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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SHOX

Z-value: 0.99

Motif logo

Transcription factors associated with SHOX

Gene Symbol Gene ID Gene Info
ENSG00000185960.14 short stature homeobox
ENSG00000185960.14 short stature homeobox

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_151316795 2.57 ENST00000260843.5
G protein-coupled receptor 87
chr1_-_242449478 1.69 ENST00000427495.5
phospholipase D family member 5
chr19_-_51019699 1.42 ENST00000358789.8
kallikrein related peptidase 10
chr5_-_1882902 1.17 ENST00000231357.7
iroquois homeobox 4
chr7_-_41703062 1.17 ENST00000242208.5
inhibin subunit beta A
chr12_-_27970273 1.16 ENST00000542963.1
ENST00000535992.5
parathyroid hormone like hormone
chr12_-_27970047 1.15 ENST00000395868.7
parathyroid hormone like hormone
chr19_-_51020154 1.09 ENST00000391805.5
ENST00000599077.1
kallikrein related peptidase 10
chr19_-_51020019 1.04 ENST00000309958.7
kallikrein related peptidase 10
chr8_+_32647080 1.03 ENST00000520502.7
ENST00000523041.2
ENST00000650819.1
neuregulin 1
chr15_+_100879822 1.00 ENST00000329841.10
ENST00000557963.1
ENST00000346623.6
aldehyde dehydrogenase 1 family member A3
chr5_+_53480619 0.94 ENST00000396947.7
ENST00000256759.8
follistatin
chr7_-_22193824 0.86 ENST00000401957.6
Rap guanine nucleotide exchange factor 5
chr7_-_22194709 0.85 ENST00000458533.5
Rap guanine nucleotide exchange factor 5
chr6_-_136466858 0.81 ENST00000544465.5
microtubule associated protein 7
chr18_+_36544544 0.78 ENST00000591635.5
formin homology 2 domain containing 3
chr13_-_85799400 0.77 ENST00000647374.2
SLIT and NTRK like family member 6
chr7_+_70596078 0.73 ENST00000644506.1
activator of transcription and developmental regulator AUTS2
chr2_+_68734773 0.72 ENST00000409202.8
Rho GTPase activating protein 25
chr1_+_160400543 0.72 ENST00000368061.3
VANGL planar cell polarity protein 2
chr6_-_136526472 0.71 ENST00000454590.5
ENST00000432797.6
microtubule associated protein 7
chr8_+_32646838 0.70 ENST00000651333.1
ENST00000652592.1
neuregulin 1
chr12_-_27972725 0.69 ENST00000545234.6
parathyroid hormone like hormone
chr11_-_117876892 0.69 ENST00000539526.5
FXYD domain containing ion transport regulator 6
chr11_-_117876719 0.68 ENST00000529335.6
ENST00000260282.8
FXYD domain containing ion transport regulator 6
chr5_+_67004618 0.68 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr4_+_68447453 0.67 ENST00000305363.9
transmembrane serine protease 11E
chr11_-_117877463 0.66 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr8_+_104223320 0.64 ENST00000339750.3
regulating synaptic membrane exocytosis 2
chr3_+_111999189 0.62 ENST00000455401.6
transgelin 3
chr20_-_51802433 0.60 ENST00000395997.3
spalt like transcription factor 4
chr13_-_75366973 0.59 ENST00000648194.1
TBC1 domain family member 4
chr3_+_111998915 0.58 ENST00000478951.6
transgelin 3
chr3_+_111998739 0.57 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr3_+_111999326 0.57 ENST00000494932.1
transgelin 3
chr12_-_52434363 0.56 ENST00000252245.6
keratin 75
chr16_+_69105636 0.56 ENST00000569188.6
hyaluronan synthase 3
chr4_-_73620391 0.55 ENST00000395777.6
ENST00000307439.10
Ras association domain family member 6
chr11_-_124320197 0.54 ENST00000624618.2
olfactory receptor family 8 subfamily D member 2
chr9_+_12693327 0.52 ENST00000388918.10
tyrosinase related protein 1
chr12_+_41437680 0.52 ENST00000649474.1
ENST00000539469.6
ENST00000298919.7
PDZ domain containing ring finger 4
chr5_+_36606355 0.51 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr4_-_25863537 0.51 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr17_+_41226648 0.51 ENST00000377721.3
keratin associated protein 9-2
chr4_+_76435216 0.50 ENST00000296043.7
shroom family member 3
chrX_+_106693838 0.48 ENST00000324342.7
ring finger protein 128
chr11_-_120138104 0.47 ENST00000341846.10
tripartite motif containing 29
chr10_+_24466487 0.46 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr12_-_89352487 0.46 ENST00000548755.1
ENST00000279488.8
dual specificity phosphatase 6
chr17_+_41237998 0.46 ENST00000254072.7
keratin associated protein 9-8
chr6_+_121437378 0.46 ENST00000650427.1
ENST00000647564.1
gap junction protein alpha 1
chr7_-_22193728 0.46 ENST00000620335.4
Rap guanine nucleotide exchange factor 5
chr17_-_41118369 0.45 ENST00000391413.4
keratin associated protein 4-11
chr8_-_17676484 0.45 ENST00000634613.1
ENST00000519066.5
microtubule associated scaffold protein 1
chr12_+_26195313 0.45 ENST00000422622.3
sarcospan
chr10_-_49762276 0.44 ENST00000374103.9
oxoglutarate dehydrogenase L
chr13_+_77535669 0.44 ENST00000535157.5
sciellin
chr10_+_24208774 0.43 ENST00000376456.8
ENST00000458595.5
ENST00000376452.7
ENST00000430453.6
KIAA1217
chr10_-_49762335 0.42 ENST00000419399.4
ENST00000432695.2
oxoglutarate dehydrogenase L
chr8_+_104223344 0.42 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr21_-_40847149 0.42 ENST00000400454.6
DS cell adhesion molecule
chr10_-_102120246 0.42 ENST00000425280.2
LIM domain binding 1
chr13_+_77535681 0.41 ENST00000349847.4
sciellin
chr13_+_77535742 0.41 ENST00000377246.7
sciellin
chr1_+_153774210 0.41 ENST00000271857.6
solute carrier family 27 member 3
chr3_-_142029108 0.40 ENST00000497579.5
transcription factor Dp-2
chr12_-_89352395 0.39 ENST00000308385.6
dual specificity phosphatase 6
chr12_-_31326111 0.39 ENST00000539409.5
SIN3-HDAC complex associated factor
chr2_+_68734861 0.39 ENST00000467265.5
Rho GTPase activating protein 25
chr7_-_25228485 0.38 ENST00000222674.2
neuropeptide VF precursor
chr3_-_191282383 0.36 ENST00000427544.6
urotensin 2B
chr8_-_42377227 0.36 ENST00000220812.3
dickkopf WNT signaling pathway inhibitor 4
chr13_-_46142834 0.35 ENST00000674665.1
lymphocyte cytosolic protein 1
chr12_-_31326142 0.34 ENST00000337682.9
SIN3-HDAC complex associated factor
chr4_-_122621011 0.34 ENST00000611104.2
ENST00000648588.1
interleukin 21
chr14_-_53956811 0.34 ENST00000559087.5
ENST00000245451.9
bone morphogenetic protein 4
chr18_-_55351977 0.34 ENST00000643689.1
transcription factor 4
chr8_-_42501224 0.33 ENST00000520262.6
ENST00000517366.1
solute carrier family 20 member 2
chr3_-_27722699 0.33 ENST00000461503.2
eomesodermin
chr14_+_22497657 0.33 ENST00000390496.1
T cell receptor alpha joining 41
chr4_-_73620629 0.32 ENST00000342081.7
Ras association domain family member 6
chr18_-_55586092 0.32 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
transcription factor 4
chr18_-_55585773 0.31 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
transcription factor 4
chr6_-_39725335 0.30 ENST00000538893.5
kinesin family member 6
chr3_-_27722316 0.30 ENST00000449599.4
eomesodermin
chr8_+_100158576 0.30 ENST00000388798.7
sperm associated antigen 1
chr12_+_19205294 0.29 ENST00000424268.5
pleckstrin homology domain containing A5
chr11_-_16356538 0.29 ENST00000683767.1
SRY-box transcription factor 6
chr10_-_102120318 0.29 ENST00000673968.1
LIM domain binding 1
chr4_-_142305935 0.29 ENST00000511838.5
inositol polyphosphate-4-phosphatase type II B
chr12_+_26195543 0.29 ENST00000242729.7
sarcospan
chr3_+_130850585 0.28 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATPase secretory pathway Ca2+ transporting 1
chr4_+_94974984 0.28 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr20_-_52105644 0.28 ENST00000371523.8
ZFP64 zinc finger protein
chr3_-_52056552 0.28 ENST00000495880.2
dual specificity phosphatase 7
chr10_+_132397168 0.28 ENST00000631148.2
ENST00000305233.6
PWWP domain containing 2B
chr4_-_142305826 0.27 ENST00000514525.1
inositol polyphosphate-4-phosphatase type II B
chr20_-_51802509 0.27 ENST00000371539.7
ENST00000217086.9
spalt like transcription factor 4
chr18_+_23992773 0.27 ENST00000304621.10
tetratricopeptide repeat domain 39C
chr9_+_470291 0.27 ENST00000382303.5
KN motif and ankyrin repeat domains 1
chr6_+_130018565 0.27 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr17_-_66229380 0.27 ENST00000205948.11
apolipoprotein H
chr7_+_18496269 0.26 ENST00000432645.6
histone deacetylase 9
chr11_-_129192291 0.26 ENST00000682385.1
Rho GTPase activating protein 32
chr17_-_9791586 0.26 ENST00000571134.2
dehydrogenase/reductase 7C
chr12_-_31325494 0.25 ENST00000543615.1
SIN3-HDAC complex associated factor
chr18_+_58341038 0.25 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr12_-_31326171 0.25 ENST00000542983.1
SIN3-HDAC complex associated factor
chr3_+_122055355 0.24 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr17_-_40799939 0.24 ENST00000306658.8
keratin 28
chrX_+_135520616 0.24 ENST00000370752.4
ENST00000639893.2
integrator complex subunit 6 like
chrX_+_105948429 0.24 ENST00000540278.1
Nik related kinase
chr2_+_161416273 0.23 ENST00000389554.8
T-box brain transcription factor 1
chr6_+_26365176 0.23 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr1_+_107139996 0.23 ENST00000370073.6
ENST00000370074.8
netrin G1
chr6_+_26365215 0.23 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr13_-_35476682 0.23 ENST00000379919.6
mab-21 like 1
chrX_+_108045050 0.22 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr2_+_158968608 0.22 ENST00000263635.8
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr6_+_26402237 0.22 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr14_+_22508602 0.22 ENST00000390504.1
T cell receptor alpha joining 33
chr6_+_26365159 0.22 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
butyrophilin subfamily 3 member A2
chr13_+_108629605 0.22 ENST00000457511.7
myosin XVI
chr3_+_4680617 0.21 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr8_-_20183127 0.21 ENST00000276373.10
ENST00000519026.5
ENST00000440926.3
ENST00000437980.3
solute carrier family 18 member A1
chrX_+_108044967 0.21 ENST00000415430.7
V-set and immunoglobulin domain containing 1
chr2_-_207167220 0.21 ENST00000421199.5
ENST00000457962.5
Kruppel like factor 7
chr8_-_20183090 0.20 ENST00000265808.11
ENST00000522513.5
solute carrier family 18 member A1
chr7_+_130344810 0.20 ENST00000497503.5
ENST00000463587.5
ENST00000461828.5
ENST00000474905.6
ENST00000494311.1
ENST00000466363.6
carboxypeptidase A5
chr8_-_108787563 0.20 ENST00000297459.4
transmembrane protein 74
chr3_-_79767987 0.20 ENST00000464233.6
roundabout guidance receptor 1
chr2_-_49974182 0.20 ENST00000412315.5
ENST00000378262.7
neurexin 1
chr9_+_121567057 0.20 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr17_-_79950828 0.20 ENST00000572862.5
ENST00000573782.5
ENST00000574427.1
ENST00000570373.5
ENST00000340848.11
ENST00000576768.5
TBC1 domain family member 16
chr14_+_61187544 0.20 ENST00000555185.5
ENST00000557294.5
ENST00000556778.5
protein kinase C eta
chr6_-_111606260 0.20 ENST00000340026.10
TRAF3 interacting protein 2
chr2_+_218270392 0.19 ENST00000248451.7
ENST00000273077.9
PNKD metallo-beta-lactamase domain containing
chr12_-_16608183 0.19 ENST00000354662.5
ENST00000538051.5
LIM domain only 3
chr11_-_129192198 0.19 ENST00000310343.13
Rho GTPase activating protein 32
chr16_+_11965193 0.19 ENST00000053243.6
ENST00000396495.3
TNF receptor superfamily member 17
chr1_+_180632001 0.19 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr13_-_103066411 0.19 ENST00000245312.5
solute carrier family 10 member 2
chr5_+_127649018 0.19 ENST00000379445.7
cortexin 3
chr19_-_3557563 0.18 ENST00000389395.7
ENST00000355415.7
major facilitator superfamily domain containing 12
chr12_+_28257195 0.18 ENST00000381259.5
coiled-coil domain containing 91
chr1_+_244352627 0.18 ENST00000366537.5
ENST00000308105.5
chromosome 1 open reading frame 100
chr20_+_43916142 0.18 ENST00000423191.6
ENST00000372999.5
TOX high mobility group box family member 2
chr8_+_106726012 0.18 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr1_+_209704836 0.18 ENST00000367027.5
hydroxysteroid 11-beta dehydrogenase 1
chr12_-_16608073 0.18 ENST00000441439.6
LIM domain only 3
chr2_+_90038848 0.17 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr10_-_1737516 0.17 ENST00000381312.6
adenosine deaminase RNA specific B2 (inactive)
chr3_+_120908072 0.17 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
syntaxin binding protein 5 like
chr4_+_70334963 0.17 ENST00000273936.6
calcium binding protein, spermatid associated 1
chr7_-_111392915 0.17 ENST00000450877.5
inner mitochondrial membrane peptidase subunit 2
chr10_+_116324440 0.17 ENST00000333254.4
coiled-coil domain containing 172
chr2_-_49974155 0.17 ENST00000635519.1
neurexin 1
chr1_-_92486916 0.17 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr3_-_98517096 0.16 ENST00000513873.1
claudin domain containing 1
chr14_+_22202561 0.16 ENST00000390460.1
T cell receptor alpha variable 26-2
chr1_+_65992389 0.16 ENST00000423207.6
phosphodiesterase 4B
chr7_+_130344837 0.16 ENST00000485477.5
ENST00000431780.6
carboxypeptidase A5
chr6_-_32190170 0.16 ENST00000375050.6
PBX homeobox 2
chr12_+_20810698 0.16 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr2_+_147845020 0.15 ENST00000241416.12
activin A receptor type 2A
chr8_+_7881387 0.15 ENST00000314357.4
defensin beta 103A
chr2_+_186694007 0.15 ENST00000304698.10
family with sequence similarity 171 member B
chr7_+_116222804 0.14 ENST00000393481.6
testin LIM domain protein
chr12_+_26195647 0.14 ENST00000535504.1
sarcospan
chr12_-_86256267 0.14 ENST00000620241.4
MGAT4 family member C
chr3_-_108529322 0.14 ENST00000273353.4
myosin heavy chain 15
chr19_+_12938598 0.14 ENST00000586760.2
ENST00000316448.10
ENST00000588454.6
calreticulin
chrX_+_69616067 0.14 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
ectodysplasin A
chr21_-_30166782 0.14 ENST00000286808.5
claudin 17
chr1_-_150765735 0.14 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
cathepsin S
chr7_-_4862015 0.14 ENST00000404991.2
poly(A) polymerase beta
chr15_+_58138368 0.14 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr14_+_22271921 0.13 ENST00000390464.2
T cell receptor alpha variable 38-1
chr19_+_44891206 0.13 ENST00000405636.6
ENST00000252487.9
ENST00000592434.5
ENST00000589649.1
ENST00000426677.7
translocase of outer mitochondrial membrane 40
chr4_+_87650277 0.13 ENST00000339673.11
ENST00000282479.8
dentin matrix acidic phosphoprotein 1
chr12_-_56934403 0.13 ENST00000293502.2
short chain dehydrogenase/reductase family 9C member 7
chr2_+_102418642 0.13 ENST00000264260.6
interleukin 18 receptor accessory protein
chr11_-_117876612 0.13 ENST00000584230.1
ENST00000526014.6
ENST00000584394.5
ENST00000614497.5
ENST00000532984.1
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr8_-_7430348 0.13 ENST00000318124.3
defensin beta 103B
chr11_-_57324907 0.13 ENST00000358252.8
tankyrase 1 binding protein 1
chr12_+_80707625 0.13 ENST00000228641.4
myogenic factor 6
chr8_+_49911604 0.13 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
syntrophin gamma 1
chr11_+_107591077 0.13 ENST00000531234.5
ENST00000265840.12
ELMO domain containing 1
chr1_+_84301694 0.12 ENST00000394834.8
ENST00000370669.5
sterile alpha motif domain containing 13
chr14_+_22304051 0.12 ENST00000390466.1
T cell receptor alpha variable 39
chr8_+_49911396 0.12 ENST00000642720.2
syntrophin gamma 1
chr6_-_37697875 0.12 ENST00000434837.8
MAM domain containing glycosylphosphatidylinositol anchor 1
chrX_-_20218941 0.12 ENST00000457145.6
ribosomal protein S6 kinase A3
chr18_+_78979811 0.12 ENST00000537592.7
spalt like transcription factor 3
chr8_+_106726115 0.12 ENST00000521592.5
oxidation resistance 1
chr13_-_94479671 0.12 ENST00000377028.10
ENST00000446125.1
dopachrome tautomerase
chr4_+_87608529 0.12 ENST00000651931.1
dentin sialophosphoprotein
chr1_-_150765785 0.12 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr4_+_41612702 0.11 ENST00000509277.5
LIM and calponin homology domains 1
chr13_-_35855627 0.11 ENST00000379893.5
doublecortin like kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.4 1.2 GO:0060279 positive regulation of ovulation(GO:0060279)
0.3 1.0 GO:0060166 olfactory pit development(GO:0060166)
0.3 0.6 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.2 0.7 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.2 0.7 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.2 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.6 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 1.7 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 1.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.5 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.3 GO:0060503 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 2.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 3.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.8 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0034769 basement membrane disassembly(GO:0034769)
0.1 0.2 GO:0002668 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.1 0.2 GO:0060723 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.1 0.8 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.4 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 0.4 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.6 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.2 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.5 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.2 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.0 0.4 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.5 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 1.1 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.5 GO:0045176 apical protein localization(GO:0045176)
0.0 0.2 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.5 GO:1902224 ketone body metabolic process(GO:1902224)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.8 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 2.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.3 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392) negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0042713 sperm ejaculation(GO:0042713) Sertoli cell proliferation(GO:0060011)
0.0 0.1 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.9 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.2 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0089712 L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.1 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.0 GO:0021592 fourth ventricle development(GO:0021592)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:1902725 regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 1.5 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0070170 regulation of tooth mineralization(GO:0070170)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 0.7 GO:0060187 cell pole(GO:0060187)
0.2 0.6 GO:0036117 hyaluranon cable(GO:0036117)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 0.4 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.3 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.7 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0060342 photoreceptor inner segment membrane(GO:0060342)
0.0 1.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.8 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.0 GO:0044307 dendritic branch(GO:0044307)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 1.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 2.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 1.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.6 GO:0034597 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 1.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 2.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.5 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.1 GO:0048185 activin binding(GO:0048185)
0.0 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 1.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 2.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.0 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.6 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 2.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins