
diaphanous related formin 1
chr17_+_70104848 0.04 ENST00000392670.5
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr11_-_107858777 0.04 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr13_-_35476682 0.04 ENST00000379919.6
MAB21L1
mab-21 like 1
chr17_-_66229380 0.04 ENST00000205948.11
APOH
apolipoprotein H
chr8_-_18684033 0.04 ENST00000614430.3
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_244862381 0.04 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr1_-_193059489 0.04 ENST00000367455.8
ENST00000421683.1
UCHL5
ubiquitin C-terminal hydrolase L5
chr16_+_19410480 0.04 ENST00000541464.5
TMC5
transmembrane channel like 5
chr20_+_57561103 0.04 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr8_+_49911604 0.04 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
SNTG1
syntrophin gamma 1
chr6_-_138499487 0.04 ENST00000343505.9
NHSL1
NHS like 1
chr7_-_81770039 0.03 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr11_-_125680869 0.03 ENST00000527795.1
ACRV1
acrosomal vesicle protein 1
chr1_-_193059296 0.03 ENST00000367450.7
ENST00000367451.8
ENST00000367454.6
ENST00000367448.5
ENST00000367449.5
UCHL5
ubiquitin C-terminal hydrolase L5
chr11_-_125680831 0.03 ENST00000315608.7
ENST00000530048.5
ENST00000533904.6
ACRV1
acrosomal vesicle protein 1
chrX_-_106903331 0.03 ENST00000411805.1
ENST00000276173.5
RIPPLY1
ripply transcriptional repressor 1
chr19_-_35812838 0.03 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr16_+_19410723 0.03 ENST00000381414.8
ENST00000396229.6
TMC5
transmembrane channel like 5
chr10_+_97584347 0.03 ENST00000370649.3
ENST00000370646.9
ENSG00000249967.1
HOGA1
novel protein
4-hydroxy-2-oxoglutarate aldolase 1
chr14_+_94026314 0.02 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr12_-_118359639 0.02 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr17_+_7407838 0.02 ENST00000302926.7
NLGN2
neuroligin 2
chr1_+_40040720 0.02 ENST00000414893.5
ENST00000372792.7
ENST00000372805.8
ENST00000414281.5
ENST00000420216.5
ENST00000372798.5
ENST00000340450.7
ENST00000435719.5
ENST00000427843.5
ENST00000417287.5
ENST00000424977.1
CAP1
cyclase associated actin cytoskeleton regulatory protein 1
chr4_-_47981535 0.02 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chr11_+_73787853 0.02 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr14_+_31561376 0.02 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr15_-_43584864 0.02 ENST00000381885.5
ENST00000396923.7
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr12_-_52385649 0.02 ENST00000257951.3
KRT84
keratin 84
chr19_-_35228699 0.02 ENST00000324675.3
FAM187B
family with sequence similarity 187 member B
chr10_-_72088533 0.02 ENST00000373109.7
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chrX_+_69616067 0.02 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
EDA
ectodysplasin A
chr8_-_18683932 0.01 ENST00000615573.4
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_90640718 0.01 ENST00000640403.1
ADGRV1
adhesion G protein-coupled receptor V1
chr19_+_45498439 0.01 ENST00000451287.7
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr6_+_118548289 0.01 ENST00000357525.6
PLN
phospholamban
chr7_-_42152444 0.01 ENST00000479210.1
GLI3
GLI family zinc finger 3
chr8_-_7486400 0.01 ENST00000335479.2
DEFB106B
defensin beta 106B
chr14_-_70416973 0.01 ENST00000555276.5
ENST00000617124.4
COX16
SYNJ2BP-COX16
cytochrome c oxidase assembly factor COX16
SYNJ2BP-COX16 readthrough
chr10_+_18260715 0.01 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr11_+_31509744 0.01 ENST00000639878.1
ENST00000379163.10
ENST00000638347.1
ENST00000350638.10
ENST00000638764.1
ENST00000639570.1
ENST00000640533.1
ENST00000638482.1
ENST00000640961.2
ENST00000640342.1
ENST00000640231.1
ENST00000640954.1
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr10_+_93612532 0.01 ENST00000371447.4
PDE6C
phosphodiesterase 6C
chr4_-_10684749 0.01 ENST00000226951.11
CLNK
cytokine dependent hematopoietic cell linker
chr6_-_89217339 0.01 ENST00000454853.7
GABRR1
gamma-aminobutyric acid type A receptor subunit rho1
chrX_-_18672101 0.01 ENST00000379984.4
RS1
retinoschisin 1
chr14_+_54754821 0.01 ENST00000555192.1
SAMD4A
sterile alpha motif domain containing 4A
chr4_-_168480477 0.01 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr4_+_168497044 0.01 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr8_+_7825137 0.01 ENST00000335186.3
DEFB106A
defensin beta 106A
chr1_+_50108856 0.01 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr9_-_14307928 0.01 ENST00000637640.1
ENST00000493697.1
ENST00000636057.1
NFIB
nuclear factor I B
chr5_+_155013755 0.00 ENST00000435029.6
KIF4B
kinesin family member 4B
chr6_+_12717660 0.00 ENST00000674637.1
PHACTR1
phosphatase and actin regulator 1
chr4_+_140343443 0.00 ENST00000338517.8
ENST00000394203.7
ENST00000506322.5
SCOC
short coiled-coil protein
chr8_-_48921419 0.00 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chrX_-_134797134 0.00 ENST00000370790.5
ENST00000493333.5
ENST00000611027.2
ENST00000343004.10
ENST00000298090.10
PABIR2
PABIR family member 2
chrX_+_134796758 0.00 ENST00000414371.6
PABIR3
PABIR family member 3
chr12_-_6124662 0.00 ENST00000261405.10
VWF
von Willebrand factor
chr4_+_168497066 0.00 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr11_-_41459592 0.00 ENST00000528697.6
ENST00000530763.5
LRRC4C
leucine rich repeat containing 4C
chr6_-_73521783 0.00 ENST00000331523.7
ENST00000356303.7
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr11_+_118304721 0.00 ENST00000361763.9
CD3E
CD3e molecule
chr17_-_40799939 0.00 ENST00000306658.8
KRT28
keratin 28

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0043017 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.0 0.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0097026 dendritic cell dendrite assembly(GO:0097026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated