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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for POU6F1

Z-value: 0.37

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.17 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg38_v1_chr12_-_51217671_51217827-0.502.0e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_91153149 0.29 ENST00000550758.1
DCN
decorin
chr2_-_201698692 0.22 ENST00000315506.11
ENST00000359962.9
ENST00000620095.4
MPP4
membrane palmitoylated protein 4
chr2_-_201698628 0.22 ENST00000602867.1
ENST00000409474.8
MPP4
membrane palmitoylated protein 4
chr2_-_201697993 0.22 ENST00000428900.6
MPP4
membrane palmitoylated protein 4
chr2_-_201698040 0.22 ENST00000396886.7
ENST00000409143.5
MPP4
membrane palmitoylated protein 4
chr6_+_151325665 0.18 ENST00000354675.10
AKAP12
A-kinase anchoring protein 12
chr13_+_101489940 0.18 ENST00000376162.7
ITGBL1
integrin subunit beta like 1
chr9_-_76906041 0.17 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
PRUNE2
prune homolog 2 with BCH domain
chr6_+_29306626 0.16 ENST00000377160.4
OR14J1
olfactory receptor family 14 subfamily J member 1
chr2_+_102104563 0.14 ENST00000409589.5
ENST00000409329.5
IL1R1
interleukin 1 receptor type 1
chr11_-_89490715 0.14 ENST00000528341.5
NOX4
NADPH oxidase 4
chr22_-_28306645 0.12 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chrX_-_123622809 0.12 ENST00000441692.5
THOC2
THO complex 2
chr1_-_197146620 0.11 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr2_-_216694794 0.09 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr7_+_48455063 0.08 ENST00000411975.5
ABCA13
ATP binding cassette subfamily A member 13
chr16_-_58684707 0.08 ENST00000564100.5
ENST00000570101.5
ENST00000562397.5
ENST00000219320.9
ENST00000564010.5
ENST00000570214.5
ENST00000563196.5
SLC38A7
solute carrier family 38 member 7
chr5_-_16916400 0.08 ENST00000513882.5
MYO10
myosin X
chr2_-_165203870 0.07 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr12_-_30735014 0.07 ENST00000433722.6
CAPRIN2
caprin family member 2
chr1_-_197146688 0.07 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr14_+_22515623 0.07 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr11_-_89491131 0.07 ENST00000343727.9
ENST00000531342.5
ENST00000375979.7
NOX4
NADPH oxidase 4
chr3_-_127822455 0.06 ENST00000265052.10
MGLL
monoglyceride lipase
chr11_-_33717409 0.06 ENST00000651485.1
CD59
CD59 molecule (CD59 blood group)
chr2_-_165204042 0.06 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr5_+_68290637 0.06 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr1_+_207325629 0.06 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chrX_-_123623155 0.06 ENST00000618150.4
THOC2
THO complex 2
chr11_+_89924064 0.05 ENST00000623787.3
TRIM49D2
tripartite motif containing 49D2
chr11_-_2301859 0.05 ENST00000456145.2
ENST00000381153.8
C11orf21
chromosome 11 open reading frame 21
chr7_+_148590760 0.05 ENST00000307003.3
C7orf33
chromosome 7 open reading frame 33
chr4_+_107824555 0.05 ENST00000394684.8
SGMS2
sphingomyelin synthase 2
chr11_-_107858777 0.05 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr22_+_31122923 0.05 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr6_+_42155399 0.04 ENST00000623004.2
ENST00000372963.4
ENST00000654459.1
GUCA1ANB
GUCA1A
GUCA1A neighbor
guanylate cyclase activator 1A
chr7_-_77798359 0.04 ENST00000257663.4
TMEM60
transmembrane protein 60
chr2_+_114461593 0.04 ENST00000409163.5
DPP10
dipeptidyl peptidase like 10
chr5_-_144170607 0.04 ENST00000448443.6
ENST00000513112.5
ENST00000519064.5
ENST00000274496.10
ENST00000522203.5
YIPF5
Yip1 domain family member 5
chr12_-_7444139 0.04 ENST00000416109.2
ENST00000313599.8
CD163L1
CD163 molecule like 1
chrX_+_120604084 0.04 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr17_-_28645108 0.04 ENST00000528896.7
KIAA0100
KIAA0100
chr14_+_67701886 0.04 ENST00000551171.6
RDH12
retinol dehydrogenase 12
chr20_-_56497608 0.04 ENST00000617620.1
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr20_+_35542038 0.04 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC3
ERGIC and golgi 3
chr9_-_86947496 0.03 ENST00000298743.9
GAS1
growth arrest specific 1
chr3_-_108529322 0.03 ENST00000273353.4
MYH15
myosin heavy chain 15
chr1_+_176463164 0.03 ENST00000367661.7
ENST00000367662.5
PAPPA2
pappalysin 2
chr4_-_168480477 0.03 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr9_-_114806031 0.03 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr15_-_84716129 0.03 ENST00000268220.12
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr6_-_111483700 0.03 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr15_-_84716153 0.03 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr12_+_102120172 0.03 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr13_+_97960192 0.02 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
IPO5
importin 5
chr9_-_4666495 0.02 ENST00000475086.5
SPATA6L
spermatogenesis associated 6 like
chr19_-_35228699 0.02 ENST00000324675.3
FAM187B
family with sequence similarity 187 member B
chr8_-_18683932 0.02 ENST00000615573.4
PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_25754699 0.02 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr15_-_84716099 0.02 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr4_+_122239965 0.02 ENST00000446180.5
KIAA1109
KIAA1109
chr1_-_151459169 0.02 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr1_+_107141022 0.02 ENST00000370067.5
ENST00000370068.6
NTNG1
netrin G1
chr11_+_2302119 0.02 ENST00000381121.7
TSPAN32
tetraspanin 32
chr15_-_84716063 0.02 ENST00000558217.5
ENST00000558196.1
ENST00000558134.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr8_-_89984609 0.02 ENST00000519426.5
ENST00000265433.8
NBN
nibrin
chr1_-_21050952 0.02 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chrX_-_100874332 0.02 ENST00000372960.8
NOX1
NADPH oxidase 1
chr9_+_128882119 0.02 ENST00000372600.9
ENST00000372599.7
LRRC8A
leucine rich repeat containing 8 VRAC subunit A
chrX_-_100874351 0.02 ENST00000372966.8
NOX1
NADPH oxidase 1
chr5_+_90640718 0.02 ENST00000640403.1
ADGRV1
adhesion G protein-coupled receptor V1
chr16_+_19410723 0.01 ENST00000381414.8
ENST00000396229.6
TMC5
transmembrane channel like 5
chr9_+_101028721 0.01 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr2_-_202911621 0.01 ENST00000261015.5
WDR12
WD repeat domain 12
chr19_-_3786254 0.01 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr8_+_117135259 0.01 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr9_-_4666347 0.01 ENST00000381890.9
ENST00000682582.1
SPATA6L
spermatogenesis associated 6 like
chr15_+_58987652 0.01 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr5_+_132873660 0.01 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chr6_-_47042306 0.01 ENST00000371253.7
ADGRF1
adhesion G protein-coupled receptor F1
chr2_-_197675578 0.01 ENST00000295049.9
RFTN2
raftlin family member 2
chr7_+_150322639 0.01 ENST00000343855.6
ZBED6CL
ZBED6 C-terminal like
chr16_+_19410480 0.01 ENST00000541464.5
TMC5
transmembrane channel like 5
chr15_+_44736522 0.01 ENST00000329464.9
ENST00000558329.5
ENST00000560442.5
ENST00000561043.5
TRIM69
tripartite motif containing 69
chr2_-_178651500 0.01 ENST00000446966.1
ENST00000426232.5
TTN
titin
chr11_-_4393650 0.01 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr8_+_117134989 0.01 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr9_-_13165442 0.01 ENST00000542239.1
ENST00000538841.5
ENST00000433359.6
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr15_+_44736556 0.01 ENST00000338264.8
TRIM69
tripartite motif containing 69
chr7_+_141790217 0.01 ENST00000247883.5
TAS2R5
taste 2 receptor member 5
chr20_+_59940362 0.01 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr9_-_110337808 0.01 ENST00000374510.8
ENST00000374507.4
ENST00000423740.7
ENST00000374511.7
TXNDC8
thioredoxin domain containing 8
chr8_+_91249307 0.01 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr1_-_151459471 0.00 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr12_+_102120240 0.00 ENST00000537257.5
ENST00000392911.6
PARPBP
PARP1 binding protein
chr12_+_119668109 0.00 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr2_+_11539833 0.00 ENST00000263834.9
GREB1
growth regulating estrogen receptor binding 1
chr17_+_7407838 0.00 ENST00000302926.7
NLGN2
neuroligin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.0 GO:0002188 translation reinitiation(GO:0002188)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0060342 photoreceptor inner segment membrane(GO:0060342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.0 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation