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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for REST

Z-value: 0.37

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.19 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908894_56909016,
hg38_v1_chr4_+_56907876_56907947		-0.561.5e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_155070317 0.22 ENST00000287907.3
HTR5A
5-hydroxytryptamine receptor 5A
chr1_+_209938207 0.14 ENST00000472886.5
SYT14
synaptotagmin 14
chr12_+_71439976 0.13 ENST00000536515.5
ENST00000540815.2
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr1_+_209938169 0.13 ENST00000367019.5
ENST00000537238.5
ENST00000637265.1
SYT14
synaptotagmin 14
chr12_+_71439789 0.11 ENST00000266674.10
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr9_-_101594995 0.11 ENST00000636434.1
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chr17_-_3433841 0.10 ENST00000248384.1
OR1E2
olfactory receptor family 1 subfamily E member 2
chr2_-_47570905 0.09 ENST00000327876.5
KCNK12
potassium two pore domain channel subfamily K member 12
chr20_+_5911501 0.08 ENST00000378961.9
ENST00000455042.1
CHGB
chromogranin B
chr11_+_20599602 0.08 ENST00000525748.6
SLC6A5
solute carrier family 6 member 5
chr12_+_113358542 0.08 ENST00000545182.6
ENST00000280800.5
PLBD2
phospholipase B domain containing 2
chr14_+_92923143 0.08 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr15_-_72320149 0.07 ENST00000287202.10
CELF6
CUGBP Elav-like family member 6
chr17_+_32486975 0.07 ENST00000313401.4
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
chr3_+_194136138 0.07 ENST00000232424.4
HES1
hes family bHLH transcription factor 1
chr1_+_154567820 0.06 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr11_-_6655788 0.06 ENST00000299441.5
DCHS1
dachsous cadherin-related 1
chr3_+_120908072 0.06 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
STXBP5L
syntaxin binding protein 5 like
chr11_-_125903190 0.06 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
PUS3
pseudouridine synthase 3
chr11_+_62613236 0.05 ENST00000278833.4
ROM1
retinal outer segment membrane protein 1
chr11_+_92969651 0.05 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr16_+_285680 0.05 ENST00000435833.1
PDIA2
protein disulfide isomerase family A member 2
chr11_-_93197932 0.05 ENST00000326402.9
SLC36A4
solute carrier family 36 member 4
chrX_-_49200174 0.05 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr14_+_93430927 0.05 ENST00000393151.6
UNC79
unc-79 homolog, NALCN channel complex subunit
chr9_+_132582581 0.05 ENST00000263610.7
BARHL1
BarH like homeobox 1
chr2_-_51032390 0.05 ENST00000404971.5
NRXN1
neurexin 1
chrX_+_7147675 0.05 ENST00000674429.1
STS
steroid sulfatase
chr19_+_39268394 0.05 ENST00000331982.6
IFNL2
interferon lambda 2
chr11_+_637244 0.05 ENST00000176183.6
DRD4
dopamine receptor D4
chr2_+_225399684 0.05 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr8_-_90082871 0.05 ENST00000265431.7
CALB1
calbindin 1
chrX_+_7147237 0.04 ENST00000666110.2
STS
steroid sulfatase
chr9_-_101594918 0.04 ENST00000374806.2
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chr2_-_51032151 0.04 ENST00000628515.2
NRXN1
neurexin 1
chr3_-_114179052 0.04 ENST00000383673.5
ENST00000295881.9
DRD3
dopamine receptor D3
chr16_+_2969270 0.04 ENST00000293978.12
PAQR4
progestin and adipoQ receptor family member 4
chr10_-_101031095 0.04 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chr16_+_2969307 0.03 ENST00000576565.1
ENST00000318782.9
PAQR4
progestin and adipoQ receptor family member 4
chr5_+_175871570 0.03 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr12_-_29783798 0.03 ENST00000552618.5
ENST00000551659.5
ENST00000539277.6
TMTC1
transmembrane O-mannosyltransferase targeting cadherins 1
chr9_-_133609325 0.03 ENST00000673969.1
FAM163B
family with sequence similarity 163 member B
chr2_-_51032091 0.03 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr12_-_57050102 0.03 ENST00000300119.8
MYO1A
myosin IA
chr2_-_27308445 0.03 ENST00000296099.2
UCN
urocortin
chr6_+_154039102 0.03 ENST00000360422.8
ENST00000330432.12
OPRM1
opioid receptor mu 1
chr3_-_114178698 0.03 ENST00000467632.5
DRD3
dopamine receptor D3
chr1_+_32886456 0.03 ENST00000373467.4
HPCA
hippocalcin
chr1_+_37793865 0.03 ENST00000397631.7
MANEAL
mannosidase endo-alpha like
chr14_+_93430853 0.03 ENST00000553484.5
UNC79
unc-79 homolog, NALCN channel complex subunit
chr1_-_151716782 0.03 ENST00000420342.1
ENST00000290583.9
CELF3
CUGBP Elav-like family member 3
chr17_+_58148384 0.03 ENST00000268912.6
ENST00000641449.1
OR4D1
olfactory receptor family 4 subfamily D member 1
chr8_+_6708626 0.03 ENST00000285518.11
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr4_-_174829212 0.03 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr19_+_40530464 0.03 ENST00000392023.1
SPTBN4
spectrin beta, non-erythrocytic 4
chr2_+_130756291 0.03 ENST00000458606.5
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr12_+_66755 0.03 ENST00000538872.6
IQSEC3
IQ motif and Sec7 domain ArfGEF 3
chr19_-_55180010 0.02 ENST00000589172.5
SYT5
synaptotagmin 5
chr6_+_158536398 0.02 ENST00000367090.4
TMEM181
transmembrane protein 181
chr3_+_75906666 0.02 ENST00000487694.7
ENST00000602589.5
ROBO2
roundabout guidance receptor 2
chr10_-_49762335 0.02 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr1_-_101996919 0.02 ENST00000370103.9
OLFM3
olfactomedin 3
chr3_+_62319037 0.02 ENST00000494481.5
C3orf14
chromosome 3 open reading frame 14
chr19_-_3971051 0.02 ENST00000545797.7
ENST00000596311.5
DAPK3
death associated protein kinase 3
chr1_+_37793787 0.02 ENST00000373045.11
MANEAL
mannosidase endo-alpha like
chr1_+_212432891 0.02 ENST00000366988.5
NENF
neudesin neurotrophic factor
chr17_-_3398410 0.02 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr3_+_62318983 0.02 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
C3orf14
chromosome 3 open reading frame 14
chr4_+_157220654 0.02 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr10_-_44385043 0.02 ENST00000374426.6
ENST00000395794.2
ENST00000374429.6
ENST00000395793.7
ENST00000343575.10
ENST00000395795.5
CXCL12
C-X-C motif chemokine ligand 12
chr10_-_49762276 0.02 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr9_-_121050264 0.02 ENST00000223642.3
C5
complement C5
chr20_+_37383648 0.02 ENST00000373567.6
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
chr9_+_135714582 0.01 ENST00000630792.2
KCNT1
potassium sodium-activated channel subfamily T member 1
chr16_+_4958289 0.01 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr9_+_135714425 0.01 ENST00000473941.5
ENST00000486577.6
KCNT1
potassium sodium-activated channel subfamily T member 1
chr5_+_71719267 0.01 ENST00000296777.5
CARTPT
CART prepropeptide
chr17_-_7315084 0.01 ENST00000570780.5
GPS2
G protein pathway suppressor 2
chr2_-_51032536 0.01 ENST00000626899.1
ENST00000406316.6
NRXN1
neurexin 1
chr10_+_59177161 0.01 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein like
chr4_+_157220691 0.01 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr11_+_45885625 0.01 ENST00000241014.6
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr16_+_31459950 0.01 ENST00000564900.1
ARMC5
armadillo repeat containing 5
chr6_+_109978256 0.01 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr1_+_154567770 0.01 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr1_-_175743529 0.01 ENST00000367674.7
ENST00000263525.6
TNR
tenascin R
chrX_-_47619850 0.01 ENST00000295987.13
ENST00000340666.5
SYN1
synapsin I
chr16_+_24256313 0.01 ENST00000005284.4
CACNG3
calcium voltage-gated channel auxiliary subunit gamma 3
chr18_-_43277482 0.01 ENST00000255224.8
ENST00000590752.5
ENST00000596867.1
SYT4
synaptotagmin 4
chr21_-_32728030 0.01 ENST00000382499.7
ENST00000433931.7
ENST00000382491.7
SYNJ1
synaptojanin 1
chr6_+_109978297 0.01 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr7_+_8433602 0.00 ENST00000405863.6
NXPH1
neurexophilin 1
chr14_-_94293071 0.00 ENST00000554723.5
SERPINA10
serpin family A member 10
chr14_-_94293024 0.00 ENST00000393096.5
SERPINA10
serpin family A member 10
chr14_-_94293260 0.00 ENST00000261994.9
SERPINA10
serpin family A member 10
chr3_-_132035004 0.00 ENST00000429747.6
CPNE4
copine 4
chr6_+_138404206 0.00 ENST00000607197.6
ENST00000367697.7
HEBP2
heme binding protein 2
chr3_-_48662877 0.00 ENST00000164024.5
CELSR3
cadherin EGF LAG seven-pass G-type receptor 3
chrX_-_153971810 0.00 ENST00000310441.12
HCFC1
host cell factor C1
chr1_+_171781635 0.00 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr9_+_137139481 0.00 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr5_-_151924824 0.00 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chr17_+_44308573 0.00 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUNDC3A
RUN domain containing 3A

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.1 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.0 0.1 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0060164 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.0 GO:0051944 positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.0 GO:0035483 gastric motility(GO:0035482) gastric emptying(GO:0035483)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.1 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors